Biggs, M.J.P., Richards, R.G., Gadegaard, N., Wilkinson, C.D.W., Oreffo, R.O.C., Dalby, M.J.
The physiochemical characteristics of a material with in vivo applications are critical for the clinical success of the implant and regulate both cellular adhesion and differentiated cellular...
Malm, J., Giannaras, D., Riehle, M.O., Gadegaard, N., Sjovall, P.
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is a promising tool for subcellular chemical analysis of biological cells. However, to obtain relevant information, the method used for...
Rossi, L., Riehle, M.O., McNamara, L.E., Burchmore, R.J.S., Dalby, M.J., McMurray, R.J., ...
Abstract not available
Kantawong, F., Burgess, K.E.V., Jayawardena, K., Hart, A., Burchmore, R.J., Gadegaard, N., ...
Topographic features can modulate cell behaviours such as proliferation, migration, differentiation and apoptosis. Biochemical mechanotransduction implies the conversion of mechanical forces (e.g....
Proteomic analysis of human osteoprogenitor response to disordered nanotopography (2008)
Kantawong, F., Burchmore, R.J.S., Gadegaard, N., Oreffo, R.O.C., Dalby, M.J.
Previous studies have shown that microgroove-initiated contact guidance can induce bone formation in osteoprogenitor cells (OPGs) and produce changes in the cell proteome. For proteomic analysis,...
Dalby, M.J., McNamara, L.E., Riehle, M.O., Burchmore, R.J.S., Kuntanawat, P., McMurray, R.J., ...
No abstract available.
Dalby, M.J., Gadegaard, N., Wilkinson, C.D.W.
It has been known for many years that cells will react to the shape of their microenvironment. It is more recently becoming clear that cells can alter their morphology, adhesions, and cytoskeleton in...
Biggs, M.J.P., Richards, R.G., Gadegaard, N., McMurray, R.J., Affrosman, S., Wilkinson, C.D.W., ...
Polymeric medical devices widely used in orthopedic surgery play key roles in fracture fixation and orthopedic implant design. Topographical modification and surface micro-roughness of these devices...
Nanotopographical control of human osteoprogenitor differentiation (2007)
Dalby, M.J., Gadegaard, N., Curtis, A.S., Oreffo, R.O.
Current load-bearing orthopaedic implants are produced in 'bio-inert' materials such as titanium alloys. When inserted into the reamed bone during hip or knee replacement surgery the implants...
From polyoxometalate building blocks to polymers and materials: the silver connection (2007)
Song, Y-F., Abbas, H., Ritchie, C., McMillian, N., Long, D-L., Gadegaard, N., ...
Molecular growth processes utilizing polyoxometalate-based building blocks with silver connecting units have been used to produce four new materials: 1, [Ag3(bhepH)8(W11.5Na0.5O40P)2]·8H2O (bhep =...
McMillan, N., Smith, L.V., De La Fuente, J.M., Parenty, A.D.C., Gadegaard, N., Pitt, A.R., ...
N-Heterocyclic cations are incorporated into proteins using 5-(2-bromoethyl)phenanthridinium bromide, which selectively reacts with either cysteine or lysine residues, resulting in...
Tubes with controllable internal nanotopography (2004)
Gadegaard, N., Dalby, M.J., Riehle, M.O., Curtis, A.S.G., Affrossman, S.
No abstract available.
Dalby, M.J., Gadegaard, N., Riehle, M.O., Wilkinson, C.D.W., Curtis, A.S.G.
In order for cells to react to topography, they must be able to sense shape. When considering nano-topography, these shapes are much smaller than the cell, but still strong responses to...
Cells react to nanoscale order and symmetry in their surroundings (2004)
Curtis, A.S.G., Gadegaard, N., Dalby, M.J., Riehle, M.O., Wilkinson, C.D.W., Aitchison, G.
Mammalian cells react to microstructured surfaces, but there is little information on the reactions to nanostructured surfaces, and such as have been tested are poorly ordered or random in their...
Rapid fibroblast adhesion to 27 nm high polymer demixed nano-topography (2004)
Dalby, M.J., Giannaras, D., Riehle, M.O., Gadegaard, N., Affrossman, S., Curtis, A.S.G.
It is well known that many cell types react strongly to micro-topography. It is rapidly becoming clear than cells will also react to nano-topography. Polymer demixing is a rapid and low-cost chemical...
Dynamic in situ electrochemical neutron reflectivity measurements (2004)
Cooper, J, Cubitt, R, Dalgleish, R, Gadegaard, N, Glidle, A, Hillman, A R, ...
Dynamic in situ electrochemical neutron reflectivity measurements (2004)
Cooper, J.M., Cubitt, R., Dalgleish, R.M., Gadegaard, N., Glidle, A., Hillman, A.R., ...
Nanofabrication of structures for cell engineering (2003)
Wilkinson, C.D.W., Thoms, S., Macintyre, D.S., Curtis, A.S.G., Riehle, M., Gadegaard, N.
Cell engineering is concerned with the combination of engineered materials with biological cells to create useful devices. Cells in the body are organised spatially and this organisation is reflected...
