Aoyama, T., Hayakawa, M., Kinoshita, T., Nio, M., Watanabe, N.
We have evaluated the contribution to the anomalous magnetic moment of the electron from six tenth-order Feynman diagrams which contain eighth-order vacuum-polarization function formed by two...
Structural effects of ice grain surfaces on the hydrogenation of CO at low temperatures (2008)
Hidaka, H., Miyauchi, N., Kouchi, A., Watanabe, N.
Experiments on the hydrogenation of CO on crystalline and amorphous ice at 15 K were carried out to investigate the structural effects of the ice surface. The effective rate of H atom addition to CO...
Miyauchi, N., Hidaka, H., Chigai, T., Nagaoka, A., Watanabe, N., Kouchi, A.
The reactions of cold H atoms with solid O2 molecules were investigated at 10 K. The formation of H2O2 and H2O has been confirmed by in-situ infrared spectroscopy. We found that the reaction proceeds...
Kinoshita, Y., Chen, J., Rapee, R.M., Bögels, S., Schneier, F.R., Choy, Y., ...
Conviction subtype Taijin-Kyofu (c-TK) is a subgroup of mental disorder characterized by conviction and strong fear of offending others in social situations. Although the concept of c-TK overlaps...
This paper refers to the prehistorical interaction of human and environments through the reconstruction of spatial structure of the site- catchment over the archaeological sites. The aim of the study...
Hidaka, H., Kouchi, A., Watanabe, N.
An experiment on the addition reaction of a D atom (deuteration) to CO on a cold ice surface is performed by deuterium atom exposure of three types of samples (pure solid CO, CO-capped H2O ice, and...
Hidaka, H., Kouchi, A., Watanabe, N.
An experiment on the addition reaction of a D atom (deuteration) to CO on a cold ice surface is performed by deuterium atom exposure of three types of samples (pure solid CO, CO-capped H2O ice, and...
Asano, T., Kobayashi, Y., Miyushi, F., Matsuyama, T., Watanabe, N., Ryu, S., ...
Background The recurrence rate after ablation of typical atrial flutter (AFL) is still higher than that of other supraventricular tachyarrhythmias. The purpose of the present study was to determine...
Watanabe, N., Kobayashi, Y., Ito, H., Onuki, T., Miyoshi, F., Ryu, S., ...
Objective It is not clear whether a 3-minute single– stage Adenosine tilt (ATP tilt) test is useful to diagnose patients with unexplained syncope. Isoproterenol (ISP) is often utilized to induce...
Kawamura, M., Kobayash, Y., Miyoshi, F., Matsuyama, T., Watanabe, N., Ryu, S., ...
Objectives Transthoracic epicardial ablation is an emerging catheter ablation strategy being used clinically at increasing frequency. This study evaluates the effects of epicardial RF ablation in the...
EFFECT OF CALCIUM TRISODIUM DTPA IN RATS WITH PUNCTURE WOUND CONTAMINATED BY 90Y-CHLORIDE (2005)
Watanabe, N., Tanada, S., Sasaki, Y.
The efficacy of diethylenetriaminepentaacetate calcium trisodium (CaNa3DTPA) in a dose of 34.7 µmol kg-1 as a function of its route of administration was investigated in rats with a puncture wound...
Wada, A., Kunieda, T., Nishimura, M., Kakizoe-Ishida, Y., Watanabe, N., Ohkawa, K., ...
“Tawny” is an autosomal recessive coat color mutation found in a wild population of Mus musculus molossinus. The inbred strain MSKR carries the mutation. The causative gene Mc1rtaw of the tawny...
Wada, A., Kunieda, T., Nishimura, M., Kakizoe-Ishida, Y., Watanabe, N., Ohkawa, K., ...
"Tawny" is an autosomal recessive coat color mutation found in a wild population of Mus musculus molossinus. The inbred strain MSKR carries the mutation. The causative gene Mc1rtaw of the tawny...
Effect of calcium trisodium DTPA in rats with puncture wound contaminated by 90Y-chloride (2005)
Watanabe, N., Tanada, S., Sasaki, Y.
The efficacy of diethylenetriaminepentaacetate calcium trisodium (CaNa3DTPA) in a dose of 34.7 μmol kg−1 as a function of its route of administration was investigated in rats with a puncture wound...
EFFECT OF CALCIUM TRISODIUM DTPA IN RATS WITH PUNCTURE WOUND CONTAMINATED BY 90Y-CHLORIDE (2005)
Watanabe, N., Tanada, S., Sasaki, Y.
The efficacy of diethylenetriaminepentaacetate calcium trisodium (CaNa3DTPA) in a dose of 34.7 µmol kg-1 as a function of its route of administration was investigated in rats with a puncture wound...
