Negative-ion implantation into thin SiO2 layer for defined nanoparticle formation (2006)
Tsuji, H, Arai, N, Gotoh, N, Minotani, T, Ishibashi, T, Okumine, T, ...
Arai, N, Tsuji, H, Ueno, K, Matsumoto, T, Gotoh, N, Aadachi, K, ...
Negative-ion implantation into thin SiO2 layer for defined nanoparticle formation (2006)
Tsuji, H, Arai, N, Gotoh, N, Minotani, T, Ishibashi, T, Okumine, T, ...
Ong, S. H., Hadari, Y. R., Gotoh, N., Guy, G. R., Schlessinger, J., Lax, I.
The docking protein FRS2 is a major downstream effector that links fibroblast growth factor (FGF) and nerve growth factor receptors with the Ras/mitogen-activated protein kinase signaling cascade. In...
Critical role for the docking-protein FRS2α in FGF receptor-mediated signal transduction pathways
Hadari, Y. R., Gotoh, N., Kouhara, H., Lax, I., Schlessinger, J.
The docking protein FRS2α has been implicated as a mediator of signaling via fibroblast growth factor receptors (FGFRs). We have demonstrated that targeted disruption of FRS2α gene causes severe...
Gotoh, N, Tojo, A, Muroya, K, Hashimoto, Y, Hattori, S, Nakamura, S, ...
Epidermal growth factor (EGF) receptor (EGFR) can induce cell growth and transformation in a ligand-dependent manner. To examine whether the autophosphorylation of EGFR correlates with the capacity...
Ong, S. H., Guy, G. R., Hadari, Y. R., Laks, S., Gotoh, N., Schlessinger, J., ...
The docking protein FRS2 was implicated in the transmission of extracellular signals from the fibroblast growth factor (FGF) or nerve growth factor (NGF) receptors to the Ras/mitogen-activated...
nfxC-type quinolone resistance in a clinical isolate of Pseudomonas aeruginosa.
Fukuda, H, Hosaka, M, Iyobe, S, Gotoh, N, Nishino, T, Hirai, K
Quinolone resistance gene nqr-T91 in a clinical isolate of Pseudomonas aeruginosa P1481 was cotransducible with catA1 in P. aeruginosa PAO. The nqr-T91 transductant, PKH-T91, was resistant to...
Hosaka, M, Gotoh, N, Nishino, T
The 54-kDa outer membrane protein (designated OprJ) of a norfloxacin-resistant nfxB mutant of Pseudomonas aeruginosa PAO1 was purified by ion-exchange high-performance liquid chromatography. Mobility...
Gotoh, N, Tsujimoto, H, Poole, K, Yamagishi, J, Nishino, T
An outer membrane protein (OprK) overproduced in a multiply antibiotic-resistant strain of Pseudomonas aeruginosa was previously identified as the product of the third gene of a multidrug resistance...
Masuda, N, Gotoh, N, Ohya, S, Nishino, T
Various Pseudomonas aeruginosa PAO1 NfxB mutants were isolated on agar plates containing cefpirome and ofloxacin. They were classified into type A and type B, based on the degrees of changes in their...
Köhler, T, Kok, M, Michea-Hamzehpour, M, Plesiat, P, Gotoh, N, Nishino, T, ...
Pseudomonas aeruginosa possesses at least two multiple drug efflux systems which are defined by the outer membrane proteins OprM and OprJ. We have found that mutants overexpressing OprM were two- and...
Tokunaga, T, Oka, K, Takemoto, A, Ohtsubo, Y, Gotoh, N, Nishino, T
The antimicrobial activity of trimethoprim is antagonized by thymidine in in vitro susceptibility tests. The purpose of this investigation was to determine whether this antagonism also occurred...
Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa.
Wong, K K, Poole, K, Gotoh, N, Hancock, R E
MexA-MexB-OprM is an efflux system in Pseudomonas aeruginosa. OprM overproduced from the cloned gene was able to complement OprM-deficient mutants but did not alter the resistance of a wild-type P....
Role of protein F in maintaining structural integrity of the Pseudomonas aeruginosa outer membrane.
Gotoh, N, Wakebe, H, Yoshihara, E, Nakae, T, Nishino, T
To investigate the functional role of protein F of the outer membrane of Pseudomonas aeruginosa, we isolated mutants devoid of protein F, and the defective gene was transferred to a wild-type strain...
