Yang Liu, Gang Chen, Nadine Norton, Wenmin Liu, Haining Zhu, Peng Zhou, ...
DNA pooling can provide an economic and efficient way to detect susceptibility loci to complex diseases. We carried out a genome screen with 400 microsatellite markers spaced at approximately 10 cm...
Yang Liu, Gang Chen, Nadine Norton, Wenmin Liu, Haining Zhu, Peng Zhou, ...
DNA pooling can provide an economic and efficient way to detect susceptibility loci to complex diseases. We carried out a genome screen with 400 microsatellite markers spaced at approximately...
Buxbaum, J. D., Georgieva, Lyudmila, Young, J. J., Plescia, C., Kajiwara, Y., Jiang, Y., ...
Neuregulin and the neuregulin receptor ERBB4 have been genetically and functionally implicated in schizophrenia. In this study, we used the yeast two-hybrid system to identify proteins that interact...
Buxbaum, J. D., Georgieva, Lyudmila, Young, J. J., Plescia, C., Kajiwara, Y., Jiang, Y., ...
Neuregulin and the neuregulin receptor ERBB4 have been genetically and functionally implicated in schizophrenia. In this study, we used the yeast two-hybrid system to identify proteins that interact...
Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia (2008)
Kirov, George, Gumus, Dilihan, Chen, Wei, Norton, Nadine, Georgieva, Lyudmila, Sari, Murat, ...
Copy number variations (CNVs) account for a substantial proportion of human genomic variation, and have been shown to cause neurodevelopmental disorders. We sought to determine the relevance of CNVs...
Identification of loci associated with schizophrenia by genome-wide association and follow-up (2008)
Donovan, Michael C., Craddock, Nicholas, Norton, Nadine, Williams, Hywel, Peirce, Timothy, Moskvina, Valentina, ...
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong...
Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia (2008)
Kirov, George, Gumus, Dilihan, Chen, Wei, Norton, Nadine, Georgieva, Lyudmila, Sari, Murat, ...
Copy number variations (CNVs) account for a substantial proportion of human genomic variation, and have been shown to cause neurodevelopmental disorders. We sought to determine the relevance of CNVs...
Analysis of copy number variation using quantitative interspecies competitive PCR (2008)
Williams, Nigel M., Williams, Hywel, Majounie, Elisa, Norton, Nadine, Glaser, Beate, Morris, Huw R., ...
Over recent years small submicroscopic DNA copy-number variants (CNVs) have been highlighted as an important source of variation in the human genome, human phenotypic diversity and disease...
Strong evidence that GNB1L is associated with schizophrenia (2007)
Williams, Nigel Melville, Glaser, Beate, Norton, Nadine, Williams, Hywel John, Pierce, Timothy, Moskvina, Valentina, ...
Evidence that a gene or genes on chromosome 22 is involved in susceptibility to schizophrenia comes from two sources: the increased incidence of schizophrenia in individuals with 22q11 deletion...
Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia (2007)
Kirov, George, Gumus, Dilihan, Chen, Wei, Norton, Nadine, Georgieva, Lyudmila, Sari, Murat, ...
Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia (2007)
Kirov, George, Gumus, Dilihan, Chen, Wei, Norton, Nadine, Georgieva, Lyudmila, Sari, Murat, ...
Georgieva, Lyudmila, Moskvina, Valentina, Peirce, Timothy Rowan, Norton, Nadine, Bray, Nicholas John, Jones, Lesley, ...
Abnormal oligodendrocyte function has been postulated as a primary etiological event in schizophrenia. Oligodendrocyte lineage transcription factor 2 (OLIG2) encodes a transcription factor central to...
Williams, Nigel Melville, Green, Elaine Karen, Dwyer, Sarah Lynne, Macgregor, Stuart, Norton, Nadine, Williams, Hywel John, ...
Williams, Nigel Melville, Green, Elaine Karen, Dwyer, Sarah Lynne, Macgregor, Stuart, Norton, Nadine, Williams, Hywel John, ...
Peirce, Timothy Rowan, Bray, Nicholas John, Williams, Nigel Melville, Norton, Nadine, Moskvina, Valentina, Preece, Anna Charlotte, ...
Context Convergent data make 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) a candidate gene for schizophrenia. Reduced expression has been reported in the schizophrenic brain. The CNP gene maps...
Peirce, Timothy Rowan, Bray, Nicholas John, Williams, Nigel Melville, Norton, Nadine, Moskvina, Valentina, Preece, Anna Charlotte, ...
Context Convergent data make 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) a candidate gene for schizophrenia. Reduced expression has been reported in the schizophrenic brain. The CNP gene maps...
