Naomi E. Kramer

Increased D-alanylation of lipoteichoic acid and a thickened septum are main determinants in the nisin resistance mechanism of Lactococcus lactis (2008)

Kramer, Naomi E., Hasper, Hester E., Morath, Siegfried, Kruijff, Ben De, Hartung, Thomas, ...

Nisin is a post-translationally modified antimicrobial peptide produced by Lactococcus lactis which binds to lipid II in the membrane to form pores and inhibit cell-wall synthesis. A nisin-resistant...

An Alternative Bactericidal Mechanism of Action for Lantibiotic Peptides That Target Lipid II (2006)

Hasper, Hester E., Kramer, Naomi E., Smith, James L., Hillman, J.D., Zachariah, Cherian, Kuipers, Oscar P., ...

Lantibiotics are polycyclic peptides containing unusual amino acids, which have binding specificity for bacterial cells, targeting the bacterial cell wall component lipid II to form pores and thereby...

Transcriptome Analysis Reveals Mechanisms by Which Lactococcus lactis Acquires Nisin Resistance (2006)

Kramer, Naomi E., Knol, Jan, Kok, Jan, Kuipers, Oscar P.

Nisin, a posttranslationally modified antimicrobial peptide produced by Lactococcus lactis, is widely used as a food preservative. Yet, the mechanisms leading to the development of nisin resistance...

A generally applicable validation scheme for the assessment of factors involved in reproducibility and quality of DNA-microarray data (2005)

Van Hijum, Sacha AFT, De Jong, Anne, Baerends, Richard JS, Karsens, Harma A, Kramer, Naomi E, Larsen, Rasmus, ...

Abstract Background In research laboratories using DNA-microarrays, usually a number of researchers perform experiments, each generating possible sources of error. There is a need for a quick and...

A Generally applicable validation scheme for the assessment of factors involved in reproducibility and quality of DNA-microarray data (2005)

De Jong, Anne, Baerends, Richard J.S., Karsens, Harma A., Kramer, Naomi E., Larsen, Rasmus, ...

Background: In research laboratories using DNA-microarrays, usually a number of researchers perform experiments, each generating possible sources of error. There is a need for a quick and robust...

A novel scheme to assess factors involved in the reproducibility of DNA-microarray data (2005)

Van Hijum, Sacha, De Jong, Anne, Baerends, Richard, Karsens, Harma A, Kramer, Naomi E, Larsen, Rasmus, ...

Abstract Background In research laboratories using DNA-microarrays, usually a number of researchers perform experiments, each generating possible sources of error. There is a need for a quick and...

A generally applicable validation scheme for the assessment of factors involved in reproducibility and quality of DNA-microarray data. Methodology article (2005)

Jong, Anne De, Baerends,Richard J.S., Karsens, Harma A., Kramer, Naomi E., Larsen, Rasmus, ...

Background: In research laboratories using DNA-microarrays, usually a number of researchers perform experiments, each generating possible sources of error. There is a need for a quick and robust...

A generally applicable validation scheme for the assessment of factors involved in reproducibility and quality of DNA-microarray data (2005)

Hengst, Chris D. Den, Larsen, Rasmus, Kramer, Naomi E., Karsens, Harma A., Baerends, Richard J.S., Jong, Anne De, ...

Background: In research laboratories using DNA-microarrays, usually a number of researchers perform experiments, each generating possible sources of error. There is a need for a quick and robust...

Resistance of Gram-positive bacteria to nisin is not determined by Lipid II levels (2004)

Kramer, Naomi E., Smid, Eddy J., Kok, Jan, Kruijff, Ben De, Kuipers, Oscar P., Breukink, Eefjan

Lipid II is essential for nisin-mediated pore formation at nano-molar concentrations. We tested whether nisin resistance could result from different Lipid II levels, by comparing the maximal Lipid II...

Transcriptome analysis and related databases of Lactococcus lactis (2002)

Kuipers, Oscar P., Jong, Anne De, Baerends, Richard J.S., Zomer, Aldert L., Karsens, Harma A., ...

Several complete genome sequences of Lactococcus lactis and their annotations will become available in the near future, next to the already published genome sequence of L. lactis ssp. lactis IL1403....

Salmonella enterica Serovar Typhi Possesses a Unique Repertoire of Fimbrial Gene Sequences

Townsend, Stacy M., Kramer, Naomi E., Edwards, Robert, Baker, Stephen, Hamlin, Nancy, Simmonds, Mark, ...

Salmonella enterica serotype Typhi differs from nontyphoidal Salmonella serotypes by its strict host adaptation to humans and higher primates. Since fimbriae have been implicated in host adaptation,...

Transcriptome Analysis Reveals Mechanisms by Which Lactococcus lactis Acquires Nisin Resistance

Kramer, Naomi E., Knol, Jan, Kok, Jan, Kuipers, Oscar P.

Nisin, a posttranslationally modified antimicrobial peptide produced by Lactococcus lactis, is widely used as a food preservative. Yet, the mechanisms leading to the development of nisin resistance...

Salmonella enterica Serovar Typhi Possesses a Unique Repertoire of Fimbrial Gene Sequences

Townsend, Stacy M., Kramer, Naomi E., Edwards, Robert, Baker, Stephen, Hamlin, Nancy, Simmonds, Mark, ...

Salmonella enterica serotype Typhi differs from nontyphoidal Salmonella serotypes by its strict host adaptation to humans and higher primates. Since fimbriae have been implicated in host adaptation,...

Transcriptome Analysis Reveals Mechanisms by Which Lactococcus lactis Acquires Nisin Resistance

Kramer, Naomi E., Knol, Jan, Kok, Jan, Kuipers, Oscar P.

Nisin, a posttranslationally modified antimicrobial peptide produced by Lactococcus lactis, is widely used as a food preservative. Yet, the mechanisms leading to the development of nisin resistance...