Galea, P., Barigye, O., Wee, L., Jain, V., Sullivan, M., Fisk, N. M.
The renin-angiotensin system (RAS) in twin–twin transfusion syndrome (TTTS) is up-regulated in the donor fetus's kidneys, but down-regulated in the recipient's. Ultrasonographic and...
Choolani, M., Ho, S.S.Y., Razvi, K., Ponnusamy, S., Baig, S., Fisk, N.M., ...
Rapid aneuploidy detection methods allow prenatal diagnosis results to be released within 48 h, but not on the same day as the invasive test. We aimed to develop a rapid fluorescence in situ...
O'Donoghue, K., Cartwright, E., Galea, P., Fisk, N. M.
Objectives Twin-twin transfusion syndrome (TTTS) results in high rates of perinatal mortality and neurological morbidity. Fetoscopic laser ablation of placental anastomoses is now established as the...
Wee, L. Y., Sullivan, M., Humphries, K., Fisk, N. M.
Objectives In this study we aimed to quantitate monochorionic twin placental blood flow in vivo through arterio-venous anastomoses (AVA) and corresponding vessels within normal cotyledons. Methods...
Sarkar, P., Bergman, K., Fisk, N. M., O'Connor, T. G., Glover, V.
Objective There is increasing evidence that antenatal stress has long-lasting effects on child development, but there is less accord on the mechanisms and the gestational window of susceptibility....
Amniotic Fluid Testosterone: Relationship with Cortisol and Gestational Age (2007)
Sarkar, P., Bergman, K., Fisk, N. M., O'Connor, T. G., Glover, V.
Introduction: Foetal exposure to testosterone is increasingly implicated in the programming of future reproductive and nonreproductive behaviour. Some outcomes associated with prenatal exposure to...
Choolani, M., Ho, S. S. Y., Razvi, K., Ponnusamy, S., Baig, S., Fisk, N. M., ...
Rapid aneuploidy detection methods allow prenatal diagnosis results to be released within 48 h, but not on the same day as the invasive test. We aimed to develop a rapid fluorescence in situ...
Maternal Anxiety at Amniocentesis and Plasma Cortisol (2006)
Sarkar, P., Bergman, K., Fisk, N. M., Glover, V.
Objectives To assess whether anticipation of amniocentesis is linked with maternal anxiety, and whether this anxiety is associated with increased maternal plasma cortisol. Methods Two hundred and...
Pasquini, L., Wimalasundera, R. C., Fichera, A., Barigye, L., Fisk, N. M.
Objectives Increased perinatal mortality in monoamniotic twin pregnancies is attributed to cord accidents in utero and at delivery. We evaluated the following parameters in monoamniotic pregnancies:...
Can Routine Commercial Cord Blood Banking Be Scientifically and Ethically Justified? (2005)
Fisk, N. M., Roberts, I. A. G., Markwald, R., Mironov, V.
Background to the debate: Umbilical cord blood—the blood that remains in the placenta after birth—can be collected and stored frozen for years. A well-accepted use of cord blood is as an...
Welsh, A. W., Rubin, J. M., Fowlkes, J. B., Fisk, N. M.
Objective This study aimed to test the applicability to the fetus of mathematical techniques developed to standardize power Doppler indices of adult regional perfusion. Method Fetal power Doppler...
Fetal plasma testosterone correlates positively with cortisol (2005)
Gitau, R., Adams, D., Fisk, N. M., Glover, V.
Background: Fetal exposure to testosterone has been implicated in programming childhood behaviour, but little is known about the determinants of fetal testosterone concentrations. Aims: To...
Wee, L. Y., Taylor, M., Watkins, N., Franke, V., Parker, K., Fisk, N. M.
To characterise arterio-venous anastomoses (AVA) in monochorionic (MC) placentae and determine (i) whether shared cotyledons lie beneath the co-termination of an artery from one twin and a vein to...
Miller, N. M., Fisk, N. M., Modi, N., Glover, V.
Objective To investigate (A) the determinants of infant stress response at delivery and (B) test the hypothesis that stress at birth, as reflected by cord arterial cortisol, influences cortisol...
Vanderheyden, T. M., Fichera, A., Pasquini, L., Tan, T. Y. T., Wee, L. Y., Frusca, T., ...
Objective To determine if absent end-diastolic flow (AEDF) in the umbilical artery (UA) has a longer latency in monochorionic (MC) twin fetuses compared to singleton or dichorionic twin (DC) fetuses....
Wee, L.Y., Sebire, N.J., Bhundia, J., Sullivan, M., Fisk, N.M.
Objective Theoretical estimates and physiological inferences suggest that the structure of a shared cotyledon differs from a non-shared cotyledon. The aim of this study was to characterise the...
Smith, R.P., Miller, S.L., Igosheva, N., Peebles, D.M., Glover, V., Jenkin, G., ...
Objective: The purpose of this study was to determine whether physical stimulation is stressful to the ovine fetus, as judged from physiologic changes that are similar to those reported for other...
Occlusion of Arterio-Arterial Anastomosis Manifesting as Acute Twin–Twin Transfusion Syndrome (2004)
Tan, T. Y. T., Denbow, M. L., Cox, P. M., Talbert, D., Fisk, N. M.
n vivo, ex vivo and modelling studies suggest that arterio-arterial anastomoses (AAAs) protect against haemodynamic imbalance in monochorionic twins and thus the development of TTTS. We report the...
Denbow, M. L., Taylor, M., Cox, P., Fisk, N. M.
We aimed to determine rates of interfetal transfusion along arterio-arterial (AA) anastomoses in monochorionic twins in vivo from analysis of Doppler waveform patterns. Twenty-one monochorionic twin...
