Lukacs, Nicholas W., Smit, Joost J., Schaller, Matthew A., Lindell, Dennis M.
The activation and maintenance of pulmonary viral disease is regulated at multiple levels and determined by the early innate response to the pathogenic stimuli. Subsequent activation events that rely...
Narala, Venkata R, Ranga, Rajesh, Smith, Monica R, Berlin, Aaron A, Standiford, Theodore J, Lukacs, Nicholas W, ...
Abstract Background While glucocorticoids are currently the most effective therapy for asthma, associated side effects limit enthusiasm for their use. Peroxisome proliferator-activated receptor-γ...
Rudd, Brian D., Luker, Gary D., Luker, Kathryn E., Peebles, Ray S., Lukacs, Nicholas W.
Activation of dendritic cells (DCs) by viruses is critical for both innate and adaptive immune responses. In this report, we investigated the role of type I interferon (IFN) in the activation of DCs...
Schaller, Matthew A., Neupane, Rupak, Rudd, Brian D., Kunkel, Steven L., Kallal, Lara E., Lincoln, Pamela, ...
Recent data have indicated that an important instructive class of signals regulating the immune response is Notch ligand-mediated activation. Using quantitative polymerase chain reaction, we observed...
Daruwalla, Zeeba, Roth, Therese M., Bianchi, Lynne M., Allen, Susan J., White, Ian O., Lukacs, Nicholas W., ...
The target-derived factors necessary for promoting initial outgrowth from the statoacoustic ganglion (SAG) to the inner ear have not been fully characterized. In the present study, conditioned medium...
Deficiency of regulatory B cells increases allergic airway inflammation (2005)
Lundy, S. K., Berlin, A. A., Martens, T. F., Lukacs, Nicholas W.
Objective: To investigate the effect of the X-linked immunodeficiency (Xid) B cell defect on the response to the cockroach allergen in mice.
Zeng, Xianying, Moore, Thomas A., Newstead, Michael W., Deng, Jane C., Lukacs, Nicholas W., Standiford, Theodore J.
CXC chemokines that lack the glutamine-leucine-arginine (ELR) motif, including interferon (IFN)-inducible protein 10 (IP-10 or CXCL10), have been shown to mediate the generation of type 1 immune...
Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis (2004)
Andrew M. LaFleur, Nicholas W. Lukacs, Steven L. Kunkel, Akihiro Matsukawa
THE aim of this study was to determine the role of CC chemokine CCL6/C10 in acute inflammation. Intraperitoneal injection of thioglycollate increased peritoneal CCL6, which peaked at 4 h and remained...
Matsukawa, Akihiro, Lukacs, Nicholas W., Hogaboam, Cory M., Chensue, Stephen W., Kunkel, Steven L.
Chemokines constitute a large family of chemotactic cytokines that belong to a super-gene family of 8–10 kDa proteins. The chemokines are considered to be primarily beneficial in host defense...
Oliveira, S.H.P., Lukacs, Nicholas W.
Objective and design: In the present study we investigated the effect of SCF and/or IgE on histamine, TNF- α and chemokines released from bone marrow-derived mast cells (BMMC) as well as chemokine...
Chemokines and their role in airway hyper-reactivity (2000)
Blease, Kate, Lukacs, Nicholas W, Hogaboam, Cory M, Kunkel, Steven L
Abstract Airway hyper-reactivity is a characteristic feature of many inflammatory lung diseases and is defined as an exaggerated degree of airway narrowing. Chemokines and their receptors are...
Orens, Jonathan B., Lukacs, Nicholas W., Kunkel, Steven L., Burdick, Marie D., Wilke, Carol A., Walz, Alfred, ...
Previous studies have shown that during the development of a mixed lymphocyte reaction (MLR) levels of the chemotactic cytokines IL-8 and MCP-1 (members of the C-X-C and C-C supergene families,...
Lukacs, Nicholas W., Strieter, Robert M., Evanoff, Holly L., Burdick, Marie D., Kunkel, Steven L.
The allogeneic mixed lymphocyte reaction (MLR) is regarded as an effective model for examining the events which occur during an allospecific immune response. Numerous studies have delineated the role...
The role of chemokines in Schistosoma mansoni granuloma formation (1994)
Lukacs, Nicholas W., Kunkel, Steven L., Strieter, Robert M., Chensue, Stephen W.
The eradication of parasitic diseases, such as schistosomiasis, has been the focus of investigations worldwide for many decades. However, attempts to control their continual spread have, at best,...
Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis (1992)
Andrew M. LaFleur, Nicholas W. Lukacs, Steven L. Kunkel, Akihiro Matsukawa
THE aim of this study was to determine the role of CC chemokine CCL6/C10 in acute inflammation. Intraperitoneal injection of thioglycollate increased peritoneal CCL6, which peaked at 4 h and remained...
Theses (M.S.)--University of New Hampshire, 1988.
Chemokines and their role in airway hyper-reactivity
Blease, Kate, Lukacs, Nicholas W, Hogaboam, Cory M, Kunkel, Steven L
Airway hyper-reactivity is a characteristic feature of many inflammatory lung diseases and is defined as an exaggerated degree of airway narrowing. Chemokines and their receptors are involved in...
Chemokines and asthma: redundancy of function or a coordinated effort?
Lukacs, Nicholas W., Oliveira, Sandra H.P., Hogaboam, Cory M.
Chen, Gwo-Hsiao, McDonald, Roderick A., Wells, Jason C., Huffnagle, Gary B., Lukacs, Nicholas W., Toews, Galen B.
Mice with a null deletion mutation in the gamma interferon (IFN-γ) receptor gene were used to study the role of IFN-γ responsiveness during experimental pulmonary cryptococcosis. Cryptococcus...
Differential Role for TLR3 in Respiratory Syncytial Virus-Induced Chemokine Expression
Rudd, Brian D., Burstein, Ezra, Duckett, Colin S., Li, Xiaoxia, Lukacs, Nicholas W.
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection in young infants worldwide. Previous studies have reported that the induction of interleukin-8/CXCL8 and...
Chemokines and their role in airway hyper-reactivity
Blease, Kate, Lukacs, Nicholas W, Hogaboam, Cory M, Kunkel, Steven L
Airway hyper-reactivity is a characteristic feature of many inflammatory lung diseases and is defined as an exaggerated degree of airway narrowing. Chemokines and their receptors are involved in...
Chemokines and asthma: redundancy of function or a coordinated effort?
Lukacs, Nicholas W., Oliveira, Sandra H.P., Hogaboam, Cory M.
Chen, Gwo-Hsiao, McDonald, Roderick A., Wells, Jason C., Huffnagle, Gary B., Lukacs, Nicholas W., Toews, Galen B.
Mice with a null deletion mutation in the gamma interferon (IFN-γ) receptor gene were used to study the role of IFN-γ responsiveness during experimental pulmonary cryptococcosis. Cryptococcus...
Differential Role for TLR3 in Respiratory Syncytial Virus-Induced Chemokine Expression
Rudd, Brian D., Burstein, Ezra, Duckett, Colin S., Li, Xiaoxia, Lukacs, Nicholas W.
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection in young infants worldwide. Previous studies have reported that the induction of interleukin-8/CXCL8 and...
Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis.
LaFleur, Andrew M, Lukacs, Nicholas W, Kunkel, Steven L, Matsukawa, Akihiro
The aim of this study was to determine the role of CC chemokine CCL6/C10 in acute inflammation. Intraperitoneal injection of thioglycollate increased peritoneal CCL6, which peaked at 4 h and remained...
Hu, Jerry S., Freeman, Christine M., Stolberg, Valerie R., Chiu, Bo Chin, Bridger, Gary J., Fricker, Simon P., ...
CXCR4 is a major receptor for CXCL12 and is known to participate in multiple physiological systems. The present study tested a second generation CXCR4 antagonist, AMD3465, for effects on highly...
John, Alison E., Thomas, Molly S., Berlin, Aaron A., Lukacs, Nicholas W.
CCL28 is a recently identified chemokine ligand for CCR10 and CCR3 that has been identified in mucosal epithelial surfaces in diverse tissues. CCL28-mediated eosinophil chemotaxis and peroxidase...
Role of Metalloelastase in a Model of Allergic Lung Responses Induced by Cockroach Allergen
Warner, Roscoe L., Lukacs, Nicholas W., Shapiro, Steven D., Bhagarvathula, Narasimharao, Nerusu, Kamalakar C., Varani, James, ...
Our laboratory and others have shown an important role of metalloelastase (MMP-12) in the pathogenesis of acute and chronic lung injury. Because chronic asthma is characterized by airway inflammation...
Lukacs, Nicholas W., Moore, Martin L., Rudd, Brian D., Berlin, Aaron A., Collins, Robert D., Olson, Sandra J., ...
In this study we performed comparisons of pulmonary responses between two different respiratory syncytial virus (RSV) antigenic subgroup A strains, A2 and Line 19. Line 19 strain induced significant...
