Evading the annotation bottleneck: using sequence similarity to search non-sequence gene data (2008)
Gilchrist, Michael J, Christensen, Mikkel B, Harland, Richard, Pollet, Nicolas, Smith, James C, Ueno, Naoto, ...
Abstract Background Non-sequence gene data (images, literature, etc.) can be found in many different public databases. Access to these data is mostly by text based methods using gene names; however,...
Ogata, Souichi, Morokuma, Junji, Hayata, Tadayoshi, Kolle, Gabriel, Niehrs, Christof, Ueno, Naoto, ...
The molecular mechanisms governing the cell behaviors underlying morphogenesis remain a major focus of research in both developmental biology and cancer biology. TGF-β ligands control cell fate...
Role of the TAK1-NLK-STAT3 pathway in TGF-{beta}-mediated mesoderm induction (2004)
Ohkawara, Bisei, Shirakabe, Kyoko, Hyodo-Miura, Junko, Matsuo, Ritsuko, Ueno, Naoto, Matsumoto, Kunihiro, ...
Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) and Nemo-like kinase (NLK) function in Xenopus, Drosophila, and Caenorhabditis elegans development. Here we report that serine...
Construction of a cDNA microarray derived from the ascidian Ciona intestinalis (2003)
Azumi, Kaoru, Takahashi, Hiroki, Miki, Yasufumi, Fujie, Manabu, Usami, Takeshi, Ishikawa, Hisayoshi, ...
A cDNA microarray was constructed from a basal chordate, the ascidian Ciona intestinalis. The draft genome of Ciona has been read and inferred to contain similar to16,000 protein-coding genes, and...
Teraoka, Hiroki, Dong, Wu, Ogawa, Shuji, Tsukiyama, Shusaku, Okuhara, Yuji, Niiyama, Masayoshi, ...
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on regional red blood cell (RBC) perfusion rate, as an index of blood flow, and lower jaw development were investigated...
Morita, Kiyokazu, Chow, King-Lau, Ueno, Naoto
We have identified a new member of the TGF-β superfamily, CET-1, from Caenorhabditis elegans, which is expressed in the ventral nerve cord and other neurons. cet-1 null mutants have shortened bodies...
Expression of BMP-2,4 Genes during Early Development in Xenopus (1995)
Toshiyuki Yamagishi, Shin-ichiro Nishimatsu, Shintaro Nomura, Makoto Asashima, Kazuo Murakami, Naoto Ueno
The transforming growth factor-β (TGF-β) family has been implicated in the regulation of cell differentiation during early development. Bone morphogenetic proteins (BMPs) are thought to play...
Iemura, Shun-ichiro, Yamamoto, Takamasa S., Takagi, Chiyo, Uchiyama, Hideho, Natsume, Tohru, Shimasaki, Shunichi, ...
In early development of Xenopus laevis, it is known that activities of polypeptide growth factors are negatively regulated by their binding proteins. In this study, follistatin, originally known as...
A functional bone morphogenetic protein system in the ovary
Shimasaki, Shunichi, Zachow, Rob J., Li, Danmei, Kim, Holly, Iemura, Shun-ichiro, Ueno, Naoto, ...
Bone morphogenetic proteins (BMPs) comprise a large group of polypeptides in the transforming growth factor β superfamily with essential physiological functions in morphogenesis and organogenesis in...
Mochii, Makoto, Yoshida, Satoru, Morita, Kiyokazu, Kohara, Yuji, Ueno, Naoto
Members of the transforming growth factor-β family play critical roles in body patterning, in both vertebrates and invertebrates. One transforming growth factor-β-related gene, dbl-1, has been...
A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-β signaling
Morita, Kiyokazu, Shimizu, Miho, Shibuya, Hiroshi, Ueno, Naoto
We have identified homologs of a human BMP receptor-associated molecule BRAM1 in Caenorhabditis elegans. One of them, BRA-1, has been found to bind DAF-1, the type I receptor in the DAF-7...
Hanazawa, Momoyo, Mochii, Makoto, Ueno, Naoto, Kohara, Yuji, Iino, Yuichi
Caenorhabditis elegans is an ideal organism for the study of the molecular basis of fundamental biological processes such as germ-line development, especially because of availability of the whole...
