Resident macrophages influence stem cell activity in the mammary gland (2009)
Gyorki, David E, Asselin-Labat, Marie-Liesse, Van Rooijen, Nico, Lindeman, Geoffrey J, Visvader, Jane E
Abstract Introduction Macrophages in the mammary gland are essential for morphogenesis of the ductal epithelial tree and have been implicated in promoting breast tumor metastasis. Although it is well...
Immune-to-brain signalling: the role of cerebral CD163-positive macrophages (2008)
Galea, Ian, Felton, Leigh M., Waters, Sara, Van Rooijen, Nico, Perry, V. Hugh, Newman, Tracey A.
Systemic inflammation induces cytokine synthesis within the central nervous system. This results in sickness behaviour and may exacerbate ongoing neuroinflammatory disease. The precise mechanisms...
Huang, Yao, Li, Zhiwei, Wang, Ningli, Van Rooijen, Nico, Cui, Qi
Abstract Background We recently showed that whereas inhibition of PI3K/akt or JAK/STAT pathway promoted retinal ganglion cell (RGC) survival after optic nerve (ON) injury in Fischer 344 (F344) rats,...
Matlung, Hanke L., Bonta, Peter, De Vries, Carlie J., Van Rooijen, Nico, VanBavel, Ed
Aims Altered blood flow affects vascular tone, attracts inflammatory cells, and leads to microvascular remodelling. We tested the hypothesis that inflammation facilitates the remodelling response,...
Zacchigna, Serena, Pattarini, Lucia, ...
Novel antiangiogenic strategies with complementary mechanisms are needed to maximize efficacy and minimize resistance to current angiogenesis inhibitors. We explored the therapeutic potential and...
Phagocyte-derived catecholamines enhance acute inflammatory injury (2007)
Flierl, Michael A., Rittirsch, Daniel, Nadeau, Brian A., Chen, Anthony J., Sarma, J. Vidya, Zetoune, Firas S., ...
It is becoming increasingly clear that the autonomic nervous system and the immune system demonstrate cross-talk during inflammation by means of sympathetic and parasympathetic pathways(1,2). We...
An antigen-specific pathway for CD8 T cells across the blood-brain barrier (2007)
Galea, Ian, Bernardes-Silva, Martine, Forse, Penny A., Van Rooijen, Nico, Liblau, Roland S., Perry, V. Hugh
CD8 T cells are nature's foremost defense in encephalitis and brain tumors. Antigen-specific CD8 T cells need to enter the brain to exert their beneficial effects. On the other hand, traffic of CD8 T...
Arnold, Ludovic, Henry, Adeline, Poron, Françoise, Baba-Amer, Yasmine, Van Rooijen, Nico, Plonquet, Anne, ...
Macrophages (MPs) are important for skeletal muscle regeneration in vivo and may exert beneficial effects on myogenic cell growth through mitogenic and antiapoptotic activities in vitro. However, MPs...
Arnold, Ludovic, Henry, Adeline, Poron, Françoise, Baba-Amer, Yasmine, Van Rooijen, Nico, Plonquet, Anne, ...
Macrophages (MPs) are important for skeletal muscle regeneration in vivo and may exert beneficial effects on myogenic cell growth through mitogenic and antiapoptotic activities in vitro. However, MPs...
Arnold, Ludovic, Henry, Adeline, Poron, Françoise, Baba-Amer, Yasmine, Van Rooijen, Nico, Plonquet, Anne, ...
Macrophages (MPs) are important for skeletal muscle regeneration in vivo and may exert beneficial effects on myogenic cell growth through mitogenic and antiapoptotic activities in vitro. However, MPs...
Scislowska-Czarnecka, Anna, Chadzinska, Magdalena, Plytycz, Barbara, Van Rooijen, Nico, ...
Increased vascular permeability leading to vascular leakage is a central feature of all inflammatory reactions and is critical for the formation of an inflammatory exudate. The leakage occurs because...
Anderson, Per, Durbeej, Madeleine, Van Rooijen, Nico, Ivars, Fredrik, ...
The endothelial cell monolayer of cerebral vessels and its basement membrane (BM) are ensheathed by the astrocyte endfeet, the leptomeningeal cells, and their associated parenchymal BM, all of which...