Hogaboam, Cory M., Blease, Kate, Mehrad, Borna, Steinhauser, Matthew L., Standiford, Theodore J., Kunkel, Steven L., ...
Clinical allergic airway disease is associated with persistent airway hyperreactivity and remodeling, but little is known about the mechanisms leading to these alterations. This paucity of...
Exaggerated Hepatic Injury Due to Acetaminophen Challenge in Mice Lacking C-C Chemokine Receptor 2
Hogaboam, Cory M., Bone-Larson, Cynthia L., Steinhauser, Matthew L., Matsukawa, Akihiro, Gosling, Jennifa, Boring, Landin, ...
Monocyte chemoattractant protein-1 is one of the major C-C chemokines that has been implicated in liver injury. The C-C chemokine receptor, CCR2, has been identified as the primary receptor that...
Collagen Deposition in a Non-Fibrotic Lung Granuloma Model after Nitric Oxide Inhibition
Hogaboam, Cory M., Gallinat, Chad S., Bone-Larson, Cynthia, Chensue, Stephen W., Lukacs, Nicholas W., Strieter, Robert M., ...
Recent studies support the concept that pulmonary granulomatous inflammation directed by interferon (IFN)-γ, interleukin (IL)-12, and nitric oxide usually resolves in the absence of fibrosis. To...
Stem Cell Factor-Induced Airway Hyperreactivity in Allergic and Normal Mice
Campbell, Emma, Hogaboam, Cory, Lincoln, Pam, Lukacs, Nicholas W.
The induction of airway hyperreactivity during allergic responses involves multiple ill-defined mechanisms. Recently a role for stem cell factor (SCF) in the development of allergic eosinophilic...
Bone-Larson, Cynthia L., Hogaboam, Cory M., Steinhauser, Matthew L., Oliveira, Sandra H. P., Lukacs, Nicholas W., Strieter, Robert M., ...
Mast cells participate in the host response during sepsis and have been shown to have a protective effect in a murine model of acute septic peritonitis and multi-organ failure initiated by cecal...
Yoshida, Ayako, Elner, Susan G., Bian, Zong-Mei, Kunkel, Steven L., Lukacs, Nicholas W., Elner, Victor M.
Thrombin, an important clotting factor, extravasates at sites of blood-retina barrier breakdown that is often associated with many retinal diseases. Here we investigated the effects of thrombin on...
Tekkanat, Kim K., Maassab, Hussein, Berlin, Aaron A., Lincoln, Pam M., Evanoff, Holly L., Kaplan, Mark H., ...
Respiratory syncytial virus (RSV) is a respiratory pathogen that can cause significant morbidity in infants and young children. Interestingly, the majority of children who acquire a RSV infection do...
Blease, Kate, Schuh, Jane M., Jakubzick, Claudia, Lukacs, Nicholas W., Kunkel, Steven L., Joshi, Bharat H., ...
Signal transducer and activator of transcription 6 (Stat6) is critical for Th2-mediated responses during allergic airway disease. To investigate the role of Stat6 in fungus-induced airway...
Shang, Xiao-Zhou, Chiu, Bo-Chin, Stolberg, Valerie, Lukacs, Nicholas W., Kunkel, Steven L., Murphy, Hedwig S., ...
Monocyte chemotactic protein-3 (MCP-3/CCL7) has potent eosinophil chemoattractant properties. The present study determined its relative contribution to the formation of Th2 cytokine-mediated (type-2)...
AMD3100, a CxCR4 Antagonist, Attenuates Allergic Lung Inflammation and Airway Hyperreactivity
Lukacs, Nicholas W., Berlin, Aaron, Schols, Dominique, Skerlj, Renato T., Bridger, Gary J.
The role of specific chemokine receptors during allergic asthmatic responses has been relatively undefined. A number of receptors are preferentially expressed on Th2 cells, including CCR4, CCR8, and...
Septic Mice Are Susceptible to Pulmonary Aspergillosis
Benjamim, Claudia F., Hogaboam, Cory M., Lukacs, Nicholas W., Kunkel, Steven L.
Clinical data underscores the fact that subsequent high mortality rates occur in patients who survive acute septic episodes. Herein, we described a clinically relevant model of experimental sepsis...
Lundy, Steven K., Berlin, Aaron A., Lukacs, Nicholas W.
Several studies have shown that exposure to bacterial lipopolysaccharide (LPS) can either prevent or inhibit asthma in humans and laboratory rodents. Much emphasis has been placed on the role of...
Reversal of long-term sepsis-induced immunosuppression by dendritic cells
Benjamim, Claudia F., Lundy, Steven K., Lukacs, Nicholas W., Hogaboam, Cory M., Kunkel, Steven L.
