Dmitrieva, Natalia I., Bulavin, Dmitry V., Fornace, Albert J., Burg, Maurice B.
Cells in the kidney medulla are subject to variable and often extreme osmotic stress during concentration of the urine. Previous studies showed that renal inner medullary epithelial (IME) cells...
Dmitrieva, Natalia I., Cai, Qi, Burg, Maurice B.
Acute exposure of cells in culture to high NaCl damages DNA and impairs its repair. However, after several hours of cell cycle arrest, cells multiply in the hypertonic medium. Here, we show that,...
Maruvada, Padma, Dmitrieva, Natalia I., East-Palmer, Joyce, Yen, Paul M.
Thyroid hormone receptors (TRs) are ligand-regulatable transcription factors. Currently, little is known about the expression of TRs or other nuclear hormone receptors during the cell cycle. We thus...
Zhang, Zheng, Dmitrieva, Natalia I., Park, Jong-Hwan, Levine, Rodney L., Burg, Maurice B.
Urea and NaCl are elevated in the renal inner medulla. We now find that a high concentration of urea or NaCl increases reactive oxygen species (ROS) in mouse renal inner medullary (mIMCD3) cells in...
Cai, Qi, Dmitrieva, Natalia I., Ferraris, Joan D., Brooks, Heddwen L., Burg, Maurice
Pax2 is a transcription factor that is crucial for kidney development, and it is also expressed in the normal adult kidney, where its physiological function is unknown. In the present study, we find...
Ku86 preserves chromatin integrity in cells adapted to high NaCl
Dmitrieva, Natalia I., Celeste, Arkady, Nussenzweig, André, Burg, Maurice B.
Cells adapted to high NaCl have many DNA breaks both in cell culture and in the renal inner medulla in vivo; yet they survive, function, and even proliferate. Here, we show that Ku86 is important for...
Dmitrieva, Natalia I., Bulavin, Dmitry V., Fornace, Albert J., Burg, Maurice B.
Cells in the kidney medulla are subject to variable and often extreme osmotic stress during concentration of the urine. Previous studies showed that renal inner medullary epithelial (IME) cells...
Dmitrieva, Natalia I., Cai, Qi, Burg, Maurice B.
Acute exposure of cells in culture to high NaCl damages DNA and impairs its repair. However, after several hours of cell cycle arrest, cells multiply in the hypertonic medium. Here, we show that,...
Maruvada, Padma, Dmitrieva, Natalia I., East-Palmer, Joyce, Yen, Paul M.
Thyroid hormone receptors (TRs) are ligand-regulatable transcription factors. Currently, little is known about the expression of TRs or other nuclear hormone receptors during the cell cycle. We thus...
Zhang, Zheng, Dmitrieva, Natalia I., Park, Jong-Hwan, Levine, Rodney L., Burg, Maurice B.
Urea and NaCl are elevated in the renal inner medulla. We now find that a high concentration of urea or NaCl increases reactive oxygen species (ROS) in mouse renal inner medullary (mIMCD3) cells in...
Cai, Qi, Dmitrieva, Natalia I., Ferraris, Joan D., Brooks, Heddwen L., Burg, Maurice
Pax2 is a transcription factor that is crucial for kidney development, and it is also expressed in the normal adult kidney, where its physiological function is unknown. In the present study, we find...
Ku86 preserves chromatin integrity in cells adapted to high NaCl
Dmitrieva, Natalia I., Celeste, Arkady, Nussenzweig, André, Burg, Maurice B.
Cells adapted to high NaCl have many DNA breaks both in cell culture and in the renal inner medulla in vivo; yet they survive, function, and even proliferate. Here, we show that Ku86 is important for...
Zhou, Xiaoming, Ferraris, Joan D., Dmitrieva, Natalia I., Liu, Yusen, Burg, Maurice B.
High NaCl rapidly activates p38 MAPK by phosphorylating it, the phosphorylation presumably being regulated by a balance of kinases and phosphatases. Kinases are known, but the phosphatases are...