Natasha Leporé

THE MULTIVARIATE A/C/E MODEL AND THE GENETICS OF FIBER ARCHITECTURE (2009)

Agatha D. Lee, Natasha Leporé, Caroline C. Brun, Marina Barysheva, Yi-yu Chou, Ming-chang Chiang, ...

We present a new algorithm to compute the voxel-wise genetic contribution to brain fiber microstructure using diffusion tensor imaging (DTI) in a dataset of 25 pairs of monozygotic (MZ) twins and 25...

Can tissue segmentation improve registration? A study of 92 twins (2009)

Yi-yu Chou, Natasha Leporé, Caroline Brun, Marina Barysheva, Katie Mcmahon, ...

Introduction: Robust and automatic non-rigid registration depends on many parameters that have not yet been systematically explored. Here we determined how tissue classification influences non-linear...

Mapping Ventricular Expansion and its Clinical Correlates in Alzheimer’s Disease and Mild Cognitive Impairment using Multi- Atlas Fluid Image Alignment (2009)

Yi-yu Chou, Natasha Leporé, Christina Avedissian, Sarah K. Madsen, Xue Hua, Clifford R. Jack, ...

We developed an automated analysis pipeline to analyze 3D changes in ventricular morphology; it provides a highly sensitive quantitative marker of Alzheimer’s disease (AD) progression for MRI...

SURFACE AND VOLUME REGISTRATION OF BRAIN MAGNETIC RESONANCE IMAGES (2009)

Natasha Leporé, A. Joshi, Richard Leahy, Caroline Brun, Yi-yu Chou, Xavier Pennec, ...

3D volumetric registration of brain images is particularly challenging in cortical regions due to their high complexity and folding. Here we develop a new combined algorithm for surface and volume...

IMPROVING FLUID REGISTRATION THROUGH WHITE MATTER SEGMENTATION (2009)

Yi-yu Chou, Natasha Leporé, Caroline C. Brun, Agatha D. Lee, Marina Barysheva, ...

Robust and automatic non-rigid registration depends on many parameters that have not yet been systematically explored. Here we determined how tissue classification influences non-linear fluid...

Multi-Atlas Tensor-Based Morphometry and its Application to a Genetic Study of 92 Twins (2009)

Natasha Leporé, Caroline Brun, Yi-yu Chou, Agatha D. Lee, Matthew Meredith, ...

Abstract. Here we develop a multi-template analysis for tensor-based morphometry (TBM) which aims to reduce error from the registration step. In conventional TBM, a single template is nonlinearly...

QUANTITATIVE GENETIC MODELING OF LATERAL VENTRICULAR SHAPE AND VOLUME USING MULTI-ATLAS FLUID IMAGE ALIGNMENT IN TWINS (2009)

Yi-yu Chou, Natasha Leporé, Marina Barysheva, Ming-chang Chiang, Katie Mcmahon, Greig De Zubicaray, ...

Despite substantial progress in measuring the 3D profile of anatomical variations in the human brain, their genetic and environmental causes remain enigmatic. We developed an automated system to...

A Tensor-Based Morphometry Study of Genetic Influences on Brain Structure Using a New Fluid Registration Method (2009)

Caroline Brun, Natasha Leporé, Xavier Pennec, Agatha D. Lee, Marina Barysheva, Grieg De Zubicaray, ...

Abstract. We incorporated a new Riemannian fluid registration algorithm into a general MRI analysis method called tensor-based morphometry to map the heritability of brain morphology in MR images...

MAPPING GENETIC INFLUENCES ON LATERAL VENTRICLES USING MULTI-ATLAS FLUID IMAGE ALIGNMENT IN TWINS (2009)

Yi-yu Chou, Natasha Leporé, Marina Barysheva, Ming-chang Chiang, Katie Mcmahon, Greig De Zubicaray, ...

Imaging genetics is a new field of brain mapping in which genetic influences on brain structure can be quantified and mapped in entire populations. Here we fitted genetic models to computational maps...

Models of Normal Variation and Local Contrasts in Hippocampal Anatomy ⋆ (2009)

Xinyang Liu, Washington Mio, Yonggang Shi, Ivo Dinov, Xiuwen Liu, Natasha Leporé, ...

