Weiss, W. J., Jacobus, N. V., Petersen, P. J., Testa, Raymond T.
The in-vitro activities of two glycylcyclines, DMG-MINO and DMG-DMDOT, and several comparative agents were determined against 263 enterococci, 102 methicillin-resistant Staphylococcus aureus and 55...
Cornick, N. A., Cuchural, G. J., Snydman, D. R., Jacobus, N. V., Iannini, P., Hill, G., ...
A nationwide survey to monitor tbe susceptibility of the Bacteroides fragilis group, which began in 1981, was continued during 1987. In addition to the eleven drugs evaluated in 1986, sulbactam, a...
Davey, P. G., Jacobus, N. V, Tally, F. P.
Spriramycin, a macrolide antibiotic, has inferior in-vitro activity to erythromycin, but superior tissue penetration. Recent publications have suggested that the in-vivo activity of spiramycin should...
Petersen, P. J., Jacobus, N. V., Weiss, W. J., Sum, P. E., Testa, R. T.
The 9-t-butylglycylamido derivative of minocycline (TBG-MINO) is a recently synthesized member of a novel group of antibiotics, the glycylcyclines. This new derivative, like the first glycylcyclines,...
Snydman, D. R., Jacobus, N. V., McDermott, L. A., Supran, S., Cuchural, G. J., Finegold, S., ...
Antimicrobial resistance, including plasmid-mediated resistance, among the species of the Bacteroides fragilis group is well documented. An analysis of the in vitro susceptibility of B. fragilis...
Snydman, D. R., Jacobus, N. V., McDermott, L. A., Lonks, J. R., Boyce, J. M.
The in vitro activity of daptomycin against 224 current gram-positive clinical isolates including vancomycin-resistant Enterococcus faecium (VREF), methicillin-resistant Staphylococcus aureus (MRSA),...
In Vitro Activities of Newer Quinolones against Bacteroides Group Organisms
Snydman, D. R., Jacobus, N. V., McDermott, L. A., Ruthazer, R., Goldstein, E., Finegold, S., ...
The activities of BMS-284576, clinafloxacin, moxifloxacin, sitafloxacin, trovafloxacin, imipenem, cefoxitin, and clindamycin against 589 Bacteroides fragilis group isolates were determined. The...
In Vitro Activities of Newer Quinolones against Bacteroides Group Organisms
Snydman, D. R., Jacobus, N. V., McDermott, L. A., Ruthazer, R., Goldstein, E., Finegold, S., ...
Bradford, P A, Jacobus, N V, Bhachech, N, Bush, K
TEM-28 (pI 6.1), expressed by an Escherichia coli clinical isolate, is a novel beta-lactamase which hydrolyzed ceftazidime, cefotaxime, and aztreonam with rates of 25, 1.1, and 5.6, respectively,...
Cuchural, G J, Tally, F P, Jacobus, N V, Cleary, T, Finegold, S M, Hill, G, ...
A nationwide susceptibility survey of 557 isolates of the Bacteroides fragilis group was continued in 1986. The most active beta-lactam drugs were imipenem and ticarcillin-clavulanic acid, which had...
Activity of trospectomycin against Bacteroides fragilis and other Bacteroides species.
The in vitro activity of trospectomycin (U-63366; 6'-n-propyl spectinomycin pentahydrate sulfate) was evaluated against 189 clinical isolates of the Bacteroides fragilis group and 65 Bacteroides...
Cuchural, G J, Tally, F P, Jacobus, N V, Aldridge, K, Cleary, T, Finegold, S M, ...
An ongoing survey of the susceptibility of the Bacteroides fragilis group of bacteria was continued at New England Medical Center in 1984 and 1985. A total of 1,229 strains were obtained from eight...
Kuck, N A, Jacobus, N V, Petersen, P J, Weiss, W J, Testa, R T
Tazobactam (YTR-830H), a novel beta-lactamase inhibitor, was compared with clavulanic acid and sulbactam for enhancement of the activity of piperacillin against beta-lactamase-producing,...
Effect of broad-spectrum parenteral antibiotics on composition of intestinal microflora of humans.
