N. Zaffaroni

Novel PVA-based hydrogel microparticles for doxorubicin delivery (2008)

Cavalieri, F, Chiessi, E, Villa, R, Vigano, L, Zaffaroni, N, Telling, MTF, ...

Micro- and nanoparticles are considered suitable drug delivery systems for their unique features, such as a large surface to volume ratio, and for the possibility to tune their size and...

Preclinical and clinical evaluation of four gemcitabine plus carboplatin schedules as front-line treatment for stage IV non-small-cell lung cancer (2003)

Bajetta, E., Stani, S. C., De Candis, D., Zaffaroni, N., Zilembo, N., Cortinovis, D., ...

Background: To explore the activity and tolerability of gemcitabine (GEM) and carboplatin (CBDCA) in non-small-cell lung cancer (NSCLC) we tested four administration sequences on H460 NSCLC cells,...

Telomerase activity in benign and malignant breast lesions: a pilot prospective study on fine-needle aspirates (1998)

Villa, R, Zaffaroni, N, Folini, M, Martelli, G, De Palo, G, Daidone, MG, ...

Lack of a correlation between micronucleus formation and radiosensitivity in established and primary cultures of human tumours.

Villa, R., Zaffaroni, N., Gornati, D., Costa, A., Silvestrini, R.

The radiation-induced genotoxic damage in three established cell lines and 15 primary cultures of human malignant melanoma and ovarian carcinoma showing different radiosensitivity was tested by the...

Effect of melphalan and hyperthermia on p34cdc2 kinase activity in human melanoma cells.

Orlandi, L., Zaffaroni, N., Bearzatto, A., Silvestrini, R.

We previously reported that combined treatment with melphalan and mild hyperthermia (1 h at 42 degrees C) caused a synergistic cytotoxic effect in JR8 melanoma cells, paralleled by a stabilisation of...

Induction of apoptosis by taxol and cisplatin and effect on cell cycle-related proteins in cisplatin-sensitive and -resistant human ovarian cells.

Zaffaroni, N., Silvestrini, R., Orlandi, L., Bearzatto, A., Gornati, D., Villa, R.

The effect of taxol (TX) and cisplatin (CDDP), singly or in association, was assessed on two human ovarian cancer cell lines, one sensitive (A2780) and one resistant (A2780 cp8) to CDDP. Cell lines...

High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma

Cairney, C J, Hoare, S F, Daidone, M-G, Zaffaroni, N, Keith, W N

Telomere length is maintained by two known mechanisms, activation of telomerase or alternative lengthening of telomeres (ALT). The ALT pathway is more commonly activated in tumours of mesenchymal...

Involvement of bcl-2 and p21waf1 proteins in response of human breast cancer cell clones to Tomudex

Orlandi, L, Bearzatto, A, Abolafio, G, De Marco, C, Daidone, M G, Zaffaroni, N

Mechanisms of resistance to Tomudex include increased thymidylate synthase activity, as well as reduced intracellular drug uptake and polyglutamation. However, little is known about other mechanisms...

Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: cytotoxicity and induction and gene-specific repair of DNA lesions

Colella, G, Pennati, M, Bearzatto, A, Leone, R, Colangelo, D, Manzotti, C, ...

A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to cisplatin. Loss of mismatch repair proteins...