Campbell, A P, Merrett, M N, Kettlewell, M, Mortensen, N J, Jewell, D P
AIMS--To investigate colonic metaplasia of goblet and columnar epithelial cells in ileal pouch mucosa; to correlate this with the degree of morphological and inflammatory change; and to assess...
Crypt cell proliferation and HLA-DR expression in pelvic ileal pouches.
De Silva, H J, Gatter, K C, Millard, P R, Kettlewell, M, Mortensen, N J, Jewell, D P
To investigate the nature of the morphological changes that occur in ileal pouches, 26 biopsy specimens from patients with functioning ileo-anal pouches (eight with pouchitis) were studied. Normal...
Roe, A M, Bartolo, D C, Mortensen, N J
A technique of evacuation proctography using a simple barium and air mixture is described. The study can be easily combined with a barium enema examination. A series of 35 patients with intractable...
Preoperative staging of local invasion in rectal cancer using endoluminal ultrasound.
Beynon, J, Roe, A M, Foy, D M, Channer, J L, Virjee, J, Mortensen, N J
Digital examination is the most commonly used method of assessing local invasion in rectal cancer, but it is highly subjective and accuracy is related to surgical experience. The use of transrectal...
Programme for early detection of gastric cancer.
Houghton, P W, Stewart, I D, Mortensen, N J, Williamson, R C
Early gastric cancer: the case for long term surveillance.
Houghton, P W, Mortensen, N J, Allan, A, Williamson, R C, Davies, J D
Thirty five patients with early gastric cancer have been treated at the Bristol Royal Infirmary since 1965. The number of cases diagnosed has doubled in the last 10 years. Epigastric pain (74%), loss...
Campbell, A P, Merrett, M N, Kettlewell, M, Mortensen, N J, Jewell, D P
AIMS--To investigate colonic metaplasia of goblet and columnar epithelial cells in ileal pouch mucosa; to correlate this with the degree of morphological and inflammatory change; and to assess...
Crypt cell proliferation and HLA-DR expression in pelvic ileal pouches.
De Silva, H J, Gatter, K C, Millard, P R, Kettlewell, M, Mortensen, N J, Jewell, D P
To investigate the nature of the morphological changes that occur in ileal pouches, 26 biopsy specimens from patients with functioning ileo-anal pouches (eight with pouchitis) were studied. Normal...
Roe, A M, Bartolo, D C, Mortensen, N J
A technique of evacuation proctography using a simple barium and air mixture is described. The study can be easily combined with a barium enema examination. A series of 35 patients with intractable...
Preoperative staging of local invasion in rectal cancer using endoluminal ultrasound.
Beynon, J, Roe, A M, Foy, D M, Channer, J L, Virjee, J, Mortensen, N J
Digital examination is the most commonly used method of assessing local invasion in rectal cancer, but it is highly subjective and accuracy is related to surgical experience. The use of transrectal...
Programme for early detection of gastric cancer.
Houghton, P W, Stewart, I D, Mortensen, N J, Williamson, R C
Early gastric cancer: the case for long term surveillance.
Houghton, P W, Mortensen, N J, Allan, A, Williamson, R C, Davies, J D
Thirty five patients with early gastric cancer have been treated at the Bristol Royal Infirmary since 1965. The number of cases diagnosed has doubled in the last 10 years. Epigastric pain (74%), loss...
Mucosal characteristics of pelvic ileal pouches.
De Silva, H J, Millard, P R, Kettlewell, M, Mortensen, N J, Prince, C, Jewell, D P
This study aimed to investigate the degree of colonic metaplasia in ileo - anal pouches. Biopsy specimens from 25 patients with functioning pouches, eight of whom had pouchitis, were studied using...
Lymphocyte and macrophage subpopulations in pelvic ileal pouches.
De Silva, H J, Jones, M, Prince, C, Kettlewell, M, Mortensen, N J, Jewell, D P
This study aimed to characterise the mucosal cellular infiltrate in ileal reservoirs with and without pouchitis (reservoir ileitis). Intraepithelial lymphocyte counts were performed in biopsy...
Pelvic and perineal complications of Crohn's disease: assessment using magnetic resonance imaging.
Haggett, P J, Moore, N R, Shearman, J D, Travis, S P, Jewell, D P, Mortensen, N J
This study evaluated the role of magnetic resonance imaging (MRI) in the demonstration of the pelvic and perianal complications of Crohn's disease. Twenty five patients with active Crohn's disease...
Samarasekera, D N, Stebbing, J F, Kettlewell, M G, Jewell, D P, Mortensen, N J
BACKGROUND--An increasing number of patients with severe or refractory ulcerative colitis involving only the rectum and sigmoid colon are being offered restorative proctocolectomy with ileal...
Gastrin and the ultrastructure of G cells in the fasting rat.
Mortensen, N J, Morris, J F, Owens, C
The effect of fasting on serum and antral gastrin concentrations and G cell ultrastructure in the rat has been examined using a radioimmunoassay and quantitative electron microscopy. Serum gastrin...
Lahaut's operation for rectal prolapse.
Mortensen, N. J., Vellacott, K. D., Wilson, M. G.
Thirty-four patients with complete rectal prolapse were treated by Lahaut's operation in which the mobilised rectosigmoid was implanted in the posterior rectus sheath. There were no prolapse...
The anatomy of the gastrin cell.
Changes in the numbers of G cells and the formation and release of gastrin granules have been studies by means of radioimmunoassay and quantitative electron microscopy. The appearance of G-cell...
Ureteric obstruction after dacron vascular replacement.
Thomas, J. M., Mortensen, N. J., Bayliss, C. R.
Ureteric obstruction is a recognised complication of aortic bifurcation grafting where the graft material is in close proximity to the ureter as it crosses the common iliac vessels. We have assessed...
An evaluation of a direct access flexible fibreoptic sigmoidoscopy service.
Vellacott, K. D., Roe, A. M., Mortensen, N. J.
During a 3 year period 146 general practitioners referred 630 patients to a direct access flexible sigmoidoscopy clinic. The yield was 53.3% with significant colonic or rectal pathology in 30%....
The malignant potential of colorectal Crohn's disease.
Wyatt, M. G., Houghton, P. W., Mortensen, N. J., Williamson, R. C.
Six patients developed colorectal carcinoma in association with Crohn's disease. The cancer was diagnosed at a mean age of 46 years and a mean 19 years after the onset of Crohn's disease. Five...
Topical adhesive as a wound dressing for elective abdominal surgery.
Borley, N. R., Mortensen, N. J.
The choice of wound dressing after abdominal surgery is not always easy. We describe a simple technique using acyanoacrylate wound adhesive to provide a water resistant, flexible, sealed dressing...
Wilson-Macdonald, J., Mortensen, N. J., Williamson, R. C.
Thirty-four patients presenting with gastric perforation over a ten year period were studied, retrospectively. Five patients (14%) died either as a result of delay in treatment or wrong diagnosis. In...
Volvulus of the transverse colon.
Volvulus of the transverse colon is a rare condition requiring early diagnosis and treatment. In the absence of ischaemic changes within the redundant bowel, success can be anticipated with...
Yoshida, K., Sugino, T., Goodison, S., Warren, B. F., Nolan, D., Wadsworth, S., ...
Telomerase is a ribonucleoprotein capable of replacing telomeric DNA sequences that are lost at each cell division. Under normal circumstances, it is active in rapidly dividing embryonic cells and in...