Giuliano, M, Barza, M, Jacobus, N V, Gorbach, S L
We compared the effects of four beta-lactam drugs with widely differing antibacterial and pharmacological properties on the composition of the intestinal flora. Cefoxitin, piperacillin, cefoperazone,...
Barza, M, Giuliano, M, Jacobus, N V, Gorbach, S L
Studies with animals have shown that the normal intestinal microflora protects against colonization by new strains ("colonization resistance") and that this protective effect may be related to the...
Antimicrobial substance from a human Lactobacillus strain.
Silva, M, Jacobus, N V, Deneke, C, Gorbach, S L
Lactobacillus sp. strain GG, which was isolated from the feces of a normal person, produced a substance with potent inhibitory activity against a wide range of bacterial species. It inhibited...
Activity of cefmetazole against anaerobic bacteria.
Cornick, N A, Jacobus, N V, Gorbach, S L
The in vitro activity of cefmetazole versus that of other antimicrobial drugs was assessed against 374 clinical isolates of Bacteroides spp., Clostridium spp., and anaerobic gram-positive cocci....
Nationwide study of the susceptibility of the Bacteroides fragilis group in the United States.
Tally, F P, Cuchural, G J, Jacobus, N V, Gorbach, S L, Aldridge, K, Cleary, T, ...
A nationwide susceptibility survey of the Bacteroides fragilis group was continued at New England Medical Center in 1983. A total of 555 strains were obtained from eight centers in the United States....
Antimicrobial spectrum of Win 49375.
Jacobus, N V, Tally, F P, Barza, M
Win 49375 had excellent activity against members of the family Enterobacteriaceae and staphylococcal species. Its activity against Pseudomonas aeruginosa was equal to that of gentamicin. Win 49375...
In vitro activity of cefbuperazone against Bacteroides spp.
Dias, M B, Jacobus, N V, Gorbach, S L, Tally, F P
The activity of cefbuperazone was tested in vitro against 287 clinical isolates of Bacteroides spp. Cefbuperazone showed good activity against B. fragilis, B. vulgatus, and other Bacteroides species,...
Susceptibility of the Bacteroides fragilis group in the United States in 1981.
Tally, F P, Cuchural, G J, Jacobus, N V, Gorbach, S L, Aldridge, K E, Cleary, T J, ...
The minimal inhibitory concentrations of nine antimicrobial agents was determined for over 750 clinical isolates of the Bacteroides fragilis group of anaerobic bacteria collected from nine centers in...
Cefoxitin inactivation by Bacteroides fragilis.
Cuchural, G J, Tally, F P, Jacobus, N V, Marsh, P K, Mayhew, J W
We have surveyed the susceptibility of 1,575 clinical isolates of the Bacteroides fragilis group of organisms to cefoxitin and eight other antimicrobial agents. Eleven isolates, 0.7% of the total,...
Bacteroides fragilis resistance to clindamycin in vitro.
Sosa, A, Tally, F P, Jacobus, N V, Gorbach, S L
Clindamycin resistance in Bacteroides fragilis was examined in 507 strains isolated from 1973 to 1981. Three groups were recognized: highly susceptible (minimum inhibitory concentration [MIC] less...
In vitro activity of azthreonam, a monobactam antibiotic.
Jacobus, N V, Ferreira, M C, Barza, M
We studied the activity of azthreonam (SQ 26,776), a novel monocyclic beta-lactam compound, against a variety of clinical isolates. It was more potent than moxalactam, cefoperazone, cefamandole,...
Testa, R T, Petersen, P J, Jacobus, N V, Sum, P E, Lee, V J, Tally, F P
N,N-Dimethylglycylamido (DMG) derivatives of minocycline and 6-demethyl-6-deoxytetracycline are new semisynthetic tetracyclines referred to as the glycylcyclines. The in vitro activities of the...
In vitro and in vivo activities of LJC10,627, a new carbapenem with stability to dehydropeptidase I.
Petersen, P J, Jacobus, N V, Weiss, W J, Testa, R T
The activity of LJC10,627 was compared with the activities of imipenem and other antibiotics. LJC10,627 was more active against most members of the family Enterobacteriaceae, Pseudomonas spp., and...
