N. H. Sigal

A paradigm for drug discovery employing encoded combinatorial libraries.

Burbaum, J J, Ohlmeyer, M H, Reader, J C, Henderson, I, Dillard, L W, Li, G, ...

Very large combinatorial libraries of small molecules on solid supports can now be synthesized and each library element can be identified after synthesis by using chemical tags. These tag-encoded...

FKB1 encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins.

Wiederrecht, G, Brizuela, L, Elliston, K, Sigal, N H, Siekierka, J J

FK 506, a powerful immunosuppressant that blocks allograft rejection by preventing T-cell activation, binds to an 11-kDa protein called the FK 506-binding protein (FKBP). Like cyclophilin, a...

Human monoclonal antibodies that protect mice against challenge with Pseudomonas aeruginosa.

Zweerink, H J, Gammon, M C, Hutchison, C F, Jackson, J J, Lombardo, D, Miner, K M, ...

Lymphocytes from healthy volunteers and from cystic fibrosis patients were transformed with Epstein-Barr virus and cultured at a limiting dilution to generate lymphoblastoid cell lines that secreted...

X-linked immunodeficient mice as a model for testing the protective efficacy of monoclonal antibodies against Pseudomonas aeruginosa.

Zweerink, H J, Gammon, M C, Hutchison, C F, Jackson, J J, Pier, G B, Puckett, J M, ...

(DBA/N[female] X CBA/2[male])F1 males have been reported to be deficient in producing antibodies against a number of antigens, including carbohydrates (I. Scher, Adv. Immunol. 35:1-71, 1982). We show...

Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell.

Gearhart, P J, Sigal, N H, Klinman, N R

The availability of anti-phosphocholine antibody of the TEPC 15 idiotype from the clonal progeny of a single precursor cell, stimulated in vitro, permitted the demonstration of monoclonal antibodies...

A paradigm for drug discovery employing encoded combinatorial libraries.

Burbaum, J J, Ohlmeyer, M H, Reader, J C, Henderson, I, Dillard, L W, Li, G, ...

Very large combinatorial libraries of small molecules on solid supports can now be synthesized and each library element can be identified after synthesis by using chemical tags. These tag-encoded...

FKB1 encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins.

Wiederrecht, G, Brizuela, L, Elliston, K, Sigal, N H, Siekierka, J J

FK 506, a powerful immunosuppressant that blocks allograft rejection by preventing T-cell activation, binds to an 11-kDa protein called the FK 506-binding protein (FKBP). Like cyclophilin, a...

Human monoclonal antibodies that protect mice against challenge with Pseudomonas aeruginosa.

Zweerink, H J, Gammon, M C, Hutchison, C F, Jackson, J J, Lombardo, D, Miner, K M, ...

Lymphocytes from healthy volunteers and from cystic fibrosis patients were transformed with Epstein-Barr virus and cultured at a limiting dilution to generate lymphoblastoid cell lines that secreted...

X-linked immunodeficient mice as a model for testing the protective efficacy of monoclonal antibodies against Pseudomonas aeruginosa.

Zweerink, H J, Gammon, M C, Hutchison, C F, Jackson, J J, Pier, G B, Puckett, J M, ...

(DBA/N[female] X CBA/2[male])F1 males have been reported to be deficient in producing antibodies against a number of antigens, including carbohydrates (I. Scher, Adv. Immunol. 35:1-71, 1982). We show...

Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell.

Gearhart, P J, Sigal, N H, Klinman, N R

The availability of anti-phosphocholine antibody of the TEPC 15 idiotype from the clonal progeny of a single precursor cell, stimulated in vitro, permitted the demonstration of monoclonal antibodies...