Re-appearance of antiferromagnetic ordering with Zn and Ni substitution in La_{2-x}Sr_xCuO_4 (2003)
Machi, T., Kato, I., Hareyama, R., Watanabe, N., Itoh, Y., Koshizuka, N., ...
The effects of nonmagnetic Zn and magnetic Ni substitution for Cu site on magnetism are studied by measurements of uniform magnetic susceptibility for lightly doped La_{2-x}Sr_xCu_{1-z}M_zO_4 (M=Zn...
Zn-Neighbor Cu NQR in Zn-Substituted YBa2Cu3O7-d and YBa2Cu4O8 (2003)
Itoh, Y., Machi, T., Kasai, C., Adachi, S., Watanabe, N., Koshizuka, N., ...
We studied local electronic states near Zn in optimally doped YBa$_2$(Cu$_{1-x}$Zn_x)$_3$O$_{7-\delta}$ and underdoped YBa$_2$(Cu$_{1-x}$Zn_x)$_4$O$_8$ via satellite signals of plane-site Cu(2)...
Watanabe, N, Ikuta, K, Okazaki, K, Nakase, H, Tabata, Y, Matsuura, M, ...
Nakase, H, Okazaki, K, Tabata, Y, Ozeki, M, Watanabe, N, Ohana, M, ...
Zn-doping dependence of the wipeout region around Zn in YBa2(Cu1-xZnx)4O8 (2001)
Itoh, Y., Machi, T., Watanabe, N., Adachi, S., Kasai, C., Koshizuka, N.
We estimated the spread of the magnetically enhanced regions (wipeout regions) around Zn ions in high-Tc superconductors YBa2(Cu1-xZnx)4O8 (x=0, 0.005, 0.01, and 0.022) at T=4.2 K, via the planar...
Cu NQR study of host and guest spin dynamics in impurity-doped YBa2Cu4O8 (2001)
Itoh, Y., Machi, T., Watanabe, N., Koshizuka, N.
We present the planar 63Cu nuclear spin-lattice relaxation study of impurity-doped YBa2(Cu1-xMx)4O8 (M=Ni, Zn) at T=4.2-300 K with Cu nuclear quadrupole resonance (NQR) spin-echo technique. In the...
Spin Dynamics near the Superconductor-to-Insulator Transition in Impurity-Doped YBa2Cu4O8 (2001)
Itoh, Y., Machi, T., Watanabe, N., Adachi, S., Koshizuka, N.
We studied low-frequency spin dynamics near the impurity-induced superconductor-to-insulator transition for underdoped high-Tc superconductor YBa2(Cu1-xMx)4O8 (M=Ni, Zn) using the Cu nuclear...
K. Ohta, K. Umeda, N. Watanabe, M. Hayakawa
ULF/ELF emission observation has been performed at Nakatsugawa observatory (geographic coordinates; 35.4° N, 137.5° E, Gifu prefecture) since January 1999. The equipment consists of...
Ohta, K., Umeda, K., Watanabe, N., Hayakawa, M.
ULF/ELF emission observation has been performed at Nakatsugawa observatory (geographic coordinates; 35.4° N, 137.5° E, Gifu prefecture) since January 1999. The equipment consists of...
Ohta, K., Umeda, K., Watanabe, N., Hayakawa, M.
ULF/ELF emission observation has been performed at Nakatsugawa observatory (geographic coordinates; 35.4° N, 137.5° E, Gifu prefecture) since January 1999. The equipment consists of...
Wang Zhai Ferrell, Trends Cell Biol, A. W. Murray, A. W. Murray, Curr Opin, ...
ine triphosphate (ATP) and 15 mM MgCl 2 . ATF2 (5 mg) and [g- P]ATP (1 mCi) were then added to the mixture, which was incubated for 10 min. Phosphorylated ATF2 was detected by electrophoresis and...
Nishimura, F., Watanabe, N., Tanaka, K.
The uniaxial thermomechanical behavior for a polycristalline Fe-9%Cr-5%Ni-14%Mn-6%Si (all wt.%) shape memory alloy is investigated for both tensile and compressive stress states. The martensite start...
Nishimura, F., Watanabe, N., Tanaka, K.
The uniaxial thermomechanical behavior for a polycristalline Fe-9%Cr-5%Ni-14%Mn-6%Si (all wt.%) shape memory alloy is investigated for both tensile and compressive stress states. The martensite start...
Nishimura, F., Watanabe, N., Tanaka, K.
The uniaxial thermomechanical behavior for a polycristalline Fe-9%Cr-5%Ni-14%Mn-6%Si (all wt.%) shape memory alloy is investigated for both tensile and compressive stress states. The martensite start...
Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice (1997)
Matsuda, H, Watanabe, N, Geba, GP, Sperl, J, Tsudzuki, M, Hiroi, J, ...
