Yasuda, Michiko, Nishizawa, Takashi, Ohigashi, Hajime, Tanaka, Takuji, Hou, De-Xing, Colburn, Nancy H., ...
(±)-13-Hydroxy-10-oxo-trans-11-octadecenoic acid (13-HOA) is one of the lipoxygenase metabolites of linoleic acid (LA) from corn germ. Recently, we reported that this metabolite suppressed the...
ZAKOWICZ, HALINA, YANG, HSIN-SHENG, STARK, CRISTI, WLODAWER, ALEXANDER, LARONDE-LEBLANC, NICOLE, COLBURN, NANCY H.
Eukaryotic initiation factor (eIF) 4A unwinds secondary and tertiary structures in the 5′-untranslated region of mRNA, permitting translation initiation. Programmed cell death 4 (Pdcd4) is a novel...
ZAKOWICZ, HALINA, YANG, HSIN-SHENG, STARK, CRISTI, WLODAWER, ALEXANDER, LARONDE-LEBLANC, NICOLE, COLBURN, NANCY H.
Eukaryotic initiation factor (eIF) 4A unwinds secondary and tertiary structures in the 5′-untranslated region of mRNA, permitting translation initiation. Programmed cell death 4 (Pdcd4) is a novel...
Hu, Jing, Nakano, Hiroyasu, Sakurai, Hiroaki, Colburn, Nancy H.
NF-κB activation is required for TNF-α-induced transformation of JB6 mouse epidermal cells. Deficient activation of p65 contributes to the lack of NF-κB activation in transformation-resistant...
Hu, Jing, Nakano, Hiroyasu, Sakurai, Hiroaki, Colburn, Nancy H.
NF-κB activation is required for TNF-α-induced transformation of JB6 mouse epidermal cells. Deficient activation of p65 contributes to the lack of NF-κB activation in transformation resistant (P-)...
Yang, Hsin-Sheng, Jansen, Aaron P., Komar, Anton A., Zheng, Xiaojing, Merrick, William C., Costes, Sylvain, ...
Pdcd4 is a novel transformation suppressor that inhibits tumor promoter-induced neoplastic transformation and the activation of AP-1-dependent transcription required for transformation. A yeast...
Vanadate-induced activation of activator protein-1: role of reactive oxygen species (1999)
Ding, Min, Li, Jian-Jian, Leonard, Stephen S., Ye, Jian-Ping, Shi, Xianglin, Colburn, Nancy H., ...
The present study was undertaken to test the hypothesis that the toxicity and carcinogenicity of vanadium might arise from elevation of reactive oxygen species leading to activation of the...
Bian, Junhui, Wang, Yuli, Smith, Mark R., Kim, Hyungtae, Jacobs, Christine, Jackman, Joany, ...
Tissue inhibitor of metalloproteinases-3(TEMP-3), a novel member of TEMP family genes, has been recently cloned and shown to be expressed in preneoplastic but not in neoplastic mouse JB6 epidermal...
Transformation reversion induced in JB6 RT101 cells by AP-1 inhibitors (1995)
Dong, Zigang, Lavrovsky, Vadim, Colburn, Nancy H.
The present study was directed to characterizing the reversion of neoplastic epidermal JB6 RT101 cells by AP-1 inhibiting drugs. Treatment of tumorigenic JB6 RT101 cells with retinoic acid (RA),...
Dong, Zigang, Cmarik, Joan L., Wendel, Edmund J., Colburn, Nancy H.
The JB6 mouse epidermal cell system has been extensively used as an in vitro model for the study of tumor promotion. The present study aimed to assess the relevance of monolayer measurements to the...
Sun, Yi, Colburn, Nancy H., Oberley, Larry W.
To understand the molecular basis of the remarkable decrease of catalase activity after immortalization and malignant transformation of mouse liver cells, expression of the catalase gene was studied...
Nakamura, Yoshiyuki, Gindhart, Thomas D., Winterstein, Dolores, Tomita, Isao, Seed, John L., Colburn, Nancy H.
Evidence has been obtained that implicates the generation of reactive oxygen species as an early and critical event in the promotion of neoplastic transformation in mouse JB6 cells. The time courses...
Lerman, Michael I., Sakai, Ayako, Kai-Tai, Yao, Colburn, Nancy H.
Homologs of the recently described mouse pro genes, that transfer sensitivity to promotion of neoplastic transformation by tumor promoters, have been cloned from a genomic library of the human...
Smith, Bonita M., Gindhart, Thomas D., Colburn, Nancy H.
The rare earth elements lanthanum and terbium (0.1–1.0 mM), pharmacological analogs of calcium, induced neoplastic transformation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-sensitive (P+)...
