Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...
The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...
Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...
The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...
Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...
The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...
Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...
The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...
Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...
The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...
Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...
The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...
Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...
The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...
Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...
The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...
Twenty proteins containing a C-terminal SOCS box form five structural classes
Hilton, Douglas J., Richardson, Rachael T., Alexander, Warren S., Viney, Elizabeth M., Willson, Tracy A., Sprigg, Naomi S., ...
The four members of the recently identified suppressor of cytokines signaling family (SOCS-1, SOCS-2, SOCS-3, and CIS, where CIS is cytokine-inducible SH2-containing protein) appear, by various...
Nicholson, Sandra E., De Souza, David, Fabri, Louis J., Corbin, Jason, Willson, Tracy A., Zhang, Jian-Guo, ...
Suppressor of cytokine signaling-3 (SOCS-3) is one member of a family of intracellular inhibitors of signaling pathways initiated by cytokines that use, among others, the common receptor subunit...
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
Starr, Robyn, Metcalf, Donald, Elefanty, Andrew G., Brysha, Marta, Willson, Tracy A., Nicola, Nicos A., ...
SOCS-1, a member of the suppressor of cytokine signaling (SOCS) family, was identified in a genetic screen for inhibitors of interleukin 6 signal transduction. SOCS-1 transcription is induced by...
Zhang, Jian-Guo, Farley, Alison, Nicholson, Sandra E., Willson, Tracy A., Zugaro, Lisa M., Simpson, Richard J., ...
The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors of several cytokine signal transduction pathways. Their expression is induced by cytokine activation of...
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
Roberts, Andrew W., Robb, Lorraine, Rakar, Steven, Hartley, Lynne, Cluse, Leonie, Nicola, Nicos A., ...
Mice lacking suppressor of cytokine signaling 3 (SOCS3) exhibited embryonic lethality with death occurring between days 11 and 13 of gestation. At this stage, SOCS3−/− embryos were slightly...
Zhang, Jian-Guo, Metcalf, Donald, Rakar, Steven, Asimakis, Maria, Greenhalgh, Christopher J., Willson, Tracy A., ...
Suppressor of Cytokine Signaling-1 (SOCS-1) is an essential physiological inhibitor of IFN-γ signaling. Mice lacking this gene die in the early postnatal period from a disease characterized by...
Functional Analysis of Asb-1 Using Genetic Modification in Mice
Kile, Benjamin T., Metcalf, Donald, Mifsud, Sandra, DiRago, Ladina, Nicola, Nicos A., Hilton, Douglas J., ...
The Asbs are a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif, which was first identified in the suppressor of cytokine signaling...
Metcalf, Donald, Mifsud, Sandra, Di Rago, Ladina, Nicola, Nicos A., Hilton, Douglas J., Alexander, Warren S.
Mice with inactivation of the gene encoding the suppressor of cytokine signaling-1 (SOCS-1) die in neonatal life with an IFN-γ-dependent inflammatory disease dominated by fatty degeneration and...
Krebs, Danielle L., Uren, Rachel T., Metcalf, Donald, Rakar, Steven, Zhang, Jian-Guo, Starr, Robyn, ...
SOCS-6 is a member of the suppressor of cytokine signaling (SOCS) family of proteins (SOCS-1 to SOCS-7 and CIS) which each contain a central SH2 domain and a carboxyl-terminal SOCS box. SOCS-1,...
Carpinelli, Marina R., Hilton, Douglas J., Metcalf, Donald, Antonchuk, Jennifer L., Hyland, Craig D., Mifsud, Sandra L., ...
Genetic screens in lower organisms, particularly those that identify modifiers of preexisting genetic defects, have been used successfully to order components of complex signaling pathways. To date,...
Brender, Christine, Columbus, Ruth, Metcalf, Donald, Handman, Emanuela, Starr, Robyn, Huntington, Nick, ...
Suppressors of cytokine signaling (SOCSs) are key regulators of cytokine-induced responses in hematopoietic as well as nonhematopoietic cells. SOCS1 and SOCS3 have been shown to modulate T-cell...
Development of hydrocephalus in mice lacking SOCS7
Krebs, Danielle L., Metcalf, Donald, Merson, Tobias D., Voss, Anne K., Thomas, Tim, Zhang, Jian-Guo, ...
SOCS7 is a member of the suppressor of cytokine signaling (SOCS) family of proteins (SOCS1-SOCS7 and CIS). SOCS proteins are composed of an N-terminal domain of variable length, a central Src...
SOCS2 negatively regulates growth hormone action in vitro and in vivo
Greenhalgh, Christopher J., Rico-Bautista, Elizabeth, Lorentzon, Mattias, Thaus, Anne L., Morgan, Phillip O., Willson, Tracy A., ...
Mice deficient in SOCS2 display an excessive growth phenotype characterized by a 30–50% increase in mature body size. Here we show that the SOCS2–/– phenotype is dependent upon the presence of...
