Teruya, Hiromitsu, Higa, Futoshi, Akamine, Morikazu, Ishikawa, Chie, Okudaira, Taeko, Tomimori, Koh, ...
Abstract Background Legionella pneumophila is a facultative intracellular bacterium, capable of replicating within the phagosomes of macrophages and monocytes, but little is known about its...
Sato, Kayoko, Imai, Yasuyuki, Higashi, Nobuaki, Kumamoto, Yosuke, Mukaida, Naofumi, Irimura, Tatsuro
Cell surface lectins are known to regulate trafficking of cells in the immune system, yet the role of macrophage galactose-type C-type lectin 1 and 2 (MGL1/2) is poorly understood. In this study,...
Sato, Kayoko, Imai, Yasuyuki, Higashi, Nobuaki, Kumamoto, Yosuke, Mukaida, Naofumi, Irimura, Tatsuro
Cell surface lectins are known to regulate trafficking of cells in the immune system, yet the role of macrophage galactose-type C-type lectin 1 and 2 (MGL1/2) is poorly understood. In this study,...
p38 MAPK phosphorylation and NF-{kappa}B activation in human crescentic glomerulonephritis (2002)
Sakai, Norihiko, Wada, Takashi, Furuichi, Kengo, Iwata, Yasunori, Yoshimoto, Keiichi, Kitagawa, Kiyoki, ...
Background. p38 mitogen‐activated protein kinase (p38 MAPK) followed by the activation of NF‐κB participates in the intracellular signal transduction and production of...
Furuichi, Kengo, Wada, Takashi, Iwata, Yasunori, Sakai, Norihiko, Yoshimoto, Keiichi, Kobayashi, Ken-ichi, ...
Background. Various types of chemokines/cytokines play important roles in ischaemia/reperfusion injury in kidneys. However, the roles of p38 mitogen‐activated protein kinase...
Watanabe, Shun-ichi, Mukaida, Naofumi, Ikeda, Naoki, Akiyama, Mariko, Harada, Akihisa, Nakanishi, Isao, ...
Septic shock remains a serious disorder associated with high mortality. Accumulating evidence indicates that TNF is a major and essential mediator of endotoxin shock. We report here that...
Harada, Akihisa, Sekido, Nobuaki, Kuno, Kouji, Aklyama, Mariko, Kasahara, Tadashi, Nakanishi, Isao, ...
In order to establish the pathophyslological roles of IL-8, rabbit IL-8 was expressed in Escherichia coli and purified to homogeneity by sequential chromatography on heparin agarose, CM-HPLC, and...
Mori, Naoki, Oishi, Kazunori, Sar, Borann, Mukaida, Naofumi, Nagatake, Tsuyoshi, Matsushima, Kouji, ...
Persistent infection with Pseudomonas aeruginosa increases interleukin-8 (IL-8) levels and causes dense neutrophil infiltrations in the airways of patients with chronic airway diseases. Recently, we...
Amano, Hideaki, Yamamoto, Hidefumi, Senba, Masachika, Oishi, Kazunori, Suzuki, Shoichi, Fukushima, Kenichi, ...
To elucidate the mechanism of the high incidence of lower respiratory tract infections in patients with diabetes mellitus, we investigated the kinetics of production of macrophage inflammatory...
Polyak, Stephen J., Khabar, Khalid S. A., Paschal, Denise M., Ezelle, Heather J., Duverlie, Gilles, Barber, Glen N., ...
Hepatitis C virus (HCV), a major cause of liver disease worldwide, is frequently resistant to the antiviral alpha interferon (IFN). The HCV nonstructural 5A (NS5A) protein has been implicated in HCV...
Mori, Naoki, Oishi, Kazunori, Sar, Borann, Mukaida, Naofumi, Nagatake, Tsuyoshi, Matsushima, Kouji, ...
Persistent infection with Pseudomonas aeruginosa increases interleukin-8 (IL-8) levels and causes dense neutrophil infiltrations in the airways of patients with chronic airway diseases. Recently, we...
