Ogawa, Momoko, Hirawa, Nobuhito, Tsuchida, Takamasa, Eguchi, Naomi, Kawabata, Yukari, Numabe, Atsushi, ...
Background. Otsuka Long-Evans Tokushima Fatty (OLETF) rats genetically develop diabetes which is associated with hypertension. In preliminary studies, urinary excretions of L-PGDS (lipocaline-type...
Ogawa, Momoko, Hirawa, Nobuhito, Tsuchida, Takamasa, Eguchi, Naomi, Kawabata, Yukari, Numabe, Atsushi, ...
Background. Otsuka Long-Evans Tokushima Fatty (OLETF) rats genetically develop diabetes which is associated with hypertension. In preliminary studies, urinary excretions of L-PGDS (lipocaline-type...
Ogawa, Momoko, Hirawa, Nobuhito, Tsuchida, Takamasa, Eguchi, Naomi, Kawabata, Yukari, Numabe, Atsushi, ...
Background. Otsuka Long-Evans Tokushima Fatty (OLETF) rats genetically develop diabetes which is associated with hypertension. In preliminary studies, urinary excretions of L-PGDS (lipocaline-type...
Manya, Hiroshi, Sato, Yuji, Eguchi, Naomi, Seiki, Kousuke, Oda, Hiroshi, Nakajima, Hiroshi, ...
Lipocalin-type prostaglandin D synthase (L-PGDS) is a highly glycosylated member of the lipocalin gene family and is secreted into various human body fluids. We comparatively analyzed the structures...
Toh, Hiroyuki, Kubodera, Hideo, Nakajima, Nobuyuki, Sekiya, Tetsuo, Eguchi, Naomi, Tanaka, Toshiki, ...
Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice
Eguchi, Naomi, Minami, Toshiaki, Shirafuji, Naoki, Kanaoka, Yoshihide, Tanaka, Takashi, Nagata, Akihisa, ...
Prostaglandin (PG) D2 is the most abundant prostanoid produced in the central nervous system of mammals and has been implicated in the modulation of neural functions such as sleep induction,...
Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep
Pinzar, Elena, Kanaoka, Yoshihide, Inui, Takashi, Eguchi, Naomi, Urade, Yoshihiro, Hayaishi, Osamu
To examine the function of prostaglandin (PG) D synthase (PGDS) gene, as well as endogenously produced PGD2 in sleep regulation in vivo, we generated transgenic (TG) mice that overexpress human PGDS...
Eguchi, Yutaka, Eguchi, Naomi, Oda, Hiroshi, Seiki, Kousuke, Kijima, Yoshiyuki, Matsu-ura, Yasuhiko, ...
Lipocalin-type prostaglandin D synthase (L-PGDS) is localized in the central nervous system and male genital organs of various mammals and is secreted as β-trace into the closed compartment of these...
Arousal effect of orexin A depends on activation of the histaminergic system
Huang, Zhi-Li, Qu, Wei-Min, Li, Wei-Dong, Mochizuki, Takatoshi, Eguchi, Naomi, Watanabe, Takeshi, ...
Orexin neurons are exclusively localized in the lateral hypothalamic area and project their fibers to the entire central nervous system, including the histaminergic tuberomammillary nucleus (TMN)....
Mizoguchi, Akira, Eguchi, Naomi, Kimura, Kazushi, Kiyohara, Yoshimoto, Qu, Wei-Min, Huang, Zhi-Li, ...
Infusion of prostaglandin (PG) D2 into the lateral ventricle of the brain induced an increase in the amount of non-rapid eye movement sleep in wild-type (WT) mice but not in mice deficient in the PGD...
Trivedi, Seema G., Newson, Justine, Rajakariar, Ravindra, Jacques, Thomas S., Hannon, Robert, Kanaoka, Yoshihide, ...
Hematopoietic prostaglandin D2 synthase (hPGD2S) metabolizes cyclooxygenase-derived prostaglandin (PG) H2 to PGD2, which is dehydrated to cyclopentenone PGs, including 15-deoxy-Δ12,14-PGJ2...
Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice
Eguchi, Naomi, Minami, Toshiaki, Shirafuji, Naoki, Kanaoka, Yoshihide, Tanaka, Takashi, Nagata, Akihisa, ...
Prostaglandin (PG) D2 is the most abundant prostanoid produced in the central nervous system of mammals and has been implicated in the modulation of neural functions such as sleep induction,...
Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep
Pinzar, Elena, Kanaoka, Yoshihide, Inui, Takashi, Eguchi, Naomi, Urade, Yoshihiro, Hayaishi, Osamu
To examine the function of prostaglandin (PG) D synthase (PGDS) gene, as well as endogenously produced PGD2 in sleep regulation in vivo, we generated transgenic (TG) mice that overexpress human PGDS...
Eguchi, Yutaka, Eguchi, Naomi, Oda, Hiroshi, Seiki, Kousuke, Kijima, Yoshiyuki, Matsu-ura, Yasuhiko, ...
Lipocalin-type prostaglandin D synthase (L-PGDS) is localized in the central nervous system and male genital organs of various mammals and is secreted as β-trace into the closed compartment of these...
Arousal effect of orexin A depends on activation of the histaminergic system
Huang, Zhi-Li, Qu, Wei-Min, Li, Wei-Dong, Mochizuki, Takatoshi, Eguchi, Naomi, Watanabe, Takeshi, ...
Orexin neurons are exclusively localized in the lateral hypothalamic area and project their fibers to the entire central nervous system, including the histaminergic tuberomammillary nucleus (TMN)....
Mizoguchi, Akira, Eguchi, Naomi, Kimura, Kazushi, Kiyohara, Yoshimoto, Qu, Wei-Min, Huang, Zhi-Li, ...
Infusion of prostaglandin (PG) D2 into the lateral ventricle of the brain induced an increase in the amount of non-rapid eye movement sleep in wild-type (WT) mice but not in mice deficient in the PGD...
Trivedi, Seema G., Newson, Justine, Rajakariar, Ravindra, Jacques, Thomas S., Hannon, Robert, Kanaoka, Yoshihide, ...
Hematopoietic prostaglandin D2 synthase (hPGD2S) metabolizes cyclooxygenase-derived prostaglandin (PG) H2 to PGD2, which is dehydrated to cyclopentenone PGs, including 15-deoxy-Δ12,14-PGJ2...
Qu, Wei-Min, Huang, Zhi-Li, Xu, Xin-Hong, Aritake, Kosuke, Eguchi, Naomi, Nambu, Fumio, ...
Prostaglandin (PG) D2 has been proposed to be essential for the initiation and maintenance of the physiological sleep of rats because intracerebroventricular administration of selenium tetrachloride...
Kilunga Kubata, B., Eguchi, Naomi, Urade, Yoshihiro, Yamashita, Kouwa, Mitamura, Toshihide, Tai, Kumiko, ...
Plasmodium falciparum causes the most severe form of human malaria, which kills ∼1.5–2.7 million people every year, but the molecular mechanisms underlying the clinical symptoms and the...
Tokudome, Satori, Sano, Motoaki, Shinmura, Ken, Matsuhashi, Tomohiro, Morizane, Shintaro, Moriyama, Hidenori, ...
Lipocalin-type prostaglandin D synthase (L-PGDS), which was originally identified as an enzyme responsible for PGD2 biosynthesis in the brain, is highly expressed in the myocardium, including in...