Scientific Commons: Nathaniel Francis Brown

Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain (2007)

Wickham, Mark E., Brown, Nathaniel Francis, Provias, John, Finlay, B. Brett, Coombes, Brian K.

BACKGROUND: Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported...

Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain (2007)

Wickham, Mark E., Brown, Nathaniel Francis, Provias, John, Finlay, B. Brett, Coombes, Brian K.

BACKGROUND: Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported...

Virulence is positively selected by transmission success between mammalian hosts (2007)

Wickham, Mark E., Brown, Nathaniel Francis, Boyle, Erin C., Coombes, Brian K., Finlay, B. Brett

Virulence, defined as damage to the host, is a trait of pathogens that evolutionary theory suggests benefits the pathogen in the ''struggle for existence'' [1]. Pathogens employ virulence mechanisms...

SseL is a salmonella-specific translocated effector integrated into the SsrB-controlled salmonella pathogenicity island 2 type III secretion system (2007)

Coombes, Brian K., Lowden, Michael J., Bishop, Jenna L., Wickham, Mark E., Brown, Nathaniel Francis, Duong, Nancy, ...

Bacterial pathogens use horizontal gene transfer to acquire virulence factors that influence host colonization, alter virulence traits, and ultimately shape the outcome of disease following...

SopD acts cooperatively with SopB during Salmonella enterica serovar Typhimurium invasion (2007)

Bakowski, Malina A., Cirulis, Judith T., Brown, Nathaniel Francis, Finlay, B. Brett, Brumell, John H.

The intracellular bacterial pathogen, Salmonella enterica serovar Typhimurium (S. typhimurium), causes disease in a variety of hosts. To invade and replicate in host cells, these bacteria subvert...

Src homology domain 2 adaptors affect adherence of Salmonella enterica serovar Typhimurium to non-phagocytic cells (2007)

Boyle, Erin C., Brown, Nathaniel Francis, Brumell, John H., Finlay, B. Brett

The ability of Salmonella enterica serovar Typhimurium (S. Typhimurium) to penetrate the intestinal epithelium is key to its pathogenesis. Bacterial invasion can be seen as a two-step process...

Virulence is positively selected by transmission success between mammalian hosts (2007)

Wickham, Mark E., Brown, Nathaniel Francis, Boyle, Erin C., Coombes, Brian K., Finlay, B. Brett

Virulence, defined as damage to the host, is a trait of pathogens that evolutionary theory suggests benefits the pathogen in the ''struggle for existence'' [1]. Pathogens employ virulence mechanisms...

SseL is a salmonella-specific translocated effector integrated into the SsrB-controlled salmonella pathogenicity island 2 type III secretion system (2007)

Coombes, Brian K., Lowden, Michael J., Bishop, Jenna L., Wickham, Mark E., Brown, Nathaniel Francis, Duong, Nancy, ...

Bacterial pathogens use horizontal gene transfer to acquire virulence factors that influence host colonization, alter virulence traits, and ultimately shape the outcome of disease following...

SopD acts cooperatively with SopB during Salmonella enterica serovar Typhimurium invasion (2007)

Bakowski, Malina A., Cirulis, Judith T., Brown, Nathaniel Francis, Finlay, B. Brett, Brumell, John H.

The intracellular bacterial pathogen, Salmonella enterica serovar Typhimurium (S. typhimurium), causes disease in a variety of hosts. To invade and replicate in host cells, these bacteria subvert...

Src homology domain 2 adaptors affect adherence of Salmonella enterica serovar Typhimurium to non-phagocytic cells (2007)

Boyle, Erin C., Brown, Nathaniel Francis, Brumell, John H., Finlay, B. Brett

The ability of Salmonella enterica serovar Typhimurium (S. Typhimurium) to penetrate the intestinal epithelium is key to its pathogenesis. Bacterial invasion can be seen as a two-step process...

Virulence is positively selected by transmission success between mammalian hosts (2007)

Wickham, Mark E., Brown, Nathaniel Francis, Boyle, Erin C., Coombes, Brian K., Finlay, B. Brett

Virulence, defined as damage to the host, is a trait of pathogens that evolutionary theory suggests benefits the pathogen in the ''struggle for existence'' [1]. Pathogens employ virulence mechanisms...

