Karami, S., Boffetta, P., Rothman, N., Hung, R. J., Stewart, T., Zaridze, D., ...
This study investigated associations between occupational pesticide exposure and renal cell carcinoma (RCC) risk. To follow-up on a previous report by Buzio et al., we also considered whether this...
Moore, L.E., Brennan, P., Karami, S., Hung, R.J., Hsu, C., Boffetta, P., ...
High consumption of cruciferous vegetables has been associated with reduced kidney cancer risk in many studies. Isothiocyanates, thought to be responsible for the chemopreventive properties of this...
Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma (2007)
Brenner, A.V., Butler, M.A., Wang, S.S., Ruder, A.M., Rothman, N., Schulte, P.A., ...
A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms...
Assessment of lifetime exposure to trihalomethanes through different routes (2006)
Villanueva, Cristina M., Cantor, K. P., Grimalt, Joan O., Castaño‐Vinyals, G., Malats, N., Silverman, D., ...
5 pages, 1 figure, 2 tables.-- PMID: 16556748 [PubMed].-- Free full-text article available at PubMed Central: http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16556748
Interleukin-1 polymorphisms associated with increased risk of gastric cancer (2000)
El Omar, E.M., Carrington, M., Chow, W-H., McColl, K.E.L., Bream, J.H., Young, H.A., ...
Helicobacter pylori infection is associated with a variety of clinical outcomes including gastric cancer and duodenal ulcer disease. The reasons for this variation are not clear, but the gastric...
Genotoxic markers among butadiene polymer workers in China (2000)
Hayes, R.B., Zhang, L., Yin, S., Swenberg, J.A., Xi, L., Wiencke, J., ...
While 1,3-butadiene is carcinogenic in rodents, cancer causation in humans is less certain. We examined a spectrum of genotoxic outcomes in 41 butadiene polymer production workers and 38 non-exposed...
Zhang, L, Rothman, N, Wang, Y, Hayes, RB, Li, G, Dosemeci, M, ...
Hayes, RB, Yin, SN, Dosemeci, M, Li, GL, Wacholder, S, Travis, LB, ...
Sinha, R., Rothman, N., Mark, S.D., Murray, S., Brown, E.D., Levander, O.A., ...
Heterocyclic aromatic amines (HAAs), such as 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), are metabolically activated by cytochrome P4501A2 (CYP1A2) and N-acetyltransferase (NAT2). We...
Kang, D.H., Rothman, N., Poirier, M.C., Greenberg, A., Hsu, C.H., Schwartz, B.S., ...
Biological markers of internal dose and macromolecular dose from PAHs provide a potential means of assessing environmental exposure to PAHs through inhalation, ingestion and percutaneous absorption....
Rothman, N., Poirier, M.C., Baser, M.E., Hansen, J.A., Gentile, C., Bowman, E.D., ...
The effect of ingesting charcoal-broiled (CB) beef on polycydic aromatic hydrocarbon (PAH)-DNA adduct levels in nucleated peripheral white blood cells (WBCs) was examined in four healthy, non-smoking...
Rothman, N, Bhatnagar, V K, Hayes, R B, Zenser, T V, Kashyap, S K, Butler, M A, ...
Several epidemiologic studies indicate that NAT2-related slow N-acetylation increases bladder cancer risk among workers exposed to aromatic amines, presumably because N-acetylation is important for...
Rothman, N, Haas, R, Hayes, R B, Li, G L, Wiemels, J, Campleman, S, ...
Occupational exposure to benzene is known to cause leukemia, but the mechanism remains unclear. Unlike most other carcinogens, benzene and its metabolites are weakly or nonmutagenic in most simple...
Rothman, N, Rothstein, D, Foor, F, Magasanik, B
We isolated mutants of Klebsiella aerogenes with insertions of transposon Tn5 linked to the structural gene for glutamine synthetase, glnA. We found that K. aerogenes, like Escherichia coli and...
