Sato, Yasunori, Laird, Nan, Suganami, Hideki, Hamada, Chikuma, Niki, Naoto, Yoshimura, Isao, ...
A genome-wide association study (GWAS) is a standard strategy for detecting disease susceptibility genes, despite unsettled controversies on many aspects, including optimal study design and...
Sato, Yasunori, Laird, Nan, Suganami, Hideki, Hamada, Chikuma, Niki, Naoto, Yoshimura, Isao, ...
A genome-wide association study (GWAS) is a standard strategy for detecting disease susceptibility genes, despite unsettled controversies on many aspects, including optimal study design and...
Sato, Yasunori, Laird, Nan, Suganami, Hideki, Hamada, Chikuma, Niki, Naoto, Yoshimura, Isao, ...
A genome-wide association study (GWAS) is a standard strategy for detecting disease susceptibility genes, despite unsettled controversies on many aspects, including optimal study design and...
Sato, Yasunori, Laird, Nan, Suganami, Hideki, Hamada, Chikuma, Niki, Naoto, Yoshimura, Isao, ...
A genome-wide association study (GWAS) is a standard strategy for detecting disease susceptibility genes, despite unsettled controversies on many aspects, including optimal study design and...
Lasky-Su, Jessica, Anney, Richard J.L., Neale, Benjamin M., Franke, Barbara, Zhou, Kaixin, Maller, Julian B., ...
A time-to-onset analysis for family-based samples was performed on the genomewide association (GWAS) data for attention deficit hyperactivity disorder (ADHD) to determine if associations exist with...
Neale, Benjamin M., Lasky-Su, Jessica, Anney, Richard, Franke, Barbara, Zhou, Kaixin, Maller, Julian B., ...
Results of behavioral genetic and molecular genetic studies have converged to suggest that genes substantially contribute to the development of attention deficit/hyperactivity disorder (ADHD), a...
Lasky-Su, Jessica, Anney, Richard J.L., Neale, Benjamin M., Franke, Barbara, Zhou, Kaixin, Maller, Julian B., ...
A time-to-onset analysis for family-based samples was performed on the genomewide association (GWAS) data for attention deficit hyperactivity disorder (ADHD) to determine if associations exist with...
EFBAT: exact family-based association tests (2007)
Schneiter, Kady, Degnan, James H, Corcoran, Christopher, Xu, Xin, Laird, Nan
Abstract Background Family-based association tests are important tools for investigating genetic risk factors of complex diseases. These tests are especially valuable for being robust to population...
Helen N. Lyon, Valur Emilsson, Anke Hinney, Iris M. Heid, Jessica Lasky-Su, Xiaofeng Zhu, ...
A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI...
Helen N Lyon, Valur Emilsson, Anke Hinney, Iris M. Heid, Jessica Lasky-Su, Xiaofeng Zhu, ...
A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI)[1]. The association between increased BMI and homozygosity for the...
Lyon, Helen N, Emilsson, Valur, Hinney, Anke, Heid, Iris M, Lasky-Su, Jessica, Zhu, Xiaofeng, ...
A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI...
Hao, Ke, Wang, Xiaobin, Niu, Tianhua, Xu, Xin, Li, Ang, Chang, Weili, ...
Preterm delivery (PTD) is the leading cause of infant mortality and morbidity worldwide. The etiology of PTD is largely unknown but is believed to be complex, encompassing multiple genetic and...
Celedón, Juan C., Lange, Christoph, Raby, Benjamin A., Litonjua, Augusto A., Palmer, Lyle J., DeMeo, Dawn L., ...
Although cigarette smoking is the primary environmental risk factor, genetic risk factors likely influence the development of chronic obstructive pulmonary disease (COPD). Linkage analysis between...
Hao, Ke, Wang, Xiaobin, Niu, Tianhua, Xu, Xin, Li, Ang, Chang, Weili, ...
Preterm delivery (PTD) is the leading cause of infant mortality and morbidity worldwide. The etiology of PTD is largely unknown but is believed to be complex, encompassing multiple genetic and...
Celedón, Juan C., Lange, Christoph, Raby, Benjamin A., Litonjua, Augusto A., Palmer, Lyle J., DeMeo, Dawn L., ...
Although cigarette smoking is the primary environmental risk factor, genetic risk factors likely influence the development of chronic obstructive pulmonary disease (COPD). Linkage analysis between...
Hao, Ke, Wang, Xiaobin, Niu, Tianhua, Xu, Xin, Li, Ang, Chang, Weili, ...
Preterm delivery (PTD) is the leading cause of infant mortality and morbidity worldwide. The etiology of PTD is largely unknown but is believed to be complex, encompassing multiple genetic and...
Celedón, Juan C., Lange, Christoph, Raby, Benjamin A., Litonjua, Augusto A., Palmer, Lyle J., DeMeo, Dawn L., ...