Differentiation of Bacteroides ovatus and Bacteroides thetaiotaomicron by means of bacteriophage.
Cooper, S W, Szymczak, E G, Jacobus, N V, Tally, F P
Two members of the Bacteroides fragilis group, B. ovatus and B. thetaiotaomicron, are difficult to distinguish by biochemical methods. They are currently identified on the basis of their variable...
In vitro activity of N-formimidoyl thienamycin (MK0787).
Tally, F P, Jacobus, N V, Gorbach, S L
The in vitro activity of N-formimidoyl thienamycin (MK0787), a stable congener of thienamycin, was determined against 200 species of aerobic and 84 species of anaerobic bacteria. The compound was...
Cuchural, G J, Tally, F P, Jacobus, N V, Gorbach, S L, Aldridge, K, Cleary, T, ...
A susceptibility survey of 537 strains of the Bacteroides fragilis group from eight centers in the United States was continued at the Tufts New England Medical Center in 1982. The results were...
Singh, M P, Petersen, P J, Jacobus, N V, Maiese, W M, Greenstein, M, Steinberg, D A
The bioxalomycins, a novel complex of broad-spectrum antibiotics, were isolated from fermentations of Streptomyces viridodiastaticus subsp. "litoralis" LL-31F508. Bioxalomycin alpha 2, the major...
In vitro activity of LY127935.
Barza, M, Tally, F P, Jacobus, N V, Gorbach, S L
The activity of LY127935, a beta-lactam antibiotic of novel structure, was studied in vitro against facultative gram-negative bacilli, Staphylococcus aureus, and Bacteroides fragilis. The strains...
In Vitro Activities of Tigecycline against the Bacteroides fragilis Group
Jacobus, N. V., McDermott, L. A., Ruthazer, R., Snydman, D. R.
The in vitro activities of tigecycline were tested against 831 isolates of the Bacteroides fragilis group representing all of the species within the group. On a weight-to-weight basis (8 μg/ml),...
Superoxide dismutase in anaerobic bacteria of clinical significance.
Tally, F P, Goldin, B R, Jacobus, N V, Gorbach, S L
Twenty-two anaerobic bacteria isolated from infected sites and normal fecal flora were assayed for superoxide dismutase (SOD). The organisms were also classified according to their oxygen tolerance...
Petersen, P. J., Jacobus, N. V., Weiss, W. J., Sum, P. E., Testa, R. T.
The 9-t-butylglycylamido derivative of minocycline (TBG-MINO) is a recently synthesized member of a novel group of antibiotics, the glycylcyclines. This new derivative, like the first glycylcyclines,...
Snydman, D. R., Jacobus, N. V., McDermott, L. A., Supran, S., Cuchural, G. J., Finegold, S., ...
Antimicrobial resistance, including plasmid-mediated resistance, among the species of the Bacteroides fragilis group is well documented. An analysis of the in vitro susceptibility of B. fragilis...
Snydman, D. R., Jacobus, N. V., McDermott, L. A., Lonks, J. R., Boyce, J. M.
The in vitro activity of daptomycin against 224 current gram-positive clinical isolates including vancomycin-resistant Enterococcus faecium (VREF), methicillin-resistant Staphylococcus aureus (MRSA),...
In Vitro Activities of Newer Quinolones against Bacteroides Group Organisms
Snydman, D. R., Jacobus, N. V., McDermott, L. A., Ruthazer, R., Goldstein, E., Finegold, S., ...
The activities of BMS-284576, clinafloxacin, moxifloxacin, sitafloxacin, trovafloxacin, imipenem, cefoxitin, and clindamycin against 589 Bacteroides fragilis group isolates were determined. The...
In Vitro Activities of Newer Quinolones against Bacteroides Group Organisms
Snydman, D. R., Jacobus, N. V., McDermott, L. A., Ruthazer, R., Goldstein, E., Finegold, S., ...
Bradford, P A, Jacobus, N V, Bhachech, N, Bush, K
TEM-28 (pI 6.1), expressed by an Escherichia coli clinical isolate, is a novel beta-lactamase which hydrolyzed ceftazidime, cefotaxime, and aztreonam with rates of 25, 1.1, and 5.6, respectively,...
