Orthostatic intolerance and the cardiovascular response to early postoperative mobilization (2009)
Bundgaard-Nielsen, M., Jørgensen, C. C., Jørgensen, T. B., Ruhnau, B., Secher, N. H., Kehlet, H.
Background A key element in enhanced postoperative recovery is early mobilization which, however, may be hindered by orthostatic intolerance, that is, an inability to sit or stand because of symptoms...
Brassard, P., Seifert, T., Secher, N. H.
Background Vasopressor agents are commonly used to increase mean arterial pressure (MAP) in order to secure a pressure gradient to perfuse vital organs. The influence of norepinephrine on cerebral...
Zaar, M., Lauritzen, B., Secher, N. H., Krantz, T., Nielsen, H. B., Madsen, P. L., ...
Background This study tested the circulatory effectiveness of post-trauma administration of a large intravascular volume expander, hydroxyethyl starch 130/0.4 (HES), vs standard lactated Ringer's...
Zaar, M., Secher, N. H., Johansson, P. I., Vainer, B., Ezban, M., Agersø, H., ...
Background We considered whether haemorrhage after a liver trauma would be reduced by early administration of a pro-haemostatic agent and evaluated the effect of i.v. vs i.m. administration of the...
Flow-related techniques for preoperative goal-directed fluid optimization (2007)
Bundgaard-Nielsen, M., Ruhnau, B., Secher, N. H., Kehlet, H.
Background. Improved postoperative outcome has been demonstrated by perioperative maximization of cardiac stroke volume (SV) with fluid challenges, so-called goal-directed therapy. Oesophageal...
Time course analysis of baroreflex sensitivity during postural stress (2006)
Westerhof, B.E., Gisolf, J, Karemaker, J.M., Wesseling, K.H., Secher, N.H., Lieshout, J.J. Van
Postural stress requires immediate autonomic nervous action to maintain blood pressure. We determined time-domain cardiac baroreflex sensitivity (BRS) and time delay (tau) between systolic blood...
MCA V-mean and the arterial lactate-to-pyruvate ratio correlate during rhythmic handgrip (2006)
Rasmussen, P., Plomgaard, P., Krogh-Madsen, R., Kim, Y.S., Lieshout, J.J. Van, Secher, N.H., ...
Regulation of cerebral blood flow during physiological activation including exercise remains unknown but may be related to the arterial lactate-topyruvate (L/P) ratio. We evaluated whether an...
The postural reduction in middle cerebral artery blood velocity is not explained by PaCO2 (2006)
Immink, R.V., Secher, N.H., Roos, C.M., Pott, F., Madsen, P.L., Lieshout, J.J. Van
In the normocapnic range, middle cerebral artery mean velocity (MCA V-mean) changes similar to 3.5% per mmHg carbon-dioxide tension in arterial blood (PaCO2) and a decrease in PaCO2 will reduce the...
Exercise induces the release of heat shock protein 72 from the human brain in vivo (2004)
G. I. Lancaster, K. Møller, B. Nielsen, N. H. Secher, M. A. Febbraio, L. Nybo
Reconstruction of brachial pressure from finger arterial pressure during orthostasis (2004)
Bogert, L.W.J., Harms, M.P.M., Pott, F., Secher, N.H., Wesseling, K.H., Lieshout, J.J. Van
Syncope, cerebral perfusion, and oxygenation (2003)
Lieshout, J.J. Van, Wieling, W., Karemaker, J.M., Secher, N.H.
Postural effects on cardiac output and mixed venous oxygen saturation in humans (2003)
Harms, M.P.M., Lieshout, J.J. Van, Jenstrup, M., Pott, F., Secher, N.H.
Middle cerebral artery blood velocity during a Valsalva maneuver in the standing position (2000)
Pott, F., Lieshout, J.J. Van, Ide, K., Madsen, P., Secher, N.H.
Middle cerebral artery blood velocity during exercise in patients with atrial fibrillation (1999)
Ide, K., Gullov, A.L., Pott, F., Lieshout, J.J. Van, Koefoed, B.G., Petersen, P., ...
Exercise induces the release of heat shock protein 72 from the human brain in vivo
Lancaster, G. I., Møller, K., Nielsen, B., Secher, N. H., Febbraio, M. A., Nybo, L.
The present study tested the hypothesis that in response to physical stress the human brain has the capacity to release heat shock protein 72 (Hsp72) in vivo. Therefore, 6 humans (males) cycled for...
Friedman, D B, Brennum, J, Sztuk, F, Hansen, O B, Clifford, P S, Bach, F W, ...
1. In order to examine the sensitivity to local anaesthetics of afferent neural feedback from working muscle during dynamic exercise, sixteen subjects cycled for 12 min before and after epidural...
Neural control of cardiovascular responses and of ventilation during dynamic exercise in man.
Strange, S, Secher, N H, Pawelczyk, J A, Karpakka, J, Christensen, N J, Mitchell, J H, ...
1. Nine subjects performed dynamic knee extension by voluntary muscle contractions and by evoked contractions with and without epidural anaesthesia. Four exercise bouts of 10 min each were performed:...
