Naoki Mori

NF-κB activation by Helicobacter pylorirequires Akt-mediated phosphorylation of p65 (2009)

Takeshima, Eriko, Tomimori, Koh, Kawakami, Hirochika, Ishikawa, Chie, Sawada, Shigeki, Tomita, Mariko, ...

Abstract Background The inflammatory response in Helicobacter pylori -infected gastric tissue is mediated by cag pathogenicity island (PAI)-dependent activation of nuclear factor-κB (NF-κB)....

Gene expression profile and pathogenicity of biofilm-forming Prevotella intermediastrain 17 (2009)

Yamanaka, Takeshi, Furukawa, Tomoyo, Matsumoto-Mashimo, Chiho, Yamane, Kazuyoshi, Sugimori, Chieko, Nambu, Takayuki, ...

Abstract Background Prevotella intermedia ( P. intermedia ), a gram-negative, black-pigmented anaerobic rod, has been implicated in the development of chronic oral infection. P. intermedia strain 17...

Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol (2009)

Machijima, Yoshiaki, Ishikawa, Chie, Sawada, Shigeki, Okudaira, Taeko, Uchihara, Jun-nosuke, Tanaka, Yuetsu, ...

Abstract Background Adult T-cell leukemia/lymphoma (ATLL) is a malignancy derived from T cells infected with human T-cell leukemia virus type 1 (HTLV-1), and it is known to be resistant to standard...

Mycolyltransferase from Mycobacterium leprae Excludes Mycolate-containing Glycolipid Substrates (2009)

Nakao, Hitomi, Matsunaga, Isamu, Morita, Daisuke, Aboshi, Takako, Harada, Toshiyuki, Nakagawa, Yoshiaki, ...

Trehalose dimycolate (TDM) is a major surface-exposed mycolyl glycolipid that contributes to the hydrophobic cell wall architecture of mycobacteria. Nevertheless, because of its potent adjuvant...

Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules (2008)

Teruya, Hiromitsu, Tomita, Mariko, Senba, Masachika, Ishikawa, Chie, Tamayose, Maki, Miyazato, Akiko, ...

Abstract Background Human T-cell leukemia virus type I (HTLV-I) is associated with pulmonary diseases, characterized by bronchoalveolar lymphocytosis, which correlates with HTLV-I proviral DNA in...

Legionella pneumophilainfection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone (2008)

Furugen, Makoto, Higa, Futoshi, Hibiya, Kenji, Teruya, Hiromitsu, Akamine, Morikazu, Haranaga, Shusaku, ...

Abstract Background Legionella pneumophila pneumonia often exacerbates acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Apoptosis of alveolar epithelial cells is considered to...

Mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells (2007)

Teruya, Hiromitsu, Higa, Futoshi, Akamine, Morikazu, Ishikawa, Chie, Okudaira, Taeko, Tomimori, Koh, ...

Abstract Background Legionella pneumophila is a facultative intracellular bacterium, capable of replicating within the phagosomes of macrophages and monocytes, but little is known about its...

Timesaving techniques for decision of electron–molecule collisions in Monte Carlo simulation of electrical discharges (2007)

Sugawara, Hirotake, Mori, Naoki, Sakai, Yosuke, Suda, Yoshiyuki

Techniques to reduce the computational load for determination of electron–molecule collisions in Monte Carlo simulations of electrical discharges have been presented. By enhancing the detection...

Timesaving techniques for decision of electron–molecule collisions in Monte Carlo simulation of electrical discharges (2007)

Sugawara, Hirotake, Mori, Naoki, Sakai, Yosuke, Suda, Yoshiyuki

Techniques to reduce the computational load for determination of electron–molecule collisions in Monte Carlo simulations of electrical discharges have been presented. By enhancing the detection...

Analysing the regularity of genomes using compression and expression simplification (2007)

Jungseok Shin, Moonyoung Kang, Xuan Nguyen, Tuan-hao Hoang, Naoki Mori, ...

Abstract. We propose expression simplification and tree compression as aids in understanding the evolution of regular structure in Genetic Programming individuals. We apply the analysis to two...