SseL is a salmonella-specific translocated effector integrated into the SsrB-controlled salmonella pathogenicity island 2 type III secretion system (2007)

Coombes, Brian K., Lowden, Michael J., Bishop, Jenna L., Wickham, Mark E., Brown, Nathaniel Francis, Duong, Nancy, ...

Bacterial pathogens use horizontal gene transfer to acquire virulence factors that influence host colonization, alter virulence traits, and ultimately shape the outcome of disease following...

SopD acts cooperatively with SopB during Salmonella enterica serovar Typhimurium invasion (2007)

Bakowski, Malina A., Cirulis, Judith T., Brown, Nathaniel Francis, Finlay, B. Brett, Brumell, John H.

The intracellular bacterial pathogen, Salmonella enterica serovar Typhimurium (S. typhimurium), causes disease in a variety of hosts. To invade and replicate in host cells, these bacteria subvert...

Src homology domain 2 adaptors affect adherence of Salmonella enterica serovar Typhimurium to non-phagocytic cells (2007)

Boyle, Erin C., Brown, Nathaniel Francis, Brumell, John H., Finlay, B. Brett

The ability of Salmonella enterica serovar Typhimurium (S. Typhimurium) to penetrate the intestinal epithelium is key to its pathogenesis. Bacterial invasion can be seen as a two-step process...

Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain (2007)

Wickham, Mark E., Brown, Nathaniel Francis, Provias, John, Finlay, B. Brett, Coombes, Brian K.

BACKGROUND: Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported...

Virulence is positively selected by transmission success between mammalian hosts (2007)

Wickham, Mark E., Brown, Nathaniel Francis, Boyle, Erin C., Coombes, Brian K., Finlay, B. Brett

Virulence, defined as damage to the host, is a trait of pathogens that evolutionary theory suggests benefits the pathogen in the ''struggle for existence'' [1]. Pathogens employ virulence mechanisms...

SseL is a salmonella-specific translocated effector integrated into the SsrB-controlled salmonella pathogenicity island 2 type III secretion system (2007)

Coombes, Brian K., Lowden, Michael J., Bishop, Jenna L., Wickham, Mark E., Brown, Nathaniel Francis, Duong, Nancy, ...

Bacterial pathogens use horizontal gene transfer to acquire virulence factors that influence host colonization, alter virulence traits, and ultimately shape the outcome of disease following...

SopD acts cooperatively with SopB during Salmonella enterica serovar Typhimurium invasion (2007)

Bakowski, Malina A., Cirulis, Judith T., Brown, Nathaniel Francis, Finlay, B. Brett, Brumell, John H.

The intracellular bacterial pathogen, Salmonella enterica serovar Typhimurium (S. typhimurium), causes disease in a variety of hosts. To invade and replicate in host cells, these bacteria subvert...

Src homology domain 2 adaptors affect adherence of Salmonella enterica serovar Typhimurium to non-phagocytic cells (2007)

Boyle, Erin C., Brown, Nathaniel Francis, Brumell, John H., Finlay, B. Brett

The ability of Salmonella enterica serovar Typhimurium (S. Typhimurium) to penetrate the intestinal epithelium is key to its pathogenesis. Bacterial invasion can be seen as a two-step process...

Salmonella enterica serovar Typhimurium effectors SopB, SopE, SopE2 and SipA disrupt tight junction structure and function (2006)

Boyle, Erin C., Brown, Nathaniel Francis, Finlay, B. Brett

Salmonella enterica serovar Typhimurium is a major cause of human gastroenteritis. Infection of epithelial monolayers by S. Typhimurium disrupts tight junctions that normally maintain the intestinal...

Mutational analysis of Salmonella translocated effector members SifA and SopD2 reveals domains implicated in translocation, subcellular localization and function (2006)

Brown, Nathaniel Francis, Szeto, Jason, Jiang, Xiuju, Coombes, Brian K., Finlay, B. Brett, Brumell, John H.

Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen causing disease in several hosts. These bacteria use two distinct type III secretion systems that inject effector...

Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection (2006)

Wickham, Mark E., Lupp, Claudia, Mascarenhas, Mariola, Vazquez, Alejandra, Coombes, Brian K., Brown, Nathaniel Francis, ...

Although O157:H7 Shiga toxin–producing Escherichia coli (STEC) are the predominant cause of hemolytic-uremic syndrome (HUS) in the world, non-O157:H7 serotypes are a medically important cause of...

Salmonella enterica serovar Typhimurium effectors SopB, SopE, SopE2 and SipA disrupt tight junction structure and function (2006)

Boyle, Erin C., Brown, Nathaniel Francis, Finlay, B. Brett

Salmonella enterica serovar Typhimurium is a major cause of human gastroenteritis. Infection of epithelial monolayers by S. Typhimurium disrupts tight junctions that normally maintain the intestinal...

Mutational analysis of Salmonella translocated effector members SifA and SopD2 reveals domains implicated in translocation, subcellular localization and function (2006)

Brown, Nathaniel Francis, Szeto, Jason, Jiang, Xiuju, Coombes, Brian K., Finlay, B. Brett, Brumell, John H.

Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen causing disease in several hosts. These bacteria use two distinct type III secretion systems that inject effector...

Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection (2006)

Wickham, Mark E., Lupp, Claudia, Mascarenhas, Mariola, Vazquez, Alejandra, Coombes, Brian K., Brown, Nathaniel Francis, ...

Although O157:H7 Shiga toxin–producing Escherichia coli (STEC) are the predominant cause of hemolytic-uremic syndrome (HUS) in the world, non-O157:H7 serotypes are a medically important cause of...

Salmonella enterica serovar Typhimurium effectors SopB, SopE, SopE2 and SipA disrupt tight junction structure and function (2006)

Boyle, Erin C., Brown, Nathaniel Francis, Finlay, B. Brett

Salmonella enterica serovar Typhimurium is a major cause of human gastroenteritis. Infection of epithelial monolayers by S. Typhimurium disrupts tight junctions that normally maintain the intestinal...

Mutational analysis of Salmonella translocated effector members SifA and SopD2 reveals domains implicated in translocation, subcellular localization and function (2006)

Brown, Nathaniel Francis, Szeto, Jason, Jiang, Xiuju, Coombes, Brian K., Finlay, B. Brett, Brumell, John H.

Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen causing disease in several hosts. These bacteria use two distinct type III secretion systems that inject effector...

Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection (2006)

Wickham, Mark E., Lupp, Claudia, Mascarenhas, Mariola, Vazquez, Alejandra, Coombes, Brian K., Brown, Nathaniel Francis, ...

Although O157:H7 Shiga toxin–producing Escherichia coli (STEC) are the predominant cause of hemolytic-uremic syndrome (HUS) in the world, non-O157:H7 serotypes are a medically important cause of...

Salmonella enterica serovar Typhimurium effectors SopB, SopE, SopE2 and SipA disrupt tight junction structure and function (2006)

Boyle, Erin C., Brown, Nathaniel Francis, Finlay, B. Brett

Salmonella enterica serovar Typhimurium is a major cause of human gastroenteritis. Infection of epithelial monolayers by S. Typhimurium disrupts tight junctions that normally maintain the intestinal...

Mutational analysis of Salmonella translocated effector members SifA and SopD2 reveals domains implicated in translocation, subcellular localization and function (2006)

Brown, Nathaniel Francis, Szeto, Jason, Jiang, Xiuju, Coombes, Brian K., Finlay, B. Brett, Brumell, John H.

Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen causing disease in several hosts. These bacteria use two distinct type III secretion systems that inject effector...

Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection (2006)

Wickham, Mark E., Lupp, Claudia, Mascarenhas, Mariola, Vazquez, Alejandra, Coombes, Brian K., Brown, Nathaniel Francis, ...

Although O157:H7 Shiga toxin–producing Escherichia coli (STEC) are the predominant cause of hemolytic-uremic syndrome (HUS) in the world, non-O157:H7 serotypes are a medically important cause of...