The Agricultural Health Study.
Alavanja, M C, Sandler, D P, McMaster, S B, Zahm, S H, McDonnell, C J, Lynch, C F, ...
The Agricultural Health Study, a large prospective cohort study has been initiated in North Carolina and Iowa. The objectives of this study are to: 1) identify and quantify cancer risks among men,...
Talaska, G, Underwood, P, Maier, A, Lewtas, J, Rothman, N, Jaeger, M
Lung cancer caused by polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs and related environmental agents is a major problem in industrialized nations. The high case-fatality rate of the disease,...
Interphase cytogenetics of workers exposed to benzene.
Zhang, L, Rothman, N, Wang, Y, Hayes, R B, Bechtold, W, Venkatesh, P, ...
Fluorescence in situ hybridization (FISH) is a powerful new technique that allows numerical chromosome aberrations (aneuploidy) to be detected in interphase cells. In previous studies, FISH has been...
Linet, M S, Yin, S N, Travis, L B, Li, C Y, Zhang, Z N, Li, D G, ...
Previous occupational cohort studies of benzene-exposed workers have for the most part used only death certificates to validate diagnoses of workers developing leukemia and other hematopoietic and...
Indirect validation of benzene exposure assessment by association with benzene poisoning.
Dosemeci, M, Yin, S N, Linet, M, Wacholder, S, Rothman, N, Li, G L, ...
We present a validation study of a quantitative retrospective exposure assessment method used in a follow-up study of workers exposed to benzene. Assessment of exposure to benzene was carried out in...
Mortality among benzene-exposed workers in China.
Hayes, R B, Yin, S N, Dosemeci, M, Li, G L, Wacholder, S, Chow, W H, ...
A large cohort of 74,828 benzene-exposed and 35,805 nonexposed workers employed between 1972 and 1987 in 12 cities in China was followed to determine mortality from all causes. Benzene-exposed study...
An epidemiologic study of early biologic effects of benzene in Chinese workers.
Rothman, N, Smith, M T, Hayes, R B, Li, G L, Irons, R D, Dosemeci, M, ...
Benzene is a recognized hematotoxin and leukemogen, but its mechanisms of action in humans are still uncertain. To provide insight into these processes, we carried out a cross-sectional study of 44...
Using biomarkers of genetic susceptibility to enhance the study of cancer etiology.
There has been increasing interest in the interaction of genetic susceptibility and xenobiotic exposures in cancer etiology. Study of gene-environment interactions may increase our ability to...
Rothman, N, Poirier, M C, Haas, R A, Correa-Villasenor, A, Ford, P, Hansen, J A, ...
Previous investigations suggest that dietary sources of polycyclic aromatic hydrocarbons (PAHs) contribute to the PAH-DNA adduct load in peripheral white blood cells (WBCs). In the current study, we...
Rothman, N, Bhatnagar, V K, Hayes, R B, Zenser, T V, Kashyap, S K, Butler, M A, ...
Several epidemiologic studies indicate that NAT2-related slow N-acetylation increases bladder cancer risk among workers exposed to aromatic amines, presumably because N-acetylation is important for...
Rothman, N, Haas, R, Hayes, R B, Li, G L, Wiemels, J, Campleman, S, ...
Occupational exposure to benzene is known to cause leukemia, but the mechanism remains unclear. Unlike most other carcinogens, benzene and its metabolites are weakly or nonmutagenic in most simple...
Rothman, N, Rothstein, D, Foor, F, Magasanik, B
We isolated mutants of Klebsiella aerogenes with insertions of transposon Tn5 linked to the structural gene for glutamine synthetase, glnA. We found that K. aerogenes, like Escherichia coli and...
The Agricultural Health Study.
Alavanja, M C, Sandler, D P, McMaster, S B, Zahm, S H, McDonnell, C J, Lynch, C F, ...