Void Fraction and Pressure Drop in Two-Phase Equilibrium Flows in a Vertical 2×3 Rod Bundle Channel : Assessment of Correlations against the Present Subchannel Data(International Conferences on Power and Energy) (2006)

Sadatomi, Michio, Kano, Keiko, Kawahara, Akimaro, Mori, Naoki, 佐田富, 道雄, 加野, 敬子, ...

In order to increase void fraction and pressure drop data in a multi-subchannel system like an actual fuel rod bundle, air-water experiments have been conducted using a vertical 2×3 rod bundle...

Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells (2006)

Tomita, Mariko, Kawakami, Hirochika, Uchihara, Jun-nosuke, Okudaira, Taeko, Masuda, Masato, Matsuda, Takehiro, ...

Abstract Background Human T-cell leukemia virus type 1 (HTLV-1), the etiologic agent for adult T-cell leukemia (ATL), induces cytokine-independent proliferation of T-cells, associated with the...

二流体モデルを用いた垂直2×3ロッド流路内気液二相流のサブチャンネルボイド率と圧力損失の予測 (2005)

佐田富, 道雄, 加野 敬子, 川原 顕磨呂, 森 直樹, サダトミ, ミチオ, カワハラ, アキマロ, ...

In order to increase void fraction and pressure drop data in a multi-subchannel system like an actual fuel rod bundle, air-water experiments have been conducted with a vertical 2×3 rod bundle...

Elevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-κB activation (2005)

Higuchi, Masaya, Matsuda, Takehiro, Mori, Naoki, Yamada, Yasuaki, Horie, Ryouichi, Watanabe, Toshiki, ...

Abstract Background Human T-cell leukemia virus type 1 (HTLV-1) is associated with the development of adult T-cell leukemia (ATL). HTLV-1 encoded Tax1 oncoprotein activates the transcription of genes...

Structural dynamics of cereal mitochondrial genomes as revealed by complete nucleotide sequencing of the wheat mitochondrial genome (2005)

Ogihara, Yasunari, Yamazaki, Yukiko, Murai, Koji, Kanno, Akira, Terachi, Toru, Shiina, Takashi, ...

The application of a new gene-based strategy for sequencing the wheat mitochondrial genome shows its structure to be a 452 528 bp circular molecule, and provides nucleotide-level evidence of...

Chemical ecology of astigmatid mites LXIX. Neryl formate [3,7-dimethyl-(Z)-2,6-octadienyl formate] as the alarm pheromone of an acarid mite, Histiogaster rotundus Woodring (Acari: Acaridae) (2003)

Hiroyuki Hiraoka, Naoki Mori, Kimiko Okabe, Ritsuo Nishida, Yasumasa Kuwahara

Alarm pheromone activity was demonstrated in a hexane rinse of the mite Histiogaster rotundus Woodring (Acari: Acaridae). Silica gel column chromatography of the hexane rinse from 1,000 mites...

Chemical ecology of astigmatid mites. LXIV. The alarm pheromone neral functions as an attractant in Schwiebea elongata (Banks) (Acari: Acaridae) (2002)

Karin Nishimura, Nobuhiro Shimizu, Naoki Mori, Yasumasa Kuwahara

Although neral [(Z)-3,7-dimethyl-2,6-octadienal] has been known as the alarm pheromone of Schwiebea elongata, reinvestigation of the pheromone resulted in recognition of another function as an...

Chemical ecology of astigmatid mites LVIII. 2-Hydroxy-6-methylbenzaldehyde: Female sex pheromone of Cosmoglyphus hughesi Samšinák (Acari: Acaridae) (2001)

Atsushi Ryono, Naoki Mori, Kimiko Okabe, Yasumasa Kuwahara

2-Hydroxy-6-methylbenzaldehyde (2,6-HMB) was identified as the female sex pheromone from the acarid mite, Cosmoglyphus hughesi. Although the sex pheromone functioned to stimulate males to tap females...

