Nicholas R. Thomson

The complete genome, comparative and functional analysis of Stenotrophomonas maltophiliareveals an organism heavily shielded by drug resistance determinants (2008)

Crossman, Lisa C, Gould, Virginia C, Dow, J Maxwell, Vernikos, Georgios S, Okazaki, Aki, Sebaihia, Mohammed, ...

Abstract Background Stenotrophomonas maltophilia is a nosocomial opportunistic pathogen of the Xanthomonadaceae. The organism has been isolated from both clinical and soil environments in addition to...

Chlamydia trachomatis: Genome sequence analysis of lymphogranuloma venereum isolates. (2008)

Thomson, Nicholas R., Holden, .Matthew T.G., Carder, C.Caroline, Lennard, Nicola, Lockey, Sarah J., Marsh, Pete, ...

Chlamydia trachomatis is the most common cause of sexually transmitted infections in the UK, a statistic that is also reflected globally. There are three biovariants of C. trachomatis: trachoma...

Ankyrin repeat domain-encoding genes in the wPip strain of Wolbachiafrom the Culex pipiensgroup (2007)

Walker, Thomas, Klasson, Lisa, Sebaihia, Mohammed, Sanders, Mandy J, Thomson, Nicholas R, Parkhill, Julian, ...

Abstract Background Wolbachia are obligate endosymbiotic bacteria maternally transmitted through the egg cytoplasm that are responsible for several reproductive disorders in their insect hosts, such...

Genetic flux over time in the Salmonellalineage (2007)

Vernikos, Georgios S, Thomson, Nicholas R, Parkhill, Julian

Abstract Background DNA sequences that are shared between closely related organisms while being absent from their common ancestor and from sister lineages of that ancestor are likely to have been...

The Complete Genome Sequence and Comparative Genome Analysis of the High Pathogenicity Yersinia enterocolitica Strain 8081 (2006)

Nicholas R. Thomson, Sarah Howard, Brendan W. Wren, Lisa Crossman, Gregory L. Challis, ...

The human enteropathogen, Yersinia enterocolitica, is a significant link in the range of Yersinia pathologies extending from mild gastroenteritis to bubonic plague. Comparison at the genomic level is...

The genome of Rhizobium leguminosarumhas recognizable core and accessory components (2006)

Young, J Peter W, Crossman, Lisa C, Johnston, Andrew WB, Thomson, Nicholas R, Ghazoui, Zara F, Hull, Katherine H, ...

Abstract Background Rhizobium leguminosarum is an α-proteobacterial N 2 -fixing symbiont of legumes that has been the subject of more than a thousand publications. Genes for the symbiotic...

Microevolution and history of the plague bacillus, Yersinia pestis (2004)

Achtman,Mark, Morelli,Giovanna, Zhu,Peixuan X., Wirth,Thierry, Diehl,Ines, Kusecek,Barica, ...

The association of historical plague pandemics with Yersinia pestis remains controversial, partly because the evolutionary history of this largely monomorphic bacterium was unknown. The...

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei

Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeño-Tárraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...

Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world...

Microevolution and history of the plague bacillus, Yersinia pestis

Achtman, Mark, Morelli, Giovanna, Zhu, Peixuan, Wirth, Thierry, Diehl, Ines, Kusecek, Barica, ...

The association of historical plague pandemics with Yersinia pestis remains controversial, partly because the evolutionary history of this largely monomorphic bacterium was unknown. The...

The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number

Collins, Nicola E., Liebenberg, Junita, De Villiers, Etienne P., Brayton, Kelly A., Louw, Elmarié, Pretorius, Alri, ...

Heartwater, a tick-borne disease of domestic and wild ruminants, is caused by the intracellular rickettsia Ehrlichia ruminantium (previously known as Cowdria ruminantium). It is a major constraint to...

The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation

Thomson, Nicholas R., Yeats, Corin, Bell, Kenneth, Holden, Matthew T.G., Bentley, Stephen D., Livingstone, Morag, ...

The obligate intracellular bacterial pathogen Chlamydophila abortus strain S26/3 (formerly the abortion subtype of Chlamydia psittaci) is an important cause of late gestation abortions in ruminants...

Escherichia coli K-12: a cooperatively developed annotation snapshot—2005

Riley, Monica, Abe, Takashi, Arnaud, Martha B., Berlyn, Mary K.B., Blattner, Frederick R., Chaudhuri, Roy R., ...

The goal of this group project has been to coordinate and bring up-to-date information on all genes of Escherichia coli K-12. Annotation of the genome of an organism entails identification of genes,...

The genome of Rhizobium leguminosarum has recognizable core and accessory components

Young, J Peter W, Crossman, Lisa C, Johnston, Andrew WB, Thomson, Nicholas R, Ghazoui, Zara F, Hull, Katherine H, ...

The genome sequence of the α-proteobacterial N2-fixing symbiont of legumes, Rhizobium leguminosarum, is described, revealing a 'core' and an 'accessory' component.

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei

Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeño-Tárraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...

Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world...

Microevolution and history of the plague bacillus, Yersinia pestis

Achtman, Mark, Morelli, Giovanna, Zhu, Peixuan, Wirth, Thierry, Diehl, Ines, Kusecek, Barica, ...

The association of historical plague pandemics with Yersinia pestis remains controversial, partly because the evolutionary history of this largely monomorphic bacterium was unknown. The...

The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number

Collins, Nicola E., Liebenberg, Junita, De Villiers, Etienne P., Brayton, Kelly A., Louw, Elmarié, Pretorius, Alri, ...

