Markevich, Nick I., Tsyganov, Mikhail A., Hoek, Jan B, Kholodenko, Boris N.
A hallmark of protein kinase/phosphatase cascades, including mitogen-activated protein kinase (MAPK) pathways, is the spatial separation of their components within cells. The top-level kinase, MAP3K,...
Signaling through Receptors and Scaffolds: Independent Interactions Reduce Combinatorial Complexity
Borisov, Nikolay M., Markevich, Nick I., Hoek, Jan B., Kholodenko, Boris N.
After activation, many receptors and their adaptor proteins act as scaffolds displaying numerous docking sites and engaging multiple targets. The consequent assemblage of a variety of protein...
Signaling through Receptors and Scaffolds: Independent Interactions Reduce Combinatorial Complexity
Borisov, Nikolay M., Markevich, Nick I., Hoek, Jan B., Kholodenko, Boris N.
After activation, many receptors and their adaptor proteins act as scaffolds displaying numerous docking sites and engaging multiple targets. The consequent assemblage of a variety of protein...
Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades
Markevich, Nick I, Tsyganov, Mikhail A, Hoek, Jan B, Kholodenko, Boris N
A hallmark of protein kinase/phosphatase cascades, including mitogen-activated protein kinase (MAPK) pathways, is the spatial separation of their components within cells. The top-level kinase, MAP3K,...
Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades
Markevich, Nick I., Hoek, Jan B., Kholodenko, Boris N.
Mitogen-activated protein kinase (MAPK) cascades can operate as bistable switches residing in either of two different stable states. MAPK cascades are often embedded in positive feedback loops, which...