Infant cortisol response after prolonged antenatal prednisolone treatment (2004)
Miller, N. M., Williamson, C., Fisk, N. M., Glover, V.
Prednisolone is widely used to treat medical conditions in pregnancy, despite the lack of long term safety studies on infants. Animal studies have shown that antenatal glucocorticoid treatment can...
Pseudo-arterio-arterial anastomoses in twin–twin transfusion syndrome (2004)
Taylor, M. J. O., Talbert, D., Fisk, N. M.
Objective It has recently been claimed that fetoscopic recognition of a haemodynamic equator within an arterio-arterial anastomosis (AAA) suggests minimal net intertwin flow. This was based on blood...
Reducing the incidence of twins and triplets (2003)
Wimalasundera, R. C., Trew, G., Fisk, N. M.
Multiple pregnancy rates remain high after assisted conception because of a misconceived assumption that transferring three or more embryos will maximize pregnancy rates. Maternal morbidity is...
O’Donoghue, K., Choolani, M., Chan, J., Kumar, S., Campagnoli, C., ...
Strategies for genetic prenatal diagnosis on fetal cells in the maternal circulation have been limited by lack of a cell type present only in fetal blood. However, the recent identification of...
Wee, L. Y., Taylor, M. J., Vanderheyden, T., Talbert, D., Fisk, N. M.
Objectives: To characterize the phenomenon of retrograde transmission of arterio-arterial anastomosis (AAA) interference patterns on umbilical artery (UA) waveform by (a) documenting the periodicity,...
Periconceptional Folic Acid and Food Fortification in the Prevention of Neural Tube Defects (2003)
Neural tube defects (NTDs), which comprise open spina bifida, anencephaly and encephalocele, complicate 1.5/1000 pregnancies in the UK,1 and represent the first congenital malformations to be...
Tan, L-K., Kumar S, Jolly, M., Gleeson, C., Johnson P, Fisk, N. M.
Objective: To evaluate whether a test amnioinfusion procedure is useful in selecting cases of midtrimester preterm premature rupture of membranes (PPROM) which may benefit from serial amnioinfusions...
ODonoghue, K., Choolani, M., Chan, J., Kumar, S., Campagnoli, C., ...
Strategies for genetic prenatal diagnosis on fetal cells in the maternal circulation have been limited by lack of a cell type present only in fetal blood. However, the recent identification of...
Karatza, A. A., Wolfenden, J. L., Taylor, M. J. O., Wee, L., Fisk, N. M., Gardiner, H. M.
Objective: To test the hypothesis that identical twins show no inter-twin differences in cardiovascular structure or physiology in fetal life unless there has been twin-twin transfusion syndrome....
Taylor, M. J. O., Shalev, E., Tanawattanacharoen, S., Jolly, M., Kumar, S., Weiner, E., ...
To evaluate bipolar diathermy as a technique for selective fetocide in the treatment of advanced (Stage III/IV) twin-twin transfusion syndrome (TTTS). Methods A prospective observational study in two...
Validation of the Quintero Staging System for Twin-Twin Transfusion Syndrome (2002)
Taylor, M. J. O, Govender, L, Jolly, M, Wee, L., Fisk, N. M
OBJECTIVE: To validate an established staging system for twin-twin transfusion syndrome. METHODS: Prospective observational study in a tertiary referral fetal medicine center of 52 consecutive cases...
Moutquin, J. M., Cabrol, D., Fisk, N. M., MacLennan, Alastair Harvey, Marsal, K., Rabinovici, J.
The definitive version is available at www.blackwell-synergy.com
Moutquin, J. M., Cabrol, D., Fisk, N. M., MacLennan, Alastair Harvey, Marsal, K., Rabinovici, J.
The definitive version is available at www.blackwell-synergy.com
Taylor, M.J.O., Denbow, M.L., Tanawattanacharoen, S., Gannon, C., Cox, P.M., Fisk, N.M.
The accuracy of in-vivo detection of arterio-arterial anastomoses (AAA) in monochorionic (MC) twins and its predictive value for twin–twin transfusion syndrome (TTTS) was assessed in 105...
Fisk, N.M., Templeton, A.A., Papadopoulos, G.C., Matlin, S.A., Wu, Z.Y.
Thirty-four women requesting laparoscopic sterilization underwent a fixed schedule regimen for multiple follicular development which included norethisterone and clomiphene citrate. Follicle...
Zosmer, N, Bajoria, R, Weiner, E, Rigby, M, Vaughan, J, Fisk, N M
OBJECTIVE--Fetal twin-twin transfusion syndrome (TTTS) presenting in the second trimester has been associated with almost no perinatal survival until recently, when serial drainage of amniotic fluid...
Holt, D E, Fisk, N M, Spencer, J A, De Louvois, J, Hurley, R, Harvey, D
The transplacental transfer of cefuroxime was determined at antenatal fetal blood sampling in a cross sectional study of 78 patients between 15-35 weeks' gestation, 8-138 minutes after a maternal...
Changes in fetal acid base status during intravascular transfusion.
Nicolini, U, Santolaya, J, Fisk, N M, Hubinont, C, Kochenour, N K, Greco, P, ...
Umbilical venous pH, PCO2, PO2, and base excess was measured immediately before and after 72 intravascular transfusions in 34 fetuses with erythroblastosis fetalis. In 67 uncomplicated transfusions,...
Fetofetal transfusion syndrome: do the neonatal criteria apply in utero?
Fisk, N M, Borrell, A, Hubinont, C, Tannirandorn, Y, Nicolini, U, Rodeck, C H
Thirteen fetuses (five twin, one triplet) were compromised by fetofetal transfusion syndrome in six pregnancies, five in the mid trimester, and one in the third trimester. This diagnosis, which was...