Nick Dorrell

Re-annotation and re-analysis of the Campylobacter jejuniNCTC11168 genome sequence (2007)

Gundogdu, Ozan, Bentley, Stephen D, Holden, Matt T, Parkhill, Julian, Dorrell, Nick, Wren, Brendan W

Abstract Background Campylobacter jejuni is the leading bacterial cause of human gastroenteritis in the developed world. To improve our understanding of this important human pathogen, the C. jejuni...

Mutational Analysis of Genes Encoding the Early Flagellar Components of Helicobacter pylori: Evidence for Transcriptional Regulation of Flagellin A Biosynthesis

Allan, Elaine, Dorrell, Nick, Foynes, Susan, Anyim, Martin, Wren, Brendan W.

We investigated the roles of fliF, fliS, flhB, fliQ, fliG, and fliI of Helicobacter pylori, predicted by homology to encode structural components of the flagellar basal body and export apparatus....

Helicobacter pylori Possesses Two CheY Response Regulators and a Histidine Kinase Sensor, CheA, Which Are Essential for Chemotaxis and Colonization of the Gastric Mucosa

Foynes, Susan, Dorrell, Nick, Ward, Stephen J., Stabler, Richard A., McColm, Andy A., Rycroft, Andrew N., ...

Infection of the mucous layer of the human stomach by Helicobacter pylori requires the bacterium to be motile and presumably chemotactic. Previous studies have shown that fully functional flagella...

The Response Regulator PhoP Is Important for Survival under Conditions of Macrophage-Induced Stress and Virulence in Yersinia pestis

Oyston, Petra C. F., Dorrell, Nick, Williams, Kerstin, Li, Shu-Rui, Green, Michael, Titball, Richard W., ...

The two-component regulatory system PhoPQ has been identified in many bacterial species. However, the role of PhoPQ in regulating virulence gene expression in pathogenic bacteria has been...

Helicobacter pylori Pore-Forming Cytolysin Orthologue TlyA Possesses In Vitro Hemolytic Activity and Has a Role in Colonization of the Gastric Mucosa

Martino, M. Celeste, Stabler, Richard A., Zhang, Zun W., Farthing, Michael J. G., Wren, Brendan W., Dorrell, Nick

Hemolysins have been found to possess a variety of functions in bacteria, including a role in virulence. Helicobacter pylori demonstrates hemolytic activity when cultured on unlysed blood agar plates...

Whole Genome Comparison of Campylobacter jejuni Human Isolates Using a Low-Cost Microarray Reveals Extensive Genetic Diversity

Dorrell, Nick, Mangan, Joseph A., Laing, Kenneth G., Hinds, Jason, Linton, Dennis, Al-Ghusein, Hasan, ...

Campylobacter jejuni is the leading cause of bacterial food-borne diarrhoeal disease throughout the world, and yet is still a poorly understood pathogen. Whole genome microarray comparisons of 11 C....

Adaptation of Campylobacter jejuni NCTC11168 to High-Level Colonization of the Avian Gastrointestinal Tract

Jones, Michael A., Marston, Kerrie L., Woodall, Claire A., Maskell, Duncan J., Linton, Dennis, Karlyshev, Andrey V., ...

The genome sequence of the human pathogen Campylobacter jejuni NCTC11168 has been determined recently, but studies on colonization and persistence in chickens have been limited due to reports that...

Explorative Multifactor Approach for Investigating Global Survival Mechanisms of Campylobacter jejuni under Environmental Conditions

Moen, Birgitte, Oust, Astrid, Langsrud, Øyvind, Dorrell, Nick, Marsden, Gemma L., Hinds, Jason, ...

Explorative approaches such as DNA microarray experiments are becoming increasingly important in microbial research. Despite these major technical advancements, approaches to study multifactor...

Intestinal Innate Immunity to Campylobacter jejuni Results in Induction of Bactericidal Human Beta-Defensins 2 and 3

Zilbauer, Matthias, Dorrell, Nick, Boughan, Parjeet K., Harris, Andrew, Wren, Brendan W., Klein, Nigel J., ...

Campylobacter jejuni is the most prevalent cause of bacterial diarrhea worldwide. Despite the serious health problems caused by this bacterium, human innate immune responses to C. jejuni infection...

Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source

Champion, Olivia L., Gaunt, Michael W., Gundogdu, Ozan, Elmi, Abdi, Witney, Adam A., Hinds, Jason, ...

