Sakamoto, Naoya, Itoh, Shoichi, Yurimoto, Hisayoshi
We report a discovery of a chemically and isotopically unique material distributed ubiquitously in fine-grained matrix of a primitive carbonaceous chondrite Acfer 094. The observations were made in...
Sun Suk Kim, Lee F. Peng, Wenyu Lin, Won-hyeok Choe, Naoya Sakamoto, Stuart L. Schreiber, ...
Background & Aims: Only half of patients with chronic hepatitis C virus (HCV) infection experience sustained virologic response to pegylated-interferon and ribavirin, which cause numerous side...
Remnants of the early solar system water enriched in heavy oxygen isotopes (2007)
Sakamoto, Naoya, Seto, Yusuke, Itoh, Shoichi, Kuramoto, Kiyoshi, Fujino, Kiyoshi, Nagashima, Kazuhide, ...
Oxygen isotopic composition of our solar system is believed to have resulted from mixing of two isotopically distinct nebular reservoirs, 16O-rich and 17,18O-rich relative to Earth. The nature and...
Remnants of the early solar system water enriched in heavy oxygen isotopes. (2007)
Sakamoto, Naoya, Seto, Yusuke, Itoh, Shoichi, Kuramoto, Kiyoshi, Fujino, Kiyoshi, Nagashima, Kazuhide, ...
Oxygen isotopic composition of our solar system is believed to have resulted from mixing of two isotopically distinct nebular reservoirs, 16O-rich and 17,18O-rich relative to Earth. The nature and...
Extreme 17,18O-rich materials from the Acfer 094 carbonaceous chondrite (2007)
Hokkaido University (北海道大学)
Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury in mice
Suzuki, Masashi, Sasaki, Norihito, Miki, Takashi, Sakamoto, Naoya, Ohmoto-Sekine, Yuki, Tamagawa, Masaji, ...
Recently it has been postulated that mitochondrial ATP-sensitive K+ (mitoKATP) channels rather than sarcolemmal KATP (sarcKATP) channels are important as end effectors and/or triggers of ischemic...
Regulation of Hepatitis C Virus Replication by Interferon Regulatory Factor 1
Kanazawa, Nobuhiko, Kurosaki, Masayuki, Sakamoto, Naoya, Enomoto, Nobuyuki, Itsui, Yasuhiro, Yamashiro, Tsuyoshi, ...
Cellular antiviral responses are mediated partly by the expression of interferon-stimulated genes, triggered by viral genomes, their transcripts and replicative intermediates. Persistent replication...
Yokota, Takanori, Sakamoto, Naoya, Enomoto, Nobuyuki, Tanabe, Yoko, Miyagishi, Makoto, Maekawa, Shinya, ...
Small interfering RNAs (siRNAs) efficiently inhibit gene expression by RNA interference. Here, we report efficient inhibition, by both synthetic and vector-derived siRNAs, of hepatitis C virus (HCV)...
Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury in mice
Suzuki, Masashi, Sasaki, Norihito, Miki, Takashi, Sakamoto, Naoya, Ohmoto-Sekine, Yuki, Tamagawa, Masaji, ...
Recently it has been postulated that mitochondrial ATP-sensitive K+ (mitoKATP) channels rather than sarcolemmal KATP (sarcKATP) channels are important as end effectors and/or triggers of ischemic...
Regulation of Hepatitis C Virus Replication by Interferon Regulatory Factor 1
Kanazawa, Nobuhiko, Kurosaki, Masayuki, Sakamoto, Naoya, Enomoto, Nobuyuki, Itsui, Yasuhiro, Yamashiro, Tsuyoshi, ...
Cellular antiviral responses are mediated partly by the expression of interferon-stimulated genes, triggered by viral genomes, their transcripts and replicative intermediates. Persistent replication...
Yokota, Takanori, Sakamoto, Naoya, Enomoto, Nobuyuki, Tanabe, Yoko, Miyagishi, Makoto, Maekawa, Shinya, ...
Small interfering RNAs (siRNAs) efficiently inhibit gene expression by RNA interference. Here, we report efficient inhibition, by both synthetic and vector-derived siRNAs, of hepatitis C virus (HCV)...
Bradykinin B2-receptor-mediated modulation of membrane currents in guinea-pig cardiomyocytes
Sakamoto, Naoya, Uemura, Hiroko, Hara, Yukio, Saito, Toshihiro, Masuda, Yoshiaki, Nakaya, Haruaki
In order to define the electrophysiological mechanism(s) responsible for bradykinin (BK)-induced positive inotropic and chronotropic responses in isolated guinea-pig atria, effects of BK on the...
Peng , Lee F., Kim, Sun Suk, Matchacheep, Sirinya, Lei, Xiaoguang, Su, Shun, Lin, Wenyu, ...
Using our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate...
Ohira, Masahiro, Ishiyama, Kohei, Tanaka, Yuka, Doskali, Marlen, Igarashi, Yuka, Tashiro, Hirotaka, ...
After liver transplantation in HCV-infected patients, the virus load inevitably exceeds pre-transplantation levels. This phenomenon reflects suppression of the host-effector immune responses that...