Ned A. Porter

Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension

Fessel, Joshua P., Porter, Ned A., Moore, Kevin P., Sheller, James R., Roberts, L. Jackson

Free radicals have been implicated in the pathogenesis of an increasing number of diseases. Lipids, which undergo peroxidation, are major targets of free radical attack. We report the discovery of a...

Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension

Fessel, Joshua P., Porter, Ned A., Moore, Kevin P., Sheller, James R., Roberts, L. Jackson

Free radicals have been implicated in the pathogenesis of an increasing number of diseases. Lipids, which undergo peroxidation, are major targets of free radical attack. We report the discovery of a...

Enzymatic synthesis of a bicyclobutane fatty acid by a hemoprotein–lipoxygenase fusion protein from the cyanobacterium Anabaena PCC 7120

Schneider, Claus, Niisuke, Katrin, Boeglin, William E., Voehler, Markus, Stec, Donald F., Porter, Ned A., ...

Biological transformations of polyunsaturated fatty acids often lead to chemically unstable products, such as the prostaglandin endoperoxides and leukotriene A4 epoxide of mammalian biology and the...

Formation of Highly Reactive Cyclopentenone Isoprostane Compounds (A3/J3-Isoprostanes) in Vivo from Eicosapentaenoic Acid*

Brooks, Joshua D., Milne, Ginger L., Yin, Huiyong, Sanchez, Stephanie C., Porter, Ned A., Morrow, Jason D.

Omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) found in marine fish oils are known to suppress inflammation associated with a wide variety of diseases. Eicosapentaenoic acid (EPA) is one of the...

Routes to 4-Hydroxynonenal: Fundamental Issues in the Mechanisms of Lipid Peroxidation*S⃞

Schneider, Claus, Porter, Ned A., Brash, Alan R.

Although investigation of the toxicological and physiological actions of α/β-unsaturated 4-hydroxyalkenals has made great progress over the last 2 decades, understanding of the chemical mechanism...