Severe sepsis leads to long-term systemic and local immunosuppression, which is the cause of a number of complications, including pulmonary infection. A therapeutic strategy that reverses this...
The chemokine receptor CCR6 is an important component of the innate immune response
Wen, Haitao, Hogaboam, Cory M., Lukacs, Nicholas W., Cook, Donald N., Lira, Sergio A.
In our initial studies we found that naÏve CCR6-deficient (CCR6 –/– ) C57BL/6 mice possessed significantly lower number of both F4/80 + macrophages and dendritic cells (DC), but higher number of...
Chemokines and their role in airway hyper-reactivity
Blease, Kate, Lukacs, Nicholas W, Hogaboam, Cory M, Kunkel, Steven L
Airway hyper-reactivity is a characteristic feature of many inflammatory lung diseases and is defined as an exaggerated degree of airway narrowing. Chemokines and their receptors are involved in...
Ziegelbauer, Karl, Gantner, Florian, Lukacs, Nicholas W, Berlin, Aaron, Fuchikami, Kinji, Niki, Toshiro, ...
Pulmonary inflammatory diseases such as asthma are characterized by chronic, cell-mediated inflammation of the bronchial mucosa.Recruitment and activation of inflammatory cells is orchestrated by a...
Nakahira, Kiichi, Kim, Hong Pyo, Geng, Xue Hui, Nakao, Atsunori, Wang, Xue, Murase, Noriko, ...
Carbon monoxide (CO), a byproduct of heme catabolism by heme oxygenase (HO), confers potent antiinflammatory effects. Here we demonstrate that CO derived from HO-1 inhibited Toll-like receptor (TLR)...
Smit, Joost J., Rudd, Brian D., Lukacs, Nicholas W.
Respiratory syncytial virus (RSV) infection is widely spread and is a major cause of bronchiolitis in infants and high-risk adults, often leading to hospitalization. RSV infection leads to...
Pioglitazone is as effective as dexamethasone in a cockroach allergen-induced murine model of asthma
Narala, Venkata R, Ranga, Rajesh, Smith, Monica R, Berlin, Aaron A, Standiford, Theodore J, Lukacs, Nicholas W, ...
Smit, Joost J., Lindell, Dennis M., Boon, Louis, Kool, Mirjam, Lambrecht, Bart N., Lukacs, Nicholas W.
Chensue, Stephen W., Lukacs, Nicholas W., Yang, Tong-Yuan, Shang, Xiaozhou, Frait, Kirsten A., Kunkel, Steven L., ...
Chemokine receptors transduce signals important for the function and trafficking of leukocytes. Recently, it has been shown that CC chemokine receptor (CCR)8 is selectively expressed by Th2 subsets,...
Matsukawa, Akihiro, Kaplan, Mark H., Hogaboam, Cory M., Lukacs, Nicholas W., Kunkel, Steven L.
Signal transducer and activator of transcription (Stat)4 and Stat6 are transcription factors that provide type 1 and type 2 response, respectively. Here, we explored the role of Stat4 and Stat6 in...
Requirement for the Chemokine Receptor Ccr6 in Allergic Pulmonary Inflammation
Lukacs, Nicholas W., Prosser, Dina M., Wiekowski, Maria, Lira, Sergio A., Cook, Donald N.
Allergic asthmatic responses in the airway are associated with airway hyperreactivity, eosinophil accumulation in the lung, and cytokine production by allergen-specific, T helper cell type 2 (Th2)...
Lu, Bao, Rutledge, Barbara J., Gu, Long, Fiorillo, Joseph, Lukacs, Nicholas W., Kunkel, Steven L., ...
Monocyte chemoattractant protein 1 (MCP-1) is a CC chemokine that attracts monocytes, memory T lymphocytes, and natural killer cells. Because other chemokines have similar target cell specificities...
Karpus, William J., Kennedy, Kevin J., Kunkel, Steven L., Lukacs, Nicholas W.
Experimental autoimmune encephalomyelitis (EAE) is a T cell–mediated autoimmune demyelinating disease of the central nervous system that serves as an animal model for multiple sclerosis....
Schaller, Matthew A., Neupane, Rupak, Rudd, Brian D., Kunkel, Steven L., Kallal, Lara E., Lincoln, Pamela, ...
Recent data have indicated that an important instructive class of signals regulating the immune response is Notch ligand–mediated activation. Using quantitative polymerase chain reaction, we...
Smit, Joost J., Boon, Louis, Lukacs, Nicholas W.