Agrawal, Smriti, Anderson, Per, Durbeej, Madeleine, Van Rooijen, Nico, Ivars, Fredrik, Opdenakker, Ghislain, ...
Abstract is not available
Blood-derived dendritic cells in an acute brain injury (2005)
Newman, Tracey A., Galea, Ian, Van Rooijen, Nico, Perry, V. Hugh
Dendritic cells (DC), while absent from the normal CNS parenchyma, have been demonstrated in delayed type hypersensitivity (DTH), experimental allergic encephalomyelitis (EAE), and some MS lesions....
RATIONALE: Inflammation and thrombosis are related via interactions between leukocytes, platelets, the vasculature, and the coagulation system. However, the mechanisms behind these interactions...
Galea, Ian, Palin, Karine, Newman, Tracey A., Van Rooijen, Nico, Perry, V. Hugh, Boche, Delphine
Perivascular macrophages are believed to have a significant role in inflammation in the central nervous system (CNS). They express a number of different receptors that point toward functions in both...
Sheikh, Nadeem A., Attard, George S., Van Rooijen, Nico, Rajananthanan, Palasingam, Hariharan, Kandasamy, Yang, Ya-Wum, ...
A major drawback of subunit vaccines is their inability to generate cytolytic T lymphocytes (CTL), a deficit attributed to segregation of the class I and class II antigen-processing pathways. We...
Schiedner, Gudrun, Brown, Brian, Johnston, Marion, ...
High-capacity adenoviral (HC-Ad) vectors expressing B-domain-deleted human or canine factor VIII from different liver-specific promoters were evaluated for gene therapy of hemophilia A. Intravenous...
Emoto, Masashi, Miyamoto, Mamiko, Emoto, Yoshiko, Yoshizawa, Izumi, Brinkmann, Volker, Van Rooijen, Nico, ...
Emoto, Masashi, Emoto, Yoshiko, Brinkmann, Volker, Miyamoto, Mamiko, Yoshizawa, Izumi, Staber, Manuela, ...
Cote, Christopher K., Van Rooijen, Nico, Welkos, Susan L.
The development of new approaches to combat anthrax requires that the pathogenesis and host response to Bacillus anthracis spores be better understood. We investigated the roles that macrophages and...
Jiang, Qingqi, DeTolla, Louis, Van Rooijen, Nico, Singh, Ishwar S., Fitzgerald, Bridget, Lipsky, Michael M., ...
Fever improves survival in acute infections, but the effects of increased core temperature on host defenses are poorly understood. Tumor necrosis factor alpha (TNF-α) is an early activator of host...
Lehner, Martin D., Ittner, Josepha, Bundschuh, Daniela S., Van Rooijen, Nico, Wendel, Albrecht, Hartung, Thomas
During infection with gram-negative bacteria, exposure of immune cells to lipopolysaccharide (LPS) from the bacterial cell membrane induces a rapid cytokine response which is essential for the...
Hanson, Laura K., Slater, Jacquelyn S., Karabekian, Zaruhi, Virgin, Herbert W., Biron, Christine A., Ruzek, Melanie C., ...
Blood monocytes or tissue macrophages play a pivotal role in the pathogenesis of murine cytomegalovirus (MCMV) infection, providing functions beneficial to both the virus and the host. In vitro and...
Xue, Shurong, Sun, Ning, Van Rooijen, Nico, Perlman, Stanley
Mice infected with the neurotropic coronavirus mouse hepatitis virus strain JHM (MHV-JHM) develop a chronic demyelinating disease with symptoms of hindlimb paralysis. Histological examination of the...
Chemokine Receptor CCR2 Is Not Essential for the Development of Experimental Cerebral Malaria
Belnoue, Elodie, Costa, Fabio T. M., Vigário, Ana M., Voza, Tatiana, Gonnet, Françoise, Landau, Irène, ...
Infection with Plasmodium berghei ANKA induces cerebral malaria in susceptible mice. Brain-sequestered CD8+ T cells are responsible for this pathology. We have evaluated the role of CCR2, a chemokine...