Although cigarette smoking is the primary environmental risk factor, genetic risk factors likely influence the development of chronic obstructive pulmonary disease (COPD). Linkage analysis between...
Field, Alison E., Coakley, Eugenie H., Must, Aviva, Spadano, Jennifer L., Laird, Nan, Dietz, William H., ...
Age, Period, and Cohort Effects on Pulmonary Function in a 24-Year Longitudinal Study (1995)
Xu, Xiping, Laird, Nan, Dockery, Douglas W., Schouten, Jan P., Rijcken, Bert, Weiss, Scott T.
This paper proposes the use of two-factor models (age-period and age-cohort models) to estimate age, period, and cohort effects on pulmonary function by using the data collected in a 24-year...
Power evaluations for family-based tests of association with incomplete parental genotypes.
Yang, Qiong, Xu, Xin, Laird, Nan
While a variety of methods have been developed to deal with incomplete parental genotype information in family-based association tests, sampling design issues with incomplete parental genotype data...
Polymorphism in Maternal LRP8 Gene Is Associated with Fetal Growth
Wang, Lin, Wang, Xiaobin, Laird, Nan, Zuckerman, Barry, Stubblefield, Philip, Xu, Xin
Fetal growth restriction (FGR) affects >200,000 pregnancies in the United States annually and is associated with increased perinatal mortality and morbidity, as well as poorer long-term health for...
Feng, Yan, Niu, Tianhua, Xing, Houxun, Xu, Xin, Chen, Changzhong, Peng, Shaojie, ...
Nicotine is the major addictive substance in cigarettes, and genes involved in sensing nicotine are logical candidates for vulnerability to nicotine addiction. We studied six single-nucleotide...
Abecasis, Goncalo, Cox, Nancy, Daly, Mark J., Kruglyak, Leonid, Laird, Nan, Markianos, Kyriacos, ...
Power evaluations for family-based tests of association with incomplete parental genotypes.
Yang, Qiong, Xu, Xin, Laird, Nan
While a variety of methods have been developed to deal with incomplete parental genotype information in family-based association tests, sampling design issues with incomplete parental genotype data...
Polymorphism in Maternal LRP8 Gene Is Associated with Fetal Growth
Wang, Lin, Wang, Xiaobin, Laird, Nan, Zuckerman, Barry, Stubblefield, Philip, Xu, Xin
Fetal growth restriction (FGR) affects >200,000 pregnancies in the United States annually and is associated with increased perinatal mortality and morbidity, as well as poorer long-term health for...
Lyon, Helen N, Emilsson, Valur, Hinney, Anke, Heid, Iris M, Lasky-Su, Jessica, Zhu, Xiaofeng, ...
A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI...
EFBAT: exact family-based association tests
Schneiter, Kady, Degnan, James H, Corcoran, Christopher, Xu, Xin, Laird, Nan
Christoph Lange, Kristel Van Steen, Toby Andrew, Helen Lyon, Dawn DeMeo, Benjamin Raby, ...
We propose a family-based association test, FBAT-PC, for studies with quantitative traits that are measured repeatedly. The traits may be influenced by partially or completely unknown factors that...
Impact of Population Stratification on Family-Based Association Tests with Longitudinal Measurements
Xiao Ding, Scott Weiss, Benjamin Raby, Christoph Lange, Nan Laird
Several family-based approaches for testing genetic association with traits obtained from longitudinal or repeated measurement studies have been previously proposed. These approaches utilize the...
On the Replication of Genetic Associations: Timing Can Be Everything!
Lasky-Su, Jessica, Lyon, Helen N., Emilsson, Valur, Heid, Iris M., Molony, Cliona, Raby, Benjamin A., ...
The failure of researchers to replicate genetic-association findings is most commonly attributed to insufficient statistical power, population stratification, or various forms of between-study...
Bertram, Lars, Lange, Christoph, Mullin, Kristina, Parkinson, Michele, Hsiao, Monica, Hogan, Meghan F., ...
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder. To date four genes have been established to either cause early-onset autosomal-dominant AD (APP, PSEN1, and PSEN21–4)...
Attempted Replication of Reported Chronic Obstructive Pulmonary Disease Candidate Gene Associations
Hersh, Craig P., DeMeo, Dawn L., Lange, Christoph, Litonjua, Augusto A., Reilly, John J., Kwiatkowski, David, ...
Case-control studies have successfully identified many significant genetic associations for complex diseases, but lack of replication has been a criticism of case-control genetic association studies...
Heid, Iris M., Huth, Cornelia, Loos, Ruth J. F., Kronenberg, Florian, Adamkova, Vera, Anand, Sonia S., ...
The INSIG2 rs7566605 polymorphism was identified for obesity (BMI≥30 kg/m2) in one of the first genome-wide association studies, but replications were inconsistent. We collected statistics from 34...