Hamshere, Marian Lindsay, Bennett, Philip, Williams, Nigel Melville, Segurado, Ricardo, Cardno, Alastair George, Norton, Nadine, ...
Context Traditionally, the search for genes involved in predisposition to major psychoses has proceeded with separate studies of schizophrenia and bipolar disorder. However, twin data suggest that,...
Hamshere, Marian Lindsay, Bennett, Philip, Williams, Nigel Melville, Segurado, Ricardo, Cardno, Alastair George, Norton, Nadine, ...
Context Traditionally, the search for genes involved in predisposition to major psychoses has proceeded with separate studies of schizophrenia and bipolar disorder. However, twin data suggest that,...
No evidence for association between polymorphisms in GRM3and schizophrenia (2005)
Norton, Nadine, Williams, Hywel J, Dwyer, Sarah, Ivanov, Dobril, Preece, Anna C, Gerrish, Amy, ...
Abstract Background Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the...
Lambert, D., Middle, F., Hamshere, Marian Lindsay, Segurado, Ricardo, Raybould, Rachel Elizabeth, Corvin, A., ...
Bipolar affective disorder (BPAD) is a common psychiatric disorder with complex genetic aetiology. We have undertaken a genome-wide scan in one of the largest samples of bipolar affected sibling...
Lambert, D., Middle, F., Hamshere, Marian Lindsay, Segurado, Ricardo, Raybould, Rachel Elizabeth, Corvin, A., ...
Bipolar affective disorder (BPAD) is a common psychiatric disorder with complex genetic aetiology. We have undertaken a genome-wide scan in one of the largest samples of bipolar affected sibling...
Streamlined analysis of pooled genotype data in SNP-based association studies (2005)
Moskvina, Valentina, Norton, Nadine, Williams, Nigel Melville, Holmans, Peter Alan, Owen, Michael John, O'Donovan, Michael Conlon
Several groups have developed methods for estimating allele frequencies in DNA pools as a fast and cheap way for detecting allelic association between genetic markers and disease. To obtain accurate...
BMC Psychiatry BioMed Central (2005)
Nadine Norton, Hywel J Williams, Sarah Dwyer, Dobril Ivanov, Anna C Preece, Amy Gerrish, ...
Research article No evidence for association between polymorphisms in GRM3 and schizophrenia
Williams, Nigel M., Preece, Anna Charlotte, Morris, D. W., Spurlock, Gillian, Bray, Nicholas John, Stephens, Mark Keith, ...
Context Recent research suggests that variation in the gene encoding dystrobrevin binding protein (DTNBP1) confers susceptibility to schizophrenia. Thus far, no specific risk haplotype has been...
Williams, Nigel Melville, Preece, Anna Charlotte, Morris, D. W., Spurlock, Gillian, Bray, Nicholas John, Stephens, Mark Keith, ...
Context Recent research suggests that variation in the gene encoding dystrobrevin binding protein (DTNBP1) confers susceptibility to schizophrenia. Thus far, no specific risk haplotype has been...
A systematic genomewide linkage study in 353 sib pairs with schizophrenia (2003)
Williams, Nigel Melville, Norton, Nadine, Williams, H., Ekholm, B., Hamshere, Marian Lindsay, Lindblom, Y., ...
We undertook a genomewide linkage study in a total of 353 affected sib pairs (ASPs) with schizophrenia. Our sample consisted of 179 ASPs from the United Kingdom, 134 from Sweden, and 40 from the...
A systematic genomewide linkage study in 353 sib pairs with schizophrenia (2003)
Williams, Nigel Melville, Norton, Nadine, Williams, H., Ekholm, B., Hamshere, Marian Lindsay, Lindblom, Y., ...
We undertook a genomewide linkage study in a total of 353 affected sib pairs (ASPs) with schizophrenia. Our sample consisted of 179 ASPs from the United Kingdom, 134 from Sweden, and 40 from the...
Chromosome 22q11 deletions, velo-cardio-facial syndrome and early-onset psychosis (2003)
Ivanov, Dobril Kirilov, Kirov, George, Norton, Nadine, Williams, Hywel John, Williams, Nigel Melville, Nikolov, Ivan, ...
BACKGROUND: Velo-cardio-facial syndrome (VCFS) is associated with interstitial deletions of chromosome 22q11. About 30% of patients with VCFS have psychosis, and the rate of these deletions in...
Monslow, Jamie, Williams, John David, Norton, Nadine, Guy, Carol, Price, Iain Kelsey, Coleman, Sharon Louise, ...
The glycosaminoglycan (GAG) hyaluronan (HA) is a key component of the vertebrate extracellular matrix (ECM) and is synthesised by the HA synthase (HAS) enzymes HAS1, HAS2 and HAS3 at the plasma...