Hasegawa, H, Kiyokawa, E, Tanaka, S, Nagashima, K, Gotoh, N, Shibuya, M, ...
CRK belongs to a family of adaptor proteins that consist mostly of SH2 and SH3 domains. Far Western blotting with CRK SH3 has demonstrated that it binds to 135- to 145-, 160-, and 180-kDa proteins....
Gotoh, N, Toyoda, M, Shibuya, M
Epidermal growth factor (EGF) induces tyrosine phosphorylation of the Shc adapter protein, which plays an important role in EGF-stimulated mitogenesis. Shc stimulates Ras/mitogen-activated protein...
Virulence of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa In Vitro and In Vivo
Aoki, S., Hirakata, Y., Kondoh, A., Gotoh, N., Yanagihara, K., Miyazaki, Y., ...
We evaluated the virulence of Pseudomonas aeruginosa carrying blaIMP, a metallo-β-lactamase gene, and the efficacy of ceftazidime, imipenem-cilastatin, and ciprofloxacin in the endogenous bacteremia...
Interleukin 3 (IL-3) not only induces DNA synthesis of haematopoietic cells but also maintains their viability by suppressing apoptosis. IL-3 stimulates tyrosine phosphorylation of the Shc adaptor...
Gotoh, N., Ito, M., Yamamoto, S., Yoshino, I., Song, N., Wang, Y., ...
Early development of the lens and retina depends upon reciprocal inductive interactions between the embryonic surface ectoderm and the underlying neuroepithelium of the optic vesicle. FGF signaling...
Gotoh, N., Manova, K., Tanaka, S., Murohashi, M., Hadari, Y., Lee, A., ...
The docking protein FRS2α is a major mediator of fibroblast growth factor (FGF) signaling. However, the physiological role of FRS2α in vivo remains unknown. In this report, we show that Frs2α-null...
Gotoh, N, Graham, A, Nikl, E, Darley-Usmar, V M
Macrophages are thought to play an important role in the pathogenesis of atherosclerosis by mediating the oxidation of low-density lipoprotein (LDL). However, it is known that these cells show...
Yamamoto, S., Yoshino, I., Shimazaki, T., Murohashi, M., Hevner, R. F., Lax, I., ...
Mammalian corticogenesis occurs through a complex process that includes neurogenesis, in which neural progenitor cells proliferate, differentiate, and migrate. It has been reported recently that...
Ong, S. H., Hadari, Y. R., Gotoh, N., Guy, G. R., Schlessinger, J., Lax, I.
The docking protein FRS2 is a major downstream effector that links fibroblast growth factor (FGF) and nerve growth factor receptors with the Ras/mitogen-activated protein kinase signaling cascade. In...
Critical role for the docking-protein FRS2α in FGF receptor-mediated signal transduction pathways
Hadari, Y. R., Gotoh, N., Kouhara, H., Lax, I., Schlessinger, J.
The docking protein FRS2α has been implicated as a mediator of signaling via fibroblast growth factor receptors (FGFRs). We have demonstrated that targeted disruption of FRS2α gene causes severe...
Gotoh, N, Tojo, A, Muroya, K, Hashimoto, Y, Hattori, S, Nakamura, S, ...
Epidermal growth factor (EGF) receptor (EGFR) can induce cell growth and transformation in a ligand-dependent manner. To examine whether the autophosphorylation of EGFR correlates with the capacity...
Ong, S. H., Guy, G. R., Hadari, Y. R., Laks, S., Gotoh, N., Schlessinger, J., ...
The docking protein FRS2 was implicated in the transmission of extracellular signals from the fibroblast growth factor (FGF) or nerve growth factor (NGF) receptors to the Ras/mitogen-activated...
nfxC-type quinolone resistance in a clinical isolate of Pseudomonas aeruginosa.
Fukuda, H, Hosaka, M, Iyobe, S, Gotoh, N, Nishino, T, Hirai, K
Quinolone resistance gene nqr-T91 in a clinical isolate of Pseudomonas aeruginosa P1481 was cotransducible with catA1 in P. aeruginosa PAO. The nqr-T91 transductant, PKH-T91, was resistant to...
