Repik, Alexander, Pincus, Steve E., Ghiran, Ionita, Nicholson-Weller, Anne, Asher, Damon R., Cerny, Anna M., ...
Complement receptor 1 (CR1) on the surface of human erythrocytes facilitates intravascular clearance of complement-opsonized pathogens. The need for complement activation can be circumvented by...
Mohamed, Nehal, Jones, Steven M., Li, Juan, Ferreira, Claudia, Chen, Xun, Kreiswirth, Barry, ...
Heteropolymers (HPs) contain a MAb directed against the Complement Receptor type 1 (CR1) on primate RBCs, chemically cross-linked to MAbs that recognize pathogens. Upon administration of HPs...
Inhibition of Staphylococcus aureus Adherence to Collagen under Dynamic Conditions
Mohamed, Nehal, Teeters, Mark A., Patti, Joseph M., Höök, Magnus, Ross, Julia M.
Staphylococcus aureus is the most common etiological agent of bacterial arthritis and acute osteomyelitis and has been shown to bind to type II collagen under static and dynamic conditions. We have...
Functional Analysis of the Staphylococcus aureus Collagen Adhesin B Domain
Snodgrass, James L., Mohamed, Nehal, Ross, Julia M., Sau, Subrata, Lee, Chia Y., Smeltzer, Mark S.
The Staphylococcus aureus collagen adhesin (CNA) occurs in at least four forms that differ in the number (one, two, three, or four) of B domains. The B domains contain 187 amino acids and are located...
Mohamed, Nehal, Li, Juan, Ferreira, Claudia S., Little, Stephen F., Friedlander, Arthur M., Spitalny, George L., ...
We investigated the ability of using monoclonal antibodies (MAbs) against anthrax protective antigen (PA), an anthrax exotoxin component, to modulate exotoxin cytotoxic activity on target macrophage...
Mohamed, Nehal, Clagett, Michelle, Li, Juan, Jones, Steven, Pincus, Steven, D'Alia, Giovanni, ...
We have developed a therapeutic for the treatment of anthrax using an affinity-enhanced monoclonal antibody (ETI-204) to protective antigen (PA), which is the central cell-binding component of the...
Inhibition of Staphylococcus aureus Adherence to Collagen under Dynamic Conditions
Mohamed, Nehal, Teeters, Mark A., Patti, Joseph M., Höök, Magnus, Ross, Julia M.
Staphylococcus aureus is the most common etiological agent of bacterial arthritis and acute osteomyelitis and has been shown to bind to type II collagen under static and dynamic conditions. We have...
Functional Analysis of the Staphylococcus aureus Collagen Adhesin B Domain
Snodgrass, James L., Mohamed, Nehal, Ross, Julia M., Sau, Subrata, Lee, Chia Y., Smeltzer, Mark S.
The Staphylococcus aureus collagen adhesin (CNA) occurs in at least four forms that differ in the number (one, two, three, or four) of B domains. The B domains contain 187 amino acids and are located...
Mohamed, Nehal, Li, Juan, Ferreira, Claudia S., Little, Stephen F., Friedlander, Arthur M., Spitalny, George L., ...
We investigated the ability of using monoclonal antibodies (MAbs) against anthrax protective antigen (PA), an anthrax exotoxin component, to modulate exotoxin cytotoxic activity on target macrophage...
Mohamed, Nehal, Clagett, Michelle, Li, Juan, Jones, Steven, Pincus, Steven, D'Alia, Giovanni, ...
We have developed a therapeutic for the treatment of anthrax using an affinity-enhanced monoclonal antibody (ETI-204) to protective antigen (PA), which is the central cell-binding component of the...