Role of the neural crest in face and brain development. (2007)
Le Douarin, Nicole M, Brito, José M, Creuzet, Sophie
Since the time of Ramon y Cajal, very significant progress has been accomplished in our knowledge of the fate of the early neural primordium. The origin of the peripheral nervous system from the...
Role of the neural crest in face and brain development. (2007)
Le Douarin, Nicole M, Brito, José M, Creuzet, Sophie
Since the time of Ramon y Cajal, very significant progress has been accomplished in our knowledge of the fate of the early neural primordium. The origin of the peripheral nervous system from the...
Real, Carla, Glavieux-Pardanaud, Corinne, Le Douarin, Nicole M, Dupin, Elisabeth
The differentiation of a given cell should be irreversible in order to ensure cell-type-specific function and stability of resident tissue. However, under stimulation in vitro or during regeneration,...
The contribution of the neural crest to the vertebrate body. (2006)
Dupin, Elisabeth, Creuzet, Sophie, Le Douarin, Nicole M
As a transitory structure providing adult tissues of the vertebrates with very diverse cell types, the neural crest (NC) has attracted for long the interest of developmental biologists and is still...
Real, Carla, Glavieux-Pardanaud, Corinne, Le Douarin, Nicole M, Dupin, Elisabeth
The differentiation of a given cell should be irreversible in order to ensure cell-type-specific function and stability of resident tissue. However, under stimulation in vitro or during regeneration,...
The contribution of the neural crest to the vertebrate body. (2006)
Dupin, Elisabeth, Creuzet, Sophie, Le Douarin, Nicole M
As a transitory structure providing adult tissues of the vertebrates with very diverse cell types, the neural crest (NC) has attracted for long the interest of developmental biologists and is still...
Baker, Clare V. H., Bronner-Fraser, Marianne, Le Douarin, Nicole M., Teillet, Marie-Aimée
We present the first in vivo study of the long-term fate and potential of early-migrating and late-migrating mesencephalic neural crest cell populations, by performing isochronic and heterochronic...
Desaki, Junzo, Kinutani, Masae, Tan-Takeuchi, Kyoko, Le Douarin, Nicole M.
The migration of leucocytes through the walls of venules was examined in detail in the posterior latissimus dorsi muscle of quail-chick spinal cord chimeras, in which flaccid paralysis of the wings...
Martin, Claude, Belo, Maurice, Le Douarin, Nicole M., Corbel, Catherine
We report here that different organ grafts are not equally competent to induce tolerance of the host even if they are performed early in development, I.e. before the host's immune system has started...
Dupin, Elisabeth, Glavieux, Corinne, Vaigot, Pierre, Le Douarin, Nicole M.
Functional signaling of endothelin 3 (ET3) and its receptor B (ETRB) has been shown to be required for the development of neural crest (NC)-derived pigment cells in mouse, but the precise role of ET3...
Cloning and characterization of a novel endothelin receptor subtype in the avian class
Lecoin, Laure, Sakurai, Takeshi, Ngo, Minh-Triet, Abe, Yoichiro, Yanagisawa, Masashi, Le Douarin, Nicole M.
Endothelin 3 (EDN 3) and the endothelin receptor B (EDNRB) are involved in the development of neural crest and particularly of the melanocytes and the enteric nervous system. We reported previously...
Thomas-Vaslin, Véronique, Damotte, Diane, Coltey, Monique, Le Douarin, Nicole M., Coutinho, Antonio, Salaün, Josselyne
To investigate the role of primary T cell repertoire selection in the immunopathogenesis of autoimmune diseases, pure thymic epithelium (TE) from nonobese diabetic (NOD) embryos was grafted into non...
Lahav, Ronit, Dupin, Elisabeth, Lecoin, Laure, Glavieux, Corinne, Champeval, Delphine, Ziller, Catherine, ...
Genetic data in the mouse have shown that endothelin 3 (ET3) and its receptor B (ETRB) are essential for the development of two neural crest (NC) derivatives, the melanocytes and the enteric nervous...
Eichmann, Anne, Corbel, Catherine, Nataf, Valérie, Vaigot, Pierre, Bréant, Christiane, Le Douarin, Nicole M.
The existence of a common precursor for endothelial and hemopoietic cells, termed the hemangioblast, has been postulated since the beginning of the century. Recently, deletion of the...
Dupin, Elisabeth, Real, Carla, Glavieux-Pardanaud, Corinne, Vaigot, Pierre, Le Douarin, Nicole M.
In vertebrate embryos, diversification of the lineages arising from the neural crest (NC) is controlled to a large extent by environmental factors. In previous work, we showed that endothelin 3 (ET3)...
Self-renewal capacity is a widespread property of various types of neural crest precursor cells
Trentin, Andréa, Glavieux-Pardanaud, Corinne, Le Douarin, Nicole M., Dupin, Elisabeth
In vertebrates, trunk neural crest (NC) generates glia, neurons, and melanocytes. In addition, it yields mesectodermal derivatives (connective tissues, chondrocytes, and myofibroblasts lining the...