Tribulatti, María Virginia, Mucci, Juan, Van Rooijen, Nico, Leguizamón, María Susana, Campetella, Oscar
Strong thrombocytopenia is observed during acute infection with Trypanosoma cruzi, the parasitic protozoan agent of American trypanosomiasis or Chagas' disease. The parasite sheds trans-sialidase, an...
Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion
Schmieg, John, Yang, Guangli, Franck, Richard W., Van Rooijen, Nico, Tsuji, Moriya
It has been shown that dendritic cells (DCs) are able to present glycolipids to natural killer (NK) T cells in vivo. However, the essential role of DCs, as well as the role of other cells in...
Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages
Maruyama, Kazuichi, Ii, Masaaki, Cursiefen, Claus, Jackson, David G., Keino, Hiroshi, Tomita, Minoru, ...
In the inflamed cornea, there is a parallel outgrowth of blood and lymphatic vessels into the normally avascular cornea. We tested whether adaptive and/or innate immune cells were actively involved...
Ali, Sumia, King, Gwendalyn D., Curtin, James F., Candolfi, Marianela, Xiong, Weidong, Liu, Chunyan, ...
In spite of preclinical efficacy and recent randomized, controlled studies with adenoviral vectors expressing herpes simplex virus-1 thymidine kinase (HSV1-TK) showing statistically significant...
Tumpey, Terrence M., García-Sastre, Adolfo, Taubenberger, Jeffery K., Palese, Peter, Swayne, David E., Pantin-Jackwood, Mary J., ...
The Spanish influenza pandemic of 1918 to 1919 swept the globe and resulted in the deaths of at least 20 million people. The basis of the pulmonary damage and high lethality caused by the 1918 H1N1...
Cote, Christopher K., Van Rooijen, Nico, Welkos, Susan L.
The development of new approaches to combat anthrax requires that the pathogenesis and host response to Bacillus anthracis spores be better understood. We investigated the roles that macrophages and...
Wang, Honglin, Peters, Thorsten, Kess, Daniel, Sindrilaru, Anca, Oreshkova, Tsvetelina, Van Rooijen, Nico, ...
The CD18 hypomorphic (CD18hypo) PL/J mouse model clinically resembling human psoriasis is characterized by reduced expression of the common chain of β2 integrins (CD11/CD18) to only 2–16% of WT...
Stratis, Athanasios, Pasparakis, Manolis, Rupec, Rudolf A., Markur, Doreen, Hartmann, Karin, Scharffetter-Kochanek, Karin, ...
Psoriasis is a common skin disease, the pathogenesis of which has not yet been resolved. In mice, epidermis-specific deletion of inhibitor of NF-κB (IκB) kinase 2 (IKK2) results in a skin phenotype...
Jiang, Qingqi, DeTolla, Louis, Van Rooijen, Nico, Singh, Ishwar S., Fitzgerald, Bridget, Lipsky, Michael M., ...
Fever improves survival in acute infections, but the effects of increased core temperature on host defenses are poorly understood. Tumor necrosis factor alpha (TNF-α) is an early activator of host...
Lehner, Martin D., Ittner, Josepha, Bundschuh, Daniela S., Van Rooijen, Nico, Wendel, Albrecht, Hartung, Thomas
During infection with gram-negative bacteria, exposure of immune cells to lipopolysaccharide (LPS) from the bacterial cell membrane induces a rapid cytokine response which is essential for the...
Hanson, Laura K., Slater, Jacquelyn S., Karabekian, Zaruhi, Virgin, Herbert W., Biron, Christine A., Ruzek, Melanie C., ...
Blood monocytes or tissue macrophages play a pivotal role in the pathogenesis of murine cytomegalovirus (MCMV) infection, providing functions beneficial to both the virus and the host. In vitro and...
Xue, Shurong, Sun, Ning, Van Rooijen, Nico, Perlman, Stanley
Mice infected with the neurotropic coronavirus mouse hepatitis virus strain JHM (MHV-JHM) develop a chronic demyelinating disease with symptoms of hindlimb paralysis. Histological examination of the...
Chemokine Receptor CCR2 Is Not Essential for the Development of Experimental Cerebral Malaria
Belnoue, Elodie, Costa, Fabio T. M., Vigário, Ana M., Voza, Tatiana, Gonnet, Françoise, Landau, Irène, ...
