Oh, Kyu-Seon, Khan, Sikandar G., Jaspers, N.G.J., Raams, Anja, Ueda, Takahiro, Lehmann, Alan, ...
Defects in the xeroderma pigmentosum type B (XPB) gene (ERCC3), a DNA helicase involved in nucleotide excision repair (NER) and an essential subunit of the basal transcription factor, TFIIH, have...
Oh, Kyu-Seon, Khan, Sikandar G., Jaspers, N.G.J., Raams, Anja, Ueda, Takahiro, Lehmann, Alan, ...
Defects in the xeroderma pigmentosum type B (XPB) gene (ERCC3), a DNA helicase involved in nucleotide excision repair (NER) and an essential subunit of the basal transcription factor, TFIIH, have...
Giglia-Mari, G., Coin, F., Ranish, J.A., Hoogstraten, D., Theil, A., Wijgers, N., ...
DNA repair-deficient trichothiodystrophy (TTD) results from mutations in the XPD and XPB subunits of the DNA repair and transcription factor TFIIH. In a third form of DNA repair-deficient TTD, called...
A temperature-sensitive disorder in basal transcription and DNA repair in man (2001)
Vermeulen, W., Rademakers, S., Jaspers, N.G.J., Appeldoorn, E., Raams, A., Klein, B., ...
The xeroderma pigmentosum group D (XPD) helicase subunit of TFIIH functions in DNA repair and transcription initiation. Different mutations in XPD give rise to three ultraviolet-sensitive syndromes:...
DNA structural elements required for ERCC1-XPF endonuclease activity. (1998)
Laat, W.L. De, Appeldoorn, E., Jaspers, N.G.J., Hoeijmakers, J.H.J.
The heterodimeric complex ERCC1-XPF is a structure-specific endonuclease responsible for the 5' incision during mammalian nucleotide excision repair (NER). Additionally, ERCC1-XPF is thought to...
Laat, W.L. De, Appeldoorn, E., Sugasawa, K., Jaspers, N.G.J., Hoeijmakers, J.H.J.
The human single-stranded DNA-binding replication A protein (RPA) is involved in various DNA-processing events. By comparing the affinity of hRPA for artificial DNA hairpin structures with 3'- or...
Mapping of the interaction domains between human repair proteins ERCC1 and XPF. (1998)
Laat, W.L. De, Sijbers, A.M., Odijk, H., Appeldoorn, E., Jaspers, N.G.J., Hoeijmakers, J.H.J.
ERCC1-XPF is a heterodimeric protein complexinvolved in nucleotide excision repair and recombinational processes. Like its homologous complex in Saccharomyces cerevisiae , Rad10-Rad1, it acts as a...
DNA repair, cancer and aging. (1998)
Hoeijmakers, J.H.J., Weeda, G., Boer, J. De, Sugasawa, K., Vermeulen, W., ...
Recombining DNA damage repair, basal transcription and human syndromes. (1997)
Hoeijmakers, J.H.J., Weeda, G., Vermeulen, W., Winkler, G.S., Boer, J. De, ...
Mammalian nucleotide excision repair and syndromes. (1997)
Vermeulen, W., Boer, J. De, Citterio, E., Gool, A.J. Van, Jaspers, N.G.J., ...
Mutational analysis of the human nucleotide excision repair gene ERCC1. (1996)
Sijbers, A.M., Odijk, H., Berg, J. Van Den, Duin, M. Van, Westerveld, A., ...
The human DNA repair protein ERCC1 resides in a complex together with the ERCC4, ERCC11 and XP-F correcting activities, thought to perform the 5' strand incision during nucleotide excision repair...
Sijbers, A.M., Laat, W.L. De, Ariza, R.A., Biggerstaff, M., Moggs, J.G., ...
Nucleotide excision repair, which is defective in xeroderma pigmentosum (XP), involves incision of a DNA strand on each side of a lesion. We isolated a human gene homologous to yeast Rad1 and found...