Adachi-Yamada, Takashi, Nakamura, Makoto, Irie, Kenji, Tomoyasu, Yoshinori, Sano, Yorikata, Mori, Eiji, ...
p38 mitogen-activated protein kinase (p38) has been extensively studied as a stress-responsive kinase, but its role in development remains unknown. The fruit fly, Drosophila melanogaster, has two p38...
TAK1 Participates in c-Jun N-Terminal Kinase Signaling during Drosophila Development
Takatsu, Yoshihiro, Nakamura, Makoto, Stapleton, Mark, Danos, Maria C., Matsumoto, Kunihiro, O'Connor, Michael B., ...
Transforming growth factor β (TGF-β)-activated kinase 1 (TAK1) is a member of the MAPKKK superfamily and has been characterized as a component of the TGF-β/bone morphogenetic protein signaling...
Morita, Kiyokazu, Flemming, Anthony J., Sugihara, Yukiko, Mochii, Makoto, Suzuki, Yo, Yoshida, Satoru, ...
Using cDNA-based array analysis combined with double-stranded RNA interference (dsRNAi), we have identified yk298h6 as a target gene of Caenorhabditis elegans TGF-β signaling. Worms overexpressing...
Ishitani, Tohru, Kishida, Satoshi, Hyodo-Miura, Junko, Ueno, Naoto, Yasuda, Jun, Waterman, Marian, ...
Wnt signaling controls a variety of developmental processes. The canonical Wnt/β-catenin pathway functions to stabilize β-catenin, and the noncanonical Wnt/Ca2+ pathway activates...
Kinoshita, Noriyuki, Iioka, Hidekazu, Miyakoshi, Akira, Ueno, Naoto
Protein kinase C (PKC) has been implicated in the Wnt signaling pathway; however, its molecular role is poorly understood. We identified novel genes encoding δ-type PKC in the Xenopus EST databases....
Restriction of BMP4 activity domains in the developing neural tube of the mouse embryo
Hu, Qiyong, Ueno, Naoto, Behringer, Richard R
Bone morphogenetic protein (BMP) signals pattern the dorsal neural tube, defining distinct neuronal progenitor cell domains along the dorsoventral axis of the developing spinal cord. These dorsally...
Role of the TAK1-NLK-STAT3 pathway in TGF-β-mediated mesoderm induction
Ohkawara, Bisei, Shirakabe, Kyoko, Hyodo-Miura, Junko, Matsuo, Ritsuko, Ueno, Naoto, Matsumoto, Kunihiro, ...
Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) and Nemo-like kinase (NLK) function in Xenopus, Drosophila, and Caenorhabditis elegans development. Here we report that serine...
Iemura, Shun-ichiro, Yamamoto, Takamasa S., Takagi, Chiyo, Uchiyama, Hideho, Natsume, Tohru, Shimasaki, Shunichi, ...
In early development of Xenopus laevis, it is known that activities of polypeptide growth factors are negatively regulated by their binding proteins. In this study, follistatin, originally known as...
A functional bone morphogenetic protein system in the ovary
Shimasaki, Shunichi, Zachow, Rob J., Li, Danmei, Kim, Holly, Iemura, Shun-ichiro, Ueno, Naoto, ...
Bone morphogenetic proteins (BMPs) comprise a large group of polypeptides in the transforming growth factor β superfamily with essential physiological functions in morphogenesis and organogenesis in...
Mochii, Makoto, Yoshida, Satoru, Morita, Kiyokazu, Kohara, Yuji, Ueno, Naoto
Members of the transforming growth factor-β family play critical roles in body patterning, in both vertebrates and invertebrates. One transforming growth factor-β-related gene, dbl-1, has been...
A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-β signaling
Morita, Kiyokazu, Shimizu, Miho, Shibuya, Hiroshi, Ueno, Naoto
We have identified homologs of a human BMP receptor-associated molecule BRAM1 in Caenorhabditis elegans. One of them, BRA-1, has been found to bind DAF-1, the type I receptor in the DAF-7...
Hanazawa, Momoyo, Mochii, Makoto, Ueno, Naoto, Kohara, Yuji, Iino, Yuichi
Caenorhabditis elegans is an ideal organism for the study of the molecular basis of fundamental biological processes such as germ-line development, especially because of availability of the whole...