Cells react to nanoscale order and symmetry in their surroundings
Curtis, A.S.G., Gadegaard, N., Dalby, M.J., Riehle, M.O., Wilkinson, C.D.W., Aitchison, G.
Mammalian cells react to microstructured surfaces, but there is little information on the reactions to nanostructured surfaces, and such as have been tested are poorly ordered or random in their...
Incorporation of N-heterocyclic cations into proteins with a highly directed chemical modification
McMillan, N., Smith, L.V., De La Fuente, J.M., Parenty, A.D.C., Gadegaard, N., Pitt, A.R., ...
N-Heterocyclic cations are incorporated into proteins using 5-(2-bromoethyl)phenanthridinium bromide, which selectively reacts with either cysteine or lysine residues, resulting in...
From polyoxometalate building blocks to polymers and materials: the silver connection
Song, Y-F., Abbas, H., Ritchie, C., McMillian, N., Long, D-L., Gadegaard, N., ...
Molecular growth processes utilizing polyoxometalate-based building blocks with silver connecting units have been used to produce four new materials: 1, [Ag3(bhepH)8(W11.5Na0.5O40P)2]·8H2O (bhep =...
Nanofabrication of structures for cell engineering
Wilkinson, C.D.W., Thoms, S., Macintyre, D.S., Curtis, A.S.G., Riehle, M., Gadegaard, N.
Cell engineering is concerned with the combination of engineered materials with biological cells to create useful devices. Cells in the body are organised spatially and this organisation is reflected...
Tubes with controllable internal nanotopography
Gadegaard, N., Dalby, M.J., Riehle, M.O., Curtis, A.S.G., Affrossman, S.
No abstract available.
Investigating filopodia sensing using arrays of defined nano-pits down to 35 nm diameter in size
Dalby, M.J., Gadegaard, N., Riehle, M.O., Wilkinson, C.D.W., Curtis, A.S.G.
In order for cells to react to topography, they must be able to sense shape. When considering nano-topography, these shapes are much smaller than the cell, but still strong responses to...
Rapid fibroblast adhesion to 27 nm high polymer demixed nano-topography
Dalby, M.J., Giannaras, D., Riehle, M.O., Gadegaard, N., Affrossman, S., Curtis, A.S.G.
It is well known that many cell types react strongly to micro-topography. It is rapidly becoming clear than cells will also react to nano-topography. Polymer demixing is a rapid and low-cost chemical...
Cells react to nanoscale order and symmetry in their surroundings
Curtis, A.S.G., Gadegaard, N., Dalby, M.J., Riehle, M.O., Wilkinson, C.D.W., Aitchison, G.
Mammalian cells react to microstructured surfaces, but there is little information on the reactions to nanostructured surfaces, and such as have been tested are poorly ordered or random in their...
Nanofabrication of structures for cell engineering
Wilkinson, C.D.W., Thoms, S., Macintyre, D.S., Curtis, A.S.G., Riehle, M., Gadegaard, N.
Cell engineering is concerned with the combination of engineered materials with biological cells to create useful devices. Cells in the body are organised spatially and this organisation is reflected...
From polyoxometalate building blocks to polymers and materials: the silver connection
Song, Y-F., Abbas, H., Ritchie, C., McMillian, N., Long, D-L., Gadegaard, N., ...
Molecular growth processes utilizing polyoxometalate-based building blocks with silver connecting units have been used to produce four new materials: 1, [Ag3(bhepH)8(W11.5Na0.5O40P)2]·8H2O (bhep =...
Incorporation of N-heterocyclic cations into proteins with a highly directed chemical modification
McMillan, N., Smith, L.V., De La Fuente, J.M., Parenty, A.D.C., Gadegaard, N., Pitt, A.R., ...
N-Heterocyclic cations are incorporated into proteins using 5-(2-bromoethyl)phenanthridinium bromide, which selectively reacts with either cysteine or lysine residues, resulting in...
Tubes with controllable internal nanotopography
Gadegaard, N., Dalby, M.J., Riehle, M.O., Curtis, A.S.G., Affrossman, S.
No abstract available.
Investigating filopodia sensing using arrays of defined nano-pits down to 35 nm diameter in size
Dalby, M.J., Gadegaard, N., Riehle, M.O., Wilkinson, C.D.W., Curtis, A.S.G.
In order for cells to react to topography, they must be able to sense shape. When considering nano-topography, these shapes are much smaller than the cell, but still strong responses to...
Rapid fibroblast adhesion to 27 nm high polymer demixed nano-topography
Dalby, M.J., Giannaras, D., Riehle, M.O., Gadegaard, N., Affrossman, S., Curtis, A.S.G.
It is well known that many cell types react strongly to micro-topography. It is rapidly becoming clear than cells will also react to nano-topography. Polymer demixing is a rapid and low-cost chemical...
The response of fibroblasts to hexagonal nanotopography fabricated by electron beam lithography
Dalby, M.J., Gadegaard, N., Wilkinson, C.D.W.
It has been known for many years that cells will react to the shape of their microenvironment. It is more recently becoming clear that cells can alter their morphology, adhesions, and cytoskeleton in...