N. J. Siegel

1H NMR study of renal trimethylamine responses to dehydration and acute volume loading in man.

Avison, M J, Rothman, D L, Nixon, T W, Long, W S, Siegel, N J

We have used volume-localized 1H NMR spectroscopy to detect and measure changes in medullary trimethylamines (TMAs) in the human kidney in vivo. Localized water-suppressed 1H spectra were collected...

Expression of parathyroid hormone-related protein in the rat glomerulus and tubule during recovery from renal ischemia.

Soifer, N E, Van Why, S K, Ganz, M B, Kashgarian, M, Siegel, N J, Stewart, A F

Parathyroid hormone-related protein (PTHrP) is widely expressed in normal adult and fetal tissues, where it acts in an autocrine/paracrine fashion, stimulates growth and differentiation, and shares...

Activation of heat-shock transcription factor by graded reductions in renal ATP, in vivo, in the rat.

Van Why, S K, Mann, A S, Thulin, G, Zhu, X H, Kashgarian, M, Siegel, N J

Renal ischemia results in both a profound fall in cellular ATP and a rapid induction of the 70 kD heat-shock protein family, HSP-70. The present studies examined the relationship between cellular ATP...

Chemical and functional correlates of postischemic renal ATP levels.

Stromski, M E, Cooper, K, Thulin, G, Gaudio, K M, Siegel, N J, Shulman, R G

Renal energy metabolism was investigated before, during, and after ischemic insults of varying durations with in vivo 31P NMR spectroscopy. The postischemic recovery of renal ATP was found to be a...

Metabolic and functional consequences of inhibiting adenosine deaminase during renal ischemia in rats.

Stromski, M E, Van Waarde, A, Avison, M J, Thulin, G, Gaudio, K M, Kashgarian, M, ...

The concentrations of renal ATP have been measured by 31P-nuclear magnetic resonance (NMR) before, during, and after bilateral renal artery occlusion. Using in vivo NMR, the initial postischemic...

1H NMR study of renal trimethylamine responses to dehydration and acute volume loading in man.

Avison, M J, Rothman, D L, Nixon, T W, Long, W S, Siegel, N J

We have used volume-localized 1H NMR spectroscopy to detect and measure changes in medullary trimethylamines (TMAs) in the human kidney in vivo. Localized water-suppressed 1H spectra were collected...

Expression of parathyroid hormone-related protein in the rat glomerulus and tubule during recovery from renal ischemia.

Soifer, N E, Van Why, S K, Ganz, M B, Kashgarian, M, Siegel, N J, Stewart, A F

Parathyroid hormone-related protein (PTHrP) is widely expressed in normal adult and fetal tissues, where it acts in an autocrine/paracrine fashion, stimulates growth and differentiation, and shares...

Activation of heat-shock transcription factor by graded reductions in renal ATP, in vivo, in the rat.

Van Why, S K, Mann, A S, Thulin, G, Zhu, X H, Kashgarian, M, Siegel, N J

Renal ischemia results in both a profound fall in cellular ATP and a rapid induction of the 70 kD heat-shock protein family, HSP-70. The present studies examined the relationship between cellular ATP...

Chemical and functional correlates of postischemic renal ATP levels.

Stromski, M E, Cooper, K, Thulin, G, Gaudio, K M, Siegel, N J, Shulman, R G

Renal energy metabolism was investigated before, during, and after ischemic insults of varying durations with in vivo 31P NMR spectroscopy. The postischemic recovery of renal ATP was found to be a...

Metabolic and functional consequences of inhibiting adenosine deaminase during renal ischemia in rats.

Stromski, M E, Van Waarde, A, Avison, M J, Thulin, G, Gaudio, K M, Kashgarian, M, ...

The concentrations of renal ATP have been measured by 31P-nuclear magnetic resonance (NMR) before, during, and after bilateral renal artery occlusion. Using in vivo NMR, the initial postischemic...

Prognostic significance of DNA-binding capacity patterns in patients with lupus nephritis.

Adler, M K, Baumgarten, A, Hecht, B, Siegel, N J

The time course of DNA binding capacity (DNA-bc) was found to correlate with the clinical course in a group of 21 patients who had biopsy-proven lupus glomerulonephritis and were treated with...

Accelerated cellular recovery after an ischemic renal injury.

Gaudio, K. M., Ardito, T. A., Reilly, H. F., Kashgarian, M., Siegel, N. J.

To determine the mode of action of the beneficial effect of adenosine triphosphate (ATP)-MgCl2, recovery of microinjected inulin, proximal tubular pressure (PTP), and cellular damage as quantitated...