Adachi-Yamada, Takashi, Nakamura, Makoto, Irie, Kenji, Tomoyasu, Yoshinori, Sano, Yorikata, Mori, Eiji, ...
p38 mitogen-activated protein kinase (p38) has been extensively studied as a stress-responsive kinase, but its role in development remains unknown. The fruit fly, Drosophila melanogaster, has two p38...
TAK1 Participates in c-Jun N-Terminal Kinase Signaling during Drosophila Development
Takatsu, Yoshihiro, Nakamura, Makoto, Stapleton, Mark, Danos, Maria C., Matsumoto, Kunihiro, O'Connor, Michael B., ...
Transforming growth factor β (TGF-β)-activated kinase 1 (TAK1) is a member of the MAPKKK superfamily and has been characterized as a component of the TGF-β/bone morphogenetic protein signaling...
Morita, Kiyokazu, Flemming, Anthony J., Sugihara, Yukiko, Mochii, Makoto, Suzuki, Yo, Yoshida, Satoru, ...
Using cDNA-based array analysis combined with double-stranded RNA interference (dsRNAi), we have identified yk298h6 as a target gene of Caenorhabditis elegans TGF-β signaling. Worms overexpressing...
Ishitani, Tohru, Kishida, Satoshi, Hyodo-Miura, Junko, Ueno, Naoto, Yasuda, Jun, Waterman, Marian, ...
Wnt signaling controls a variety of developmental processes. The canonical Wnt/β-catenin pathway functions to stabilize β-catenin, and the noncanonical Wnt/Ca2+ pathway activates...
Kinoshita, Noriyuki, Iioka, Hidekazu, Miyakoshi, Akira, Ueno, Naoto
Protein kinase C (PKC) has been implicated in the Wnt signaling pathway; however, its molecular role is poorly understood. We identified novel genes encoding δ-type PKC in the Xenopus EST databases....
Role of the TAK1-NLK-STAT3 pathway in TGF-β-mediated mesoderm induction
Ohkawara, Bisei, Shirakabe, Kyoko, Hyodo-Miura, Junko, Matsuo, Ritsuko, Ueno, Naoto, Matsumoto, Kunihiro, ...
Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) and Nemo-like kinase (NLK) function in Xenopus, Drosophila, and Caenorhabditis elegans development. Here we report that serine...
Restriction of BMP4 activity domains in the developing neural tube of the mouse embryo
Hu, Qiyong, Ueno, Naoto, Behringer, Richard R
Bone morphogenetic protein (BMP) signals pattern the dorsal neural tube, defining distinct neuronal progenitor cell domains along the dorsoventral axis of the developing spinal cord. These dorsally...
TGF-β signaling-mediated morphogenesis: modulation of cell adhesion via cadherin endocytosis
Ogata, Souichi, Morokuma, Junji, Hayata, Tadayoshi, Kolle, Gabriel, Niehrs, Christof, Ueno, Naoto, ...
The molecular mechanisms governing the cell behaviors underlying morphogenesis remain a major focus of research in both developmental biology and cancer biology. TGF-β ligands control cell fate...
Coordination of Cell Polarity during Xenopus Gastrulation
Shindo, Asako, Yamamoto, Takamasa S., Ueno, Naoto
Cell polarity is an essential feature of animal cells contributing to morphogenesis. During Xenopus gastrulation, it is known that chordamesoderm cells are polarized and intercalate each other...
Essential role of MARCKS in cortical actin dynamics during gastrulation movements
Iioka, Hidekazu, Ueno, Naoto, Kinoshita, Noriyuki
Myristoylated alanine-rich C kinase substrate (MARCKS) is an actin-binding, membrane-associated protein expressed during Xenopus embryogenesis. We analyzed its function in cytoskeletal regulation...
Evading the annotation bottleneck: using sequence similarity to search non-sequence gene data
Gilchrist, Michael J, Christensen, Mikkel B, Harland, Richard, Pollet, Nicolas, Smith, James C, Ueno, Naoto, ...
Hida, Naoki, Awais, Muhammad, Takeuchi, Masaki, Ueno, Naoto, Tashiro, Mayuri, Takagi, Chiyo, ...
Networks of protein-protein interactions play key roles in numerous important biological processes in living subjects. An effective methodology to assess protein-protein interactions in living cells...