The Agricultural Health Study, a large prospective cohort study has been initiated in North Carolina and Iowa. The objectives of this study are to: 1) identify and quantify cancer risks among men,...
Talaska, G, Underwood, P, Maier, A, Lewtas, J, Rothman, N, Jaeger, M
Lung cancer caused by polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs and related environmental agents is a major problem in industrialized nations. The high case-fatality rate of the disease,...
Interphase cytogenetics of workers exposed to benzene.
Zhang, L, Rothman, N, Wang, Y, Hayes, R B, Bechtold, W, Venkatesh, P, ...
Fluorescence in situ hybridization (FISH) is a powerful new technique that allows numerical chromosome aberrations (aneuploidy) to be detected in interphase cells. In previous studies, FISH has been...
Linet, M S, Yin, S N, Travis, L B, Li, C Y, Zhang, Z N, Li, D G, ...
Previous occupational cohort studies of benzene-exposed workers have for the most part used only death certificates to validate diagnoses of workers developing leukemia and other hematopoietic and...
Indirect validation of benzene exposure assessment by association with benzene poisoning.
Dosemeci, M, Yin, S N, Linet, M, Wacholder, S, Rothman, N, Li, G L, ...
We present a validation study of a quantitative retrospective exposure assessment method used in a follow-up study of workers exposed to benzene. Assessment of exposure to benzene was carried out in...
Mortality among benzene-exposed workers in China.
Hayes, R B, Yin, S N, Dosemeci, M, Li, G L, Wacholder, S, Chow, W H, ...
A large cohort of 74,828 benzene-exposed and 35,805 nonexposed workers employed between 1972 and 1987 in 12 cities in China was followed to determine mortality from all causes. Benzene-exposed study...
An epidemiologic study of early biologic effects of benzene in Chinese workers.
Rothman, N, Smith, M T, Hayes, R B, Li, G L, Irons, R D, Dosemeci, M, ...
Benzene is a recognized hematotoxin and leukemogen, but its mechanisms of action in humans are still uncertain. To provide insight into these processes, we carried out a cross-sectional study of 44...
Using biomarkers of genetic susceptibility to enhance the study of cancer etiology.
There has been increasing interest in the interaction of genetic susceptibility and xenobiotic exposures in cancer etiology. Study of gene-environment interactions may increase our ability to...
Rothman, N, Poirier, M C, Haas, R A, Correa-Villasenor, A, Ford, P, Hansen, J A, ...
Previous investigations suggest that dietary sources of polycyclic aromatic hydrocarbons (PAHs) contribute to the PAH-DNA adduct load in peripheral white blood cells (WBCs). In the current study, we...
Kang, D, Rothman, N, Cho, S H, Lim, H S, Kwon, H J, Kim, S M, ...
OBJECTIVES--Increased risk of lung cancer has been associated with employment in the steel industry. This association is thought to be due in part to increased concentrations of polycyclic aromatic...
Rothman, N., Bechtold, W. E., Yin, S. N., Dosemeci, M., Li, G. L., Wang, Y. Z., ...
OBJECTIVES: Animal inhalation studies and theoretical models suggest that the pattern of formation of benzene metabolites changes as exposure to benzene increases. To determine if this occurs in...
Evaluation of Methyprylon in Chronic Insomniac Patients with Various Physical Disorders*
Billow, B. W., Whiteman, N., Carey, R., Cabodevilla, A., Barnes, L., Rothman, N., ...
Assessment of lifetime exposure to trihalomethanes through different routes
Villanueva, C M, Cantor, K P, Grimalt, J O, Castaño‐Vinyals, G, Malats, N, Silverman, D, ...
Karami, S., Boffetta, P., Rothman, N., Hung, R. J., Stewart, T., Zaridze, D., ...
This study investigated associations between occupational pesticide exposure and renal cell carcinoma (RCC) risk. To follow-up on a previous report by Buzio et al., we also considered whether this...