Reflex increase in blood pressure induced by leg compression in man.
Williamson, J W, Mitchell, J H, Olesen, H L, Raven, P B, Secher, N H
1. We tested the hypotheses that the increase in mean arterial pressure with the application of external leg compression in man is (i) blocked with epidural anaesthesia, and (ii) dependent upon the...
Autonomic blockade and cardiovascular responses to static exercise in partially curarized man.
Mitchell, J H, Reeves, D R, Rogers, H B, Secher, N H, Victor, R G
1. The cardiovascular responses, heart rate and mean arterial pressure, were followed in seventeen human subjects who performed static handgrip contractions for 2 min at the same absolute force (15%...
Epidural anaesthesia and cardiovascular responses to static exercise in man.
Mitchell, J H, Reeves, D R, Rogers, H B, Secher, N H
1. In human subjects, sustained static contractions of the knee extensors were performed in one leg with the same absolute (10% of the initial maximal voluntary contraction) and relative (30% of the...
Friedman, D B, Jensen, F B, Mitchell, J H, Secher, N H
1. We tested the 'muscle-heart reflex' hypothesis for the immediate increases in heart rate and blood pressure at the onset of static exercise in man by performing complete blockade of afferent...
Cardiovascular and ventilatory responses to dynamic exercise during epidural anaesthesia in man.
Fernandes, A, Galbo, H, Kjaer, M, Mitchell, J H, Secher, N H, Thomas, S N
1. In order to evaluate the importance of afferent neural feedback from the working muscles for cardiovascular and ventilatory responses to dynamic exercise, epidural anaesthesia was induced at...
Cardiovascular responses to brief static contractions in man with topical nervous blockade.
Lassen, A, Mitchell, J H, Reeves, D R, Rogers, H B, Secher, N H
1. We tested the hypothesis that afferent nerves from working muscles are important in determining the heart rate and blood pressure responses to brief maximal static exercise. 2. In twenty human...
Galbo, H, Kjaer, M, Secher, N H
1. In ten young men the ventilatory, cardiovascular, catecholamine and metabolic responses to maximal dynamic leg exercise on a stationary bicycle were followed during partial neuromuscular blockade...
Iwamoto, G A, Mitchell, J H, Mizuno, M, Secher, N H
1. In decerebrated cats the cardiovascular, heart rate and blood pressure responses to static muscle contractions were followed from the onset of stimulation of the cut L7-S1 ventral roots. Heart...
Heart rate at the onset of static exercise in man with partial neuromuscular blockade.
In human subjects the length of the first complete cardiac cycle after the onset of static finger or hand muscle contractions was recorded. Graded contractions as well as maximal contractions in...
Partial neuromuscular blockade and cardiovascular responses to static exercise in man.
Leonard, B, Mitchell, J H, Mizuno, M, Rube, N, Saltin, B, Secher, N H
In human subjects sustained static contractions of the quadriceps femoris in one leg were performed with the same absolute and the same relative intensity before and after partial neuromuscular...
Sander-Jensen, K, Secher, N H, Bie, P, Warberg, J, Schwartz, T W
Heart rate and arterial blood pressure were monitored in 20 consecutive patients during resuscitation from haemorrhagic shock. The mean blood loss (2.3 (SEM 0.3) 1) corresponded to 36(4)% of their...
Exercise induces the release of heat shock protein 72 from the human brain in vivo
Lancaster, G. I., Møller, K., Nielsen, B., Secher, N. H., Febbraio, M. A., Nybo, L.
The present study tested the hypothesis that in response to physical stress the human brain has the capacity to release heat shock protein 72 (Hsp72) in vivo. Therefore, 6 humans (males) cycled for...
Friedman, D B, Brennum, J, Sztuk, F, Hansen, O B, Clifford, P S, Bach, F W, ...
1. In order to examine the sensitivity to local anaesthetics of afferent neural feedback from working muscle during dynamic exercise, sixteen subjects cycled for 12 min before and after epidural...
Neural control of cardiovascular responses and of ventilation during dynamic exercise in man.
Strange, S, Secher, N H, Pawelczyk, J A, Karpakka, J, Christensen, N J, Mitchell, J H, ...
1. Nine subjects performed dynamic knee extension by voluntary muscle contractions and by evoked contractions with and without epidural anaesthesia. Four exercise bouts of 10 min each were performed:...
Reflex increase in blood pressure induced by leg compression in man.
Williamson, J W, Mitchell, J H, Olesen, H L, Raven, P B, Secher, N H
1. We tested the hypotheses that the increase in mean arterial pressure with the application of external leg compression in man is (i) blocked with epidural anaesthesia, and (ii) dependent upon the...
Autonomic blockade and cardiovascular responses to static exercise in partially curarized man.
Mitchell, J H, Reeves, D R, Rogers, H B, Secher, N H, Victor, R G
1. The cardiovascular responses, heart rate and mean arterial pressure, were followed in seventeen human subjects who performed static handgrip contractions for 2 min at the same absolute force (15%...
Epidural anaesthesia and cardiovascular responses to static exercise in man.