2,4-D Resistance in a Tobacco Cell Culture Variant II. Effects of 2,4-D on Nucleic Acid and Protein Synthesis and Cell Respiration (1986)

Nakamura, Chiharu, Mori, Naoki, Nakata, Masanobu, Ono, Hajime

The effects of 2,4-D on nucleic acid and protein synthesis and cell respiration were compared between a 2,4-D-resistant variant and its wild-type cell lines of tobacco (Nicotiana tabacum L.). The...

Essential Role of Transcription Factor Nuclear Factor-κB in Regulation of Interleukin-8 Gene Expression by Nitrite Reductase from Pseudomonas aeruginosa in Respiratory Epithelial Cells

Mori, Naoki, Oishi, Kazunori, Sar, Borann, Mukaida, Naofumi, Nagatake, Tsuyoshi, Matsushima, Kouji, ...

Persistent infection with Pseudomonas aeruginosa increases interleukin-8 (IL-8) levels and causes dense neutrophil infiltrations in the airways of patients with chronic airway diseases. Recently, we...

Activation of Intercellular Adhesion Molecule 1 Expression by Helicobacter pylori Is Regulated by NF-κB in Gastric Epithelial Cancer Cells

Mori, Naoki, Wada, Akihiro, Hirayama, Toshiya, Parks, Thomas P., Stratowa, Christian, Yamamoto, Naoki

Interactions between leukocytes and epithelial cells may play a key role in Helicobacter pylori-associated gastric mucosal inflammation. This process is mediated by various cell adhesion molecules....

Induction of Monocyte Chemoattractant Protein 1 by Helicobacter pylori Involves NF-κB

Mori, Naoki, Ueda, Atsuhisa, Geleziunas, Romas, Wada, Akihiro, Hirayama, Toshiya, Yoshimura, Teizo, ...

Helicobacter pylori stimulates secretion of monocyte chemoattractant protein 1 (MCP-1) from gastric epithelial cells. Secretion of this chemokine may be instrumental in monocyte infiltration of the...

Rapid Tumor Formation of Human T-Cell Leukemia Virus Type 1-Infected Cell Lines in Novel NOD-SCID/γcnull Mice: Suppression by an Inhibitor against NF-κB

Dewan, M. Zahidunnabi, Terashima, Kazuo, Taruishi, Midori, Hasegawa, Hideki, Ito, Mamoru, Tanaka, Yuetsu, ...

We established a novel experimental model for human T-cell leukemia virus type 1 (HTLV-1)-induced tumor using NOD-SCID/γcnull (NOG) mice. This model is very useful for investigating the mechanism of...

Helicobacter pylori Induces RANTES through Activation of NF-κB

Mori, Naoki, Krensky, Alan M., Geleziunas, Romas, Wada, Akihiro, Hirayama, Toshiya, Sasakawa, Chihiro, ...

Helicobacter pylori-infected gastric mucosa displays a conspicuous infiltration of mononuclear cells and neutrophils. RANTES (short for “regulated upon activation, normal T cell expressed and...

Apoptosis Induced by the Histone Deacetylase Inhibitor FR901228 in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines and Primary Adult T-Cell Leukemia Cells

Mori, Naoki, Matsuda, Takehiro, Tadano, Masayuki, Kinjo, Takao, Yamada, Yasuaki, Tsukasaki, Kunihiro, ...

Inhibition of histone deacetylase (HDAC) activity induces growth arrest, differentiation, and, in certain cell types, apoptosis. FR901228, FK228, or depsipeptide, is an HDAC inhibitor effective in...

Resistance to Apo2 Ligand (Apo2L)/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Mediated Apoptosis and Constitutive Expression of Apo2L/TRAIL in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines

Matsuda, Takehiro, Almasan, Alex, Tomita, Mariko, Uchihara, Jun-nosuke, Masuda, Masato, Ohshiro, Kazuiku, ...

Adult T-cell leukemia (ATL), a CD4+-T-cell malignancy caused by human T-cell leukemia virus type 1 (HTLV-1), is difficult to cure, and novel treatments are urgently needed. Apo2 ligand (Apo2L; also...