Expression of C-terminal src kinase in human colorectal cancer cell lines (1995)
Watanabe, N, Matsuda, S, Kuramochi, S, Tsuzuku, J, Yamamoto, T, Endo, K
Ikeda, S, Watanabe, N, Inoue, K, Kiyanagi, Y, Inaba, A, Takeda, S, ...
MERRILL, GARY F, DOWNEY, H FRED, YONEKURA, S, WATANABE, N, JONES, CARL E
To test the hypothesis that adenosine contributes to the coronary hyperaemia produced by regional non-ischaemic myocardial hypoxia coronary blood flow and myocardial oxygen extraction and consumption...
MARS - A multi-angle rotor spectrometer at the pulsed neutron source ISIS (1987)
Taylor, A D, Ward, R C, Williams, W G, Endoh, Y, Watanabe, N
(ed F Atchison, W Fischer) SIN Report 40926 p535 (1987)
Functional Deterioration of the Peritoneum: Does It Occur in the Absence of Peritonitis? (1987)
Ota, K., Mineshima, M., Watanabe, N., Naganuma, S.
Peritoneal function in relation to the occurrence of peritonitis and the osmolarity of the dialysate was studied in 72 CAPD patients with a mean duration of treatment of 16.5±9.0 months (group 1)....
AlxGa1-xAs/AlyGa1-yAs VISIBLE LASERS GROWN BY MOCVD (1982)
Mori, Y., Matsuda, O., Ikeda, M., Kaneko, K., Watanabe, N.
AlGaAs/AlGaAs double-heterostructure (DH) visible lasers with low threshold current densities have been grown by metalorganic chemical vapor deposition (MOCVD). Proton-isolated narrow stripe visible...
NEUTRON DIFFRACTION STUDY OF AMORPHOUS BINARY ALLOYS (1982)
Mizoguchi, T., Nishioka, N., Yamada, S., Suemasa, T., Yoda, S., Akutsu, N., ...
For structural investigation of amorphous alloys TOF neutron diffraction experiments were carried out with the pulse neutron source at the National Laboratory for High Energy Physics in Japan....
AlxGa1-xAs/AlyGa1-yAs VISIBLE LASERS GROWN BY MOCVD (1982)
Mori, Y., Matsuda, O., Ikeda, M., Kaneko, K., Watanabe, N.
AlGaAs/AlGaAs double-heterostructure (DH) visible lasers with low threshold current densities have been grown by metalorganic chemical vapor deposition (MOCVD). Proton-isolated narrow stripe visible...
NEUTRON DIFFRACTION STUDY OF AMORPHOUS BINARY ALLOYS (1982)
Mizoguchi, T., Nishioka, N., Yamada, S., Suemasa, T., Yoda, S., Akutsu, N., ...
For structural investigation of amorphous alloys TOF neutron diffraction experiments were carried out with the pulse neutron source at the National Laboratory for High Energy Physics in Japan....
AlxGa1-xAs/AlyGa1-yAs VISIBLE LASERS GROWN BY MOCVD (1982)
Mori, Y., Matsuda, O., Ikeda, M., Kaneko, K., Watanabe, N.
AlGaAs/AlGaAs double-heterostructure (DH) visible lasers with low threshold current densities have been grown by metalorganic chemical vapor deposition (MOCVD). Proton-isolated narrow stripe visible...
NEUTRON DIFFRACTION STUDY OF AMORPHOUS BINARY ALLOYS (1982)
Mizoguchi, T., Nishioka, N., Yamada, S., Suemasa, T., Yoda, S., Akutsu, N., ...
For structural investigation of amorphous alloys TOF neutron diffraction experiments were carried out with the pulse neutron source at the National Laboratory for High Energy Physics in Japan....
Does superoxide underlie the pathogenesis of hypertension?
Nakazono, K, Watanabe, N, Matsuno, K, Sasaki, J, Sato, T, Inoue, M
Although active oxygen species play important roles in the pathogenesis of various diseases, the molecular mechanism for oxygen toxicity in vascular diseases remains to be elucidated. Since...
In vitro antimycobacterial activities of pyrazinamide analogs.
Yamamoto, S, Toida, I, Watanabe, N, Ura, T
We synthesized various pyrazine derivatives and pyrazinamide analogs and assayed their antimycobacterial activities in vitro in order to find new drugs which are more active against Mycobacterium...
In vitro and in vivo antibacterial activities of ER-35786, a new antipseudomonal carbapenem.
Ohba, F, Nakamura-Kamijo, M, Watanabe, N, Katsu, K
ER-35786 is a new parenteral 1 beta-methyl carbapenem with a broad antibacterial spectrum and a potent antipseudomonal activity. It showed high in vitro activity, comparable to those of meropenem and...
In vitro evaluation of E1040, a new cephalosporin with potent antipseudomonal activity.
