Nancy E. Phillips

Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism (2009)

Bishop, Kenneth D., Harris, John E., Mordes, John P., Greiner, Dale L., Rossini, Aldo A., Czech, Michael P., ...

Recent studies have implicated the cell surface receptor Programmed Death-1 (PD-1) in numerous models of T cell anergy, though the specific mechanisms by which the PD-1 signal maintains tolerance is...

Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance (2007)

Thornley, Thomas B., Phillips, Nancy E., Beaudette-Zlatanova, Britte C., Markees, Thomas G., Bahl, Kapil, Brehm, Michael A., ...

TLR activation of innate immunity prevents the induction of transplantation tolerance and shortens skin allograft survival in mice treated with costimulation blockade. The mechanism by which TLR...

Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody (2004)

Markees, Thomas G., Pearson, Todd, Cuthbert, Amy, Pearson, Andrea L., Shultz, Leonard D., Leif, Jean H., ...

BACKGROUND: Treatment with anti-CD154 monoclonal antibody (mAb) plus a donor-specific transfusion (DST) of spleen cells prolongs skin allograft survival in mice through a mechanism involving deletion...

Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells (2004)

Harris, John E., Bishop, Kenneth D., Phillips, Nancy E., Mordes, John P., Greiner, Dale L., Rossini, Aldo A., ...

Ag-specific immune tolerance results from the induction of cellular mechanisms that limit T cell responses to selective Ags. One of these mechanisms is characterized by attenuated proliferation and...

Blockade of CD40-mediated signaling is sufficient for inducing islet but not skin transplantation tolerance (2003)

Phillips, Nancy E., Markees, Thomas G., Mordes, John P., Greiner, Dale L., Rossini, Aldo A.

Treatment of mice with a single donor-specific transfusion (DST) plus a brief course of anti-CD154 mAb to block CD40-mediated signaling uniformly induces donor-specific transplantation tolerance....

Skin allograft maintenance in a new synchimeric model system of tolerance (2001)

Iwakoshi, Neal N., Markees, Thomas G., Turgeon, Nicole A., Thornley, Thomas B., Cuthbert, Amy, Leif, Jean, ...

Treatment of mice with a single donor-specific transfusion plus a brief course of anti-CD154 mAb uniformly induces donor-specific transplantation tolerance characterized by the deletion of...

Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade (2000)

Turgeon, Nicole A., Iwakoshi, Neal N., Phillips, Nancy E., Meyers, William C., Welsh, Raymond M., Greiner, Dale L., ...

BACKGROUND: Treatment with a single donor-specific transfusion (DST) plus a brief course of anti-CD154 monoclonal antibody (mAb) prolongs skin allograft survival in mice. It is known that...

Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner (1999)

Iwakoshi, Neal N., Mordes, John P., Markees, Thomas G., Phillips, Nancy E., Rossini, Aldo A., Greiner, Dale L.

A two-element protocol consisting of one donor-specific transfusion (DST) plus a brief course of anti-CD154 mAb greatly prolongs the survival of murine islet, skin, and cardiac allografts. To study...

NOD mice have a generalized defect in their response to transplantation tolerance induction (1999)

Markees, Thomas G., Serreze, David V., Phillips, Nancy E., Sorli, Christopher H., Gordon, Ethel J., Shultz, Leonard D., ...

A protocol consisting of a single donor-specific transfusion (DST) plus a brief course of anti-CD154 monoclonal antibody (anti-CD40 ligand mAb) induces permanent islet allograft survival in...

Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4 (1998)

Markees, Thomas G., Phillips, Nancy E., Gordon, Ethel J., Noelle, Randolph J., Shultz, Leonard D., Mordes, John P., ...

Treatment of C57BL/6 mice with one transfusion of BALB/c spleen cells and anti-CD154 (anti-CD40-ligand) antibody permits BALB/c islet grafts to survive indefinitely and BALB/c skin grafts to survive...

Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand (1995)

Parker, David C., Greiner, Dale L., Phillips, Nancy E., Appel, Michael C., Steele, Alan W., Durie, Fiona H., ...

Combined treatment with allogeneic small lymphocytes or T-depleted small lymphocytes plus a blocking antibody to CD40 ligand (CD40L) permitted indefinite pancreatic islet allograft survival in 37 of...

Effects of IL-4 and Fc gamma receptor II engagement on Egr-1 expression during stimulation of B lymphocytes by membrane immunoglobulin crosslinking (1993)

Klaus, Stephen J., Phillips, Nancy E., Parker, David C.

Egr-1 is an immediate early gene that is rapidly upregulated in response to mitogenic signals induced by antigen receptor crosslinking on murine B lymphocytes. It has been shown that levels of Egr-1...