Nicole Kirchhof

Microarray Analysis of Neurosphere Cells Treated Chromatin Modifying Agents (2008)

David Ruau, Christine Hacker, Nicole Kirchhof, Tim Beissbarth, Ralf D. Kirsch, Carolin Schmittwolf, ...

Abstract: DNA microarray analysis provides a powerful tool for determining changes in gene expression on a genome wide scale. The chromatin modifying agents 5-Aza-2’-deoxycytidine (AzaC) and...

In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents

Schmittwolf, Carolin, Kirchhof, Nicole, Jauch, Anna, Dürr, Michael, Harder, Friedrich, Zenke, Martin, ...

Modifications of DNA and chromatin are fundamental for the establishment and maintenance of cell type-specific gene expression patterns that constitute cellular identities. To test whether the...

Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse

Carlson, Corey M., Frandsen, Joel L., Kirchhof, Nicole, McIvor, R. Scott, Largaespada, David A.

The Sleeping Beauty (SB) transposon system can integrate foreign sequences of DNA in the genome of mouse somatic cells eliciting long-term expression in vivo. This technology holds great promise for...

In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents

Schmittwolf, Carolin, Kirchhof, Nicole, Jauch, Anna, Dürr, Michael, Harder, Friedrich, Zenke, Martin, ...

Modifications of DNA and chromatin are fundamental for the establishment and maintenance of cell type-specific gene expression patterns that constitute cellular identities. To test whether the...

Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse

Carlson, Corey M., Frandsen, Joel L., Kirchhof, Nicole, McIvor, R. Scott, Largaespada, David A.

The Sleeping Beauty (SB) transposon system can integrate foreign sequences of DNA in the genome of mouse somatic cells eliciting long-term expression in vivo. This technology holds great promise for...

A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy

Chen, Weili, Li, Quanzhi, Hudson, Wendy A., Kumar, Ashish, Kirchhof, Nicole, Kersey, John H.

The 2 most frequent human MLL hematopoietic malignancies involve either AF4 or AF9 as fusion partners; each has distinct biology but the role of the fusion partner is not clear. We produced Mll-AF4...