Watanabe, N, Katsu, K, Moriyama, M, Kitoh, K
E1040 is a new parenteral cephalosporin with a broad antibacterial spectrum and potent antipseudomonal activity. The compound was four- to eightfold more active than ceftazidime and cefsulodin...
Watanabe, N, Yugawa, T, Ikawa, Y, Amanuma, H
Friend spleen focus-forming virus (F-SFFV) causes acute erythroleukemia in mice and encodes in its defective env gene an Env-like membrane glycoprotein (gp55). The F-SFFV env gene has three...
In vitro evaluation of E1077, a new cephalosporin with a broad antibacterial spectrum.
Watanabe, N, Hiruma, R, Katsu, K
E1077 is a novel parenteral cephalosporin with a wide spectrum of potent antibacterial activity against aerobic and anaerobic gram-positive and gram-negative bacteria. Against methicillin-susceptible...
Kawanishi, J, Kato, J, Sasaki, K, Fujii, S, Watanabe, N, Niitsu, Y
Detachment of cell-cell adhesion is indispensable for the first step of invasion and metastasis of cancer. This mechanism is frequently associated with the impairment of either E-cadherin expression...
Watanabe, N, McAdam, S N, Boyson, J E, Piekarczyk, M S, Yasutomi, Y, Watkins, D I, ...
The use of the simian immunodeficiency virus (SIV) macaque model for assessing human immunodeficiency virus vaccine strategies will be facilitated by the characterization of predominant SIV cytotoxic...
Watanabe, N, Nishi, M, Ikawa, Y, Amanuma, H
The 3' half of the env gene of the dualtropic Friend mink cell focus-forming virus was modified by replacing the restriction enzyme fragment of the genome DNA with the corresponding fragment of the...
Watanabe, N, Nishi, M, Ikawa, Y, Amanuma, H
To determine the biological significance of the 585-base-pair deletion in the env gene of Friend spleen focus-forming virus (SFFV) encoding a leukemogenic glycoprotein (gp55), we examined the...
Amanuma, H, Watanabe, N, Nishi, M, Ikawa, Y
In order to obtain evidence for the essential role of the single base insertion occurring at the 3' end of the env-related gene of Friend spleen focus-forming virus (SFFV) encoding the leukemogenic...
Watanabe, N, Katakura, K, Kobayashi, A, Okumura, K, Ovary, Z
To elucidate the roles of IgE antibody in host responses to helminth infection, selective IgE-deficient SJA/9 mice were infected with the nematode parasites Nippostrongylus brasiliensis, which...
Cutaneous leishmaniasis in mast cell-deficient W/Wv mice.
Katakura, K, Saito, S, Hamada, A, Matsuda, H, Watanabe, N
Genetically mast cell-deficient W/Wv mice infected with Leishmania amazonensis showed progressive development of ulcerative skin lesions. However, no significant differences between the W/Wv mice and...
beta-Lactam resistance of motile Aeromonas isolates from clinical and environmental sources.
Morita, K, Watanabe, N, Kurata, S, Kanamori, M
The MICs of various beta-lactams for 182 isolates of Aeromonas species, i.e., A. hydrophila (n = 101), A. sobria (n = 69), and A. caviae (n = 12), from clinical and environmental sources were...
Fujita, T, Reis, L F, Watanabe, N, Kimura, Y, Taniguchi, T, Vilcek, J
Nuclear protein IRF-1 (interferon regulatory factor 1) was earlier shown to bind to cis-acting regulatory elements present on interferon (IFN)-alpha/beta genes and some IFN-inducible genes. Here we...
Watanabe, N, Akasaka, K, Shiroya, T, Obinata, M, Shimada, H
Newly synthesized DNA was separated from the bulk of the DNA by pulse-labeling with BUdR and centrifugation in an alkaline CsCl buoyant density gradient. The content of histone gene in the newly...
Regulation of immunoglobulin E production in mice immunized with an extract of Toxoplasma gondii.
Repeated infection with Toxoplasma gondii could not induce immunoglobulin E (IgE) antibody production. When mice were injected intraperitoneally twice over a 3-week interval with an extract of...
Watanabe, N, Sakakibara, J, Hovanessian, A G, Taniguchi, T, Fujita, T
Expression of the Type I IFN (i.e., IFN-alpha s and IFN-beta) genes is efficiently induced by viruses at the transcriptional level. This induction is mediated by at least two types of positive...
Suzuki, Y, Watanabe, N, Kobayashi, A
The effect of Toxoplasma infection on primary antibody responses to both T-dependent and T-independent antigens was examined in mice. Drastic suppression of primary responses to sheep erythrocytes...
Nonspecific suppression of initiation of memory cells in Toxoplasma gondii-infected mice.
