N. J. N. HARPER

Neuromuscular monitoring in intensive care patients: milliamperage requirements for supramaximal stimulation{dagger} (2001)

Harper, N. J. N., Greer, R., Conway, D.

We investigated the effects of peripheral oedema on the supramaximal current required for neuromuscular monitoring of critically ill patients. We studied 32 sedated patients who had not needed a...

Optimum dose of neostigmine at two levels of atracurium-induced neuromuscular block (1994)

HARPER, N. J. N., WALLACE, M., HALL, I.A.

There is controversy about the optimum dose of neostigmine for antagonizing neuromuscular block. We have studied 57 patients undergoing gynaecological surgery to establish a dose-response...

Monitoring neuromuscular block by acceleromyography: comparison of the Mini-Accelograph with the Myograph 2000 (1994)

HARPER, N. J. N., MARTLEW, R., STRANG, T., WALLACE, M.

The precision of the compact Mini-Accelograph (M-A) was compared with the Myograph 2000 (MYO). Neuromuscular block resulting from atracurium was measured simultaneously by the MYO and the M-A applied...

NON-INVASIVE MEASUREMENT OF CARDIAC OUTPUT DURING INDUCTION OF ANAESTHESIA AND TRACHEAL INTUBATION: THIOPENTONE AND PROPOFOL COMPARED (1991)

VOHRA, A., THOMAS, A. N., HARPER, N. J. N., POLLARD, B. J.

We have investigated the haemodynamic changes in response to induction of anaesthesia and tracheal intubation in patients who received either thiopentone 5 mg kg−1 or propofol 3 mg kg−1 followed...

USE OF CONTINUOUS PROLONGED ADMINISTRATION OF ATRACURIUM IN THE ITU TO A PATIENT WITH MYASTHENIA GRAVIS (1989)

POLLARD, B. J., HARPER, N. J. N., DORAN, B. R. H.

The case is described of a patient with myasthenia gravis who required prolonged controlled ventilation for respiratory failure. Muscular relaxation was obtained with a continuous infusion of...

CONCENTRATIONS OF ATRACURIUM AND LAUDANOSINE IN CEREBROSPINAL FLUID AND PLASMA DURING INTRACRANIAL SURGERY (1989)

EDDLESTION, J. M., HARPER, N. J. N., POLLARD, B. J., EDWARDS, D., GWINNUTT, C. L.

Concentrations of atracurium and laudanosine in cerebrospinal fluid (CSF) and plasma were assayed in nine patients receiving atracurium infusions of 111–251 min duration to maintain neuromuscular...

ANTAGONISM OF MODERATE DEGREES OF VECURONIUM-INDUCED NEUROMUSCULAR BLOCK BY SMALL DOSES OF NEOSTIGMINE (1989)

JOHNSON, R. A., HARPER, N. J. N.

We have studied the influence of a reduced dose of neostigmine on recovery from vecuroniuminduced neuromuscular block in 26 adult patients, using electromyographic responses to train-of-four (TOF)...

COMPARISON OF THE ADDUCTOR POLLICIS AND THE FIRST DORSAL INTEROSSEOUS MUSCLES DURING ATRACURIUM AND VECURONIUM BLOCKADE: AN ELECTROMYOGRAPHIC STUDY (1988)

HARPER, N. J. N.

The pattern of neuromuscular blockade in the first dorsal interosseous muscle (1st DI) and the adductor pollicis muscle was compared electromyographically following atracurium or vecuronium. There...

EFFECTS OF ATRACURIUM AND VECURONIUM ON THE LATENCY AND THE DURATION OF THE NEGATIVE DEFLECTION OF THE EVOKED COMPOUND ACTION POTENTIAL OF THE ADDUCTOR POLLICIS (1987)

PUGH, N. D., HARPER, N. J. N., HEALY, T. E. J., PETTS, H. V.

The effect of atracurium or vecuronium on the depolarization phase of the evoked compound action potential of the adductor pollicis has been investigated in 30 adult patients. Patients were studied...

CHANGES IN THE POWER SPECTRUM OF THE EVOKED COMPOUND ACTION POTENTIAL OF THE ADDUCTOR POLLICIS WITH THE ONSET OF NEUROMUSCULAR BLOCKADE (1987)

HARPER, N. J. N., PUGH, N. D., HEALY, T. E. J., PETTS, H. V.

The effects of neuromuscular blockade by atracurium and vecuronium on the power spectrum of the evoked compound action potential (ECAP) of the adductor pollicis were investigated in 30 adult patients...

EVOKED ELECTROMYOGRAPHIC AND MECHANICAL RESPONSES OF THE ADDUCTOR POLLICIS COMPARED DURING THE ONSET OF NEUROMUSCULAR BLOCKADE BY ATRACURIUM OR ALCURONIUM, AND DURING ANTAGONISM BY NEOSTIGMINE (1986)

HARPER, N. J. N., BRADSHAW, E. G., HEALY, T. E. J.

The effects of atracurium and alcuronium on the evoked mechanical and electromyographic responses of the adductor pollicis were investigated in 30 adult patients. The ulnar nerve was stimulated with...

ANTAGONISM OF ALCURONIUM WITH EDROPHONIUM OR NEOSTIGMINE (1984)

HARPER, N. J. N., BRADSHAW, E. G., HEALY, T. E. J.

The reversal of slcuronium by edrophonium 1 mgkg−1 or neostigmine 35.7μkg−1 was compered in 23 patients undergoing elective ophthalmic surgery. Ncuromuscular transmission was assessed by...