Bray, Nicholas John, Buckland, Paul Robert, Williams, Nigel Melville, Williams, Hywel John, Norton, Nadine, Owen, Michael John, ...
The gene encoding catechol-O-methyltransferase (COMT) is a strong candidate for schizophrenia susceptibility, owing to the role of COMT in dopamine metabolism, and the location of the gene within the...
Anney, R. J., Rees, Mark Ian, Bryan, E., Spurlock, Gillian, Williams, N., Norton, Nadine, ...
The dopamine D3 receptor gene (DRD3) is a candidate for a number of psychiatric conditions including schizophrenia, bipolar disorder and alcohol and drug abuse. Previous studies have reported...
Anney, R. J., Rees, Mark Ian, Bryan, E., Spurlock, Gillian, Williams, Nigel Melville, Norton, Nadine, ...
The dopamine D3 receptor gene (DRD3) is a candidate for a number of psychiatric conditions including schizophrenia, bipolar disorder and alcohol and drug abuse. Previous studies have reported...
Williams, Nigel Melville, Spurlock, Gillian, Norton, Nadine, Williams, Hywel John, Hamshere, Marian Lindsay, Krawczak, Michael, ...
We examined whether variation within six genes from the VCFS critical region at 22q11 (DGSC, Stk22A1, DGSI, Gscl, Slc25A1 and Znf74) confers susceptibility to schizophrenia. We screened the exons and...
Williams, Nigel Melville, Bowen, Timothy, Spurlock, Gillian, Norton, Nadine, Williams, Hywel John, Hoogendoorn, Bastiaan, ...
The glutamatergic system is the major excitatory neurotransmitter system in the CNS. Glutamate receptors, and in particular N-methyl-D-aspartate (NMDA) receptors, have been proposed as mediators of...
No evidence for association between polymorphisms in GRM3 and schizophrenia
Norton, Nadine, Williams, Hywel J, Dwyer, Sarah, Ivanov, Dobril, Preece, Anna C, Gerrish, Amy, ...
Localization of the Gene for Distal Hereditary Motor Neuronopathy VII (dHMN-VII) to Chromosome 2q14
McEntagart, Meriel, Norton, Nadine, Williams, Hywel, Teare, M. Dawn, Dunstan, Melanie, Baker, Philip, ...
Distal hereditary motor neuronopathy type VII (dHMN-VII) is an autosomal dominant disorder characterized by distal muscular atrophy and vocal cord paralysis. We performed a genomewide linkage search...
No evidence for association between polymorphisms in GRM3 and schizophrenia
Norton, Nadine, Williams, Hywel J, Dwyer, Sarah, Ivanov, Dobril, Preece, Anna C, Gerrish, Amy, ...
Bray, Nicholas J., Buckland, Paul R., Williams, Nigel M., Williams, Hywel J., Norton, Nadine, Owen, Michael J., ...
The gene encoding catechol-O-methyltransferase (COMT) is a strong candidate for schizophrenia susceptibility, owing to the role of COMT in dopamine metabolism, and the location of the gene within the...
Localization of the Gene for Distal Hereditary Motor Neuronopathy VII (dHMN-VII) to Chromosome 2q14
McEntagart, Meriel, Norton, Nadine, Williams, Hywel, Teare, M. Dawn, Dunstan, Melanie, Baker, Philip, ...
Distal hereditary motor neuronopathy type VII (dHMN-VII) is an autosomal dominant disorder characterized by distal muscular atrophy and vocal cord paralysis. We performed a genomewide linkage search...
Georgieva, Lyudmila, Moskvina, Valentina, Peirce, Tim, Norton, Nadine, Bray, Nicholas J., Jones, Lesley, ...
Abnormal oligodendrocyte function has been postulated as a primary etiological event in schizophrenia. Oligodendrocyte lineage transcription factor 2 (OLIG2) encodes a transcription factor central to...
Analysis of copy number variation using quantitative interspecies competitive PCR
Williams, Nigel M., Williams, Hywel, Majounie, Elisa, Norton, Nadine, Glaser, Beate, Morris, Huw R., ...
Over recent years small submicroscopic DNA copy-number variants (CNVs) have been highlighted as an important source of variation in the human genome, human phenotypic diversity and disease...
Liu, Yang, Chen, Gang, Norton, Nadine, Liu, Wenmin, Zhu, Haining, Zhou, Peng, ...
DNA pooling can provide an economic and efficient way to detect susceptibility loci to complex diseases. We carried out a genome screen with 400 microsatellite markers spaced at approximately 10 cm...