Suzuki, Y, Watanabe, N, Kobayashi, A
The effect of Toxoplasma infection on initiation and expression of memory cells to dinitrophenol (DNP)-conjugated protein antigens in humoral immune responses was studied in mice. Marked suppression...
Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle.
Watanabe, N, Broome, M, Hunter, T
In higher eukaryotes, the cyclin-dependent kinases (CDKs) are negatively regulated by phosphorylation on threonine 14 (T14) and tyrosine 15 (Y15). In fission yeast, the Wee1 and mitosis inhibitory...
Thiopeptin, a New Feed-Additive Antibiotic: Biological Studies and Field Trials
Mine, K., Miyairi, N., Takano, N., Mori, S., Watanabe, N.
Thiopeptin is a new antibiotic, produced by Streptomyces tateyamensis and developed solely for animal use as a feed additive. The antibiotic content in animal tissue and feed was assayed in terms of...
Ishizaki, T, Maekawa, M, Fujisawa, K, Okawa, K, Iwamatsu, A, Fujita, A, ...
The small GTP-binding protein Rho functions as a molecular switch in the formation of focal adhesions and stress fibers, cytokinesis and transcriptional activation. The biochemical mechanism...
Staining pattern of type IV collagen and prognosis in early stage adenocarcinoma of the lung.
Watanabe, N, Nakajima, I, Abe, S, Ogura, S, Isobe, H, Kawakami, Y
AIMS--To examine the prognostic value of basement membrane expression in early stage adenocarcinoma of the lung. METHODS--Using antibodies to type IV collagen, basement membrane expression at the...
Kurose, I, Saito, H, Miura, S, Ebinuma, H, Higuchi, H, Watanabe, N, ...
Previous studies have indicated that nitric oxide (NO) released from Kupffer cells modulates biological viability of cocultured hepatoma cells. This study was designed to evaluate the mechanisms by...
Aizawa, S, Suda, Y, Furuta, Y, Yagi, T, Takeda, N, Watanabe, N, ...
A group of retroviruses carrying truncated viral genes has recently been suggested as the cause of new patterns of diseases. One such virus is the replication defective component of the Friend murine...
Nishizawa, M, Okazaki, K, Furuno, N, Watanabe, N, Sagata, N
The c-mos proto-oncogene product, Mos, functions in both early (germinal vesicle breakdown) and late (metaphase II arrest) steps during meiotic maturation in Xenopus oocytes. In the early step, Mos...
Watanabe, N, Madaule, P, Reid, T, Ishizaki, T, Watanabe, G, Kakizuka, A, ...
Rho small GTPase regulates cell morphology, adhesion and cytokinesis through the actin cytoskeleton. We have identified a protein, p140mDia, as a downstream effector of Rho. It is a mammalian homolog...
Watanabe, N, Iwamura, T, Shinoda, T, Fujita, T
The candidate oncoprotein BCL-3 has been shown to function as a transcriptional co-activator for homodimers of NF-kappaB p50 and p50B. We expressed BCL-3 ectopically in pro-B cell lines and found...
The masculinization of the fetus during pregnancy due to inhalation of diesel exhaust.
This study was conducted to determine the impact of diesel exhaust inhalation on the fetus. Seventy-two pregnant rats and 18 nonpregnant rats were divided into three groups: a group exposed to total...
Cell signalling by oxidized lipids and the role of reactive oxygen species in the endothelium
Zmijewski, J.W., Landar, A., Watanabe, N., Dickinson, D.A., Noguchi, N., Darley-Usmar, V.M.
The controlled formation of ROS (reactive oxygen species) and RNS (reactive nitrogen species) is now known to be critical in cellular redox signalling. As with the more familiar...
Inhalation of diesel engine exhaust affects spermatogenesis in growing male rats.
We conducted experiments to determine whether diesel engine exhaust affects reproductive endocrine function in growing rats. The rats were assigned to three groups: a group exposed to total diesel...
Does superoxide underlie the pathogenesis of hypertension?
Nakazono, K, Watanabe, N, Matsuno, K, Sasaki, J, Sato, T, Inoue, M
Although active oxygen species play important roles in the pathogenesis of various diseases, the molecular mechanism for oxygen toxicity in vascular diseases remains to be elucidated. Since...
In vitro antimycobacterial activities of pyrazinamide analogs.
Yamamoto, S, Toida, I, Watanabe, N, Ura, T
We synthesized various pyrazine derivatives and pyrazinamide analogs and assayed their antimycobacterial activities in vitro in order to find new drugs which are more active against Mycobacterium...
In vitro and in vivo antibacterial activities of ER-35786, a new antipseudomonal carbapenem.
Ohba, F, Nakamura-Kamijo, M, Watanabe, N, Katsu, K
ER-35786 is a new parenteral 1 beta-methyl carbapenem with a broad antibacterial spectrum and a potent antipseudomonal activity. It showed high in vitro activity, comparable to those of meropenem and...
