Nicholas J. Murgolo

Mapping and characterization of the epitope(s) of Sch 55700, a humanized mAb, that inhibits human IL-5 (1999)

Zhang, Ji, Kuvelkar, Reshma, Murgolo, Nicholas J., Taremi, S. Shane, Chou, Chuan-Chu, Wang, Peng, ...

mAb against human IL-5 inhibit pulmonary eosinophilia, tissue damage and airway hyper-reactivity in allergic animal models. Sch 55700 is a humanized, neutralizing anti-IL-5 antibody. To better...

Structure and humanization of a rat monoclonal Fab to human interleukin-5 (1996)

Cook, William J., Walter, Leigh J., Murgolo, Nicholas J., Chou, Chuan-Chu, Petro, Mary, Zavodny, Paul J., ...

The X-ray crystal structure of a rat monoclonal Fab JES1-39D10, raised against recombinant human interleukin-5, has been determined with the use of molecular replacement techniques and refined at 2.7...

The Differential Sensitivity of Human and Rhesus Macaque CCR5 to Small-Molecule Inhibitors of Human Immunodeficiency Virus Type 1 Entry Is Explained by a Single Amino Acid Difference and Suggests a Mechanism of Action for These Inhibitors

Billick, Erika, Seibert, Christoph, Pugach, Pavel, Ketas, Tom, Trkola, Alexandra, Endres, Michael J., ...

AD101 and SCH-C are two chemically related small molecules that inhibit the entry of human immunodeficiency virus type 1 (HIV-1) via human CCR5. AD101 also inhibits HIV-1 entry via rhesus macaque...

The Differential Sensitivity of Human and Rhesus Macaque CCR5 to Small-Molecule Inhibitors of Human Immunodeficiency Virus Type 1 Entry Is Explained by a Single Amino Acid Difference and Suggests a Mechanism of Action for These Inhibitors

Billick, Erika, Seibert, Christoph, Pugach, Pavel, Ketas, Tom, Trkola, Alexandra, Endres, Michael J., ...

AD101 and SCH-C are two chemically related small molecules that inhibit the entry of human immunodeficiency virus type 1 (HIV-1) via human CCR5. AD101 also inhibits HIV-1 entry via rhesus macaque...