Nakamura, Yoshiyuki, Colburn, Nancy H., Gindhart, Thomas D.
The role of reactive oxygen (RO) in the promotion of neoplastic transformation of JB6 mouse epidermal cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) was investigated using inhibitors of RO...
Gindhart, Thomas D., Srinivas, Leela, Colburn, Nancy H.
Benzoyl peroxide (BzPo), a free radical generator with tumor promoting activity on mouse skin, is shown to promote neoplastic transformation of JB6 mouse epidermal cells in vitro. Repeated exposures...
Diwan, Bhalchandra A., Ward, Jerrold M., Rice, Jerry M., Colburn, Nancy H., Spangler, Edwin F.
Di(2-ethylhexyl)phthalate (DEHP), a confirmed promoter of hepatocellular cardnogenesis in mice, was studied for tumorpromoting activity on the skin of SENCAR mice in vivo and on JB6 mouse epidermal...
Srinivas, Leela, Colburn, Nancy H.
Tumor promoters such as phorbol esters and benzoyl peroxide are free radical generators which produce elevation of reactive oxygen. Tumor promoters also produce a decrease in trisialoganglioside (GT)...
Dion, L. David, Luca, Luigi M. De, Colburn, Nancy H.
Since tumor promoting phorbol esters produce a variety of glycoprotein synthesis changes and since retinoids act both as antipromoters and modulators of glycoprotein synthesis, we sought to ascertain...
The irreversible shift in anchorage independence by phorbol ester responsive mouse epidermal cell lines appears to occur not by a mechanism involving selection of preexisting transformants but by...
Includes reprints of two magazine articles by the author and others.
Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation
Cmarik, Joan L., Min, Hongzhong, Hegamyer, Glenn, Zhan, Shuning, Kulesz-Martin, Molly, Yoshinaga, Hidetoshi, ...
An mRNA differential display comparison of mouse JB6 promotion-sensitive (P+) and -resistant (P−) cells identified a novel gene product that inhibits neoplastic transformation. The JB6 P+ and P−...
Young, Matthew R., Nair, Rajalakshmi, Bucheimer, Natalie, Tulsian, Preety, Brown, Nicole, Chapp, Cristi, ...
Mitogen-activated protein (MAP) kinase, extracellular-signal-regulated kinases (ERKs) play an important role in activating AP-1-dependent transcription. Studies using the JB6 mouse epidermal model...
Yang, Hsin-Sheng, Jansen, Aaron P., Komar, Anton A., Zheng, Xiaojing, Merrick, William C., Costes, Sylvain, ...
Pdcd4 is a novel transformation suppressor that inhibits tumor promoter-induced neoplastic transformation and the activation of AP-1-dependent transcription required for transformation. A yeast...
Colburn, Nancy H., Talmadge, Catherine B., Gindhart, Thomas D.
Sensitivity to promotion of transformation by tumor promoters in mouse epidermal JB6 cells appears to have a genetic basis since the phenotypes of both promotable and nonpromotable JB6 cells derived...
Yang, Hsin-Sheng, Cho, Myung-Haing, Zakowicz, Halina, Hegamyer, Glenn, Sonenberg, Nahum, Colburn, Nancy H.
Αn α-helical MA-3 domain appears in several translation initiation factors, including human eukaryotic translation initiation factor 4G (eIF4G) and DAP-5/NAT1/p97, as well as in the tumor...
Suzukawa, Kazumi, Weber, Thomas J, Colburn, Nancy H
The promotion-sensitive mouse epidermal JB6 cells (clone 41) have been used to identify the tumor-promoting activity of various compounds. Because treatment by tumor promoters...
ZAKOWICZ, HALINA, YANG, HSIN-SHENG, STARK, CRISTI, WLODAWER, ALEXANDER, LARONDE-LEBLANC, NICOLE, COLBURN, NANCY H.
Eukaryotic initiation factor (eIF) 4A unwinds secondary and tertiary structures in the 5′-untranslated region of mRNA, permitting translation initiation. Programmed cell death 4 (Pdcd4) is a novel...
Yang, Hsin-Sheng, Matthews, Connie P., Clair, Timothy, Wang, Qing, Baker, Alyson R., Li, Chou-Chi H., ...
Programmed cell death 4 (Pdcd4) suppresses neoplastic transformation by inhibiting the activation of c-Jun and consequently AP-1-dependent transcription. We report that Pdcd4 blocks c-Jun activation...
Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation
Cmarik, Joan L., Min, Hongzhong, Hegamyer, Glenn, Zhan, Shuning, Kulesz-Martin, Molly, Yoshinaga, Hidetoshi, ...
An mRNA differential display comparison of mouse JB6 promotion-sensitive (P+) and -resistant (P−) cells identified a novel gene product that inhibits neoplastic transformation. The JB6 P+ and P−...