Abstract. We develop a model of continuous spherical shapes and use it to analyze the anatomy of the hippocampus. To account for the geometry of bends and folds, the model relies on a geodesic metric...

Paul M. Thompson 1, and the Alzheimer's Disease Neuroimaging Initiative (2009)

Yi-yu Chou, Natasha Leporé, Christina Avedissian, Sarah K. Madsen, Xue Hua, Clifford R. Jack, ...

Abstract. We developed an automated analysis pipeline to analyze 3D changes in ventricular morphology; it provides a highly sensitive quantitative marker of Alzheimer’s disease (AD) progression for...

3D pattern of brain changes in deaf subjects using Tensor-Based Morphometry (2009)

Natasha Leporé, Patrick Vachon, Franco Lepore, Yi-yu Chou, Caroline Brun, Agatha D. Lee, ...

INTRODUCTION: In the congenital deaf, functional reorganization is known to occur throughout brain regions normally associated with hearing. However, the anatomical correlates of these changes are...

BEST INDIVIDUAL TEMPLATE SELECTION FROM DEFORMATION TENSOR MINIMIZATION (2009)

Natasha Leporé, Caroline Brun, Yi-yu Chou, Agatha D. Lee, Marina Barysheva, Xavier Pennec, ...

We study the influence of the choice of template in tensorbased morphometry. Using 3D brain MR images from 10 monozygotic twin pairs, we defined a tensor-based distance in the log-Euclidean framework...

COMPARISON OF FRACTIONAL AND GEODESIC ANISOTROPY IN DIFFUSION TENSOR IMAGES OF 90 MONOZYGOTIC AND DIZYGOTIC TWINS (2009)

Agatha D. Lee, Natasha Leporé, Marina Barysheva, Yi-yu Chou, Caroline Brun, Sarah K. Madsen, ...

We used diffusion tensor magnetic resonance imaging (DTI) to reveal the extent of genetic effects on brain fiber microstructure, based on tensor-derived measures, in 22 pairs of monozygotic (MZ)...

Gene Effects Mapped Using Fractional and Geodesic Anisotropy in Diffusion Tensor Images of 92 Monozygotic and Dizygotic (2009)

Agatha D. Lee, Natasha Leporé, Marina Barysheva, Yiyu Chou, Caroline Brun, Sarah K. Madsen, ...

Abstract. We used tensor-derived measures to map the extent of genetic effects on brain fiber microstructure, in 23 monozygotic and 23 dizygotic twin pairs. All 92 DTI volumes were fluidly registered...

LANDMARK MATCHING ON THE SPHERE USING DISTANCE FUNCTIONS (2008)

Natasha Leporé, Alex Leow, Paul Thompson

Nonlinear registration of 3D surfaces is important in many medical imaging applications, including the mapping of longitudinal changes in anatomy, or of multi-subject functional MRI data to a...

AUTOMATED 3D MAPPING & SHAPE ANALYSIS OF THE LATERAL VENTRICLES VIA FLUID REGISTRATION OF MULTIPLE SURFACE-BASED ATLASES (2008)

Yi-yu Chou, Natasha Leporé, Stephen E. Rose, Owen T. Carmichael, James T. Becker, ...

We developed and validated a new method to create automated 3D parametric surface models of the lateral ventricles, designed for monitoring degenerative disease effects in clinical neuroscience...

A New Registration Method Based on LogEuclidean Tensor Metrics and its Application to Genetic Studies, ISBI 2008, in press (2008)

Caroline Brun, Natasha Leporé, Xavier Pennec, Yi-yu Chou, Agatha D. Lee, Grieg De Zubicaray, ...

In structural brain MRI, group differences or changes in brain structures can be detected using Tensor-Based Morphometry (TBM). This method consists of two steps: (1) a non-linear registration step,...

MAPPING GENETIC INFLUENCES ON VENTRICULAR STRUCTURE IN TWINS (2008)

Yi-yu Chou, Natasha Leporé, Ming-chang Chiang, Christina Avedissian, Marina Barysheva, Katie Mcmahon, ...

doi:10.1016/j.neuroimage.2008.10.036