Infection with Plasmodium berghei ANKA induces cerebral malaria in susceptible mice. Brain-sequestered CD8+ T cells are responsible for this pathology. We have evaluated the role of CCR2, a chemokine...
Tribulatti, María Virginia, Mucci, Juan, Van Rooijen, Nico, Leguizamón, María Susana, Campetella, Oscar
Strong thrombocytopenia is observed during acute infection with Trypanosoma cruzi, the parasitic protozoan agent of American trypanosomiasis or Chagas' disease. The parasite sheds trans-sialidase, an...
Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion
Schmieg, John, Yang, Guangli, Franck, Richard W., Van Rooijen, Nico, Tsuji, Moriya
It has been shown that dendritic cells (DCs) are able to present glycolipids to natural killer (NK) T cells in vivo. However, the essential role of DCs, as well as the role of other cells in...
Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages
Maruyama, Kazuichi, Ii, Masaaki, Cursiefen, Claus, Jackson, David G., Keino, Hiroshi, Tomita, Minoru, ...
In the inflamed cornea, there is a parallel outgrowth of blood and lymphatic vessels into the normally avascular cornea. We tested whether adaptive and/or innate immune cells were actively involved...
Tumpey, Terrence M., García-Sastre, Adolfo, Taubenberger, Jeffery K., Palese, Peter, Swayne, David E., Pantin-Jackwood, Mary J., ...
The Spanish influenza pandemic of 1918 to 1919 swept the globe and resulted in the deaths of at least 20 million people. The basis of the pulmonary damage and high lethality caused by the 1918 H1N1...
Cote, Christopher K., Van Rooijen, Nico, Welkos, Susan L.
The development of new approaches to combat anthrax requires that the pathogenesis and host response to Bacillus anthracis spores be better understood. We investigated the roles that macrophages and...
Wang, Honglin, Peters, Thorsten, Kess, Daniel, Sindrilaru, Anca, Oreshkova, Tsvetelina, Van Rooijen, Nico, ...
The CD18 hypomorphic (CD18hypo) PL/J mouse model clinically resembling human psoriasis is characterized by reduced expression of the common chain of β2 integrins (CD11/CD18) to only 2–16% of WT...
Stratis, Athanasios, Pasparakis, Manolis, Rupec, Rudolf A., Markur, Doreen, Hartmann, Karin, Scharffetter-Kochanek, Karin, ...
Psoriasis is a common skin disease, the pathogenesis of which has not yet been resolved. In mice, epidermis-specific deletion of inhibitor of NF-κB (IκB) kinase 2 (IKK2) results in a skin phenotype...
Tacke, Frank, Alvarez, David, Kaplan, Theodore J., Jakubzick, Claudia, Spanbroek, Rainer, Llodra, Jaime, ...
Monocytes participate critically in atherosclerosis. There are 2 major subsets expressing different chemokine receptor patterns: CCR2+CX3CR1+Ly-6Chi and CCR2–CX3CR1++Ly-6Clo monocytes. Both C-C...
Bauer, Dirk, Schmitz, Andreas, Van Rooijen, Nico, Steuhl, Klaus-Peter, Heiligenhaus, Arnd
Recently it has been shown that selective subconjunctival macrophage depletion reduced the incidence and severity of stromal herpes simplex virus (HSV) keratitis in mice. In this study, we examined...
Breitbach, Katrin , Klocke, Sonja, Tschernig, Thomas, Van Rooijen, Nico, Baumann, Ulrich, Steinmetz, Ivo
Infection with the soil bacterium Burkholderia pseudomallei can result in a variety of clinical outcomes, including asymptomatic infection. The initial immune defense mechanisms which might...
Frid, Maria G., Brunetti, Jacqueline A., Burke, Danielle L., Carpenter, Todd C., Davie, Neil J., Reeves, John T., ...
Vascular remodeling in chronic hypoxic pulmonary hypertension includes marked fibroproliferative changes in the pulmonary artery (PA) adventitia. Although resident PA fibroblasts have long been...
Distinctive Roles of Neutrophils and Monocytes in Anti-Thy-1 Nephritis
Westerhuis, Ralf, Van Straaten, Suzanne C., Van Rooijen, Nico, Verhagen, Nicole A. M., Dijkstra, Christine D., ...
