N. Vicker

The effects of thermal annealing on the obliquely deposited Ag–Ge–S thin films (2009)

Wang, F., Dunn, W. P., Jain, M., De Leo, C., Vicker, N., Savage, Richard N., ...

Obliquely deposited thin films of ternary Ag-Ge-S glasses are characterized in this work. Thin films are fabricated in a vacuum thermal evaporator at different evaporation angles and examined by...

Inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (2008)

Su, X., Vicker, N., Potter, B. V. L., Lawton, G., Witty, D. R.

17β-Hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer (2008)

Day, J. M., Foster, P. A., Tutill, H. J., Parsons, M. F. C., Newman, S. P., Chander, S. K., ...

Novel inhibitors of 17β-hydroxysteroid dehydrogenase type 1: templates for design (2008)

Allan, G. M., Vicker, N., Lawrence, H. R., Tutill, H. J., Day, J. M., Huchet, M., ...

Novel non-steroidal inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (2007)

Vicker, N., Su, X., Ganeshapillai, D., Smith, A., Purohit, A., Reed, M. J., ...

Inhibition of human and rat 11β-hydroxysteroid dehydrogenase type 1 by 18β-glycyrrhetinic acid derivatives (2007)

Su, X., Vicker, N., Lawrence, H., Smith, A., Purohit, A., Reed, M. J., ...

17 beta-Hydroxysteroid dehydrogenase Type 1 and Type 2: Association between mRNA expression and activity in cell lines (2006)

Day, J. M., Tutill, H. J., Newman, S. P., Purohit, A., Lawrence, H. R., Vicker, N., ...

17 beta-Hydroxysteroid dehydrogenases (17 beta-HSDs) are a family of enzymes that regulate steroid availability within a tissue by catalysing the interconversion of active and inactive forms. Type 1...

Focused libraries of 16-substituted estrone derivatives and modified E-ring steroids: Inhibitors of 17 beta-hydroxysteroid dehydrogenase type 1 (2006)

Vicker, N., Lawrence, H. R., Allan, G. M., Bubert, C., Smith, A., Tutill, H. J., ...

17 beta-Hydroxysteroid dehydrogenase type 1 (17 beta-HSD1), an oxidoreductase which has a preferential reductive activity using NADPH as cofactor, converts estrone to estradiol and is expressed in...

Modification of estrone at the 6, 16, and 17 positions: Novel potent inhibitors of 17 beta-hydroxysteroid dehydrogenase type 1 (2006)

Allan, G. M., Lawrence, H. R., Cornet, J., Bubert, C., Fischer, D. S., Vicker, N., ...

The 17 beta-hydroxy steroid dehydrogenases (17 beta-HSDs) catalyze the interconversion between the oxidized and reduced forms of androgens and estrogens at the 17 position. The 17 beta-HSD type 1...

Focused libraries of 16-substituted estrone derivatives and modified e-ring steroids: inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (2006)

Vicker, N., Lawrence, H. R., Allan, G. M., Bubert, C., Smith, A., Tutill, H. J., ...

Benzothiazole derivatives as novel inhibitors of human 11β-hydroxysteroid dehydrogenase type (2006)

Su, X., Vicker, N., Ganeshapillai, D., Smith, A., Purohit, A., Reed, M. J., ...

The regulation and inhibition of 17β-hydroxysteroid dehydrogenase in breast cancer (2006)

Purohit, A., Tutill, H. J., Day, J. M., Chander, S. K., Lawrence, H. R., Allan, G. M., ...

17β-hydroxysteroid dehydrogenase Type 1 and Type 2: association between mRNA expression and activity in cell lines (2006)

Day, J. M., Tutill, H. J., Newman, S. P., Purohit, A., Lawrence, H. R., Vicker, N., ...

Rapid microwave-assisted reductive amination of ketones with anilines (2006)

Bailey, H. V., Heaton, W., Vicker, N., Potter, B. V. L.

Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17 β -hydroxysteroid dehydrogenase type 1 (2006)

Allan, G. M., Lawrence, H. R., Cornet, J., Bubert, C., Fischer, D. S., Vicker, N., ...

Novel, potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (2006)

Allan, G. M., Bubert, C., Vicker, N., Smith, A., Tutill, H. J., Purohit, A., ...

E-ring modified steroids as novel potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (2005)

Fischer, D.S., Allan, G.M., Bubert, C., Vicker, N., Smith, A., Tutill, H.J., ...

17β-Hydroxysteroid dehydrogenases (17β-HSDs) are an important class of steroidogenic enzymes that regulate the bioavailability of active estrogens and androgens and are as yet a relatively...

Novel and potent 17 beta-hydroxysteroid dehydrogenase type 1 inhibitors (2005)

Lawrence, H. R., Vicker, N., Allan, G. M., Smith, A., Mahon, M. F., Tutill, H. J., ...

Structure-based drug design using the crystal structure of human 17 beta-hydroxysteroid dehydrogenase type 1 (17 beta-HSD1) led to the discovery of novel, selective, and the most potent inhibitors of...

E-ring modified steroids as novel potent inhibitors of 17 beta-hydroxysteroid dehydrogenase type 1 (2005)

Fischer, D. S., Allan, G. M., Bubert, C., Vicker, N., Smith, A., Tutill, H. J., ...

17 beta-Hydroxysteroid dehydrogenases (17 beta-HSDs) are an important class of steroidogenic enzymes that regulate the bioavailability of active estrogens and androgens and are as yet a relatively...

Novel and potent 17 β -hydroxysteroid dehydrogenase type 1 inhibitors (2005)

Lawrence, H. R., Vicker, N., Allan, G. M., Smith, A., Mahon, M. F., Tutill, H. J., ...

E-ring modified steroids as novel potent inhibitors of 17 β -hydroxysteroid dehydrogenase type 1 (2005)

Fischer, D. S., Allan, G. M., Bubert, C., Vicker, N., Smith, A., Tutill, H. J., ...

A novel 18β-glycyrrhetinic acid analogue as a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase 2 (2004)

Vicker, N., Su, X., Lawrence, H., Cruttenden, A., Purohit, A., Reed, M. J., ...

Novel 18β-glycyrrhetinic acid analogues as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenases (2004)

Su, X., Lawrence, H., Ganeshapillai, D., Cruttenden, A., Purohit, A., Reed, M. J., ...

Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates (2003)

Ho, Y. T., Purohit, A., Vicker, N., Newman, S. P., Robinson, J. J., Leese, M. P., ...

Carbonic anhydrases (CAs) are expressed by many solid tumours where they may act to confer a growth advantage on malignant tissues. 111 this Study we have examined the ability of a series of...

Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II (2003)

Vicker, N., Ho, Y., Robinson, J., Woo, L. W. L., Purohit, A., Reed, M. J., ...

Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates (2003)

Ho, Y. T., Purohit, A., Vicker, N., Newman, S. P., Robinson, J. J., Leese, M. P., ...

Estrone 3-sulfate mimics, inhibitors of estrone sulfatase activity: homology model construction and docking studies (2002)

Howarth, N. M., Purohit, A., Robinson, J. J., Vicker, N., Reed, M. J., Potter, B. V. L.

Concerning the structure of photobilirubin II.

Stoll, M S, Vicker, N, Gray, C H, Bonnett, R

Evidence is presented which supports the postulate that the photobilirubins IIA and IIB are diastereoisomers in which the C-3 vinyl group has cyclized intramolecularly. The evidence comes principally...

Concerning the structure of photobilirubin II.

Stoll, M S, Vicker, N, Gray, C H, Bonnett, R

Evidence is presented which supports the postulate that the photobilirubins IIA and IIB are diastereoisomers in which the C-3 vinyl group has cyclized intramolecularly. The evidence comes principally...