Nicholson, Sandra E., Metcalf, Donald, Sprigg, Naomi S., Columbus, Ruth, Walker, Francesca, Silva, Anabel, ...
The suppressors of cytokine signaling (SOCS) proteins are a family of SH2 domain-containing intracellular inhibitors of cytokine signal transduction that act by several different mechanisms. Recent...
Burgess, Antony W., Metcalf, Donald, Russell, Sue H. M., Nicola, Nicos A.
The formation of mature haemopoietic cells is controlled by hormones that specifically stimulate the progenitor cells of the granulocyte/macrophage, eosinophil, megakaryocyte and erythroid pathways....
Fairlie, W Douglas, De Souza, David, Nicola, Nicos A, Baca, Manuel
Cytokines of the interleukin-6 family utilize the shared cytokine receptor gp130 in the formation of active signalling complexes. Tyrosine-757 (Y757) on this receptor is critical for negative...
Twenty proteins containing a C-terminal SOCS box form five structural classes
Hilton, Douglas J., Richardson, Rachael T., Alexander, Warren S., Viney, Elizabeth M., Willson, Tracy A., Sprigg, Naomi S., ...
The four members of the recently identified suppressor of cytokines signaling family (SOCS-1, SOCS-2, SOCS-3, and CIS, where CIS is cytokine-inducible SH2-containing protein) appear, by various...
Nicholson, Sandra E., De Souza, David, Fabri, Louis J., Corbin, Jason, Willson, Tracy A., Zhang, Jian-Guo, ...
Suppressor of cytokine signaling-3 (SOCS-3) is one member of a family of intracellular inhibitors of signaling pathways initiated by cytokines that use, among others, the common receptor subunit...
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
Starr, Robyn, Metcalf, Donald, Elefanty, Andrew G., Brysha, Marta, Willson, Tracy A., Nicola, Nicos A., ...
SOCS-1, a member of the suppressor of cytokine signaling (SOCS) family, was identified in a genetic screen for inhibitors of interleukin 6 signal transduction. SOCS-1 transcription is induced by...
Zhang, Jian-Guo, Farley, Alison, Nicholson, Sandra E., Willson, Tracy A., Zugaro, Lisa M., Simpson, Richard J., ...
The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors of several cytokine signal transduction pathways. Their expression is induced by cytokine activation of...
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
Roberts, Andrew W., Robb, Lorraine, Rakar, Steven, Hartley, Lynne, Cluse, Leonie, Nicola, Nicos A., ...
Mice lacking suppressor of cytokine signaling 3 (SOCS3) exhibited embryonic lethality with death occurring between days 11 and 13 of gestation. At this stage, SOCS3−/− embryos were slightly...
Zhang, Jian-Guo, Metcalf, Donald, Rakar, Steven, Asimakis, Maria, Greenhalgh, Christopher J., Willson, Tracy A., ...
Suppressor of Cytokine Signaling-1 (SOCS-1) is an essential physiological inhibitor of IFN-γ signaling. Mice lacking this gene die in the early postnatal period from a disease characterized by...
Functional Analysis of Asb-1 Using Genetic Modification in Mice
Kile, Benjamin T., Metcalf, Donald, Mifsud, Sandra, DiRago, Ladina, Nicola, Nicos A., Hilton, Douglas J., ...
The Asbs are a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif, which was first identified in the suppressor of cytokine signaling...
Metcalf, Donald, Mifsud, Sandra, Di Rago, Ladina, Nicola, Nicos A., Hilton, Douglas J., Alexander, Warren S.
Mice with inactivation of the gene encoding the suppressor of cytokine signaling-1 (SOCS-1) die in neonatal life with an IFN-γ-dependent inflammatory disease dominated by fatty degeneration and...
Krebs, Danielle L., Uren, Rachel T., Metcalf, Donald, Rakar, Steven, Zhang, Jian-Guo, Starr, Robyn, ...
SOCS-6 is a member of the suppressor of cytokine signaling (SOCS) family of proteins (SOCS-1 to SOCS-7 and CIS) which each contain a central SH2 domain and a carboxyl-terminal SOCS box. SOCS-1,...
Carpinelli, Marina R., Hilton, Douglas J., Metcalf, Donald, Antonchuk, Jennifer L., Hyland, Craig D., Mifsud, Sandra L., ...
Genetic screens in lower organisms, particularly those that identify modifiers of preexisting genetic defects, have been used successfully to order components of complex signaling pathways. To date,...
Brender, Christine, Columbus, Ruth, Metcalf, Donald, Handman, Emanuela, Starr, Robyn, Huntington, Nick, ...
Suppressors of cytokine signaling (SOCSs) are key regulators of cytokine-induced responses in hematopoietic as well as nonhematopoietic cells. SOCS1 and SOCS3 have been shown to modulate T-cell...