Heartwater, a tick-borne disease of domestic and wild ruminants, is caused by the intracellular rickettsia Ehrlichia ruminantium (previously known as Cowdria ruminantium). It is a major constraint to...

The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation

Thomson, Nicholas R., Yeats, Corin, Bell, Kenneth, Holden, Matthew T.G., Bentley, Stephen D., Livingstone, Morag, ...

The obligate intracellular bacterial pathogen Chlamydophila abortus strain S26/3 (formerly the abortion subtype of Chlamydia psittaci) is an important cause of late gestation abortions in ruminants...

Escherichia coli K-12: a cooperatively developed annotation snapshot—2005

Riley, Monica, Abe, Takashi, Arnaud, Martha B., Berlyn, Mary K.B., Blattner, Frederick R., Chaudhuri, Roy R., ...

The goal of this group project has been to coordinate and bring up-to-date information on all genes of Escherichia coli K-12. Annotation of the genome of an organism entails identification of genes,...

The genome of Rhizobium leguminosarum has recognizable core and accessory components

Young, J Peter W, Crossman, Lisa C, Johnston, Andrew WB, Thomson, Nicholas R, Ghazoui, Zara F, Hull, Katherine H, ...

The genome sequence of the α-proteobacterial N2-fixing symbiont of legumes, Rhizobium leguminosarum, is described, revealing a 'core' and an 'accessory' component.

The Complete Genome Sequence and Comparative Genome Analysis of the High Pathogenicity Yersinia enterocolitica Strain 8081

Thomson, Nicholas R, Howard, Sarah, Wren, Brendan W, Holden, Matthew T. G, Crossman, Lisa, Challis, Gregory L, ...

The human enteropathogen, Yersinia enterocolitica, is a significant link in the range of Yersinia pathologies extending from mild gastroenteritis to bubonic plague. Comparison at the genomic level is...

A bimodal pattern of relatedness between the Salmonella Paratyphi A and Typhi genomes: Convergence or divergence by homologous recombination?

Didelot, Xavier, Achtman, Mark, Parkhill, Julian, Thomson, Nicholas R., Falush, Daniel

All Salmonella can cause disease but severe systemic infections are primarily caused by a few lineages. Paratyphi A and Typhi are the deadliest human restricted serovars, responsible for ∼600,000...

Multidrug-Resistant Salmonella enterica Serovar Paratyphi A Harbors IncHI1 Plasmids Similar to Those Found in Serovar Typhi▿

Holt, Kathryn E., Thomson, Nicholas R., Wain, John, Phan, Minh Duy, Nair, Satheesh, Hasan, Rumina, ...

Salmonella enterica serovars Typhi and Paratyphi A cause systemic infections in humans which are referred to as enteric fever. Multidrug-resistant (MDR) serovar Typhi isolates emerged in the 1980s,...

Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes

Sebaihia, Mohammed, Peck, Michael W., Minton, Nigel P., Thomson, Nicholas R., Holden, Matthew T.G., Mitchell, Wilfrid J., ...

Clostridium botulinum is a heterogeneous Gram-positive species that comprises four genetically and physiologically distinct groups of bacteria that share the ability to produce botulinum neurotoxin,...

The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children

MacLennan, Calman A., Gondwe, Esther N., Msefula, Chisomo L., Kingsley, Robert A., Thomson, Nicholas R., White, Sarah A., ...

Nontyphoidal strains of Salmonella (NTS) are a common cause of bacteremia among African children. Cell-mediated immune responses control intracellular infection, but they do not protect against...

Genetic flux over time in the Salmonella lineage

Vernikos, Georgios S, Thomson, Nicholas R, Parkhill, Julian

From a whole-genome comparative analysis of Salmonella, Escherichia coli and Shigella strains, the relative time of insertion of putative horizontally acquired genes in three Salmonella strains were...

Chlamydia trachomatis: Genome sequence analysis of lymphogranuloma venereum isolates

Thomson, Nicholas R., Holden, Matthew T.G., Carder, Caroline, Lennard, Nicola, Lockey, Sarah J., Marsh, Pete, ...

Chlamydia trachomatis is the most common cause of sexually transmitted infections in the UK, a statistic that is also reflected globally. There are three biovariants of C. trachomatis: trachoma...

Different Pathways to Acquiring Resistance Genes Illustrated by the Recent Evolution of IncW Plasmids▿ †

Revilla, Carlos, Garcillán-Barcia, M. Pilar, Fernández-López, Raúl, Thomson, Nicholas R., Sanders, Mandy, Cheung, Martin, ...

DNA sequence analysis of five IncW plasmids (R388, pSa, R7K, pIE321, and pIE522) demonstrated that they share a considerable portion of their genomes and allowed us to define the IncW backbone. Among...

Molecular Characterization of the Salmonella enterica Serovar Typhi Vi-Typing Bacteriophage E1▿

Pickard, Derek, Thomson, Nicholas R., Baker, Stephen, Wain, John, Pardo, Mercedes, Goulding, David, ...

Some bacteriophages target potentially pathogenic bacteria by exploiting surface-associated virulence factors as receptors. For example, phage have been identified that exhibit specificity for Vi...

Complete Genome Sequence of Uropathogenic Proteus mirabilis, a Master of both Adherence and Motility▿ †

Pearson, Melanie M., Sebaihia, Mohammed, Churcher, Carol, Quail, Michael A., Seshasayee, Aswin S., Luscombe, Nicholas M., ...

The gram-negative enteric bacterium Proteus mirabilis is a frequent cause of urinary tract infections in individuals with long-term indwelling catheters or with complicated urinary tracts (e.g., due...