Campylobacter jejuni is the predominant cause of bacterial gastroenteritis worldwide, but traditional typing methods are unable to discriminate strains from different sources that cause disease in...

Mutational Analysis of Genes Encoding the Early Flagellar Components of Helicobacter pylori: Evidence for Transcriptional Regulation of Flagellin A Biosynthesis

Allan, Elaine, Dorrell, Nick, Foynes, Susan, Anyim, Martin, Wren, Brendan W.

We investigated the roles of fliF, fliS, flhB, fliQ, fliG, and fliI of Helicobacter pylori, predicted by homology to encode structural components of the flagellar basal body and export apparatus....

Helicobacter pylori Possesses Two CheY Response Regulators and a Histidine Kinase Sensor, CheA, Which Are Essential for Chemotaxis and Colonization of the Gastric Mucosa

Foynes, Susan, Dorrell, Nick, Ward, Stephen J., Stabler, Richard A., McColm, Andy A., Rycroft, Andrew N., ...

Infection of the mucous layer of the human stomach by Helicobacter pylori requires the bacterium to be motile and presumably chemotactic. Previous studies have shown that fully functional flagella...

The Response Regulator PhoP Is Important for Survival under Conditions of Macrophage-Induced Stress and Virulence in Yersinia pestis

Oyston, Petra C. F., Dorrell, Nick, Williams, Kerstin, Li, Shu-Rui, Green, Michael, Titball, Richard W., ...

The two-component regulatory system PhoPQ has been identified in many bacterial species. However, the role of PhoPQ in regulating virulence gene expression in pathogenic bacteria has been...

Helicobacter pylori Pore-Forming Cytolysin Orthologue TlyA Possesses In Vitro Hemolytic Activity and Has a Role in Colonization of the Gastric Mucosa

Martino, M. Celeste, Stabler, Richard A., Zhang, Zun W., Farthing, Michael J. G., Wren, Brendan W., Dorrell, Nick

Hemolysins have been found to possess a variety of functions in bacteria, including a role in virulence. Helicobacter pylori demonstrates hemolytic activity when cultured on unlysed blood agar plates...

Whole Genome Comparison of Campylobacter jejuni Human Isolates Using a Low-Cost Microarray Reveals Extensive Genetic Diversity

Dorrell, Nick, Mangan, Joseph A., Laing, Kenneth G., Hinds, Jason, Linton, Dennis, Al-Ghusein, Hasan, ...

Campylobacter jejuni is the leading cause of bacterial food-borne diarrhoeal disease throughout the world, and yet is still a poorly understood pathogen. Whole genome microarray comparisons of 11 C....

Adaptation of Campylobacter jejuni NCTC11168 to High-Level Colonization of the Avian Gastrointestinal Tract

Jones, Michael A., Marston, Kerrie L., Woodall, Claire A., Maskell, Duncan J., Linton, Dennis, Karlyshev, Andrey V., ...

The genome sequence of the human pathogen Campylobacter jejuni NCTC11168 has been determined recently, but studies on colonization and persistence in chickens have been limited due to reports that...

Explorative Multifactor Approach for Investigating Global Survival Mechanisms of Campylobacter jejuni under Environmental Conditions

Moen, Birgitte, Oust, Astrid, Langsrud, Øyvind, Dorrell, Nick, Marsden, Gemma L., Hinds, Jason, ...

Explorative approaches such as DNA microarray experiments are becoming increasingly important in microbial research. Despite these major technical advancements, approaches to study multifactor...

Intestinal Innate Immunity to Campylobacter jejuni Results in Induction of Bactericidal Human Beta-Defensins 2 and 3

Zilbauer, Matthias, Dorrell, Nick, Boughan, Parjeet K., Harris, Andrew, Wren, Brendan W., Klein, Nigel J., ...

Campylobacter jejuni is the most prevalent cause of bacterial diarrhea worldwide. Despite the serious health problems caused by this bacterium, human innate immune responses to C. jejuni infection...

Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source

Champion, Olivia L., Gaunt, Michael W., Gundogdu, Ozan, Elmi, Abdi, Witney, Adam A., Hinds, Jason, ...

Campylobacter jejuni is the predominant cause of bacterial gastroenteritis worldwide, but traditional typing methods are unable to discriminate strains from different sources that cause disease in...