Mediavilla-Varela, Melanie, Pacheco, Fabio J, Almaguel, Frankis, Perez, Jossymar, Sahakian, Eva, Daniels, Tracy R, ...
Abstract Background Hormone-refractory prostate cancer (HRPC) is characterized by poor response to chemotherapy and high mortality, particularly among African American men when compared to other...
Thomas S. Griffith, Jonathan M. Fialkov, David L. Scott, Takeo Azuhata, Richard D. Williams, Nathan R. Wall, ...
The lack of effective therapy for disseminated renal cell carcinoma (RCC) has stimulated the search for novel treatments including immunotherapeutic strategies. However, poor therapeutic responses...
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis (2004)
Dohi, Takehiko, Beltrami, Elena, Wall, Nathan R., Plescia, Janet, Altieri, Dario C.
Evasion of apoptosis is a hallmark of cancer, but the molecular circuitries of this process are not understood. Here we show that survivin, a member of the inhibitor of apoptosis gene family that is...
Blanc-Brude, Olivier P., Mesri, Mehdi, Wall, Nathan R., Plescia, Janet, Dohi, Takehiko, Altieri, Dario C.
PURPOSE: Molecular antagonists of the inhibitor of apoptosis protein survivin have shown promise as novel anticancer strategies for triggering tumor cell apoptosis, dysregulating mitotic progression,...
Wall, Nathan R., O'Connor, Daniel S., Plescia, Janet, Pommier, Yves, Altieri, Dario C.
Survivin is a member of the inhibitor of apoptosis gene family that is expressed in most human cancers and may facilitate evasion from apoptosis and aberrant mitotic progression. Here, exposure of...
Differentiation of malignant human B-cell acute lymphoblastic leukemia / (2000)
Wall, Nathan R. (Nathan Robert)
Typescript.
Cancer gene therapy using a survivin mutant adenovirus
Mesri, Mehdi, Wall, Nathan R., Li, Jia, Kim, Richard W., Altieri, Dario C.
We have constructed a replication-deficient adenovirus encoding a nonphosphorylatable Thr34→Ala mutant of the apoptosis inhibitor survivin (pAd-T34A) to target tumor cell viability in vitro and in...
Chen, Jing, Wall, Nathan R., Kocher, Kerry, Duclos, Nicole, Fabbro, Doriano, Neuberg, Donna, ...
Small molecule inhibitors, such as imatinib, are effective therapies for tyrosine kinase fusions BCR-ABL–TEL-PDGFβR–mediated human leukemias, but resistance may develop. The unique fusion...
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis
Dohi, Takehiko, Beltrami, Elena, Wall, Nathan R., Plescia, Janet, Altieri, Dario C.
Evasion of apoptosis is a hallmark of cancer, but the molecular circuitries of this process are not understood. Here we show that survivin, a member of the inhibitor of apoptosis gene family that is...
Cancer gene therapy using a survivin mutant adenovirus
Mesri, Mehdi, Wall, Nathan R., Li, Jia, Kim, Richard W., Altieri, Dario C.
We have constructed a replication-deficient adenovirus encoding a nonphosphorylatable Thr34→Ala mutant of the apoptosis inhibitor survivin (pAd-T34A) to target tumor cell viability in vitro and in...
Chen, Jing, Wall, Nathan R., Kocher, Kerry, Duclos, Nicole, Fabbro, Doriano, Neuberg, Donna, ...
Small molecule inhibitors, such as imatinib, are effective therapies for tyrosine kinase fusions BCR-ABL–TEL-PDGFβR–mediated human leukemias, but resistance may develop. The unique fusion...
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis
Dohi, Takehiko, Beltrami, Elena, Wall, Nathan R., Plescia, Janet, Altieri, Dario C.
Evasion of apoptosis is a hallmark of cancer, but the molecular circuitries of this process are not understood. Here we show that survivin, a member of the inhibitor of apoptosis gene family that is...