In vitro evaluation of E1040, a new cephalosporin with potent antipseudomonal activity.
Watanabe, N, Katsu, K, Moriyama, M, Kitoh, K
E1040 is a new parenteral cephalosporin with a broad antibacterial spectrum and potent antipseudomonal activity. The compound was four- to eightfold more active than ceftazidime and cefsulodin...
Watanabe, N, Yugawa, T, Ikawa, Y, Amanuma, H
Friend spleen focus-forming virus (F-SFFV) causes acute erythroleukemia in mice and encodes in its defective env gene an Env-like membrane glycoprotein (gp55). The F-SFFV env gene has three...
In vitro evaluation of E1077, a new cephalosporin with a broad antibacterial spectrum.
Watanabe, N, Hiruma, R, Katsu, K
E1077 is a novel parenteral cephalosporin with a wide spectrum of potent antibacterial activity against aerobic and anaerobic gram-positive and gram-negative bacteria. Against methicillin-susceptible...
Kawanishi, J, Kato, J, Sasaki, K, Fujii, S, Watanabe, N, Niitsu, Y
Detachment of cell-cell adhesion is indispensable for the first step of invasion and metastasis of cancer. This mechanism is frequently associated with the impairment of either E-cadherin expression...
Watanabe, N, McAdam, S N, Boyson, J E, Piekarczyk, M S, Yasutomi, Y, Watkins, D I, ...
The use of the simian immunodeficiency virus (SIV) macaque model for assessing human immunodeficiency virus vaccine strategies will be facilitated by the characterization of predominant SIV cytotoxic...
Watanabe, N, Nishi, M, Ikawa, Y, Amanuma, H
The 3' half of the env gene of the dualtropic Friend mink cell focus-forming virus was modified by replacing the restriction enzyme fragment of the genome DNA with the corresponding fragment of the...
Watanabe, N, Nishi, M, Ikawa, Y, Amanuma, H
To determine the biological significance of the 585-base-pair deletion in the env gene of Friend spleen focus-forming virus (SFFV) encoding a leukemogenic glycoprotein (gp55), we examined the...
Amanuma, H, Watanabe, N, Nishi, M, Ikawa, Y
In order to obtain evidence for the essential role of the single base insertion occurring at the 3' end of the env-related gene of Friend spleen focus-forming virus (SFFV) encoding the leukemogenic...
Watanabe, N, Katakura, K, Kobayashi, A, Okumura, K, Ovary, Z
To elucidate the roles of IgE antibody in host responses to helminth infection, selective IgE-deficient SJA/9 mice were infected with the nematode parasites Nippostrongylus brasiliensis, which...
Cutaneous leishmaniasis in mast cell-deficient W/Wv mice.
Katakura, K, Saito, S, Hamada, A, Matsuda, H, Watanabe, N
Genetically mast cell-deficient W/Wv mice infected with Leishmania amazonensis showed progressive development of ulcerative skin lesions. However, no significant differences between the W/Wv mice and...
beta-Lactam resistance of motile Aeromonas isolates from clinical and environmental sources.
Morita, K, Watanabe, N, Kurata, S, Kanamori, M
The MICs of various beta-lactams for 182 isolates of Aeromonas species, i.e., A. hydrophila (n = 101), A. sobria (n = 69), and A. caviae (n = 12), from clinical and environmental sources were...
Fujita, T, Reis, L F, Watanabe, N, Kimura, Y, Taniguchi, T, Vilcek, J
Nuclear protein IRF-1 (interferon regulatory factor 1) was earlier shown to bind to cis-acting regulatory elements present on interferon (IFN)-alpha/beta genes and some IFN-inducible genes. Here we...
Watanabe, N, Akasaka, K, Shiroya, T, Obinata, M, Shimada, H
Newly synthesized DNA was separated from the bulk of the DNA by pulse-labeling with BUdR and centrifugation in an alkaline CsCl buoyant density gradient. The content of histone gene in the newly...
Regulation of immunoglobulin E production in mice immunized with an extract of Toxoplasma gondii.
Repeated infection with Toxoplasma gondii could not induce immunoglobulin E (IgE) antibody production. When mice were injected intraperitoneally twice over a 3-week interval with an extract of...
Watanabe, N, Sakakibara, J, Hovanessian, A G, Taniguchi, T, Fujita, T
Expression of the Type I IFN (i.e., IFN-alpha s and IFN-beta) genes is efficiently induced by viruses at the transcriptional level. This induction is mediated by at least two types of positive...
Suzuki, Y, Watanabe, N, Kobayashi, A
The effect of Toxoplasma infection on primary antibody responses to both T-dependent and T-independent antigens was examined in mice. Drastic suppression of primary responses to sheep erythrocytes...
Nonspecific suppression of initiation of memory cells in Toxoplasma gondii-infected mice.