Cuchural, G J, Tally, F P, Jacobus, N V, Cleary, T, Finegold, S M, Hill, G, ...
A nationwide susceptibility survey of 557 isolates of the Bacteroides fragilis group was continued in 1986. The most active beta-lactam drugs were imipenem and ticarcillin-clavulanic acid, which had...
Activity of trospectomycin against Bacteroides fragilis and other Bacteroides species.
The in vitro activity of trospectomycin (U-63366; 6'-n-propyl spectinomycin pentahydrate sulfate) was evaluated against 189 clinical isolates of the Bacteroides fragilis group and 65 Bacteroides...
Cuchural, G J, Tally, F P, Jacobus, N V, Aldridge, K, Cleary, T, Finegold, S M, ...
An ongoing survey of the susceptibility of the Bacteroides fragilis group of bacteria was continued at New England Medical Center in 1984 and 1985. A total of 1,229 strains were obtained from eight...
Kuck, N A, Jacobus, N V, Petersen, P J, Weiss, W J, Testa, R T
Tazobactam (YTR-830H), a novel beta-lactamase inhibitor, was compared with clavulanic acid and sulbactam for enhancement of the activity of piperacillin against beta-lactamase-producing,...
Effect of broad-spectrum parenteral antibiotics on composition of intestinal microflora of humans.
Giuliano, M, Barza, M, Jacobus, N V, Gorbach, S L
We compared the effects of four beta-lactam drugs with widely differing antibacterial and pharmacological properties on the composition of the intestinal flora. Cefoxitin, piperacillin, cefoperazone,...
Barza, M, Giuliano, M, Jacobus, N V, Gorbach, S L
Studies with animals have shown that the normal intestinal microflora protects against colonization by new strains ("colonization resistance") and that this protective effect may be related to the...
Antimicrobial substance from a human Lactobacillus strain.
Silva, M, Jacobus, N V, Deneke, C, Gorbach, S L
Lactobacillus sp. strain GG, which was isolated from the feces of a normal person, produced a substance with potent inhibitory activity against a wide range of bacterial species. It inhibited...
Activity of cefmetazole against anaerobic bacteria.
Cornick, N A, Jacobus, N V, Gorbach, S L
The in vitro activity of cefmetazole versus that of other antimicrobial drugs was assessed against 374 clinical isolates of Bacteroides spp., Clostridium spp., and anaerobic gram-positive cocci....
Nationwide study of the susceptibility of the Bacteroides fragilis group in the United States.
Tally, F P, Cuchural, G J, Jacobus, N V, Gorbach, S L, Aldridge, K, Cleary, T, ...
A nationwide susceptibility survey of the Bacteroides fragilis group was continued at New England Medical Center in 1983. A total of 555 strains were obtained from eight centers in the United States....
Antimicrobial spectrum of Win 49375.
Jacobus, N V, Tally, F P, Barza, M
Win 49375 had excellent activity against members of the family Enterobacteriaceae and staphylococcal species. Its activity against Pseudomonas aeruginosa was equal to that of gentamicin. Win 49375...
In vitro activity of cefbuperazone against Bacteroides spp.
Dias, M B, Jacobus, N V, Gorbach, S L, Tally, F P
The activity of cefbuperazone was tested in vitro against 287 clinical isolates of Bacteroides spp. Cefbuperazone showed good activity against B. fragilis, B. vulgatus, and other Bacteroides species,...
Susceptibility of the Bacteroides fragilis group in the United States in 1981.
Tally, F P, Cuchural, G J, Jacobus, N V, Gorbach, S L, Aldridge, K E, Cleary, T J, ...
The minimal inhibitory concentrations of nine antimicrobial agents was determined for over 750 clinical isolates of the Bacteroides fragilis group of anaerobic bacteria collected from nine centers in...
Cefoxitin inactivation by Bacteroides fragilis.
