Nicholas J. Hand

Null Mutations in a Nudix Gene, ygdP, Implicate an Alarmone Response in a Novel Suppression of Hybrid Jamming

Hand, Nicholas J., Silhavy, Thomas J.

Induction of the toxic LamB-LacZ protein fusion, Hyb42-1, leads to a lethal generalized protein export defect. The prlF1 suppressor causes hyperactivation of the cytoplasmic Lon protease and relieves...

Archaeal and Bacterial SecD and SecF Homologs Exhibit Striking Structural and Functional Conservation

Hand, Nicholas J., Klein, Reinhard, Laskewitz, Anke, Pohlschröder, Mechthild

The majority of secretory proteins are translocated into and across hydrophobic membranes via the universally conserved Sec pore. Accessory proteins, including the SecDF-YajC Escherichia coli...

Null Mutations in a Nudix Gene, ygdP, Implicate an Alarmone Response in a Novel Suppression of Hybrid Jamming

Hand, Nicholas J., Silhavy, Thomas J.

Induction of the toxic LamB-LacZ protein fusion, Hyb42-1, leads to a lethal generalized protein export defect. The prlF1 suppressor causes hyperactivation of the cytoplasmic Lon protease and relieves...

Archaeal and Bacterial SecD and SecF Homologs Exhibit Striking Structural and Functional Conservation

Hand, Nicholas J., Klein, Reinhard, Laskewitz, Anke, Pohlschröder, Mechthild

The majority of secretory proteins are translocated into and across hydrophobic membranes via the universally conserved Sec pore. Accessory proteins, including the SecDF-YajC Escherichia coli...