Bandoh, S., Fujita, J., Ohtsuki, Y., Ueda, Y., Hojo, S., Tokuda, M., ...
OBJECTIVE—KL-6 is a mucin-like high molecular weight glycoprotein, which is strongly expressed on type II alveolar pneumocytes and bronchiolar epithelial cells. It has been demonstrated that the...
Yokoyama, A, Kohno, N, Hirasawa, Y, Kondo, K, Abe, M, Inoue, Y, ...
We measured soluble IL-6 receptor (sIL-6R) levels in serum and bronchoalveolar lavage fluids (BALF) from patients with interstitial pneumonia of unknown etiology (IP) (n = 17), sarcoidosis (n = 8)...
Hirai, T, Masaki, T, Kuratsune, M, Yorioka, N, Kohno, N
Proliferation of mesangial cells is a hallmark of glomerular disease, and understanding the regulatory mechanisms is critically important. The purpose of this study was to examine the relationship...
Effect of different sensitizing doses of antigen in a murine model of atopic asthma
Sakai, K, Yokoyama, A, Kohno, N, Hiwada, K
The dose of antigen is assumed to be one of the important factors in the polarized development of helper T cell subsets, i.e. Th1 or Th2 cells. We investigated the effect of the sensitizing antigen...
Circulating KL-6 levels in patients with drug induced pneumonitis
Ohnishi, H, Yokoyama, A, Yasuhara, Y, Watanabe, A, Naka, T, Hamada, H, ...
Background: The circulating level of KL-6/MUC1 is a sensitive marker for various interstitial lung diseases. Previous case reports have suggested that KL-6 may also be increased in some patients with...
Awaya, H, Takeshima, Y, Furonaka, O, Kohno, N, Inai, K
Aims: To investigate the importance of gene amplification and EGFR (epidermal growth factor receptor) and HER2 protein expression during the progression of adenocarcinoma of the lung.
Interactions of doxorubicin and cis-platin in squamous carcinoma cells in culture.
Kohno, N., Ohnuma, T., Kaneko, M., Holland, J. F.
Doxorubicin (DXR) has a positive inoculum effect and penetrates poorly into the core of multicellular tumour spheroids (MTS). Cis-platin (DDP) displays neither of these characteristics. We evaluated...
p16 protein expression is associated with a poor prognosis in squamous cell carcinoma of the lung
Huang, C-I, Taki, T, Higashiyama, M, Kohno, N, Miyake, M
An immunohistochemical analysis for p16 protein was performed in 171 patients with non-small-cell lung cancer (NSCLC). Sixty-two carcinomas (36.3%) were classified as p16-negative. p16-negative...