Anti-Thy-1.1 glomerulonephritis as an experimental model for mesangial proliferative glomerulonephritis was induced in Wistar rats by a single injection of monoclonal IgG2a–anti-Thy-1.1 antibody...
Lundberg, Patric, Welander, Paula V., Edwards, Carl K., Van Rooijen, Nico, Cantin, Edouard
Tumor necrosis factor (TNF) is a multifunctional cytokine that has a role in induction and regulation of host innate and adaptive immune responses. The importance of TNF antiviral mechanisms is...
Importance of Kupffer Cells for T-Cell-Dependent Liver Injury in Mice
Schümann, Jens, Wolf, Dominik, Pahl, Andreas, Brune, Kay, Papadopoulos, Thomas, Van Rooijen, Nico, ...
T cells seem to be responsible for liver damage in any type of acute hepatitis. Nevertheless, the importance of Kupffer cells (KCs) for T-cell-dependent liver failure is unclear. Here we focus on the...
Activator Protein-1 Activation in Acute Lung Injury
Guo, Ren-Feng, Lentsch, Alex B., Sarma, J. Vidya, Sun, Lei, Riedemann, Niels C., McClintock, Shannon D., ...
The role of activator protein-1 (AP-1) in inflammation is primarily unknown. AP-1 was evaluated in nuclear extracts from alveolar macrophages and whole lung nuclear extracts during acute lung injury...
Evans, Krystal J., Hansen, Diana S., Van Rooijen, Nico, Buckingham, Lynn A., Schofield, Louis
Severe malarial anemia (SMA) is the most frequent life-threatening complication of malaria and may contribute to the majority of malarial deaths worldwide. To explore the mechanisms of pathogenesis,...
Carbonetti, Nicholas H., Artamonova, Galina V., Van Rooijen, Nico, Ayala, Victor I.
Pertussis toxin (PT), a secreted virulence factor of Bordetella pertussis, ADP ribosylates mammalian Gi proteins and plays an important early role in respiratory tract infection by this pathogen in a...
Van Amerongen, Machteld J., Harmsen, Martin C., Van Rooijen, Nico, Petersen, Arjen H.
Macrophages have been suggested to be beneficial for myocardial wound healing. We investigated the role of macrophages in myocardial wound healing by inhibition of macrophage infiltration after...
Tacke, Frank, Ginhoux, Florent, Jakubzick, Claudia, Van Rooijen, Nico, Merad, Miriam, Randolph, Gwendalyn J.
Monocytes are circulating precursors for tissue macrophages and dendritic cells (DCs) but are not recognized to directly participate in antigen presentation. We developed techniques to label mouse...
Agrawal, Smriti, Anderson, Per, Durbeej, Madeleine, Van Rooijen, Nico, Ivars, Fredrik, Opdenakker, Ghislain, ...
The endothelial cell monolayer of cerebral vessels and its basement membrane (BM) are ensheathed by the astrocyte endfeet, the leptomeningeal cells, and their associated parenchymal BM, all of which...
Arnold, Ludovic, Henry, Adeline, Poron, Françoise, Baba-Amer, Yasmine, Van Rooijen, Nico, Plonquet, Anne, ...
Macrophages (MPs) are important for skeletal muscle regeneration in vivo and may exert beneficial effects on myogenic cell growth through mitogenic and antiapoptotic activities in vitro. However, MPs...
Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells
Wang, Hui, Madariaga, Maria Lucia, Wang, Shumei, Van Rooijen, Nico, Oldenborg, Per-Arne, Yang, Yong-Guang
Macrophages recognize CD47 as a marker of “self” and phagocytose CD47null hematopoietic cells. Using CD47 chimera models, here, we show that the phagocytic activity of macrophages against...
An antigen-specific pathway for CD8 T cells across the blood-brain barrier
Galea, Ian, Bernardes-Silva, Martine, Forse, Penny A., Van Rooijen, Nico, Liblau, Roland S., Perry, V. Hugh
CD8 T cells are nature's foremost defense in encephalitis and brain tumors. Antigen-specific CD8 T cells need to enter the brain to exert their beneficial effects. On the other hand, traffic of CD8 T...