Xeroderma pigmentosum-Cockayne syndrome complex : a further case (1996)
Kleijer, W.J., Jaspers, N.G.J., Simons, P.J., Schuitema-Dijkstra, A.R., Raams, A., ...
Vuuren, A.J. Van, Appeldoorn, E., Odijk, H., Humbert, S., Eker, A.P.M., Jaspers, N.G.J., ...
The nucleotide excision repair (NER) protein ERCC1 is part of a functional complex, which harbors in addition the repair correcting activities of ERCC4, ERCC11 and human XPF. ERCC1 is not associated...
Nucleotide excision repair in the test tube. (1995)
Jaspers, N.G.J., Hoeijmakers, J.H.J.
The eukaryotic nucleotide excision-repair pathway has been reconstituted in vitro, an achievement that should hasten the full enzymological characterization of this highly complex DNA-repair pathway.
Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2/TFIIH. (1994)
Vuuren, A.J. Van, Vermeulen, W., Ma, L., Weeda, G., Appeldoorn, E., Jaspers, N.G.J., ...
ERCC3 was initially identified as a gene correcting the nucleotide excision repair (NER) defect of xeroderma pigmentosum complementation group B (XP-B). The recent finding that its gene product is...
Xeroderma pigmentosum complementation group G associated with Cockayne's syndrome. (1993)
Vermeulen, W., Jaeken, J., Jaspers, N.G.J., Bootsma, D., Hoeijmakers, J.H.J.
Xeroderma pigmentosum (XP) and Cockayne syndrome (CS) are two rare inherited disorders with a clinical and cellular hypersensitivity to the UV component of the sunlight spectrum. Although the two...
Vuuren, A.J. Van, Appeldoorn, E., Odijk, H., Yasui, A., Jaspers, N.G.J., Bootsma, D., ...
Nucleotide excision repair (NER), one of the major cellular DNA repair systems, removes a wide range of lesions in a multi-enzyme reaction. In man, a NER defect due to a mutation in one of at least...
Xeroderma pigmentosum group A correcting protein from Calf Thymus. (1992)
Eker, A.P.M., Vermeulen, W., Miura, N., Tanaka, K., Jaspers, N.G.J., Hoeijmakers, J.H.J., ...
A proteinous factor was purified from calf thymus and HeLa cells, which specifically corrects the excision repair defect of xeroderma pigmentosum complementation group A (XP-A) cells. Recovery of...
Roza, L., Vermeulen, W., Eker, A.P.M., Jaspers, N.G.J., Lohman, P.H.M., ...
UV-induced thymine dimers (10 J/m2 of UV-C) were assayed in normal human and xeroderma pigmentosum (XP) fibroblasts with a monoclonal antibody against these dimers and quantitative fluorescence...
Isolation and characterization of genes involved in mammalian excision repair. (1989)
Hoeijmakers, J.H.J., Duin, M. Van, Koken, M., Yasui, A., Jaspers, N.G.J., Westerveld, A., ...
In vitro correction of cells from patients with mutagen hypersensitivity. (1989)
Jaspers, N.G.J., Roza, L., Vermeulen, W., Eker, A., Hoeijmakers, J.H.J., ...
Analysis of mammalian excision repair: from mutants to genes and gene products (1988)
Hoeijmakers, J.H.J., Duin, M. Van, Weeda, G., Troelstra, C., Eker, A.P.M., ...
Niedernhofer, Laura J., Odijk, Hanny, Budzowska, Magda, Van Drunen, Ellen, Maas, Alex, Theil, Arjan F., ...
Interstrand cross-links (ICLs) are an extremely toxic class of DNA damage incurred during normal metabolism or cancer chemotherapy. ICLs covalently tether both strands of duplex DNA, preventing the...
Niedernhofer, Laura J., Odijk, Hanny, Budzowska, Magda, Van Drunen, Ellen, Maas, Alex, Theil, Arjan F., ...
Interstrand cross-links (ICLs) are an extremely toxic class of DNA damage incurred during normal metabolism or cancer chemotherapy. ICLs covalently tether both strands of duplex DNA, preventing the...