Pendeville-Samain, Hélène, Carpino, Nick, Marine, Jean-Christophe, Takahashi, Yukata, Muller, Marc, Martial, Joseph, ...
Overexpression and inhibitor studies have suggested that the c-Myc target gene for ornithine decarboxylase (ODC), the enzyme which converts ornithine to putrescine, plays an important role in diverse...
Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity
Kashige, Nobuhiro, Carpino, Nick, Kobayashi, Ryuji
The t(9;22) chromosomal translocation is found in almost all patients with chronic myelogenous leukemia. The resultant Bcr-Abl fusion gene expresses a chimeric fusion protein p210bcr-abl with...
The Ornithine Decarboxylase Gene Is Essential for Cell Survival during Early Murine Development
Pendeville, Hélène, Carpino, Nick, Marine, Jean-Christophe, Takahashi, Yutaka, Muller, Marc, Martial, Joseph A., ...
Overexpression and inhibitor studies have suggested that the c-Myc target gene for ornithine decarboxylase (ODC), the enzyme which converts ornithine to putrescine, plays an important role in diverse...
Carpino, Nick, Kobayashi, Ryuji, Zang, Heesuk, Takahashi, Yutaka, Jou, Shiann-Tarrng, Feng, Jian, ...
In a screen for proteins that interact with Jak2, we identified a previously uncharacterized 70-kDa protein and cloned the corresponding cDNA. The predicated sequence indicates that p70 contains an...
Jou, Shiann-Tarng, Carpino, Nick, Takahashi, Yutaka, Piekorz, Roland, Chao, Jyh-Rong, Carpino, Neena, ...
Many receptor and nonreceptor tyrosine kinases activate phosphoinositide 3-kinases (PI3Ks). To assess the role of the δ isoform of the p110 catalytic subunit of PI3Ks, we derived enzyme-deficient...
SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation
Takahashi, Yutaka, Carpino, Nick, Cross, James C., Torres, Miguel, Parganas, Evan, Ihle, James N.
Suppressor of cytokine signaling 3 (SOCS3) binds cytokine receptors and thereby suppresses cytokine signaling. Deletion of SOCS3 causes an embryonic lethality that is rescued by a tetraploid rescue...
Wang, Demin, Moriggl, Richard, Stravopodis, Dimitrios, Carpino, Nick, Marine, Jean–Christophe, Teglund, Stephan, ...
Cytokines induce the tyrosine phosphorylation and associated activation of signal transducers and acti– vators of transcription (Stat). The mechanisms by which this response is terminated are...
Absence of an Essential Role for Thymic Stromal Lymphopoietin Receptor in Murine B-Cell Development
Carpino, Nick, Thierfelder, William E., Chang, Ming-shi, Saris, Chris, Turner, Steven J., Ziegler, Steven F., ...
The murine cytokine thymic stromal lymphopoietin (TSLP) supports the development of B220+ IgM+ immature B cells and induces thymocyte proliferation in vitro. Human TSLP, by contrast, activates CD11c+...
Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity
Kashige, Nobuhiro, Carpino, Nick, Kobayashi, Ryuji
The t(9;22) chromosomal translocation is found in almost all patients with chronic myelogenous leukemia. The resultant Bcr-Abl fusion gene expresses a chimeric fusion protein p210bcr-abl with...
The Ornithine Decarboxylase Gene Is Essential for Cell Survival during Early Murine Development
Pendeville, Hélène, Carpino, Nick, Marine, Jean-Christophe, Takahashi, Yutaka, Muller, Marc, Martial, Joseph A., ...
Overexpression and inhibitor studies have suggested that the c-Myc target gene for ornithine decarboxylase (ODC), the enzyme which converts ornithine to putrescine, plays an important role in diverse...
Carpino, Nick, Kobayashi, Ryuji, Zang, Heesuk, Takahashi, Yutaka, Jou, Shiann-Tarrng, Feng, Jian, ...
In a screen for proteins that interact with Jak2, we identified a previously uncharacterized 70-kDa protein and cloned the corresponding cDNA. The predicated sequence indicates that p70 contains an...
Jou, Shiann-Tarng, Carpino, Nick, Takahashi, Yutaka, Piekorz, Roland, Chao, Jyh-Rong, Carpino, Neena, ...
Many receptor and nonreceptor tyrosine kinases activate phosphoinositide 3-kinases (PI3Ks). To assess the role of the δ isoform of the p110 catalytic subunit of PI3Ks, we derived enzyme-deficient...
SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation
Takahashi, Yutaka, Carpino, Nick, Cross, James C., Torres, Miguel, Parganas, Evan, Ihle, James N.
Suppressor of cytokine signaling 3 (SOCS3) binds cytokine receptors and thereby suppresses cytokine signaling. Deletion of SOCS3 causes an embryonic lethality that is rescued by a tetraploid rescue...
Wang, Demin, Moriggl, Richard, Stravopodis, Dimitrios, Carpino, Nick, Marine, Jean–Christophe, Teglund, Stephan, ...
Cytokines induce the tyrosine phosphorylation and associated activation of signal transducers and acti– vators of transcription (Stat). The mechanisms by which this response is terminated are...
Absence of an Essential Role for Thymic Stromal Lymphopoietin Receptor in Murine B-Cell Development
Carpino, Nick, Thierfelder, William E., Chang, Ming-shi, Saris, Chris, Turner, Steven J., Ziegler, Steven F., ...
The murine cytokine thymic stromal lymphopoietin (TSLP) supports the development of B220+ IgM+ immature B cells and induces thymocyte proliferation in vitro. Human TSLP, by contrast, activates CD11c+...
Kleinman, Holly, Ford, Bradley, Keller, James, Carpino, Nick, Nassar, Nicolas
The C-terminal domain of the signaling protein Sts-1 has been expressed in bacteria, purified and crystallized and diffraction data sets have been collected from two crystal forms.