Suzuki, Y, Watanabe, N, Kobayashi, A
The effect of Toxoplasma infection on initiation and expression of memory cells to dinitrophenol (DNP)-conjugated protein antigens in humoral immune responses was studied in mice. Marked suppression...
Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle.
Watanabe, N, Broome, M, Hunter, T
In higher eukaryotes, the cyclin-dependent kinases (CDKs) are negatively regulated by phosphorylation on threonine 14 (T14) and tyrosine 15 (Y15). In fission yeast, the Wee1 and mitosis inhibitory...
Thiopeptin, a New Feed-Additive Antibiotic: Biological Studies and Field Trials
Mine, K., Miyairi, N., Takano, N., Mori, S., Watanabe, N.
Thiopeptin is a new antibiotic, produced by Streptomyces tateyamensis and developed solely for animal use as a feed additive. The antibiotic content in animal tissue and feed was assayed in terms of...
Ishizaki, T, Maekawa, M, Fujisawa, K, Okawa, K, Iwamatsu, A, Fujita, A, ...
The small GTP-binding protein Rho functions as a molecular switch in the formation of focal adhesions and stress fibers, cytokinesis and transcriptional activation. The biochemical mechanism...
Staining pattern of type IV collagen and prognosis in early stage adenocarcinoma of the lung.
Watanabe, N, Nakajima, I, Abe, S, Ogura, S, Isobe, H, Kawakami, Y
AIMS--To examine the prognostic value of basement membrane expression in early stage adenocarcinoma of the lung. METHODS--Using antibodies to type IV collagen, basement membrane expression at the...
Kurose, I, Saito, H, Miura, S, Ebinuma, H, Higuchi, H, Watanabe, N, ...
Previous studies have indicated that nitric oxide (NO) released from Kupffer cells modulates biological viability of cocultured hepatoma cells. This study was designed to evaluate the mechanisms by...
Aizawa, S, Suda, Y, Furuta, Y, Yagi, T, Takeda, N, Watanabe, N, ...
A group of retroviruses carrying truncated viral genes has recently been suggested as the cause of new patterns of diseases. One such virus is the replication defective component of the Friend murine...
Nishizawa, M, Okazaki, K, Furuno, N, Watanabe, N, Sagata, N
The c-mos proto-oncogene product, Mos, functions in both early (germinal vesicle breakdown) and late (metaphase II arrest) steps during meiotic maturation in Xenopus oocytes. In the early step, Mos...
Watanabe, N, Madaule, P, Reid, T, Ishizaki, T, Watanabe, G, Kakizuka, A, ...
Rho small GTPase regulates cell morphology, adhesion and cytokinesis through the actin cytoskeleton. We have identified a protein, p140mDia, as a downstream effector of Rho. It is a mammalian homolog...
Watanabe, N, Iwamura, T, Shinoda, T, Fujita, T
The candidate oncoprotein BCL-3 has been shown to function as a transcriptional co-activator for homodimers of NF-kappaB p50 and p50B. We expressed BCL-3 ectopically in pro-B cell lines and found...
The masculinization of the fetus during pregnancy due to inhalation of diesel exhaust.
This study was conducted to determine the impact of diesel exhaust inhalation on the fetus. Seventy-two pregnant rats and 18 nonpregnant rats were divided into three groups: a group exposed to total...
Inhalation of diesel engine exhaust affects spermatogenesis in growing male rats.
We conducted experiments to determine whether diesel engine exhaust affects reproductive endocrine function in growing rats. The rats were assigned to three groups: a group exposed to total diesel...
Takamoto, M, Wang, Z X, Watanabe, N, Matsuzawa, A, Nariuchi, H, Sugane, K
Mutant mice deficient in CD4+ T cells and their normal and heterozygous littermates were infected with Toxocara canis, and compared for eosinophilia, total and Toxocara-specific immunoglobulin E...
Korenaga, M, Watanabe, N, Abe, T, Hashiguchi, Y
Treatment of mice with recombinant interleukin-3 (rIL-3) accelerated an IL-4-dependent IgE production following infection with Trichinella spiralis. When mice were treated with a total of 1.5 x 10(4)...
Distribution of HLA-B27 in patients with juvenile rheumatoid arthritis.
Mitsui, H, Juji, T, Sonozaki, H, Seki, H, Watanabe, N
HLA antigens were examined in 27 patients with juvenile rheumatoid arthritis. HLA-B27 was found in none. The result was different from most other previously reported studies. The most likely...
Tsuji, N, Watanabe, N, Okamoto, T, Niitsu, Y
Many previous reports using experimental animal models of pancreatitis have suggested that oxygen free radicals play an important part in initiation and development of pancreatitis. Infiltration of...
Hibi, T, Ohara, M, Toda, K, Hara, A, Ogata, H, Iwao, Y, ...