Structural dynamics of cereal mitochondrial genomes as revealed by complete nucleotide sequencing of the wheat mitochondrial genome

Ogihara, Yasunari, Yamazaki, Yukiko, Murai, Koji, Kanno, Akira, Terachi, Toru, Shiina, Takashi, ...

The application of a new gene-based strategy for sequencing the wheat mitochondrial genome shows its structure to be a 452 528 bp circular molecule, and provides nucleotide-level evidence of...

Tax-Independent Constitutive IκB Kinase Activation in Adult T-Cell Leukemia Cells1

Hironaka, Noriko, Mochida, Kanako, Mori, Naoki, Maeda, Michiyuki, Yamamoto, Naoki, Yamaoka, Shoji

Adult T-cell leukemia (ATL) is a fatal T-cell malignancy that arises long after infection with human T-cell leukemia virus type I (HTLV-I). We reported previously that nuclear factor-κB (NF-κB) was...

Essential Role of Transcription Factor Nuclear Factor-κB in Regulation of Interleukin-8 Gene Expression by Nitrite Reductase from Pseudomonas aeruginosa in Respiratory Epithelial Cells

Mori, Naoki, Oishi, Kazunori, Sar, Borann, Mukaida, Naofumi, Nagatake, Tsuyoshi, Matsushima, Kouji, ...

Persistent infection with Pseudomonas aeruginosa increases interleukin-8 (IL-8) levels and causes dense neutrophil infiltrations in the airways of patients with chronic airway diseases. Recently, we...

Activation of Intercellular Adhesion Molecule 1 Expression by Helicobacter pylori Is Regulated by NF-κB in Gastric Epithelial Cancer Cells

Mori, Naoki, Wada, Akihiro, Hirayama, Toshiya, Parks, Thomas P., Stratowa, Christian, Yamamoto, Naoki

Interactions between leukocytes and epithelial cells may play a key role in Helicobacter pylori-associated gastric mucosal inflammation. This process is mediated by various cell adhesion molecules....

Induction of Monocyte Chemoattractant Protein 1 by Helicobacter pylori Involves NF-κB

Mori, Naoki, Ueda, Atsuhisa, Geleziunas, Romas, Wada, Akihiro, Hirayama, Toshiya, Yoshimura, Teizo, ...

Helicobacter pylori stimulates secretion of monocyte chemoattractant protein 1 (MCP-1) from gastric epithelial cells. Secretion of this chemokine may be instrumental in monocyte infiltration of the...

Rapid Tumor Formation of Human T-Cell Leukemia Virus Type 1-Infected Cell Lines in Novel NOD-SCID/γcnull Mice: Suppression by an Inhibitor against NF-κB

Dewan, M. Zahidunnabi, Terashima, Kazuo, Taruishi, Midori, Hasegawa, Hideki, Ito, Mamoru, Tanaka, Yuetsu, ...

We established a novel experimental model for human T-cell leukemia virus type 1 (HTLV-1)-induced tumor using NOD-SCID/γcnull (NOG) mice. This model is very useful for investigating the mechanism of...

Helicobacter pylori Induces RANTES through Activation of NF-κB

Mori, Naoki, Krensky, Alan M., Geleziunas, Romas, Wada, Akihiro, Hirayama, Toshiya, Sasakawa, Chihiro, ...

Helicobacter pylori-infected gastric mucosa displays a conspicuous infiltration of mononuclear cells and neutrophils. RANTES (short for “regulated upon activation, normal T cell expressed and...

Apoptosis Induced by the Histone Deacetylase Inhibitor FR901228 in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines and Primary Adult T-Cell Leukemia Cells

Mori, Naoki, Matsuda, Takehiro, Tadano, Masayuki, Kinjo, Takao, Yamada, Yasuaki, Tsukasaki, Kunihiro, ...

Inhibition of histone deacetylase (HDAC) activity induces growth arrest, differentiation, and, in certain cell types, apoptosis. FR901228, FK228, or depsipeptide, is an HDAC inhibitor effective in...

Resistance to Apo2 Ligand (Apo2L)/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Mediated Apoptosis and Constitutive Expression of Apo2L/TRAIL in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines

Matsuda, Takehiro, Almasan, Alex, Tomita, Mariko, Uchihara, Jun-nosuke, Masuda, Masato, Ohshiro, Kazuiku, ...