A type IV pilin, PilA, contributes to adherence of Burkholderia pseudomallaei and virulence in vivo. (2005)

Essex-Lopresti, Angela E., Boddey, Justin Andrew, Thomas, Richard, Smith, Martin P., Hartley, M. Gill, Atkins, Timothy, ...

The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced...

Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine (2005)

Brown, Nathaniel Francis, Vallance, Bruce A., Coombes, Brian K., Vandez, Yanet, Coburn, Bryan A., Finlay, B. Brett

Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that causes disease in mice that resembles human typhoid. Typhoid pathogenesis consists of distinct phases in the...

Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine (2005)

Brown, Nathaniel Francis, Vallance, Bruce A., Coombes, Brian K., Vandez, Yanet, Coburn, Bryan A., Finlay, B. Brett

Yes

A type IV pilin, PilA, contributes to adherence of Burkholderia pseudomallaei and virulence in vivo. (2005)

Essex-Lopresti, Angela E., Boddey, Justin Andrew, Thomas, Richard, Smith, Martin P., Hartley, M. Gill, Atkins, Timothy, ...

The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced...

Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine (2005)

Brown, Nathaniel Francis, Vallance, Bruce A., Coombes, Brian K., Vandez, Yanet, Coburn, Bryan A., Finlay, B. Brett

Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that causes disease in mice that resembles human typhoid. Typhoid pathogenesis consists of distinct phases in the...

Negative regulation of Salmonella pathogenicity island 2 is required for contextual control of virulence during typhoid (2005)

Coombes, Brian K., Lowden, Michael J., Wickham, Mark E., Brown, Nathaniel Francis, Finlay, B. Brett

Short RNA regulatory molecules, microRNAs, and short interfering RNAs participate in a range of developmental gene networks by base-pairing with their target sequences. Consistent with these...

Genetic and molecular analysis of GogB, a phage-encoded type III-secreted substrate in Salmonella enterica serovar typhimurium with autonomous expression from its associated phage (2005)

Coombes, Brian K., Wickham, Mark E., Brown, Nathaniel Francis, Lemire, Sebastien, Bossi, Lionello, Hsiao, William W. L., ...

Salmonella enterica serovar Typhimurium is lysogenized by several temperate bacteriophages that encode lysogenic conversion genes, which can act as virulence factors during infection and contribute...

Negative regulation of Salmonella pathogenicity island 2 is required for contextual control of virulence during typhoid (2005)

Coombes, Brian K., Lowden, Michael J., Wickham, Mark E., Brown, Nathaniel Francis, Finlay, B. Brett

Short RNA regulatory molecules, microRNAs, and short interfering RNAs participate in a range of developmental gene networks by base-pairing with their target sequences. Consistent with these...

Genetic and molecular analysis of GogB, a phage-encoded type III-secreted substrate in Salmonella enterica serovar typhimurium with autonomous expression from its associated phage (2005)

Coombes, Brian K., Wickham, Mark E., Brown, Nathaniel Francis, Lemire, Sebastien, Bossi, Lionello, Hsiao, William W. L., ...

Salmonella enterica serovar Typhimurium is lysogenized by several temperate bacteriophages that encode lysogenic conversion genes, which can act as virulence factors during infection and contribute...

Negative regulation of Salmonella pathogenicity island 2 is required for contextual control of virulence during typhoid (2005)

Coombes, Brian K., Lowden, Michael J., Wickham, Mark E., Brown, Nathaniel Francis, Finlay, B. Brett

Short RNA regulatory molecules, microRNAs, and short interfering RNAs participate in a range of developmental gene networks by base-pairing with their target sequences. Consistent with these...

Genetic and molecular analysis of GogB, a phage-encoded type III-secreted substrate in Salmonella enterica serovar typhimurium with autonomous expression from its associated phage (2005)

Coombes, Brian K., Wickham, Mark E., Brown, Nathaniel Francis, Lemire, Sebastien, Bossi, Lionello, Hsiao, William W. L., ...

Salmonella enterica serovar Typhimurium is lysogenized by several temperate bacteriophages that encode lysogenic conversion genes, which can act as virulence factors during infection and contribute...