Hosaka, M, Gotoh, N, Nishino, T
The 54-kDa outer membrane protein (designated OprJ) of a norfloxacin-resistant nfxB mutant of Pseudomonas aeruginosa PAO1 was purified by ion-exchange high-performance liquid chromatography. Mobility...
Gotoh, N, Tsujimoto, H, Poole, K, Yamagishi, J, Nishino, T
An outer membrane protein (OprK) overproduced in a multiply antibiotic-resistant strain of Pseudomonas aeruginosa was previously identified as the product of the third gene of a multidrug resistance...
Masuda, N, Gotoh, N, Ohya, S, Nishino, T
Various Pseudomonas aeruginosa PAO1 NfxB mutants were isolated on agar plates containing cefpirome and ofloxacin. They were classified into type A and type B, based on the degrees of changes in their...
Köhler, T, Kok, M, Michea-Hamzehpour, M, Plesiat, P, Gotoh, N, Nishino, T, ...
Pseudomonas aeruginosa possesses at least two multiple drug efflux systems which are defined by the outer membrane proteins OprM and OprJ. We have found that mutants overexpressing OprM were two- and...
Tokunaga, T, Oka, K, Takemoto, A, Ohtsubo, Y, Gotoh, N, Nishino, T
The antimicrobial activity of trimethoprim is antagonized by thymidine in in vitro susceptibility tests. The purpose of this investigation was to determine whether this antagonism also occurred...
Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa.
Wong, K K, Poole, K, Gotoh, N, Hancock, R E
MexA-MexB-OprM is an efflux system in Pseudomonas aeruginosa. OprM overproduced from the cloned gene was able to complement OprM-deficient mutants but did not alter the resistance of a wild-type P....
Role of protein F in maintaining structural integrity of the Pseudomonas aeruginosa outer membrane.
Gotoh, N, Wakebe, H, Yoshihara, E, Nakae, T, Nishino, T
To investigate the functional role of protein F of the outer membrane of Pseudomonas aeruginosa, we isolated mutants devoid of protein F, and the defective gene was transferred to a wild-type strain...
Hasegawa, H, Kiyokawa, E, Tanaka, S, Nagashima, K, Gotoh, N, Shibuya, M, ...
CRK belongs to a family of adaptor proteins that consist mostly of SH2 and SH3 domains. Far Western blotting with CRK SH3 has demonstrated that it binds to 135- to 145-, 160-, and 180-kDa proteins....
Gotoh, N, Toyoda, M, Shibuya, M
Epidermal growth factor (EGF) induces tyrosine phosphorylation of the Shc adapter protein, which plays an important role in EGF-stimulated mitogenesis. Shc stimulates Ras/mitogen-activated protein...
Virulence of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa In Vitro and In Vivo
Aoki, S., Hirakata, Y., Kondoh, A., Gotoh, N., Yanagihara, K., Miyazaki, Y., ...
We evaluated the virulence of Pseudomonas aeruginosa carrying blaIMP, a metallo-β-lactamase gene, and the efficacy of ceftazidime, imipenem-cilastatin, and ciprofloxacin in the endogenous bacteremia...
Interleukin 3 (IL-3) not only induces DNA synthesis of haematopoietic cells but also maintains their viability by suppressing apoptosis. IL-3 stimulates tyrosine phosphorylation of the Shc adaptor...
Gotoh, N., Ito, M., Yamamoto, S., Yoshino, I., Song, N., Wang, Y., ...
Early development of the lens and retina depends upon reciprocal inductive interactions between the embryonic surface ectoderm and the underlying neuroepithelium of the optic vesicle. FGF signaling...
Gotoh, N., Manova, K., Tanaka, S., Murohashi, M., Hadari, Y., Lee, A., ...
The docking protein FRS2α is a major mediator of fibroblast growth factor (FGF) signaling. However, the physiological role of FRS2α in vivo remains unknown. In this report, we show that Frs2α-null...
Gotoh, N, Graham, A, Nikl, E, Darley-Usmar, V M
Macrophages are thought to play an important role in the pathogenesis of atherosclerosis by mediating the oxidation of low-density lipoprotein (LDL). However, it is known that these cells show...
Yamamoto, S., Yoshino, I., Shimazaki, T., Murohashi, M., Hevner, R. F., Lax, I., ...
Mammalian corticogenesis occurs through a complex process that includes neurogenesis, in which neural progenitor cells proliferate, differentiate, and migrate. It has been reported recently that...