Adult T-cell leukemia (ATL), a CD4+-T-cell malignancy caused by human T-cell leukemia virus type 1 (HTLV-1), is difficult to cure, and novel treatments are urgently needed. Apo2 ligand (Apo2L; also...

Structural dynamics of cereal mitochondrial genomes as revealed by complete nucleotide sequencing of the wheat mitochondrial genome

Ogihara, Yasunari, Yamazaki, Yukiko, Murai, Koji, Kanno, Akira, Terachi, Toru, Shiina, Takashi, ...

The application of a new gene-based strategy for sequencing the wheat mitochondrial genome shows its structure to be a 452 528 bp circular molecule, and provides nucleotide-level evidence of...

Tax-Independent Constitutive IκB Kinase Activation in Adult T-Cell Leukemia Cells1

Hironaka, Noriko, Mochida, Kanako, Mori, Naoki, Maeda, Michiyuki, Yamamoto, Naoki, Yamaoka, Shoji

Adult T-cell leukemia (ATL) is a fatal T-cell malignancy that arises long after infection with human T-cell leukemia virus type I (HTLV-I). We reported previously that nuclear factor-κB (NF-κB) was...

Human T-Cell Leukemia Virus Type 1 Tax Dysregulates β-Catenin Signaling▿

Tomita, Mariko, Kikuchi, Akira, Akiyama, Tetsu, Tanaka, Yuetsu, Mori, Naoki

Dysregulation of β-catenin signaling has been implicated in the malignant transformation of cells. However, the role of β-catenin in the human T-cell leukemia virus type 1 (HTLV-1)-induced...

Helicobacter pylori Induces CCL20 Expression▿

Tomimori, Koh, Uema, Eriko, Teruya, Hiromitsu, Ishikawa, Chie, Okudaira, Taeko, Senba, Masachika, ...

CCL20 attracts immature dendritic cells and memory T cells and plays a role on mucosal surfaces in inflammation. However, whether Helicobacter pylori infection induces CCL20 in human gastric...

Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells

Tomita, Mariko, Semenza, Gregg L., Michiels, Canine, Matsuda, Takehiro, Uchihara, Jun-Nosuke, Okudaira, Taeko, ...

HTLV-1 (human T-cell leukaemia virus type 1) is the causative agent for ATL (adult T-cell leukaemia). HTLV-1 Tax can activate the PI3K (phosphoinositide 3-kinase)/Akt signalling pathway, which is...

Active role of fatty acid amino acid conjugates in nitrogen metabolism in Spodoptera litura larvae

Yoshinaga, Naoko, Aboshi, Takako, Abe, Hiroaki, Nishida, Ritsuo, Alborn, Hans T., Tumlinson, James H., ...

Since the first fatty acid amino acid conjugate (FAC) was isolated from regurgitant of Spodoptera exigua larvae in 1997 [volicitin: N-(17-hydroxylinolenoyl)-l-glutamine], their role as elicitors of...

Helicobacter pylori-Induced Interleukin-12 p40 Expression▿

Takeshima, Eriko, Tomimori, Koh, Teruya, Hiromitsu, Ishikawa, Chie, Senba, Masachika, D'Ambrosio, Daniele, ...

Interleukin-12 (IL-12) is a heterodimeric cytokine produced by antigen-presenting cells that promotes the development of T-helper lymphocyte 1 (Th1). Chronic gastritis induced by Helicobacter pylori...

Human T-Cell Leukemia Virus Type I-Mediated Repression of PDZ-LIM Domain-Containing Protein 2 Involves DNA Methylation But Independent of the Viral Oncoprotein Tax1

Yan, Pengrong, Qu, Zhaoxia, Ishikawa, Chie, Mori, Naoki, Xiao, Gutian

Human T-cell leukemia virus type I (HTLV-I) is the etiological agent of adult T-cell leukemia (ATL). Our recent studies have shown that one important mechanism of HTLV-I-Mediated tumorigenesis is...