Development of hydrocephalus in mice lacking SOCS7
Krebs, Danielle L., Metcalf, Donald, Merson, Tobias D., Voss, Anne K., Thomas, Tim, Zhang, Jian-Guo, ...
SOCS7 is a member of the suppressor of cytokine signaling (SOCS) family of proteins (SOCS1-SOCS7 and CIS). SOCS proteins are composed of an N-terminal domain of variable length, a central Src...
SOCS2 negatively regulates growth hormone action in vitro and in vivo
Greenhalgh, Christopher J., Rico-Bautista, Elizabeth, Lorentzon, Mattias, Thaus, Anne L., Morgan, Phillip O., Willson, Tracy A., ...
Mice deficient in SOCS2 display an excessive growth phenotype characterized by a 30–50% increase in mature body size. Here we show that the SOCS2–/– phenotype is dependent upon the presence of...
Nicholson, Sandra E., Metcalf, Donald, Sprigg, Naomi S., Columbus, Ruth, Walker, Francesca, Silva, Anabel, ...
The suppressors of cytokine signaling (SOCS) proteins are a family of SH2 domain-containing intracellular inhibitors of cytokine signal transduction that act by several different mechanisms. Recent...
Burgess, Antony W., Metcalf, Donald, Russell, Sue H. M., Nicola, Nicos A.
The formation of mature haemopoietic cells is controlled by hormones that specifically stimulate the progenitor cells of the granulocyte/macrophage, eosinophil, megakaryocyte and erythroid pathways....
Fairlie, W Douglas, De Souza, David, Nicola, Nicos A, Baca, Manuel
Cytokines of the interleukin-6 family utilize the shared cytokine receptor gp130 in the formation of active signalling complexes. Tyrosine-757 (Y757) on this receptor is critical for negative...
Majewski, Ian J., Metcalf, Donald, Mielke, Lisa A., Krebs, Danielle L., Ellis, Sarah, Carpinelli, Marina R., ...
We have generated mice from a N-ethyl-N-nitrosourea mutagenesis screen that carry a mutation in the translation initiation codon of Gata-1, termed Plt13, which is equivalent to mutations found in...
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene
Alexander, Warren S., Viney, Elizabeth M., Zhang, Jian-Guo, Metcalf, Donald, Kauppi, Maria, Hyland, Craig D., ...
An N-ethyl-N-nitrosourea mutagenesis screen in mice was performed to isolate regulators of circulating platelet number. We report here recessive thrombocytopenia and kidney disease in plt1 mice,...
Agm1/Pgm3-Mediated Sugar Nucleotide Synthesis Is Essential for Hematopoiesis and Development▿
Greig, Kylie T., Antonchuk, Jennifer, Metcalf, Donald, Morgan, Phillip O., Krebs, Danielle L., Zhang, Jian-Guo, ...
Carbohydrate modification of proteins includes N-linked and O-linked glycosylation, proteoglycan formation, glycosylphosphatidylinositol anchor synthesis, and O-GlcNAc modification. Each of these...
Huyton, Trevor, Zhang, Jian-Guo, Luo, Cindy S., Lou, Mei-Zhen, Hilton, Douglas J., Nicola, Nicos A., ...
Leukemia inhibitory factor (LIF) receptor is a cell surface receptor that mediates the actions of LIF and other IL-6 type cytokines through the formation of high-affinity signaling complexes with...
Dynamics of the SPRY domain–containing SOCS box protein 2: Flexibility of key functional loops
Yao, Shenggen, Liu, Ming S., Masters, Seth L., Zhang, Jian-Guo, Babon, Jeffrey J., Nicola, Nicos A., ...
The SPRY domain was identified originally as a sequence repeat in the dual-specificity kinase splA and ryanodine receptors and subsequently found in many other distinct proteins, including more than...
White, Christine A., Zhang, Jian-Guo, Salamonsen, Lois A., Baca, Manuel, Fairlie, W. Douglas, Metcalf, Donald, ...
Blastocyst implantation is a critical stage in the establishment of pregnancy. Leukemia inhibitory factor (LIF) is essential for mouse blastocyst implantation and also plays a role in human...
Boyle, Kristy, Egan, Paul, Rakar, Steven, Willson, Tracy A., Wicks, Ian P., Metcalf, Donald, ...
Suppressor of cytokine signaling 3 (SOCS3) is a negative regulator of granulocyte-colony stimulating factor (G-CSF) signaling in vivo. SOCS proteins regulate cytokine signaling by binding, via their...
Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl−/− mice
Kauppi, Maria, Murphy, James M., De Graaf, Carolyn A., Hyland, Craig D., Greig, Kylie T., Metcalf, Donald, ...
In an N-nitroso-N-ethylurea (ENU) mutagenesis screen using Mpl−/− mice, we isolated a semidominant suppressor of thrombocytopenia, termed Plt6. The gene mutated in Plt6 mice encodes the...