Cuchural, G J, Tally, F P, Jacobus, N V, Marsh, P K, Mayhew, J W
We have surveyed the susceptibility of 1,575 clinical isolates of the Bacteroides fragilis group of organisms to cefoxitin and eight other antimicrobial agents. Eleven isolates, 0.7% of the total,...
Bacteroides fragilis resistance to clindamycin in vitro.
Sosa, A, Tally, F P, Jacobus, N V, Gorbach, S L
Clindamycin resistance in Bacteroides fragilis was examined in 507 strains isolated from 1973 to 1981. Three groups were recognized: highly susceptible (minimum inhibitory concentration [MIC] less...
In vitro activity of azthreonam, a monobactam antibiotic.
Jacobus, N V, Ferreira, M C, Barza, M
We studied the activity of azthreonam (SQ 26,776), a novel monocyclic beta-lactam compound, against a variety of clinical isolates. It was more potent than moxalactam, cefoperazone, cefamandole,...
Testa, R T, Petersen, P J, Jacobus, N V, Sum, P E, Lee, V J, Tally, F P
N,N-Dimethylglycylamido (DMG) derivatives of minocycline and 6-demethyl-6-deoxytetracycline are new semisynthetic tetracyclines referred to as the glycylcyclines. The in vitro activities of the...
In vitro and in vivo activities of LJC10,627, a new carbapenem with stability to dehydropeptidase I.
Petersen, P J, Jacobus, N V, Weiss, W J, Testa, R T
The activity of LJC10,627 was compared with the activities of imipenem and other antibiotics. LJC10,627 was more active against most members of the family Enterobacteriaceae, Pseudomonas spp., and...
Differentiation of Bacteroides ovatus and Bacteroides thetaiotaomicron by means of bacteriophage.
Cooper, S W, Szymczak, E G, Jacobus, N V, Tally, F P
Two members of the Bacteroides fragilis group, B. ovatus and B. thetaiotaomicron, are difficult to distinguish by biochemical methods. They are currently identified on the basis of their variable...
In vitro activity of N-formimidoyl thienamycin (MK0787).
Tally, F P, Jacobus, N V, Gorbach, S L
The in vitro activity of N-formimidoyl thienamycin (MK0787), a stable congener of thienamycin, was determined against 200 species of aerobic and 84 species of anaerobic bacteria. The compound was...
Cuchural, G J, Tally, F P, Jacobus, N V, Gorbach, S L, Aldridge, K, Cleary, T, ...
A susceptibility survey of 537 strains of the Bacteroides fragilis group from eight centers in the United States was continued at the Tufts New England Medical Center in 1982. The results were...
Singh, M P, Petersen, P J, Jacobus, N V, Maiese, W M, Greenstein, M, Steinberg, D A
The bioxalomycins, a novel complex of broad-spectrum antibiotics, were isolated from fermentations of Streptomyces viridodiastaticus subsp. "litoralis" LL-31F508. Bioxalomycin alpha 2, the major...
In vitro activity of LY127935.
Barza, M, Tally, F P, Jacobus, N V, Gorbach, S L
The activity of LY127935, a beta-lactam antibiotic of novel structure, was studied in vitro against facultative gram-negative bacilli, Staphylococcus aureus, and Bacteroides fragilis. The strains...
In Vitro Activities of Tigecycline against the Bacteroides fragilis Group
Jacobus, N. V., McDermott, L. A., Ruthazer, R., Snydman, D. R.
The in vitro activities of tigecycline were tested against 831 isolates of the Bacteroides fragilis group representing all of the species within the group. On a weight-to-weight basis (8 μg/ml),...
Superoxide dismutase in anaerobic bacteria of clinical significance.
Tally, F P, Goldin, B R, Jacobus, N V, Gorbach, S L
Twenty-two anaerobic bacteria isolated from infected sites and normal fecal flora were assayed for superoxide dismutase (SOD). The organisms were also classified according to their oxygen tolerance...
Snydman, D. R., Jacobus, N. V., McDermott, L. A., Ruthazer, R., Golan, Y., Goldstein, E. J. C., ...
The susceptibility trends for the species of the Bacteroides fragilis group against various antibiotics from 1997 to 2004 were determined by using data for 5,225 isolates referred by 10 medical...