An assessment of the portability of ancestry informative markers between human populations (2009)
Myles, Sean, Stoneking, Mark, Timpson, Nic
Abstract Background Recent work has shown that population stratification can have confounding effects on genetic association studies and statistical methods have been developed to correct for these...
Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype (2009)
Brennan, Paul, McKay, James, Moore, Lee, Zaridze, David, Mukeria, Anush, Szeszenia-Dabrowska, Neonilia, ...
Background Obesity is a risk factor for several cancers although appears to have an inverse association with cancers strongly related to tobacco. Studying obesity is difficult due to numerous biases...
Worldwide population differentiation at disease-associated SNPs (2008)
Myles, Sean, Davison, Dan, Barrett, Jeffrey, Stoneking, Mark, Timpson, Nic
Abstract Background Recent genome-wide association (GWA) studies have provided compelling evidence of association between genetic variants and common complex diseases. These studies have made use of...
Worldwide population differentiation at disease-associated SNPs (2008)
Myles, Sean, Davison, Dan, Barrett, Jeffrey, Stoneking, Mark, Timpson, Nic
George Davey Smith, Debbie A. Lawlor, Roger Harbord, Nic Timpson, Ian Day, Shah Ebrahim
BackgroundIn conventional epidemiology confounding of the exposure of interest with lifestyle or socioeconomic factors, and reverse causation whereby disease status influences exposure rather than...
Davey Smith, George, Lawlor, Debbie A., Harbord, Roger, Timpson, Nic, Rumley, Ann, Lowe, Gordon D.O., ...
Background: C-reactive protein (CRP) has repeatedly been associated with blood pressure and prevalent and incident hypertension, but whether a causal link exists is uncertain. Methods and Results: We...
Smith, George Davey, Lawlor, Debbie A, Harbord, Roger, Timpson, Nic, Day, Ian, Ebrahim, Shah
In a cross-sectional study Davey Smith and colleagues show why observational studies can produce misleading claims regarding potential causal factors for disease, and illustrate the use of mendelian...