Wang, J., Short, D., Sebire, N. J., Lindsay, I., Newlands, E. S., Schmid, P., ...
Objectives: To evaluate the efficacy and toxicity of paclitaxel and cisplatin alternating with paclitaxel and etoposide doublet regimen (TP/TE), for salvage of patients with high-risk gestational...
Cohen, J.M., Sebire, N.J., Harvey, J., Gaspar, H.B., Cathy, C., Jones, A., ...
Lymphoproliferative disease (LPD) is a recognized complication of primary immunodeficiency (PID) and immunodysregulatory syndromes. Historically, it has a very poor outcome. For patients surviving...
Jindal, P., Regan, L., Fourkala, E.O., Rai, R., Moore, G., Goldin, R.D., ...
BACKGROUND: Histopathological examination of products of conception from miscarriages is part of routine clinical practice. The extent of additional clinically relevant information provided by this...
Influence of parity on first trimester endovascular trophoblast invasion (2006)
Prefumo, F., Ganapathy, R., Thilaganathan, B., Sebire, N.J.
Objective: To assess the effect of parity on endovascular trophoblastic invasion in early pregnancy. Design: Observational study. Setting: Teaching hospital. Patient(s): Healthy women at 10–14...
Papageorghiou, A.T., Avgidou, K., Bakoulas, V., Sebire, N.J., Nicolaides, K.H.
BACKGROUND: Triplet pregnancies are associated with a high risk of miscarriage and early preterm birth. It is uncertain if the outcome is improved by embryo reduction (ER). METHODS: We examined...
Jindal, P., Regan, L., Fourkala, E.O., Rai, R., Moore, G., Goldin, R.D., ...
BACKGROUND: Histopathological examination of products of conception from miscarriages is part of routine clinical practice. The extent of additional clinically relevant information provided by this...
Papageorghiou, A.T., Avgidou, K., Bakoulas, V., Sebire, N.J., Nicolaides, K.H.
BACKGROUND: Triplet pregnancies are associated with a high risk of miscarriage and early preterm birth. It is uncertain if the outcome is improved by embryo reduction (ER). METHODS: We examined...
Zhao, J., Moss, J., Sebire, N.J., Cui, Q.C., Seckl, M.J., Xiang, Y., ...
BACKGROUND: Familial recurrent hydatidiform mole is an extremely rare autosomal recessive condition in which affected individuals have a predisposition to molar pregnancies that are diploid but...
Papageorghiou, A.T., Avgidou, K., Bakoulas, V., Sebire, N.J., Nicolaides, K.H.
BACKGROUND: Triplet pregnancies are associated with a high risk of miscarriage and early preterm birth. It is uncertain if the outcome is improved by embryo reduction (ER). METHODS: We examined...
Jindal, P., Regan, L., Fourkala, E.O., Rai, R., Moore, G., Goldin, R.D., ...
BACKGROUND: Histopathological examination of products of conception from miscarriages is part of routine clinical practice. The extent of additional clinically relevant information provided by this...
Histopathological features of chronic granulomatous disease (CGD) in childhood (2005)
Levine, S., Smith, V.V., Malone, M., Sebire, N.J.
Aims: To describe the spectrum of histopathological features encountered in children with chronic granulomatous disease (CGD) at a specialist centre. Methods and results: The histopathological...
Wee, L.Y., Sebire, N.J., Bhundia, J., Sullivan, M., Fisk, N.M.
Objective Theoretical estimates and physiological inferences suggest that the structure of a shared cotyledon differs from a non-shared cotyledon. The aim of this study was to characterise the...
Zhao, J., Moss, J., Sebire, N.J., Cui, Q.C., Seckl, M.J., Xiang, Y., ...
BACKGROUND: Familial recurrent hydatidiform mole is an extremely rare autosomal recessive condition in which affected individuals have a predisposition to molar pregnancies that are diploid but...
Prefumo, F., Sebire, N.J., Thilaganathan, B.
BACKGROUND: Defective trophoblastic invasion in early pregnancy is involved in the pathogenesis of pre‐ eclampsia. This study investigates the relationship between Doppler assessment of uterine...
Sebire, N.J., Backos, M., El Gaddal, S., Goldin, R.D., Regan, L.
Objective: To examine whether there are characteristic histological features in placentas from ongoing pregnancies of patients with a history of recurrent miscarriage, with and without primary...
Outcome of twin pregnancies with complete hydatidiform mole and healthy co-twin (2002)
Sebire, N.J., Foskett, M., Paradinas, F.J., Fisher, R.A., Francis, R.J., Short, D., ...
We assessed 77 twin pregnancies, comprising complete hydatidiform mole (CHM) and healthy co-twin, to ascertain the risks to the mother and baby of continuing the pregnancy, versus termination. 24...
Makrydimas, G., Sebire, N.J., Thornton, S.E., Zagorianakou, N., Lolis, D., Fisher, R.A.
Hydatidiform molar change, characterized by abnormal fetoplacental development and placental villous trophoblast hyperplasia, results from genetically abnormal conception, in which there is an excess...
Sebire, N.J., Fox, H., Backos, M., Rai, R., Paterson, C., Regan, L.
BACKGROUND: Primary antiphospholipid antibody syndrome (PAPS) is an established cause of recurrent pregnancy loss, traditionally presumed to be due to `intraplacental thromboses'. This study examines...
Early prediction of severe twin-to-twin transfusion syndrome (2000)
Sebire, N.J., Souka, A., Skentou, H., Geerts, L., Nicolaides, K.H.
This extended series of 303 monochorionic twin pregnancies examined at 10–14 weeks gestation explores the possible association of increased fetal nuchal translucency thickness (NT) in the early...
Myogenin and MyoD1 expression in paediatric rhabdomyosarcomas
The diagnosis of paediatric solid tumours is often based on small tissue needle biopsies in which many different entities demonstrate a “small round cell tumour” phenotype and in which there may...
Sebire, N J, Haselden, S, Malone, M, Davies, E G, Ramsay, A D
Patients with primary immunodeficiencies such as the Wiskott-Aldrich syndrome (WAS) are prone to develop Epstein-Barr virus (EBV) related lymphoproliferative disorders (LPDs). EBV LPD is most...
Pathology of astrovirus associated diarrhoea in a paediatric bone marrow transplant recipient
Sebire, N J, Malone, M, Shah, N, Anderson, G, Gaspar, H B, Cubitt, W D
Human astrovirus infection often causes outbreaks of self limiting diarrhoea, but may also infect patients who are immunodeficient or immunocompromised. Although there are previous publications...
Anderson, G, Smith, V V, Malone, M, Sebire, N J
Background: A range of metabolic diseases can result in abnormal accumulation of metabolic byproducts, resulting in abnormal lymphocyte cytoplasmic vacuolation, identifiable on routine blood film...
Smith, V V, Anderson, G, Malone, M, Sebire, N J
Background: Microscopic examination of scalp hair can provide important diagnostic information in a range of paediatric conditions. It is a non-invasive and cost effective investigation, which is not...