N. J. van Orsouw

Rapid design of denaturing gradient-based two-dimensional electrophoretic gene mutational scanning tests.

Van Orsouw, N J, Dhanda, R K, Rines, R D, Smith, W M, Sigalas, I, Eng, C, ...

With the current rapid pace at which human disease genes are identified there is a need for practical, cost-efficient genetic screening tests. Two-dimensional electrophoretic separation of...

Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions.

Khrapko, K, Bodyak, N, Thilly, W G, Van Orsouw, N J, Zhang, X, Coller, H A, ...

Quantitative information on the cell-to-cell distribution of all possible mitochondrial DNA (mtDNA) mutations in young and aged tissues is needed to assess the relevance of these mutations to the...

Rapid design of denaturing gradient-based two-dimensional electrophoretic gene mutational scanning tests.

Van Orsouw, N J, Dhanda, R K, Rines, R D, Smith, W M, Sigalas, I, Eng, C, ...

With the current rapid pace at which human disease genes are identified there is a need for practical, cost-efficient genetic screening tests. Two-dimensional electrophoretic separation of...

Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions.

Khrapko, K, Bodyak, N, Thilly, W G, Van Orsouw, N J, Zhang, X, Coller, H A, ...

Quantitative information on the cell-to-cell distribution of all possible mitochondrial DNA (mtDNA) mutations in young and aged tissues is needed to assess the relevance of these mutations to the...

A highly accurate, low cost test for BRCA1 mutations

Van Orsouw, N. J, Dhanda, R., Elhaji, Y., Narod, S., Li, F., Eng, C., ...

The hereditary breast and ovarian cancer syndrome is associated with a high frequency of BRCA1 mutations. However, the widespread use of BRCA1 testing has been limited to date by three principal...