Respiratory virus infections can significantly influence the development of airway disease by both predisposing and exacerbating the developing lung immune environment. In contrast, the initiation of...
Dolgachev, Vladislav, Berlin, Aaron A., Lukacs, Nicholas W.
In the present studies the role of stem cell factor (SCF) in mediating eosinophil and fibroblast activation during their interaction was investigated. SCF was significantly higher in fibroblasts...
A Key Role for CC Chemokine Receptor 1 in T-Cell-Mediated Respiratory Inflammation
Schaller, Matthew A., Kallal, Lara E., Lukacs, Nicholas W.
CC chemokine receptor 1 (CCR1) is found on a variety of cells in the immune system and has been shown to play an important role in the host response to pathogens. These studies used a murine model of...
Bianchi, Lynne M., Daruwalla, Zeeba, Roth, Therese M., Attia, Naweah P., Lukacs, Nicholas W., Richards, Ayo-Lynn, ...
The target-derived factors necessary for promoting initial outgrowth from the statoacoustic ganglion (SAG) to the inner ear have not been fully characterized. In the present study, conditioned medium...
Ito, Toshihiro, Schaller, Matthew, Hogaboam, Cory M., Standiford, Theodore J., Sandor, Matyas, Lukacs, Nicholas W., ...
TLR9 activation is important for the maintenance of mycobacteria-elicited pulmonary granulomatous responses, hallmarks of protective immune responses following mycobacterial infection. However, the...
Quercetin Blocks Airway Epithelial Cell Chemokine Expression
Nanua, Suparna, Zick, Suzanna M., Andrade, Juan E., Sajjan, Umadevi S., Burgess, John R., Lukacs, Nicholas W., ...
Quercetin (3,3′,4′,5,7-pentahydroxyflavone), a dietary flavonoid, is an inhibitor of phosphatidylinositol (PI) 3-kinase and potent antioxidant. We hypothesized that quercetin blocks airway...
Effect of Cigarette Smoke Extract on Dendritic Cells and Their Impact on T-Cell Proliferation
Mortaz, Esmaeil, Kraneveld, Aletta D., Smit, Joost J., Kool, Mirjam, Lambrecht, Bart N., Kunkel, Steven L., ...
Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation. Cigarette smoke has been considered a major player in the pathogenesis of COPD. The inflamed airways of...
Toll-like Receptors, Notch Ligands, and Cytokines Drive the Chronicity of Lung Inflammation
Raymond, Tracy, Schaller, Matthew, Hogaboam, Cory M., Lukacs, Nicholas W., Rochford, Rosemary, Kunkel, Steven L.
Current dogma supports the concept that the expression of a disease-inducing signature cytokine phenotype is important to the maintenance stage of chronic lung disorders. This cytokine phenotype has...
TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events
Cavassani, Karen A., Ishii, Makoto, Wen, Haitao, Schaller, Matthew A., Lincoln, Pamela M., Lukacs, Nicholas W., ...
Ligands from dying cells are a source of Toll-like receptor (TLR) activating agents. Although TLR3 is known to respond to RNA from necrotic cells, the relative importance of this response in vivo...
Newcomb, Dawn C., Sajjan, Umadevi S., Nagarkar, Deepti R., Wang, Qiong, Nanua, Suparna, Zhou, Ying, ...
Rationale: Infection with rhinovirus (RV) triggers exacerbations of asthma and chronic obstructive lung disease.
Role of Stem Cell Factor and Bone Marrow-Derived Fibroblasts in Airway Remodeling
Dolgachev, Vladislav A., Ullenbruch, Matthew R., Lukacs, Nicholas W., Phan, Sem H.
Recent evidence suggests that bone marrow-derived fibroblasts are involved in airway remodeling in asthma, but the role and mechanism of recruitment of these fibroblasts remains unclear. Stem cell...
Lukacs, Nicholas W., Berlin, Aaron A., Franz-Bacon, Karin, Šášik, Roman, Sprague, L. James, Ly, Tai Wei, ...
Prostaglandin D2, the ligand for the G protein-coupled receptors DP1 and CRTH2, has been implicated in the pathogenesis of the allergic response in diseases such as asthma, rhinitis, and atopic...
Moore, Martin L., Chi, Michael H., Luongo, Cindy, Lukacs, Nicholas W., Polosukhin, Vasiliy V., Huckabee, Matthew M., ...
Respiratory syncytial virus (RSV) is the leading cause of respiratory failure and viral death in infants. Abundant airway mucus contributes to airway obstruction in RSV disease. Interleukin-13...