Naoto Tsuchiya

Results of Treatment of 112 Cases of Primary CNS Lymphoma (2008)

Yamanaka, Ryuya, Morii, Ken, Shinbo, Yoshikatsu, Homma, Junpei, Sano, Masakazu, Tsuchiya, Naoto, ...

Background Chemotherapy with or without radiotherapy is the mainstay of treatment for primary central nervous system lymphoma (PCNSL). High-dose methotrexate (MTX) is the most effective drug...

Destruction of quadruplex by proteins, and its biological implications in replication and telomere maintenance (2003)

Enokizono, Yoshiaki, Matsugami, Akimasa, Uesugi, Seiichi, Fukuda, Hirokazu, Tsuchiya, Naoto, Sugimura, Takashi, ...

The minisatellite DNA Pc-1 consists of tandem repeats of d(GGCAG). We previously reported that a d(GGCAG)n strand folds into an intramolecular quadruplex under physiological conditions and that...

Cloning and Characterization of a cDNA Encoding a Novel Heterogeneous Nuclear Ribonucleoprotein-Like Protein and Its Expression in Myeloid Leukemia Cells (1998)

Tsuchiya, Naoto, Kamei, Daisuke, Takano, Akira, Matsui, Takaaki, Yamada, Michiyuki

We isolated a cDNA encoding a novel heterogeneous nuclear ribonucleoprotein (hnRNP)like protein on DNA affinity screening of a K562 cDNA expression library with an oligodeoxynucleotide (JKT41)...

Genomic Organization of the OS-9 Gene Amplified in Human Sarcomas (1997)

Kimura, Yukiko, Nakazawa, Megumi, Tsuchiya, Naoto, Asakawa, Shuichi, Shimizu, Nobuyoshi, Yamada, Michiyuki

The OS-9 gene is frequently amplified in human sarcomas. We isolated and characterized an OS-9 genomic DNA from a human BAC library. Sequencing of the genomic DNA showed that the gene spanned...

Purification and Identification of a Novel and Four Known Serine Proteinase Inhibitors Secreted by Human Glioblastoma Cells (1996)

Koshikawa, Naohiko, Nakamura, Takashi, Tsuchiya, Naoto, Isaji, Mitsuko, Yasumitsu, Hidetaro, Umeda, Makoto, ...

Our previous studies have shown that some human cancer cell lines produce pancreatic trypsinogen, plasminogen, and tissue-type kallikrein. To understand the regulatory mechanism of these proteinases,...

Unfolding of quadruplex structure in the G-rich strand of the minisatellite repeat by the binding protein UP1

Fukuda, Hirokazu, Katahira, Masato, Tsuchiya, Naoto, Enokizono, Yoshiaki, Sugimura, Takashi, Nagao, Minako, ...

The mouse hypervariable minisatellite (MN) Pc-1 consists of tandem repeats of d(GGCAG) and flanked sequences. We have previously demonstrated that single-stranded d(GGCAG)n folds into the...

Unfolding of quadruplex structure in the G-rich strand of the minisatellite repeat by the binding protein UP1

Fukuda, Hirokazu, Katahira, Masato, Tsuchiya, Naoto, Enokizono, Yoshiaki, Sugimura, Takashi, Nagao, Minako, ...

The mouse hypervariable minisatellite (MN) Pc-1 consists of tandem repeats of d(GGCAG) and flanked sequences. We have previously demonstrated that single-stranded d(GGCAG)n folds into the...

Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells

Tazawa, Hiroshi, Tsuchiya, Naoto, Izumiya, Masashi, Nakagama, Hitoshi

Accumulating evidence suggests a role for microRNAs in human carcinogenesis as novel types of tumor suppressors or oncogenes. However, their precise biological role remains largely elusive. In the...