Chou, H. H., Hayakawa, T., Diaz, S., Krings, M., Indriati, E., Leakey, M., ...
Humans are genetically deficient in the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an Alu- mediated inactivating mutation of the gene encoding the enzyme...
Horai, S, Hayasaka, K, Kondo, R, Tsugane, K, Takahata, N
We analyzed the complete mitochondrial DNA (mtDNA) sequences of three humans (African, European, and Japanese), three African apes (common and pygmy chimpanzees, and gorilla), and one orangutan in an...
Obata, Y, Satta, Y, Moriwaki, K, Shiroishi, T, Hasegawa, H, Takahashi, T, ...
In contrast to well-studied "classical" class I genes of the major histocompatibility complex (MHC), the biology of nonclassical class I genes remains largely unexamined. The mouse TL genes...
Intensity of natural selection at the major histocompatibility complex loci.
Satta, Y, O'hUigin, C, Takahata, N, Klein, J
Long persistence of allelic lineages, prevalence of nonsynonymous over synonymous substitutions in the peptide-binding region (PBR), and deviation from neutrality of the expected gene identity...
The synonymous substitution rate of the major histocompatibility complex loci in primates.
Satta, Y, O'hUigin, C, Takahata, N, Klein, J
Because the divergence of many allelic lineages at the major histocompatibility complex (MHC) loci predates species divergence, standard methods of calculating synonymous substitution rates are not...
Evolution of the mouse t haplotype: recent and worldwide introgression to Mus musculus.
Morita, T, Kubota, H, Murata, K, Nozaki, M, Delarbre, C, Willison, K, ...
Mouse t haplotypes are variants of chromosome 17, consisting of four inversions. Despite the homozygous lethality and pleiotropic effect on embryonic development, sperm production, and recombination,...
Different alleles undergoing strong symmetric balancing selection show a simple genealogical structure (allelic genealogy), similar to the gene genealogy described by the coalescence process for a...
Evolution of Drosophila mitochondrial DNA and the history of the melanogaster subgroup.
The nucleotide sequences of a common region of 15 mitochondrial DNAs (mtDNAs) sampled from the Drosophila melanogaster subgroup were determined. The region is 2527 base pairs long, including most of...
To account for the transmission of mitochondrial DNA between conspecific species Drosophila pseudoobscura and D. persimilis in sympatry reported by J.R. Powell [Powell, J.R. (1983) Proc. Natl. Acad....
Effect of temporal fluctuation of selection coefficient on gene frequency in a population.
Takahata, N, Ishii, K, Matsuda, H
The diffusion equations describing the change of gene frequencies are extended to indlude the effect of temporal fluctuation of selection coefficient that may persist for some generations. The...
We studied the fixation of null alleles at independent duplicate loci, assuming that wild-type active alleles mutate irreversibly to nonfunctional null alleles and that the population is finite and...
A genealogical relationship among genes at a locus (gene tree) sampled from three related populations was examined with special reference to population relatedness (population tree). A...
To explain the long-term persistence of polymorphic alleles (trans-specific polymorphism) at the major histocompatibility complex (MHC) loci in rodents and primates, a computer simulation study was...
Incomplete Maternal Transmission of Mitochondrial DNA in Drosophila
Kondo, R., Satta, Y., Matsuura, E. T., Ishiwa, H., Takahata, N., Chigusa, S. I.
The possibility of incomplete maternal transmission of mitochondrial DNA (mtDNA) in Drosophila, previously suggested by the presence of heteroplasmy, was examined by intra- and interspecific...
In a geographically structured population, the interplay among gene migration, genetic drift and natural selection raises intriguing evolutionary problems, but the rigorous mathematical treatment is...
Polymorphism and Balancing Selection at Major Histocompatibility Complex Loci
Takahata, N., Satta, Y., Klein, J.
Amino acid replacements in the peptide-binding region (PBR) of the functional major histocompatibility complex (Mhc) genes appear to be driven by balancing selection. Of the various types of...
Horai, S, Hayasaka, K, Kondo, R, Tsugane, K, Takahata, N
We analyzed the complete mitochondrial DNA (mtDNA) sequences of three humans (African, European, and Japanese), three African apes (common and pygmy chimpanzees, and gorilla), and one orangutan in an...
Obata, Y, Satta, Y, Moriwaki, K, Shiroishi, T, Hasegawa, H, Takahashi, T, ...
In contrast to well-studied "classical" class I genes of the major histocompatibility complex (MHC), the biology of nonclassical class I genes remains largely unexamined. The mouse TL genes...