Reciprocal relationships between Fgf8 and neural crest cells in facial and forebrain development
Creuzet, Sophie, Schuler, Bernadette, Couly, Gérard, Le Douarin, Nicole M.
Fgf8 exerts a strong effect on the mesenchymal cells of neural crest (NC) origin that are fated to form the facial skeleton. Surgical extirpation of facial skeletogenic NC domain (including...
Dupin, Elisabeth, Glavieux, Corinne, Vaigot, Pierre, Le Douarin, Nicole M.
Functional signaling of endothelin 3 (ET3) and its receptor B (ETRB) has been shown to be required for the development of neural crest (NC)-derived pigment cells in mouse, but the precise role of ET3...
Cloning and characterization of a novel endothelin receptor subtype in the avian class
Lecoin, Laure, Sakurai, Takeshi, Ngo, Minh-Triet, Abe, Yoichiro, Yanagisawa, Masashi, Le Douarin, Nicole M.
Endothelin 3 (EDN 3) and the endothelin receptor B (EDNRB) are involved in the development of neural crest and particularly of the melanocytes and the enteric nervous system. We reported previously...
Thomas-Vaslin, Véronique, Damotte, Diane, Coltey, Monique, Le Douarin, Nicole M., Coutinho, Antonio, Salaün, Josselyne
To investigate the role of primary T cell repertoire selection in the immunopathogenesis of autoimmune diseases, pure thymic epithelium (TE) from nonobese diabetic (NOD) embryos was grafted into non...
Lahav, Ronit, Dupin, Elisabeth, Lecoin, Laure, Glavieux, Corinne, Champeval, Delphine, Ziller, Catherine, ...
Genetic data in the mouse have shown that endothelin 3 (ET3) and its receptor B (ETRB) are essential for the development of two neural crest (NC) derivatives, the melanocytes and the enteric nervous...
Eichmann, Anne, Corbel, Catherine, Nataf, Valérie, Vaigot, Pierre, Bréant, Christiane, Le Douarin, Nicole M.
The existence of a common precursor for endothelial and hemopoietic cells, termed the hemangioblast, has been postulated since the beginning of the century. Recently, deletion of the...
Dupin, Elisabeth, Real, Carla, Glavieux-Pardanaud, Corinne, Vaigot, Pierre, Le Douarin, Nicole M.
In vertebrate embryos, diversification of the lineages arising from the neural crest (NC) is controlled to a large extent by environmental factors. In previous work, we showed that endothelin 3 (ET3)...
Self-renewal capacity is a widespread property of various types of neural crest precursor cells
Trentin, Andréa, Glavieux-Pardanaud, Corinne, Le Douarin, Nicole M., Dupin, Elisabeth
In vertebrates, trunk neural crest (NC) generates glia, neurons, and melanocytes. In addition, it yields mesectodermal derivatives (connective tissues, chondrocytes, and myofibroblasts lining the...
Reciprocal relationships between Fgf8 and neural crest cells in facial and forebrain development
Creuzet, Sophie, Schuler, Bernadette, Couly, Gérard, Le Douarin, Nicole M.
Fgf8 exerts a strong effect on the mesenchymal cells of neural crest (NC) origin that are fated to form the facial skeleton. Surgical extirpation of facial skeletogenic NC domain (including...
Brito, José M., Teillet, Marie-Aimée, Le Douarin, Nicole M.
We have investigated the role of Sonic hedgehog (Shh) in the development of facial structures by depriving chicken embryos of the most anterior sources of this morphogen, including the prechordal...
The cephalic neural crest exerts a critical effect on forebrain and midbrain development
Creuzet, Sophie E., Martinez, Salvador, Le Douarin, Nicole M.
Encephalisation is the most important characteristic in the evolutionary transition leading from protochordates to vertebrates. This event has coincided with the emergence of a transient and...
Creuzet, Sophie, Couly, Gérard, Le Douarin, Nicole M
Studies carried out in the avian embryo and based on the construction of quail–chick chimeras have shown that most of the skull and all the facial and visceral skeleton are derived from the...
Martin, Claude, Ohki-Hamazaki, Hiroko, Corbel, Catherine, Coltey, Monique, Le Douarin, Nicole M.
In previous experiments, we have demonstrated that limb buds engrafted during embryonic life at E4, between MHC-mismatched chick embryos, are not only tolerated after birth, but induce in the...
Calloni, Giordano W., Glavieux-Pardanaud, Corinne, Le Douarin, Nicole M., Dupin, Elisabeth
In the vertebrate embryo, the cephalic neural crest cells (CNCCs) produce cells belonging to two main lineages: the neural [including neurons, glial cells of the peripheral nervous system (PNS), and...