Nathalie Malo

An efficient method for the detection and elimination of systematic error in high-throughput screening (2007)

Makarenkov, Vladimir, Zentilli, Pablo, Kevorkov, Dmytro, Gagarin, Andrei, Malo, Nathalie, Nadon, Robert

Motivation: High-throughput screening (HTS) is an early-stage process in drug discovery which allows thousands of chemical compounds to be tested in a single study. We report a method for correcting...

HTS-Corrector: software for the statistical analysis and correction of experimental high-throughput screening data (2006)

Makarenkov, Vladimir, Kevorkov, Dmytro, Zentilli, Pablo, Gagarin, Andrei, Malo, Nathalie, Nadon, Robert

Motivation: High-throughput screening (HTS) plays a central role in modern drug discovery, allowing for testing of >100 000 compounds per screen. The aim of our work was to develop and implement...

Accommodating Linkage Disequilibrium in Genetic-Association Analyses via Ridge Regression

Malo, Nathalie, Libiger, Ondrej, Schork, Nicholas J.

Large-scale genetic-association studies that take advantage of an extremely dense set of genetic markers have begun to produce very compelling statistical associations between multiple makers...