Intensity of natural selection at the major histocompatibility complex loci.
Satta, Y, O'hUigin, C, Takahata, N, Klein, J
Long persistence of allelic lineages, prevalence of nonsynonymous over synonymous substitutions in the peptide-binding region (PBR), and deviation from neutrality of the expected gene identity...
The synonymous substitution rate of the major histocompatibility complex loci in primates.
Satta, Y, O'hUigin, C, Takahata, N, Klein, J
Because the divergence of many allelic lineages at the major histocompatibility complex (MHC) loci predates species divergence, standard methods of calculating synonymous substitution rates are not...
Evolution of the mouse t haplotype: recent and worldwide introgression to Mus musculus.
Morita, T, Kubota, H, Murata, K, Nozaki, M, Delarbre, C, Willison, K, ...
Mouse t haplotypes are variants of chromosome 17, consisting of four inversions. Despite the homozygous lethality and pleiotropic effect on embryonic development, sperm production, and recombination,...
Different alleles undergoing strong symmetric balancing selection show a simple genealogical structure (allelic genealogy), similar to the gene genealogy described by the coalescence process for a...
Evolution of Drosophila mitochondrial DNA and the history of the melanogaster subgroup.
The nucleotide sequences of a common region of 15 mitochondrial DNAs (mtDNAs) sampled from the Drosophila melanogaster subgroup were determined. The region is 2527 base pairs long, including most of...
To account for the transmission of mitochondrial DNA between conspecific species Drosophila pseudoobscura and D. persimilis in sympatry reported by J.R. Powell [Powell, J.R. (1983) Proc. Natl. Acad....
Effect of temporal fluctuation of selection coefficient on gene frequency in a population.
Takahata, N, Ishii, K, Matsuda, H
The diffusion equations describing the change of gene frequencies are extended to indlude the effect of temporal fluctuation of selection coefficient that may persist for some generations. The...
We studied the fixation of null alleles at independent duplicate loci, assuming that wild-type active alleles mutate irreversibly to nonfunctional null alleles and that the population is finite and...
A genealogical relationship among genes at a locus (gene tree) sampled from three related populations was examined with special reference to population relatedness (population tree). A...
To explain the long-term persistence of polymorphic alleles (trans-specific polymorphism) at the major histocompatibility complex (MHC) loci in rodents and primates, a computer simulation study was...
Incomplete Maternal Transmission of Mitochondrial DNA in Drosophila
Kondo, R., Satta, Y., Matsuura, E. T., Ishiwa, H., Takahata, N., Chigusa, S. I.
The possibility of incomplete maternal transmission of mitochondrial DNA (mtDNA) in Drosophila, previously suggested by the presence of heteroplasmy, was examined by intra- and interspecific...
In a geographically structured population, the interplay among gene migration, genetic drift and natural selection raises intriguing evolutionary problems, but the rigorous mathematical treatment is...
Polymorphism and Balancing Selection at Major Histocompatibility Complex Loci
Takahata, N., Satta, Y., Klein, J.
Amino acid replacements in the peptide-binding region (PBR) of the functional major histocompatibility complex (Mhc) genes appear to be driven by balancing selection. Of the various types of...
The origin and age of haplochromine fishes in Lake Victoria, east Africa.
Nagl, S, Tichy, H, Mayer, W E, Takezaki, N, Takahata, N, Klein, J
According to a widely held view, the more than 300 species of haplochromine cichlid fishes in Lake Victoria (LV), East Africa, originated from a single founder species in less than 12,000 years. This...
Increased activity of oligo-2',5'-adenylate synthetase in Down's syndrome and epilepsy.
Fujii, N, Oguma, K, Fujii, M, Fukatsu, R, Takahata, N, Kitabatake, M
The level of oligo-2',5'-adenylate synthetase activity is a good marker for the response of cells to interferon. This enzyme can polymerize ATP to form oligonucleotides in the presence of...
Chronic brainstem encephalitis with mental symptoms and ataxia: report of three cases with necropsy.
Three necropsied cases of chronic, sporadic brainstem encephalitis of unknown aetiology are presented. Since their outstanding symptoms were dementia and ataxia of a progressive nature, a...
Residual neurobehavioural effects associated with chronic exposure to mercury vapour.
Kishi, R, Doi, R, Fukuchi, Y, Satoh, H, Satoh, T, Ono, A, ...
To find the residual effects of long term exposure to mercury vapour, neurobehavioural tests were given to ex-mercury miners about 18 years after the end of mercury exposure. Seventy six male...