Young, Matthew R., Nair, Rajalakshmi, Bucheimer, Natalie, Tulsian, Preety, Brown, Nicole, Chapp, Cristi, ...
Mitogen-activated protein (MAP) kinase, extracellular-signal-regulated kinases (ERKs) play an important role in activating AP-1-dependent transcription. Studies using the JB6 mouse epidermal model...
Yang, Hsin-Sheng, Jansen, Aaron P., Komar, Anton A., Zheng, Xiaojing, Merrick, William C., Costes, Sylvain, ...
Pdcd4 is a novel transformation suppressor that inhibits tumor promoter-induced neoplastic transformation and the activation of AP-1-dependent transcription required for transformation. A yeast...
Colburn, Nancy H., Talmadge, Catherine B., Gindhart, Thomas D.
Sensitivity to promotion of transformation by tumor promoters in mouse epidermal JB6 cells appears to have a genetic basis since the phenotypes of both promotable and nonpromotable JB6 cells derived...
Yang, Hsin-Sheng, Cho, Myung-Haing, Zakowicz, Halina, Hegamyer, Glenn, Sonenberg, Nahum, Colburn, Nancy H.
Αn α-helical MA-3 domain appears in several translation initiation factors, including human eukaryotic translation initiation factor 4G (eIF4G) and DAP-5/NAT1/p97, as well as in the tumor...
Suzukawa, Kazumi, Weber, Thomas J, Colburn, Nancy H
The promotion-sensitive mouse epidermal JB6 cells (clone 41) have been used to identify the tumor-promoting activity of various compounds. Because treatment by tumor promoters...
Yang, Hsin-Sheng, Matthews, Connie P., Clair, Timothy, Wang, Qing, Baker, Alyson R., Li, Chou-Chi H., ...
Programmed cell death 4 (Pdcd4) suppresses neoplastic transformation by inhibiting the activation of c-Jun and consequently AP-1-dependent transcription. We report that Pdcd4 blocks c-Jun activation...
ZAKOWICZ, HALINA, YANG, HSIN-SHENG, STARK, CRISTI, WLODAWER, ALEXANDER, LARONDE-LEBLANC, NICOLE, COLBURN, NANCY H.
Eukaryotic initiation factor (eIF) 4A unwinds secondary and tertiary structures in the 5′-untranslated region of mRNA, permitting translation initiation. Programmed cell death 4 (Pdcd4) is a novel...
Structural Basis for Inhibition of Translation by the Tumor Suppressor Pdcd4▿
LaRonde-LeBlanc, Nicole, Santhanam, Arti N., Baker, Alyson R., Wlodawer, Alexander, Colburn, Nancy H.
The tumor suppressor function of Programmed Cell Death 4 (Pdcd4) is achieved through interactions between Pdcd4 and components of the translation initiation complex, namely, the RNA helicase eIF4A...
Young, Matthew R, Ileva, Lilia V, Bernardo, Marcelino, Riffle, Lisa A, Jones, Yava L, Kim, Young S, ...
Early detection of precancerous tissue has significantly improved survival of most cancers including colorectal cancer (CRC). Animal models designed to study the early stages of cancer are valuable...
Elevated Inorganic Phosphate Stimulates Akt-ERK1/2-Mnk1 Signaling in Human Lung Cells
Chang, Seung-Hee, Yu, Kyeong Nam, Lee, Yeon-Sook, An, Gil-Hwan, Beck, George R., Colburn, Nancy H., ...
Inorganic phosphate (Pi) plays a critical role in diverse cellular functions. Among three classes of sodium/phosphate co-transporters (NPTs), two types have been identified in mammalian lung. The...
Role of 3′UTRs in the Translation of mRNAs Regulated by Oncogenic eIF4E—A Computational Inference
Santhanam, Arti N., Bindewald, Eckart, Rajasekhar, Vinagolu K., Larsson, Ola, Sonenberg, Nahum, Colburn, Nancy H., ...
Eukaryotic cap-dependent mRNA translation is mediated by the initiation factor eIF4E, which binds mRNAs and stimulates efficient translation initiation. eIF4E is often overexpressed in human cancers....
Santhanam, Arti N., Bindewald, Eckart, Rajasekhar, Vinagolu K., Larsson, Ola, Sonenberg, Nahum, Colburn, Nancy H., ...
Wei, Qiou, Jiang, Hong, Matthews, Connie P., Colburn, Nancy H.
Previous studies have shown that a dominant negative form of c-Jun (TAM67) suppresses mouse skin carcinogenesis both in vitro and in vivo. The current study identifies Sulfiredoxin (Srx) as a unique...