Serum anticolon antibody and in vitro anti-colon antibody production by peripheral blood and mucosal lymphocytes was investigated in patients with ulcerative colitis. The frequency of serum anticolon...
Kohda, K, Ito, N, Ohwada, M, Morita, K, Watanabe, N, Kohgo, Y, ...
We have evaluated the radioimmunoassay for type I procollagen carboxy terminal peptide (type I C-peptide), which is liberated from type I procollagen during its conversion to collagen, in the...
Regression of fundic gland polyps following acquisition of Helicobacter pylori
Watanabe, N, Seno, H, Nakajima, T, Yazumi, S, Miyamoto, S, Matsumoto, S, ...
The prevalence of Helicobacter pylori infection is very low in patients with fundic gland polyps (FGPs) of the stomach. We report here two cases with multiple FGPs that regressed following new H...
Watanabe, N, Akasaka, T, Yamaura, Y, Akiyama, M, Kaji, S, Saito, Y, ...
Watanabe, M, Aiso, S, Hibi, T, Watanabe, N, Iwao, Y, Yoshida, T, ...
Recently it has been reported that patients with ulcerative colitis (UC) often have thymus abnormalities, although the precise mechanisms which induce those abnormalities remain unclear. We have...
Watanabe, N, Hizuta, A, Tanaka, N, Orita, K
We analysed TCR-gamma delta expression in tumour-infiltrating lymphocytes (TIL) obtained from 13 patients with colorectal cancer and simultaneously isolated the T lymphocytes from normal intestinal...
Nucleolar organiser regions as a marker of growth rate in squamous cell carcinoma of the lung.
Abe, S, Sukoh, N, Ogura, S, Kunikane, H, Watanabe, N, Nakajima, I, ...
BACKGROUND: The numbers of nucleolar organiser regions (AgNORs) per cell has been considered as an indicator of the cellular proliferative activity. A study was carried out to examine whether AgNOR...
Pituitary cretinism in two sisters.
Kohno, H, Watanabe, N, Ootsuka, M, Kajiwara, M, Gohya, N
Two sisters with cretinism are reported. Each showed low levels of serum triiodothyronine, thyroxine, and thyroid-stimulating hormone (TSH). In the elder sister, serum TSH did not increase after...
MATSUMOTO, S, NANNO, M, WATANABE, N, MIYASHITA, M, AMASAKI, H, SUZUKI, K, ...
In this study we aimed to elucidate the physiological role of γδ intraepithelial lymphocytes (IEL) in the mouse intestine. For this purpose, we used T-cell receptor (TCR) Vγ4/Vδ5 transgenic mice...
Highly bright X-ray generator using heat of fusion with a specially designed rotating anticathode
Sakabe, N., Ohsawa, S., Sugimura, T., Ikeda, M., Tawada, M., Watanabe, N., ...
A very compact X-ray generator, 4.3 times more brilliant than can be attained by a conventional rotating-anticathode X-ray generator, has been developed using a U-shaped rotating anticathode and a...
Mahara, K., Kato, J., Terui, T., Takimoto, R., Horimoto, M., Murakami, T., ...
To explore the mechanism of increased collagen deposition in scirrhous carcinoma of the stomach, an attempt was made to define the role of transforming growth factor beta 1 (TGF-beta 1), secreted...
Oriuchi, N., Watanabe, N., Sugiyama, S., Higuchi, T., Imai, K., Yamanaka, H., ...
Biodistribution of chimeric mouse/human monoclonal antibody against non-specific cross-reacting antigen (chNCA Ab) was studied in athymic mice and patients with metastatic bone disease. 99mTc-chNCA...
Niitsu, Y., Ito, N., Kohda, K., Owada, M., Morita, K., Sato, S., ...
Human gastric carcinomas were tested for their immunohistochemical reactivity with anti-type I procollagen antiserum. In all specimens of scirrhous carcinomas, staining of the tumour cells was...
Yajima, T, Yagihashi, A, Kameshima, H, Kobayashi, D, Hirata, K, Watanabe, N
Telomerase adds hexameric repeats of 5′-TTAGGG-3′ termed telomeres to ends of chromosomal DNA. This enzyme has been implicated in cellular immortalization and cellular senescence. Recently, a...
Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin
Matsumura, Y, Hamaguchi, T, Ura, T, Muro, K, Yamada, Y, Shimada, Y, ...
Human TSLP directly enhances expansion of CD8+ T cells
Akamatsu, T, Watanabe, N, Kido, M, Saga, K, Tanaka, J, Kuzushima, K, ...
Human thymic stromal lymphopoietin (TSLP) promotes CD4+ T-cell proliferation both directly and indirectly through dendritic cell (DC) activation. Although human TSLP-activated DCs induce CD8+ T-cell...