Natasha Wood

Experimental evidence indicating that mastreviruses probably did not co-diverge with their hosts (2009)

Harkins, Gordon W, Delport, Wayne, Duffy, Siobain, Wood, Natasha, Monjane, Adérito L, Owor, Betty E, ...

Abstract Background Despite the demonstration that geminiviruses, like many other single stranded DNA viruses, are evolving at rates similar to those of RNA viruses, a recent study has suggested that...

A Model of Directional Selection Applied to the Evolution of Drug Resistance in HIV-1 (2007)

Seoighe, Cathal, Ketwaroo, Farahnaz, Pillay, Visva, Scheffler, Konrad, Wood, Natasha, Duffet, Rodger, ...

Understanding how pathogens acquire resistance to drugs is important for the design of treatment strategies, particularly for rapidly evolving viruses such as HIV-1. Drug treatment can exert strong...

A Model of Directional Selection Applied to the Evolution of Drug Resistance in HIV-1 (2007)

Seoighe, Cathal, Ketwaroo, Farahnaz, Pillay, Visva, Scheffler, Konrad, Wood, Natasha, Duffet, Rodger, ...

Understanding how pathogens acquire resistance to drugs is important for the design of treatment strategies, particularly for rapidly evolving viruses such as HIV-1. Drug treatment can exert strong...

Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

Keele, Brandon F., Giorgi, Elena E., Salazar-Gonzalez, Jesus F., Decker, Julie M., Pham, Kimmy T., Salazar, Maria G., ...

The precise identification of the HIV-1 envelope glycoprotein (Env) responsible for productive clinical infection could be instrumental in elucidating the molecular basis of HIV-1 transmission and in...

HIV Evolution in Early Infection: Selection Pressures, Patterns of Insertion and Deletion, and the Impact of APOBEC

Wood, Natasha, Bhattacharya, Tanmoy, Keele, Brandon F., Giorgi, Elena, Liu, Michael, Gaschen, Brian, ...

The pattern of viral diversification in newly infected individuals provides information about the host environment and immune responses typically experienced by the newly transmitted virus. For...