Amano, Hideaki, Yamamoto, Hidefumi, Senba, Masachika, Oishi, Kazunori, Suzuki, Shoichi, Fukushima, Kenichi, ...
To elucidate the mechanism of the high incidence of lower respiratory tract infections in patients with diabetes mellitus, we investigated the kinetics of production of macrophage inflammatory...
Polyak, Stephen J., Khabar, Khalid S. A., Paschal, Denise M., Ezelle, Heather J., Duverlie, Gilles, Barber, Glen N., ...
Hepatitis C virus (HCV), a major cause of liver disease worldwide, is frequently resistant to the antiviral alpha interferon (IFN). The HCV nonstructural 5A (NS5A) protein has been implicated in HCV...
Ato, Manabu, Iwabuchi, Kazuya, Shimada, Shigeki, Mukaida, Naofumi, Onoé, Kazunori
Monocyte chemoattractant protein-1 (MCP-1) is a protective cytokine in murine endotoxaemia induced by lipopolysaccharide (LPS). In this study, LPS-induced pathophysiology in the human (h) MCP-1...
Blockade of CCR2 Ameliorates Progressive Fibrosis in Kidney
Kitagawa, Kiyoki, Wada, Takashi, Furuichi, Kengo, Hashimoto, Hiroyuki, Ishiwata, Yoshiro, Asano, Masahide, ...
Fibrosis is a hallmark of progressive organ diseases. Monocyte chemoattractant protein (MCP)-1, also termed as macrophage chemotactic and activating factor (MCAF/CCL2) and its receptor, CCR2 are...
Kimura, Akihiko, Ishida, Yuko, Hayashi, Takahito, Wada, Takashi, Yokoyama, Hitoshi, Sugaya, Takeshi, ...
Subcutaneous injection of sodium arsenite (NaAs, 12.5 mg/kg) into BALB/c [wild-type (WT)] mice causes acute renal dysfunction characterized by severe hemorrhages, acute tubular necrosis, and cast...
Lu, Peirong, Nakamoto, Yasunari, Nemoto-Sasaki, Yoko, Fujii, Chifumi, Wang, Hui, Hashii, Minako, ...
Hepatoma cell lines can produce a massive amount of chemokines in response to various stimuli including hepatitis viruses and their products. However, it remains elusive on the types of chemokine...
Ishida, Yuko, Kimura, Akihiko, Kondo, Toshikazu, Hayashi, Takahito, Ueno, Masaya, Takakura, Nobuyuki, ...
We investigated the pathogenic roles of CC chemokine ligand (CCL)3 and its receptors, CC chemokine receptor (CCR)1 and CCR5, in bleomycin (BLM)-induced pulmonary fibrosis (PF). An intratracheal...
Fujimura, Masaki, Myou, Shigeharu, Nomura, Masaharu, Matsuda, Tamotsu, Harada, Akihisa, Mukaida, Naofumi, ...
Although repeated intranasal administration of interleukin-8 (IL-8) causes bronchial hyperresponsiveness (BHR) mediated via thromboxane A2 (TXA2) and airway neutrophil accumulation in guinea-pigs,...
Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis
Popivanova, Boryana K., Kitamura, Kazuya, Wu, Yu, Kondo, Toshikazu, Kagaya, Takashi, Kaneko, Shiuchi, ...
The inflammatory bowel disease ulcerative colitis (UC) frequently progresses to colon cancer. To understand the mechanisms by which UC patients develop colon carcinomas, we used a mouse model of the...
Mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells
Teruya, Hiromitsu, Higa, Futoshi, Akamine, Morikazu, Ishikawa, Chie, Okudaira, Taeko, Tomimori, Koh, ...
The α Chemokine, Interleukin 8, Inhibits the Antiviral Action of Interferon α
Khabar, Khalid S.A., Al-Zoghaibi, Fahad, Al-Ahdal, Mohammed N., Murayama, Tsugiya, Dhalla, Mohammed, Mukaida, Naofumi, ...
Interferon (IFN) exhibits a potent antiviral activity in vitro and plays a major role in the early defense against viruses. Like IFN, the proinflammatory chemokine, interleukin (IL)-8, is induced by...