Mitchell, J H, Reeves, D R, Rogers, H B, Secher, N H
1. In human subjects, sustained static contractions of the knee extensors were performed in one leg with the same absolute (10% of the initial maximal voluntary contraction) and relative (30% of the...
Friedman, D B, Jensen, F B, Mitchell, J H, Secher, N H
1. We tested the 'muscle-heart reflex' hypothesis for the immediate increases in heart rate and blood pressure at the onset of static exercise in man by performing complete blockade of afferent...
Cardiovascular and ventilatory responses to dynamic exercise during epidural anaesthesia in man.
Fernandes, A, Galbo, H, Kjaer, M, Mitchell, J H, Secher, N H, Thomas, S N
1. In order to evaluate the importance of afferent neural feedback from the working muscles for cardiovascular and ventilatory responses to dynamic exercise, epidural anaesthesia was induced at...
Cardiovascular responses to brief static contractions in man with topical nervous blockade.
Lassen, A, Mitchell, J H, Reeves, D R, Rogers, H B, Secher, N H
1. We tested the hypothesis that afferent nerves from working muscles are important in determining the heart rate and blood pressure responses to brief maximal static exercise. 2. In twenty human...
Galbo, H, Kjaer, M, Secher, N H
1. In ten young men the ventilatory, cardiovascular, catecholamine and metabolic responses to maximal dynamic leg exercise on a stationary bicycle were followed during partial neuromuscular blockade...
Iwamoto, G A, Mitchell, J H, Mizuno, M, Secher, N H
1. In decerebrated cats the cardiovascular, heart rate and blood pressure responses to static muscle contractions were followed from the onset of stimulation of the cut L7-S1 ventral roots. Heart...
Heart rate at the onset of static exercise in man with partial neuromuscular blockade.
In human subjects the length of the first complete cardiac cycle after the onset of static finger or hand muscle contractions was recorded. Graded contractions as well as maximal contractions in...
Partial neuromuscular blockade and cardiovascular responses to static exercise in man.
Leonard, B, Mitchell, J H, Mizuno, M, Rube, N, Saltin, B, Secher, N H
In human subjects sustained static contractions of the quadriceps femoris in one leg were performed with the same absolute and the same relative intensity before and after partial neuromuscular...
Sander-Jensen, K, Secher, N H, Bie, P, Warberg, J, Schwartz, T W
Heart rate and arterial blood pressure were monitored in 20 consecutive patients during resuscitation from haemorrhagic shock. The mean blood loss (2.3 (SEM 0.3) 1) corresponded to 36(4)% of their...
Mesenteric, coeliac and splanchnic blood flow in humans during exercise
Perko, M J, Nielsen, H B, Skak, C, Clemmesen, J O, Schroeder, T V, Secher, N H
Exercise reduces splanchnic blood flow, but the mesenteric contribution to this response is uncertain.In nineteen humans, superior mesenteric and coeliac artery flows were determined by duplex...
Effects of partial neuromuscular blockade on carotid baroreflex function during exercise in humans
Gallagher, K M, Fadel, P J, Strømstad, M, Ide, K, Smith, S A, Querry, R G, ...
This investigation was designed to determine the contribution of central command to the resetting of the carotid baroreflex during static and dynamic exercise in humans.Thirteen subjects performed...
Gallagher, K M, Fadel, P J, Strømstad, M, Ide, K, Smith, S A, Querry, R G, ...
This investigation was designed to determine the contribution of the exercise pressor reflex to the resetting of the carotid baroreflex during exercise.Ten subjects performed 3.5 min of static...
Arm blood flow and metabolism during arm and combined arm and leg exercise in humans
The cardiovascular response to exercise with several groups of skeletal muscle suggests that work with the arms may decrease leg blood flow. This study evaluated whether intense exercise with the...
Arm Blood Flow and Oxygenation on the Transition from Arm to Combined Arm and Leg Exercise in Humans
Volianitis, S, Krustrup, P, Dawson, E, Secher, N H
The cardiovascular response to exercise with several groups of skeletal muscle implies that work with the legs may reduce arm blood flow. This study followed arm blood flow (Q̇arm) and oxygenation...
Wilson, T E, Tollund, C, Yoshiga, C C, Dawson, E A, Nissen, P, Secher, N H, ...
Central venous pressure (CVP) provides information regarding right ventricular filling pressure, but is often assumed to reflect left ventricular filling pressure. It remains unknown whether this...
Effects of passive heating on central blood volume and ventricular dimensions in humans
Crandall, C G, Wilson, T E, Marving, J, Vogelsang, T W, Kjaer, A, Hesse, B, ...
Mixed findings regarding the effects of whole-body heat stress on central blood volume have been reported. This study evaluated the hypothesis that heat stress reduces central blood volume and alters...
Volianitis, S, Fabricius-Bjerre, A, Overgaard, A, Strømstad, M, Bjarrum, M, Carlson, C, ...
Intense exercise decreases the cerebral metabolic ratio of O2 to carbohydrates (glucose +½ lactate) and the cerebral lactate uptake depends on its arterial concentration, but whether these variables...