Nancy Guillén

Virulence and Functions of Myosin II Are Inhibited by Overexpression of Light Meromyosin in Entamoeba histolytica

Arhets, Philippe, Olivo, Jean-Christophe, Gounon, Pierre, Sansonetti, Philippe, Guillén, Nancy

Several changes in cell morphology take place during the capping of surface receptors in Entamoeba histolytica. The amoebae develop the uroid, an appendage formed by membrane invaginations, which...

Fate of Entamoeba histolytica during Establishment of Amoebic Liver Abscess Analyzed by Quantitative Radioimaging and Histology

Rigothier, Marie-Christine, Khun, Hout, Tavares, Paulo, Cardona, Ana, Huerre, Michel, Guillén, Nancy

The protozoan parasite Entamoeba histolytica is the causative agent of amoebiasis, a human disease characterized by dysentery and liver abscess. The physiopathology of hepatic lesions can be...

Roles of Cell Adhesion and Cytoskeleton Activity in Entamoeba histolytica Pathogenesis: a Delicate Balance

Tavares, Paulo, Rigothier, Marie-Christine, Khun, Huot, Roux, Pascal, Huerre, Michel, Guillén, Nancy

The protozoan parasite Entamoeba histolytica colonizes the human large bowel. Invasion of the intestinal epithelium causes amoebic colitis and opens the route for amoebic liver abscesses. The...

Human Tumor Necrosis Factor is a Chemoattractant for the Parasite Entamoeba histolytica

Blazquez, Samantha, Zimmer, Christophe, Guigon, Ghislaine, Olivo-Marin, Jean-Christophe, Guillén, Nancy, Labruyère, Elisabeth

In an analysis of the molecular factors triggering amebiasis, we investigated the chemotaxis of Entamoeba histolytica toward tumor necrosis factor (TNF) in vitro, using quantitative imaging...

Stress by Heat Shock Induces Massive Down Regulation of Genes and Allows Differential Allelic Expression of the Gal/GalNAc Lectin in Entamoeba histolytica†

Weber, Christian, Guigon, Ghislaine, Bouchier, Christiane, Frangeul, Lionel, Moreira, Sandrine, Sismeiro, Odile, ...

Gene expression analysis by microarray assay revealed that when exposed to stress, Entamoeba histolytica exhibits a specific heat shock response, together with a dramatic overall reduction in gene...

Virulence and Functions of Myosin II Are Inhibited by Overexpression of Light Meromyosin in Entamoeba histolytica

Arhets, Philippe, Olivo, Jean-Christophe, Gounon, Pierre, Sansonetti, Philippe, Guillén, Nancy

Several changes in cell morphology take place during the capping of surface receptors in Entamoeba histolytica. The amoebae develop the uroid, an appendage formed by membrane invaginations, which...

Fate of Entamoeba histolytica during Establishment of Amoebic Liver Abscess Analyzed by Quantitative Radioimaging and Histology

Rigothier, Marie-Christine, Khun, Hout, Tavares, Paulo, Cardona, Ana, Huerre, Michel, Guillén, Nancy

The protozoan parasite Entamoeba histolytica is the causative agent of amoebiasis, a human disease characterized by dysentery and liver abscess. The physiopathology of hepatic lesions can be...

Roles of Cell Adhesion and Cytoskeleton Activity in Entamoeba histolytica Pathogenesis: a Delicate Balance

Tavares, Paulo, Rigothier, Marie-Christine, Khun, Huot, Roux, Pascal, Huerre, Michel, Guillén, Nancy

The protozoan parasite Entamoeba histolytica colonizes the human large bowel. Invasion of the intestinal epithelium causes amoebic colitis and opens the route for amoebic liver abscesses. The...

Human Tumor Necrosis Factor is a Chemoattractant for the Parasite Entamoeba histolytica

Blazquez, Samantha, Zimmer, Christophe, Guigon, Ghislaine, Olivo-Marin, Jean-Christophe, Guillén, Nancy, Labruyère, Elisabeth

In an analysis of the molecular factors triggering amebiasis, we investigated the chemotaxis of Entamoeba histolytica toward tumor necrosis factor (TNF) in vitro, using quantitative imaging...

Stress by Heat Shock Induces Massive Down Regulation of Genes and Allows Differential Allelic Expression of the Gal/GalNAc Lectin in Entamoeba histolytica†

Weber, Christian, Guigon, Ghislaine, Bouchier, Christiane, Frangeul, Lionel, Moreira, Sandrine, Sismeiro, Odile, ...

Gene expression analysis by microarray assay revealed that when exposed to stress, Entamoeba histolytica exhibits a specific heat shock response, together with a dramatic overall reduction in gene...

Bioinformatics and Functional Analysis of an Entamoeba histolytica Mannosyltransferase Necessary for Parasite Complement Resistance and Hepatical Infection

Weber, Christian, Blazquez, Samantha, Marion, Sabrina, Ausseur, Christophe, Vats, Divya, Krzeminski, Mickael, ...

The glycosylphosphatidylinositol (GPI) moiety is one of the ways by which many cell surface proteins, such as Gal/GalNAc lectin and proteophosphoglycans (PPGs) attach to the surface of Entamoeba...

Protection against Invasive Amebiasis by a Single Monoclonal Antibody Directed against a Lipophosphoglycan Antigen Localized on the Surface of Entamoeba histolytica

Marinets, Alexandra, Zhang, Tonghai, Guillén, Nancy, Gounon, Pierre, Bohle, Barbara, Vollmann, Ute, ...

A panel of monoclonal antibodies was raised from mice immunized with a membrane preparation from Entamoeba histolytica, the pathogenic species causing invasive amebiasis in humans. Antibody EH5 gave...

The Kinetics of the Hydrogen/Deuterium Exchange of Epidermal Growth Factor Receptor Ligands

Iloro, Ibon, Narváez, Daniel, Guillén, Nancy, Camacho, Carlos M., Guillén, Lalisse, Cora, Elsa, ...

Five highly homologous epidermal growth factor receptor ligands were studied by mass spectral analysis, hydrogen/deuterium (H/D) exchange via attenuated total reflectance Fourier transform-infrared...

An ex-vivo Human Intestinal Model to Study Entamoeba histolytica Pathogenesis

Bansal, Devendra, Ave, Patrick, Kerneis, Sophie, Frileux, Pascal, Boché, Olivier, Baglin, Anne Catherine, ...

Amoebiasis (a human intestinal infection affecting 50 million people every year) is caused by the protozoan parasite Entamoeba histolytica. To study the molecular mechanisms underlying human colon...