A type IV pilin, PilA, contributes to adherence of Burkholderia pseudomallaei and virulence in vivo. (2005)

Essex-Lopresti, Angela E., Boddey, Justin Andrew, Thomas, Richard, Smith, Martin P., Hartley, M. Gill, Atkins, Timothy, ...

The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced...

Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine (2005)

Brown, Nathaniel Francis, Vallance, Bruce A., Coombes, Brian K., Vandez, Yanet, Coburn, Bryan A., Finlay, B. Brett

Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that causes disease in mice that resembles human typhoid. Typhoid pathogenesis consists of distinct phases in the...

Negative regulation of Salmonella pathogenicity island 2 is required for contextual control of virulence during typhoid (2005)

Coombes, Brian K., Lowden, Michael J., Wickham, Mark E., Brown, Nathaniel Francis, Finlay, B. Brett

Short RNA regulatory molecules, microRNAs, and short interfering RNAs participate in a range of developmental gene networks by base-pairing with their target sequences. Consistent with these...

Genetic and molecular analysis of GogB, a phage-encoded type III-secreted substrate in Salmonella enterica serovar typhimurium with autonomous expression from its associated phage (2005)

Coombes, Brian K., Wickham, Mark E., Brown, Nathaniel Francis, Lemire, Sebastien, Bossi, Lionello, Hsiao, William W. L., ...

Salmonella enterica serovar Typhimurium is lysogenized by several temperate bacteriophages that encode lysogenic conversion genes, which can act as virulence factors during infection and contribute...

Expression and secretion of Salmonella pathogenicity island-2 virulence genes in response to acidification exhibit differential requirements of a functional type III secretion apparatus and SsaL (2004)

Coombes, Brian K., Brown, Nathaniel Francis, Vandez, Yanet, Brumell, John H., Finlay, B. Brett

Salmonella pathogenicity island (SPI)-2 is pivotal to the intracellular survival of Salmonella and for virulence in mammals. SPI-2 encodes virulence factors (called effectors) that are translocated...

Expression and secretion of Salmonella pathogenicity island-2 virulence genes in response to acidification exhibit differential requirements of a functional type III secretion apparatus and SsaL (2004)

Coombes, Brian K., Brown, Nathaniel Francis, Vandez, Yanet, Brumell, John H., Finlay, B. Brett

Salmonella pathogenicity island (SPI)-2 is pivotal to the intracellular survival of Salmonella and for virulence in mammals. SPI-2 encodes virulence factors(called effectors) that are translocated...

Expression and secretion of Salmonella pathogenicity island-2 virulence genes in response to acidification exhibit differential requirements of a functional type III secretion apparatus and SsaL (2004)

Coombes, Brian K., Brown, Nathaniel Francis, Vandez, Yanet, Brumell, John H., Finlay, B. Brett

Salmonella pathogenicity island (SPI)-2 is pivotal to the intracellular survival of Salmonella and for virulence in mammals. SPI-2 encodes virulence factors (called effectors) that are translocated...

Jiang, Xiuju, Rossanese, Olivia W., Brown, Nathaniel Francis, Kujat-Choy, Sonya, Galán, Jorge E., Finlay, B. Brett, ...

Salmonella resides within host cells in a vacuole that it modifies through the action of virulence proteins called effectors. Here we examined the role of two related effectors, SopD and SopD2, in...

Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7 (2004)

Gruenheid, Samantha, Sekirov, Inna, Thomas, Nikhil A., Deng, Wanyin, O'Donnell, Paul, Goode, David, ...

Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 uses a specialized protein translocation apparatus, the type III secretion system (TTSS), to deliver bacterial effector proteins into host cells....

Jiang, Xiuju, Rossanese, Olivia W., Brown, Nathaniel Francis, Kujat-Choy, Sonya, Galán, Jorge E., Finlay, B. Brett, ...

Salmonella resides within host cells in a vacuole that it modifies through the action of virulence proteins called effectors. Here we examined the role of two related effectors, SopD and SopD2, in...

Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7 (2004)

Gruenheid, Samantha, Sekirov, Inna, Thomas, Nikhil A., Deng, Wanyin, O'Donnell, Paul, Goode, David, ...

Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 uses a specialized protein translocation apparatus, the type III secretion system (TTSS), to deliver bacterial effector proteins into host cells....

Jiang, Xiuju, Rossanese, Olivia W., Brown, Nathaniel Francis, Kujat-Choy, Sonya, Galán, Jorge E., Finlay, B. Brett, ...

Salmonella resides within host cells in a vacuole that it modifies through the action of virulence proteins called effectors. Here we examined the role of two related effectors, SopD and SopD2, in...

Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7 (2004)

Gruenheid, Samantha, Sekirov, Inna, Thomas, Nikhil A., Deng, Wanyin, O'Donnell, Paul, Goode, David, ...

Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 uses a specialized protein translocation apparatus, the type III secretion system (TTSS), to deliver bacterial effector proteins into host cells....

Identification of a novel two-partner secretion system from Burkholderia pseudomallei. (2004)

Brown, Nathaniel Francis, Logue, Carie-Anne, Boddey, Justin Andrew, Scott, R., Hirst, Robert G, Beacham, Ifor Rhys

Two adjacent genes, bpaA and bpaB, whose products display significant similarity to a number of two-partner secretion (TPS) systems have been identified in Burkholderia pseudomallei strain 08, but...

Expression and secretion of Salmonella pathogenicity island-2 virulence genes in response to acidification exhibit differential requirements of a functional type III secretion apparatus and SsaL (2004)

Coombes, Brian K., Brown, Nathaniel Francis, Vandez, Yanet, Brumell, John H., Finlay, B. Brett

Salmonella pathogenicity island (SPI)-2 is pivotal to the intracellular survival of Salmonella and for virulence in mammals. SPI-2 encodes virulence factors (called effectors) that are translocated...

Jiang, Xiuju, Rossanese, Olivia W., Brown, Nathaniel Francis, Kujat-Choy, Sonya, Galán, Jorge E., Finlay, B. Brett, ...

Salmonella resides within host cells in a vacuole that it modifies through the action of virulence proteins called effectors. Here we examined the role of two related effectors, SopD and SopD2, in...

Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7 (2004)

Gruenheid, Samantha, Sekirov, Inna, Thomas, Nikhil A., Deng, Wanyin, O'Donnell, Paul, Goode, David, ...

Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 uses a specialized protein translocation apparatus, the type III secretion system (TTSS), to deliver bacterial effector proteins into host cells....

SseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells (2003)

Coombes, Brian K., Brown, Nathaniel Francis, Kujat-Choy, Sonya, Vallance, Bruce A., Finlay, B. Brett

The Salmonella pathogenicity island-2 (SPI2) is a virulence locus on the bacterial chromosome required for intracellular proliferation and systemic infection in mice. Cell culture models and a murine...

SopD2 is a novel type III secreted effector of Salmonella typhimurium that targets late endocytic compartments upon delivery into host cells (2003)

Brumell, John H., Kujat-Choy, Sonya, Brown, Nathaniel Francis, Vallance, Bruce A., Knodler, Leigh A., Finlay, B. Brett

Salmonella typhimurium is a facultative intracellular pathogen that utilizes two type III secretion systems to deliver virulence proteins into host cells. These proteins, termed effectors, alter host...

SseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells (2003)

Coombes, Brian K., Brown, Nathaniel Francis, Kujat-Choy, Sonya, Vallance, Bruce A., Finlay, B. Brett

The Salmonella pathogenicity island-2 (SPI2) is a virulence locus on the bacterial chromosome required for intracellular proliferation and systemic infection in mice. Cell culture models and a murine...

SopD2 is a novel type III secreted effector of Salmonella typhimurium that targets late endocytic compartments upon delivery into host cells (2003)

Brumell, John H., Kujat-Choy, Sonya, Brown, Nathaniel Francis, Vallance, Bruce A., Knodler, Leigh A., Finlay, B. Brett

Salmonella typhimurium is a facultative intracellular pathogen that utilizes two type III secretion systems to deliver virulence proteins into host cells. These proteins, termed effectors, alter host...

SseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells (2003)

Coombes, Brian K., Brown, Nathaniel Francis, Kujat-Choy, Sonya, Vallance, Bruce A., Finlay, B. Brett

The Salmonella pathogenicity island-2 (SPI2) is a virulence locus on the bacterial chromosome required for intracellular proliferation and systemic infection in mice. Cell culture models and a murine...

SopD2 is a novel type III secreted effector of Salmonella typhimurium that targets late endocytic compartments upon delivery into host cells (2003)

Brumell, John H., Kujat-Choy, Sonya, Brown, Nathaniel Francis, Vallance, Bruce A., Knodler, Leigh A., Finlay, B. Brett

Salmonella typhimurium is a facultative intracellular pathogen that utilizes two type III secretion systems to deliver virulence proteins into host cells. These proteins, termed effectors, alter host...

Searching for virulence Burkholderia pseudomallei genes by immunoscreening the λ ZAPII expressed genomic library (2003)

Jitsurong, Siroj, Chirathaworn, C., Brown, Nathaniel Francis, Beacham, Ifor Rhys, Tumwasorn, S.

The λZAP II expressed genomic library of B. pseudomallei was screened with pooled melioidosis serum preabsorbed with E. coli host cell. The positive clones were detected by using protein A-CDP-star...

Searching for virulence Burkholderia pseudomallei genes by immunoscreening the λ ZAPII expressed genomic library (2003)

Jitsurong, Siroj, Chirathaworn, C., Brown, Nathaniel Francis, Beacham, Ifor Rhys, Tumwasorn, S.

The λZAP II expressed genomic library of B. pseudomallei was screened with pooled melioidosis serum preabsorbed with E. coli host cell. The positive clones were detected by using protein A-CDP-star...

SseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells (2003)

Coombes, Brian K., Brown, Nathaniel Francis, Kujat-Choy, Sonya, Vallance, Bruce A., Finlay, B. Brett

The Salmonella pathogenicity island-2 (SPI2) is a virulence locus on the bacterial chromosome required for intracellular proliferation and systemic infection in mice. Cell culture models and a murine...

SopD2 is a novel type III secreted effector of Salmonella typhimurium that targets late endocytic compartments upon delivery into host cells (2003)

Brumell, John H., Kujat-Choy, Sonya, Brown, Nathaniel Francis, Vallance, Bruce A., Knodler, Leigh A., Finlay, B. Brett

Salmonella typhimurium is a facultative intracellular pathogen that utilizes two type III secretion systems to deliver virulence proteins into host cells. These proteins, termed effectors, alter host...

Searching for virulence Burkholderia pseudomallei genes by immunoscreening the λ ZAPII expressed genomic library (2003)

Jitsurong, Siroj, Chirathaworn, C., Brown, Nathaniel Francis, Beacham, Ifor Rhys, Tumwasorn, S.

The λZAP II expressed genomic library of B. pseudomallei was screened with pooled melioidosis serum preabsorbed with E. coli host cell. The positive clones were detected by using protein A-CDP-star...

Adherence of Burkholderia pseudomallei cells to cultured human epithelial cell lines is regulated by growth temperature. (2002)

Brown, Nathaniel Francis, Boddey, Justin Andrew, Flegg, Cameron, Beacham, Ifor Rhys

We have investigated the adherence of Burkholderia pseudomallei, cultured under a number of different conditions, to six human epithelial cell lines. While several complex medium compositions had...

Adherence of Burkholderia pseudomallei cells to cultured human epithelial cell lines is regulated by growth temperature. (2002)

Brown, Nathaniel Francis, Boddey, Justin Andrew, Flegg, Cameron, Beacham, Ifor Rhys

We have investigated the adherence of Burkholderia pseudomallei, cultured under a number of different conditions, to six human epithelial cell lines. While several complex medium compositions had...

Adherence of Burkholderia pseudomallei cells to cultured human epithelial cell lines is regulated by growth temperature. (2002)

Brown, Nathaniel Francis, Boddey, Justin Andrew, Flegg, Cameron, Beacham, Ifor Rhys

We have investigated the adherence of Burkholderia pseudomallei, cultured under a number of different conditions, to six human epithelial cell lines. While several complex medium compositions had...

Nathaniel Francis Brown

Publication List Details