Qu, Chunfeng, Edwards, Emmerson W., Tacke, Frank, Angeli, Véronique, Llodrá, Jaime, Sanchez-Schmitz, Guzman, ...
Studying the influence of chemokine receptors (CCRs) on monocyte fate may reveal information about which subpopulations of monocytes convert to dendritic cells (DCs) and the migration pathways that...
Couper, Kevin N., Blount, Daniel G., Hafalla, Julius C. R., Van Rooijen, Nico, De Souza, J. Brian, Riley, Eleanor M.
In most models of blood-stage malaria infection, proinflammatory immune responses are required for control of infection and elimination of parasites. We hypothesized therefore that the fulminant...
Price, Jason D., Simpfendorfer, Kim R., Mantena, Radhakrishnam R., Holden, James, Heath, William R., Van Rooijen, Nico, ...
Interleukin-12 (IL-12) and IL-18 are both central to the induction of gamma interferon (IFN-γ), and various roles for IL-12 and IL-18 in control of intracellular microbial infections have been...
Nolte, Martijn A., Beliën, Jeroen A.M., Schadee-Eestermans, Inge, Jansen, Wendy, Unger, Wendy W.J., Van Rooijen, Nico, ...
Access to the splenic white pulp is restricted to lymphocytes and dendritic cells. Here we show that movement of molecules from the blood into these confined areas is also limited. Large molecules,...
The Role of Macrophages in T Cell–mediated Autoimmune Diabetes in Nonobese Diabetic Mice
Jun, Hee-Sook, Yoon, Chang-Soon, Zbytnuik, Lori, Van Rooijen, Nico, Yoon, Ji-Won
We have shown previously that the inactivation of macrophages in nonobese diabetic (NOD) mice results in the prevention of diabetes; however, the mechanisms involved remain unknown. In this study, we...
Badell, Edgar, Oeuvray, Claude, Moreno, Alicia, Soe, Soe, Van Rooijen, Nico, Bouzidi, Ahmed, ...
We have recently described that sustained Plasmodium falciparum growth could be obtained in immunodeficient mice. We now report the potential of this new mouse model by assaying the effect of the...
Mucosal Damage and Neutropenia Are Required for Candida albicans Dissemination
Koh, Andrew Y, Köhler, Julia R, Coggshall, Kathleen T, Van Rooijen, Nico, Pier, Gerald B
Candida albicans fungemia in cancer patients is thought to develop from initial gastrointestinal (GI) colonization with subsequent translocation into the bloodstream after administration of...
Alveolar Macrophages Are Indispensable for Controlling Influenza Viruses in Lungs of Pigs▿
Kim, Heui Man, Lee, Young-Won, Lee, Ki-Ja, Kim, Hyun Soo, Cho, Sung Whan, Van Rooijen, Nico, ...
Alveolar macrophages constitutively reside in the respiratory tracts of pigs and humans. An in vivo role of alveolar macrophages in defending against influenza viruses in mice infected with a...
Macrophages Are Mediators of Gastritis in Acute Helicobacter pylori Infection in C57BL/6 Mice▿
Kaparakis, Maria, Walduck, Anna K., Price, Jason D., Pedersen, John S., Van Rooijen, Nico, Pearse, Martin J., ...
Helicobacter pylori is the etiological agent of human chronic gastritis, a condition seen as a precursor to the development of gastrointestinal ulcers or gastric cancer. This study utilized the...
Bréchot, Nicolas, Gomez, Elisa, Bignon, Marine, Khallou-Laschet, Jamila, Dussiot, Michael, Cazes, Aurélie, ...
McGill, Jodi, Van Rooijen, Nico, Legge, Kevin L.
Influenza infections induce a rapid, but transient, dendritic cell (DC) migration from the lungs to the lymph nodes (LNs) that is followed by substantial recruitment of DCs into the lungs without...
Halin, Sofia, Rudolfsson, Stina Häggström, Van Rooijen, Nico, Bergh, Anders
Tumor-associated macrophages are involved in angiogenesis and tumor progression, but their role and specific site of action in prostate cancer remain unknown. To explore this, Dunning R-3327 AT-1 rat...
Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP
Bystrom, Jonas, Evans, Ian, Newson, Justine, Stables, Melanie, Toor, Iqbal, Van Rooijen, Nico, ...
Neutralizing injurious stimuli, proinflammatory mediator catabolism, and polymorphonuclear leukocyte (PMN) clearance are determinants of inflammatory resolution. To this, we recently added...
Getts, Daniel R., Terry, Rachael L., Getts, Meghann Teague, Müller, Marcus, Rana, Sabita, Shrestha, Bimmi, ...
In a lethal West Nile virus (WNV) model, central nervous system infection triggered a threefold increase in CD45int/CD11b+/CD11c− microglia at days 6–7 postinfection (p.i.). Few microglia were...
Cawood, Ryan, Chen, Hannah H., Carroll, Fionnadh, Bazan-Peregrino, Miriam, Van Rooijen, Nico, Seymour, Leonard W.
Replicating viruses have broad applications in biomedicine, notably in cancer virotherapy and in the design of attenuated vaccines; however, uncontrolled virus replication in vulnerable tissues can...
Tang, Paul C.Y., Qin, Lingfeng, Zielonka, Jacek, Zhou, Jing, Matte-Martone, Catherine, Bergaya, Sonia, ...
Vascular remodeling normalizes abnormal hemodynamic stresses through structural changes affecting vessel size and wall thickness. We investigated the role of inflammation in flow-mediated vascular...
TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus
Lee, Pui Y., Kumagai, Yutaro, Li, Yi, Takeuchi, Osamu, Yoshida, Hideo, Weinstein, Jason, ...
Increased type I interferon (IFN-I) production and IFN-stimulated gene (ISG) expression are linked to the pathogenesis of systemic lupus erythematosus (SLE). Although the mechanisms responsible for...
Effect of Neutralizing Sera on Factor X-Mediated Adenovirus Serotype 5 Gene Transfer▿
Parker, Alan L., Waddington, Simon N., Buckley, Suzanne M. K., Custers, Jerome, Havenga, Menzo J. E., Van Rooijen, Nico, ...
The deployment of adenovirus serotype 5 (Ad5)-based vectors is hampered by preexisting immunity. When such vectors are delivered intravenously, hepatocyte transduction is mediated by the...
Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function
Campion, Sarah N., Johnson, Rachel, Aleksunes, Lauren M., Goedken, Michael J., Van Rooijen, Nico, Scheffer, George L., ...
During acetaminophen (APAP) hepatotoxicity, increased expression of multidrug resistance-associated proteins 2, 3, and 4 (Mrp2-4) occurs. Mrp4 is the most significantly upregulated transporter in...
Resident macrophages influence stem cell activity in the mammary gland
Gyorki, David E, Asselin-Labat, Marie-Liesse, Van Rooijen, Nico, Lindeman, Geoffrey J, Visvader, Jane E
Larsson, Christer, Lundqvist, Jenny, Van Rooijen, Nico, Bergström, Sven
Louse-borne relapsing fever (LBRF) borreliosis is caused by Borrelia recurrentis, and it is a deadly although treatable disease that is endemic in the Horn of Africa but has epidemic potential....
Hippen, Keli L., Harker-Murray, Paul, Porter, Stephen B., Merkel, Sarah C., Londer, Aryel, Taylor, Dawn K., ...
Previously, we showed that human umbilical cord blood (UCB) regulatory T cells (Tregs) could be expanded approximately 100-fold using anti-CD3/28 monoclonal antibody (mAb)–coated beads to provide...
Zhao, Jincun, Zhao, Jingxian, Van Rooijen, Nico, Perlman, Stanley
Severe Acute Respiratory Syndrome caused substantial morbidity and mortality during the 2002–2003 epidemic. Many of the features of the human disease are duplicated in BALB/c mice infected with a...
Role of Lung-marginated Monocytes in an In Vivo Mouse Model of Ventilator-induced Lung Injury
Wilson, Michael R., O'Dea, Kieran P., Zhang, Da, Shearman, Alexander D., Van Rooijen, Nico, Takata, Masao
Rationale: Recruited leukocytes play an important role in ventilator-induced lung injury, although studies have focused predominantly on neutrophils. Inflammatory subset Gr-1high monocytes are...